Martin Hirst

A two-hybrid system for transactivator bait proteins.

Isolation and identification of L-dopa decarboxylase as a protein that binds to and enhances transcriptional activity of the androgen receptor using the repressed transactivator yeast two-hybrid system.

Novel avian influenza H7N3 strain outbreak, British Columbia.

A mouse atlas of gene expression: large-scale digital gene-expression profiles from precisely defined developing C57BL/6J mouse tissues and cells.

Transcriptome analysis for Caenorhabditis elegans based on novel expressed sequence tags.

In-depth characterization of the microRNA transcriptome in a leukemia progression model.

ELT-2 is the predominant transcription factor controlling differentiation and function of the C. elegans intestine, from embryo to adult.

De novo genome sequence assembly of a filamentous fungus using Sanger, 454 and Illumina sequence data.

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.

SNVMix: predicting single nucleotide variants from next-generation sequencing of tumors.

Digital gene expression by tag sequencing on the illumina genome analyzer.

Whole-genome profiling of mutagenesis in Caenorhabditis elegans.

Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver.

System-level analysis of neuroblastoma tumor-initiating cells implicates AURKB as a novel drug target for neuroblastoma.

ARID1A mutations in endometriosis-associated ovarian carcinomas.

Genome and transcriptome analyses of the mountain pine beetle-fungal symbiont Grosmannia clavigera, a lodgepole pine pathogen.

Next generation sequencing based approaches to epigenomics.

DNA methylation and SETDB1/H3K9me3 regulate predominantly distinct sets of genes, retroelements, and chimeric transcripts in mESCs.

deFuse: an algorithm for gene fusion discovery in tumor RNA-Seq data.

Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex.

Using next-generation sequencing for the diagnosis of rare disorders: a family with retinitis pigmentosa and skeletal abnormalities.

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma.

Retrotransposon-induced heterochromatin spreading in the mouse revealed by insertional polymorphisms.

Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers.

Feature-based classifiers for somatic mutation detection in tumour-normal paired sequencing data.

Next generation sequencing of prostate cancer from a patient identifies a deficiency of methylthioadenosine phosphorylase, an exploitable tumor target.

JointSNVMix: a probabilistic model for accurate detection of somatic mutations in normal/tumour paired next-generation sequencing data.

Integrated genome and transcriptome sequencing identifies a novel form of hybrid and aggressive prostate cancer.

The clonal and mutational evolution spectrum of primary triple-negative breast cancers.

Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer.

Use of mutation profiles to refine the classification of endometrial carcinomas.

Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia.

Mutation discovery in regions of segmental cancer genome amplifications with CoNAn-SNV: a mixture model for next generation sequencing of tumors.

Spark: a navigational paradigm for genomic data exploration.

DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution.

The genetic landscape of high-risk neuroblastoma.

Epigenomics: sequencing the methylome.

DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape.

Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm.

Estimating absolute methylation levels at single CpG resolution from methylation enrichment and restriction enzyme sequencing methods.

Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells.

Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice.

A clinically validated diagnostic second-generation sequencing assay for detection of hereditary BRCA1 and BRCA2 mutations.

Complete Bordetella avium, Bordetella hinzii and Bordetella trematum lipid A structures and genomic sequence analyses of the loci involved in their modifications.

Regulatory variation: an emerging vantage point for cancer biology.

Clonal analysis via barcoding reveals diverse growth and differentiation of transplanted mouse and human mammary stem cells.

Draft Genome Sequences of Six Rhodobacter capsulatus Strains, YW1, YW2, B6, Y262, R121, and DE442.

A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis.

Regulatory network decoded from epigenomes of surface ectoderm-derived cell types.

Loss of the Notch effector RBPJ promotes tumorigenesis.

DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts.

Epigenetic and transcriptional determinants of the human breast.

Intermediate DNA methylation is a conserved signature of genome regulation.

Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden.

Integrative analysis of 111 reference human epigenomes.

Epigenome data release: a participant-centered approach to privacy protection.

MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation.

Barcoding reveals complex clonal dynamics of de novo transformed human mammary cells.

The genomic and transcriptomic landscape of anaplastic thyroid cancer: implications for therapy.

Genome-Wide Profiles of Extra-cranial Malignant Rhabdoid Tumors Reveal Heterogeneity and Dysregulated Developmental Pathways.

Putative BRAF activating fusion in a medullary thyroid cancer.

Robust high-performance nanoliter-volume single-cell multiple displacement amplification on planar substrates.

Analysis of Normal Human Mammary Epigenomes Reveals Cell-Specific Active Enhancer States and Associated Transcription Factor Networks.

Nucleosome Density ChIP-Seq Identifies Distinct Chromatin Modification Signatures Associated with MNase Accessibility.

The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery.

SnapShot: Epigenomic Assays.

Atrophin controls developmental signaling pathways via interactions with Trithorax-like.

Draft Genome Sequence of the Pelagic Photoferrotroph Chlorobium phaeoferrooxidans.

Automated high throughput nucleic acid purification from formalin-fixed paraffin-embedded tissue samples for next generation sequence analysis.

Whole-genome analysis reveals unexpected dynamics of mutant subclone development in a patient with JAK2-V617F-positive chronic myeloid leukemia.

Increasing quality, throughput and speed of sample preparation for strand-specific messenger RNA sequencing.

Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b.

Characterization of the human thyroid epigenome.

The [PSI +] yeast prion does not wildly affect proteome composition whereas selective pressure exerted on [PSI +] cells can promote aneuploidy.

Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy.