Dirk Schmidt-Arras

Functional significance of novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) for human myeloma cell growth and survival.

Flt3 receptor tyrosine kinase as a drug target in leukemia.

Design and biological evaluation of linear and cyclic phosphopeptide ligands of the N-terminal SH2 domain of protein tyrosine phosphatase SHP-1.

Cellular inhibition of protein tyrosine phosphatase 1B by uncharged thioxothiazolidinone derivatives.

Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality.

Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability.

The pro- and anti-inflammatory properties of the cytokine interleukin-6.

Adaptation of a 2D in-gel kinase assay to trace phosphotransferase activities in the human pathogen Leishmania donovani.

Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10.

The crystal structure of the MAP kinase LmaMPK10 from Leishmania major reveals parasite-specific features and regulatory mechanisms.

Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease.

gp130 activation is regulated by D2-D3 interdomain connectivity.

Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17.

Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells.

Oncogenic deletion mutants of gp130 signal from intracellular compartments.

Polo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor α ectodomain shedding.

Transgenic analysis of the Leishmania MAP kinase MPK10 reveals an auto-inhibitory mechanism crucial for stage-regulated activity and parasite viability.

IL-6 pathway in the liver: From physiopathology to therapy.

A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis.

Tetraspanin 8 is an interactor of the metalloprotease meprin β within tetraspanin-enriched microdomains.

Tetraspanin 8 is an interactor of the metalloprotease meprin β within tetraspanin-enriched microdomains.

Constitutive gp130 activation rapidly accelerates the transformation of human hepatocytes via an impaired oxidative stress response.

IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice.

Synergistic killing of FLT3ITD-positive AML cells by combined inhibition of tyrosine-kinase activity and N-glycosylation.

Microbiomarkers in inflammatory bowel diseases: caveats come with caviar.

A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis.