Department of Microbiology and Immunology,
Michael Smith Laboratories Centre for High-Throughput Biology,
Department of Microbiology and Immunology, Michael Smith Laboratories Centre for High-Throughput Biology
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A two-hybrid system for transactivator bait proteins.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2001 | Pubmed ID: 11447261
Isolation and identification of L-dopa decarboxylase as a protein that binds to and enhances transcriptional activity of the androgen receptor using the repressed transactivator yeast two-hybrid system.
The Biochemical journal Oct, 2003 | Pubmed ID: 12864730
Novel avian influenza H7N3 strain outbreak, British Columbia.
Emerging infectious diseases Dec, 2004 | Pubmed ID: 15663859
A mouse atlas of gene expression: large-scale digital gene-expression profiles from precisely defined developing C57BL/6J mouse tissues and cells.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2005 | Pubmed ID: 16352711
Transcriptome analysis for Caenorhabditis elegans based on novel expressed sequence tags.
BMC biology Jul, 2008 | Pubmed ID: 18611272
In-depth characterization of the microRNA transcriptome in a leukemia progression model.
Genome research Nov, 2008 | Pubmed ID: 18849523
ELT-2 is the predominant transcription factor controlling differentiation and function of the C. elegans intestine, from embryo to adult.
Developmental biology Mar, 2009 | Pubmed ID: 19111532
De novo genome sequence assembly of a filamentous fungus using Sanger, 454 and Illumina sequence data.
Genome biology , 2009 | Pubmed ID: 19747388
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.
Nature genetics Feb, 2010 | Pubmed ID: 20081860
SNVMix: predicting single nucleotide variants from next-generation sequencing of tumors.
Bioinformatics (Oxford, England) Mar, 2010 | Pubmed ID: 20130035
Digital gene expression by tag sequencing on the illumina genome analyzer.
Current protocols in human genetics Apr, 2010 | Pubmed ID: 20373513
Whole-genome profiling of mutagenesis in Caenorhabditis elegans.
Genetics Jun, 2010 | Pubmed ID: 20439774
Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver.
Genome research Aug, 2010 | Pubmed ID: 20551221
System-level analysis of neuroblastoma tumor-initiating cells implicates AURKB as a novel drug target for neuroblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research Sep, 2010 | Pubmed ID: 20651058
ARID1A mutations in endometriosis-associated ovarian carcinomas.
The New England journal of medicine Oct, 2010 | Pubmed ID: 20942669
Genome and transcriptome analyses of the mountain pine beetle-fungal symbiont Grosmannia clavigera, a lodgepole pine pathogen.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2011 | Pubmed ID: 21262841
Next generation sequencing based approaches to epigenomics.
Briefings in functional genomics Dec, 2010 | Pubmed ID: 21266347
DNA methylation and SETDB1/H3K9me3 regulate predominantly distinct sets of genes, retroelements, and chimeric transcripts in mESCs.
Cell stem cell Jun, 2011 | Pubmed ID: 21624812
deFuse: an algorithm for gene fusion discovery in tumor RNA-Seq data.
PLoS computational biology May, 2011 | Pubmed ID: 21625565
Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex.
Cancer cell Jul, 2011 | Pubmed ID: 21741595
Using next-generation sequencing for the diagnosis of rare disorders: a family with retinitis pigmentosa and skeletal abnormalities.
The Journal of pathology Sep, 2011 | Pubmed ID: 21792934
Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma.
Nature Aug, 2011 | Pubmed ID: 21796119
Retrotransposon-induced heterochromatin spreading in the mouse revealed by insertional polymorphisms.
PLoS genetics Sep, 2011 | Pubmed ID: 21980304
Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers.
The Journal of pathology Jan, 2012 | Pubmed ID: 22072542
Feature-based classifiers for somatic mutation detection in tumour-normal paired sequencing data.
Bioinformatics (Oxford, England) Jan, 2012 | Pubmed ID: 22084253
Next generation sequencing of prostate cancer from a patient identifies a deficiency of methylthioadenosine phosphorylase, an exploitable tumor target.
Molecular cancer therapeutics Mar, 2012 | Pubmed ID: 22252602
JointSNVMix: a probabilistic model for accurate detection of somatic mutations in normal/tumour paired next-generation sequencing data.
Bioinformatics (Oxford, England) Apr, 2012 | Pubmed ID: 22285562
Integrated genome and transcriptome sequencing identifies a novel form of hybrid and aggressive prostate cancer.
The Journal of pathology May, 2012 | Pubmed ID: 22294438
The clonal and mutational evolution spectrum of primary triple-negative breast cancers.
Nature Apr, 2012 | Pubmed ID: 22495314
Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer.
Genome research Oct, 2012 | Pubmed ID: 22637570
Use of mutation profiles to refine the classification of endometrial carcinomas.
The Journal of pathology Sep, 2012 | Pubmed ID: 22653804
Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia.
Cancer cell Aug, 2012 | Pubmed ID: 22897847
Mutation discovery in regions of segmental cancer genome amplifications with CoNAn-SNV: a mixture model for next generation sequencing of tumors.
PloS one , 2012 | Pubmed ID: 22916110
Spark: a navigational paradigm for genomic data exploration.
Genome research Nov, 2012 | Pubmed ID: 22960372
DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution.
Nature methods Nov, 2012 | Pubmed ID: 23042453
The genetic landscape of high-risk neuroblastoma.
Nature genetics Mar, 2013 | Pubmed ID: 23334666
Epigenomics: sequencing the methylome.
Methods in molecular biology (Clifton, N.J.) , 2013 | Pubmed ID: 23412782
DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape.
Nature genetics Jul, 2013 | Pubmed ID: 23708189
Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm.
Genome research Jun, 2013 | Pubmed ID: 23804400
Estimating absolute methylation levels at single CpG resolution from methylation enrichment and restriction enzyme sequencing methods.
Genome research Jun, 2013 | Pubmed ID: 23804401
Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells.
Nature Aug, 2013 | Pubmed ID: 23812591
Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice.
Blood Oct, 2013 | Pubmed ID: 24030380
A clinically validated diagnostic second-generation sequencing assay for detection of hereditary BRCA1 and BRCA2 mutations.
The Journal of molecular diagnostics : JMD Nov, 2013 | Pubmed ID: 24094589
Complete Bordetella avium, Bordetella hinzii and Bordetella trematum lipid A structures and genomic sequence analyses of the loci involved in their modifications.
Innate immunity Aug, 2014 | Pubmed ID: 24127384
Regulatory variation: an emerging vantage point for cancer biology.
Wiley interdisciplinary reviews. Systems biology and medicine Jan-Feb, 2014 | Pubmed ID: 24254976
Clonal analysis via barcoding reveals diverse growth and differentiation of transplanted mouse and human mammary stem cells.
Cell stem cell Feb, 2014 | Pubmed ID: 24440600
Draft Genome Sequences of Six Rhodobacter capsulatus Strains, YW1, YW2, B6, Y262, R121, and DE442.
Genome announcements Feb, 2014 | Pubmed ID: 24526637
A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis.
Blood Jun, 2014 | Pubmed ID: 24802772
Regulatory network decoded from epigenomes of surface ectoderm-derived cell types.
Nature communications Nov, 2014 | Pubmed ID: 25421844
Loss of the Notch effector RBPJ promotes tumorigenesis.
The Journal of experimental medicine Jan, 2015 | Pubmed ID: 25512468
DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts.
Nature communications Dec, 2014 | Pubmed ID: 25532760
Epigenetic and transcriptional determinants of the human breast.
Nature communications Feb, 2015 | Pubmed ID: 25690954
Intermediate DNA methylation is a conserved signature of genome regulation.
Nature communications , 2015 | Pubmed ID: 25691127
Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden.
The Journal of pathology Jun, 2015 | Pubmed ID: 25692284
Integrative analysis of 111 reference human epigenomes.
Nature Feb, 2015 | Pubmed ID: 25693563
Epigenome data release: a participant-centered approach to privacy protection.
Genome biology Jul, 2015 | Pubmed ID: 26185018
MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation.
Nature communications Aug, 2015 | Pubmed ID: 26245647
Barcoding reveals complex clonal dynamics of de novo transformed human mammary cells.
Nature Dec, 2015 | Pubmed ID: 26633636
The genomic and transcriptomic landscape of anaplastic thyroid cancer: implications for therapy.
BMC cancer Dec, 2015 | Pubmed ID: 26680454
Genome-Wide Profiles of Extra-cranial Malignant Rhabdoid Tumors Reveal Heterogeneity and Dysregulated Developmental Pathways.
Cancer cell Mar, 2016 | Pubmed ID: 26977886
Putative BRAF activating fusion in a medullary thyroid cancer.
Cold Spring Harbor molecular case studies Mar, 2016 | Pubmed ID: 27148585
Robust high-performance nanoliter-volume single-cell multiple displacement amplification on planar substrates.
Proceedings of the National Academy of Sciences of the United States of America 07, 2016 | Pubmed ID: 27412862
Analysis of Normal Human Mammary Epigenomes Reveals Cell-Specific Active Enhancer States and Associated Transcription Factor Networks.
Cell reports Nov, 2016 | Pubmed ID: 27851968
Nucleosome Density ChIP-Seq Identifies Distinct Chromatin Modification Signatures Associated with MNase Accessibility.
Cell reports Nov, 2016 | Pubmed ID: 27851972
The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery.
Cell Nov, 2016 | Pubmed ID: 27863232
SnapShot: Epigenomic Assays.
Cell Nov, 2016 | Pubmed ID: 27863253
Atrophin controls developmental signaling pathways via interactions with Trithorax-like.
eLife Mar, 2017 | Pubmed ID: 28327288
Draft Genome Sequence of the Pelagic Photoferrotroph Chlorobium phaeoferrooxidans.
Genome announcements Mar, 2017 | Pubmed ID: 28360175
Automated high throughput nucleic acid purification from formalin-fixed paraffin-embedded tissue samples for next generation sequence analysis.
PloS one , 2017 | Pubmed ID: 28570594
Whole-genome analysis reveals unexpected dynamics of mutant subclone development in a patient with JAK2-V617F-positive chronic myeloid leukemia.
Experimental hematology Sep, 2017 | Pubmed ID: 28602946
Increasing quality, throughput and speed of sample preparation for strand-specific messenger RNA sequencing.
BMC genomics Jul, 2017 | Pubmed ID: 28679365
Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b.
Epigenetics & chromatin , 2017 | Pubmed ID: 28706564
Characterization of the human thyroid epigenome.
The Journal of endocrinology Nov, 2017 | Pubmed ID: 28808080
The [PSI +] yeast prion does not wildly affect proteome composition whereas selective pressure exerted on [PSI +] cells can promote aneuploidy.
Scientific reports Aug, 2017 | Pubmed ID: 28814753
Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy.
Nature Sep, 2017 | Pubmed ID: 28854171
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