John K. Olynyk

A population-based study of the biochemical and clinical expression of the H63D hemochromatosis mutation.

Liver biopsy in the 21st century: where and why?

Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse.

Iron and the response to treatment of hepatitis C.

Flexible sigmoidoscopy screening for colorectal neoplasia in average-risk people: evaluation of a five-year rescreening interval.

Aldehydic products of lipid peroxidation do not directly activate rat hepatic stellate cells.

Effects of body iron stores and haemochromatosis genotypes on coronary heart disease outcomes in the Busselton health study.

Oval cell-mediated liver regeneration: Role of cytokines and growth factors.

Iron overload in blacks: ironing out the issues.

Cost-effectiveness of colorectal cancer screening: comparison of community-based flexible sigmoidoscopy with fecal occult blood testing and colonoscopy.

Differential effects of gadolinium chloride on Kupffer cells in vivo and in vitro.

Screening for hemochromatosis: patients with liver disease, families, and populations.

Evolution of untreated hereditary hemochromatosis in the Busselton population: a 17-year study.

Screening sigmoidoscopy for colorectal cancer: further pieces in the jigsaw.

Kupffer cell cytokines interleukin-1beta and interleukin-10 combine to inhibit phosphoenolpyruvate carboxykinase and gluconeogenesis in cultured hepatocytes.

Nontransferrin-bound iron uptake by hepatocytes is increased in the Hfe knockout mouse model of hereditary hemochromatosis.

Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers.

Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance.

CD14-positive hepatic monocytes/macrophages increase in hereditary hemochromatosis.

Duration of hepatic iron exposure increases the risk of significant fibrosis in hereditary hemochromatosis: a new role for magnetic resonance imaging.

Is HFE involved in increased hepcidin expression and hypoferremia in inflammation and anemia of chronic disease?

Oncostatin M induces an acute phase response but does not modulate the growth or maturation-status of liver progenitor (oval) cells in culture.

Iron overload.

Hepatic expression of the tumor necrosis factor family member lymphotoxin-beta is regulated by interleukin (IL)-6 and IL-1beta: transcriptional control mechanisms in oval cells and hepatoma cell lines.

Inhibition of adult liver progenitor (oval) cell growth and viability by an agonist of the peroxisome proliferator activated receptor (PPAR) family member gamma, but not alpha or delta.

Hereditary haemochromatosis: to screen or not to screen?

Liver inflammation and cytokine production, but not acute phase protein synthesis, accompany the adult liver progenitor (oval) cell response to chronic liver injury.

Effects of HFE gene mutations and alcohol on iron status, liver biochemistry and morbidity.

Jekyll and Hyde: evolving perspectives on the function and potential of the adult liver progenitor (oval) cell.

Lymphotoxin-beta production following bile duct ligation: possible role for Kupffer cells.

Limited iron export by hepatocytes contributes to hepatic iron-loading in the Hfe knockout mouse.

Screening for HFE and iron overload.

Hepatic oval cell response to the choline-deficient, ethionine supplemented model of murine liver injury is attenuated by the administration of a cyclo-oxygenase 2 inhibitor.

Antiproliferative effects of interferon alpha on hepatic progenitor cells in vitro and in vivo.

Population-based study of the relationship between mutations in the hemochromatosis (HFE) gene and arthritis.

Differential findings for CD14-positive hepatic monocytes/macrophages in primary biliary cirrhosis, chronic hepatitis C and nonalcoholic steatohepatitis.

Normal iron metabolism and the pathophysiology of iron overload disorders.

Evaluation of the "Cellscreen" system for proliferation studies on liver progenitor cells.

Attenuated liver progenitor (oval) cell and fibrogenic responses to the choline deficient, ethionine supplemented diet in the BALB/c inbred strain of mice.

Waiting times for colonoscopy and colorectal cancer diagnosis.

Isolation, culture and immortalisation of hepatic oval cells from adult mice fed a choline-deficient, ethionine-supplemented diet.

Liver iron transport.

Outcomes after 10 years of a community-based flexible sigmoidoscopy screening program for colorectal carcinoma.

Clinical expression of hemochromatosis gene (HFE) variants.

Interferon-gamma exacerbates liver damage, the hepatic progenitor cell response and fibrosis in a mouse model of chronic liver injury.

The regulation of cellular iron metabolism.

Transferrin receptor 2 mediates uptake of transferrin-bound and non-transferrin-bound iron.

HCV, iron, and oxidative stress: the new choreography of hepcidin.

Iron-overload-related disease in HFE hereditary hemochromatosis.

The role of Hfe in transferrin-bound iron uptake by hepatocytes.

Noncitrus fruits as novel dietary environmental modifiers of iron stores in people with or without HFE gene mutations.

Body mass index is a stronger predictor of alanine aminotransaminase levels than alcohol consumption.

Prevalence, characteristics, and prognostic significance of HFE gene mutations in type 2 diabetes: the Fremantle Diabetes Study.

C-kit inhibition by imatinib mesylate attenuates progenitor cell expansion and inhibits liver tumor formation in mice.

Clinical perspectives on hereditary hemochromatosis.

Hereditary hemochromatosis in the post-HFE era.

The natural history of serum iron indices for HFE C282Y homozygosity associated with hereditary hemochromatosis.

Predicting iron overload in hyperferritinemia.

Lymphotoxin-beta receptor signaling regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury.

Haemochromatosis HFE gene polymorphisms as potential modifiers of hereditary nonpolyposis colorectal cancer risk and onset age.

NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: an eleven-year follow-up study.

Making sense of differing bowel cancer screening guidelines.

Screening for coeliac disease using anti-tissue transglutaminase antibody assays, and prevalence of the disease in an Australian community.

Serum alanine aminotransferase, metabolic syndrome, and cardiovascular disease in an Australian population.

HFE C282Y/H63D compound heterozygotes are at low risk of hemochromatosis-related morbidity.

A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis.

The role of transferrin receptor 1 and 2 in transferrin-bound iron uptake in human hepatoma cells.

Human liver progenitor cell lines are readily established from non-tumorous tissue adjacent to hepatocellular carcinoma.

Mutations in the HFE gene and cardiovascular disease risk: an individual patient data meta-analysis of 53 880 subjects.

HFE C282Y homozygotes are at increased risk of breast and colorectal cancer.

Relationship between brain R(2) and liver and serum iron concentrations in elderly men.

Iron uptake from plasma transferrin by a transferrin receptor 2 mutant mouse model of haemochromatosis.

Iron: an emerging factor in colorectal carcinogenesis.

PAHA model: an alternative non-invasive predictor of liver cirrhosis in patients with chronic hepatitis B infection.

A cross-sectional community study of serum iron measures and cognitive status in older adults.

Phenotypic expression of hereditary hemochromatosis: what have we learned from the population studies?

Pentoxifylline improves haemoglobin and interleukin-6 levels in chronic kidney disease.

Tumor necrosis factor-like weak inducer of apoptosis is a mitogen for liver progenitor cells.

HFE Cys282Tyr homozygotes with serum ferritin concentrations below 1000 microg/L are at low risk of hemochromatosis.

Hepatic iron loading in mice increases cholesterol biosynthesis.

Serum iron markers are inadequate for guiding iron repletion in chronic kidney disease.

Diagnosis and management of iron deficiency anaemia: a clinical update.

Clinical penetrance of C282Y homozygous HFE hemochromatosis.

Gender-specific differences in adipose distribution and adipocytokines influence adolescent nonalcoholic fatty liver disease.

Liver and serum iron: discrete regulators of hepatic hepcidin expression.

Natural history and management of HFE-hemochromatosis.

Significant association between thyroid hormones and erythrocyte indices in euthyroid subjects.

A comparison of self-reported and record-linked blood donation history in an Australian cohort.

Screening for hereditary haemochromatosis.

Brain transcriptome perturbations in the Hfe(-/-) mouse model of genetic iron loading.

Disruption of hemochromatosis protein and transferrin receptor 2 causes iron-induced liver injury in mice.

Cholesteryl ester transfer protein gene polymorphisms increase the risk of fatty liver in females independent of adiposity.

Changes in brain transcripts related to Alzheimer's disease in a model of HFE hemochromatosis are not consistent with increased Alzheimer's disease risk.

Long-term mortality risks associated with mild anaemia in older persons: the Busselton Health Study.

Assessing iron overload: are we there yet?

Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease.

Pharmacokinetics and safety of deferasirox in subjects with chronic kidney disease undergoing haemodialysis.

The Western dietary pattern is prospectively associated with nonalcoholic fatty liver disease in adolescence.

Diagnostic performance of a rapid magnetic resonance imaging method of measuring hepatic steatosis.

Importance of cardiometabolic risk factors in the association between nonalcoholic fatty liver disease and arterial stiffness in adolescents.

Iron and hepatic carcinogenesis.

Factors that affect serum levels of ferritin in Australian adults and implications for follow-up.

Role of TWEAK in coregulating liver progenitor cell and fibrogenic responses.

Dietary iron enhances colonic inflammation and IL-6/IL-11-Stat3 signaling promoting colonic tumor development in mice.

Lower fructose intake may help protect against development of nonalcoholic fatty liver in adolescents with obesity.

Texture-based classification of liver fibrosis using MRI.

TWEAK and LTβ Signaling during Chronic Liver Disease.

Low serum 25-hydroxyvitamin D concentrations associate with non-alcoholic fatty liver disease in adolescents independent of adiposity.

Higher ferritin levels, but not serum iron or transferrin saturation, are associated with Type 2 diabetes mellitus in adult men and women free of genetic haemochromatosis.

Childhood adiposity trajectories and risk of nonalcoholic fatty liver disease in adolescents.

Analysis of the intrahepatic ductular reaction and progenitor cell responses in hepatitis C virus recurrence after liver transplantation.

Natural history of HFE simple heterozygosity for C282Y and H63D: a prospective 12-year study.

The impact of phlebotomy in nonalcoholic fatty liver disease: A prospective, randomized, controlled trial.

Authors' response.

Reduced mortality due to phlebotomy in moderately iron-loaded HFE haemochromatosis? The need for clinical trials.

Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration.

Reply: To PMID 25524401.

Should HFE p.C282Y homozygotes with moderately elevated serum ferritin be treated? A randomised controlled trial comparing iron reduction with sham treatment (Mi-iron).

Adverse metabolic phenotype of adolescent girls with non-alcoholic fatty liver disease plus polycystic ovary syndrome compared with other girls and boys.

The role of liver progenitor cells during liver regeneration, fibrogenesis, and carcinogenesis.

Red blood cell transfusion is associated with further bleeding and fresh-frozen plasma with mortality in nonvariceal upper gastrointestinal bleeding.

Characterization of hepatic and cardiac iron deposition during standard treatment of anaemia in haemodialysis.

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics.

Association between serum hepcidin-25 and primary resistance to erythropoiesis-stimulating agents in chronic kidney disease: a secondary analysis of the HERO trial.

Divergent Inflammatory, Fibrogenic, and Liver Progenitor Cell Dynamics in Two Common Mouse Models of Chronic Liver Injury.

Identification of a thalidomide derivative that selectively targets tumorigenic liver progenitor cells and comparing its effects with lenalidomide and sorafenib.

Higher concentrations of serum iron and transferrin saturation but not serum ferritin are associated with cancer outcomes.

Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases.

Stereological Analysis of Liver Biopsy Histology Sections as a Reference Standard for Validating Non-Invasive Liver Fat Fraction Measurements by MRI.

Evaluation of Different Normalization and Analysis Procedures for Illumina Gene Expression Microarray Data Involving Small Changes.

Dysregulated Erythropoietin, Hepcidin, and Bone Marrow Iron Metabolism Contribute to Interferon-Induced Anemia in Hepatitis C.

Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicentre randomized blinded trial : A randomized trial of IV iron in critical illness.

HFE p.C282Y homozygosity predisposes to rapid serum ferritin rise after menopause: A genotype-stratified cohort study of hemochromatosis in Australian women.

Diagnosing and preventing iron overload.

Infant nutrition and maternal obesity influence the risk of non-alcoholic fatty liver disease in adolescents.

Association of Transferrin Saturation With the Arthropathy of Hereditary Hemochromatosis.

Gender differences between parental pregnancy characteristics and nonalcoholic fatty liver disease in adolescents.

Taurocholate induces biliary differentiation of liver progenitor cells causing hepatic stellate cell chemotaxis in the Ductular Reaction: Role in pediatric cystic fibrosis liver disease.

Reduction of body iron in HFE-related haemochromatosis and moderate iron overload (Mi-Iron): a multicentre, participant-blinded, randomised controlled trial.

A prospective cohort examination of haematological parameters in relation to cancer death and incidence: the Busselton Health Study.