Mingyao Liu

Latner Thoracic Surgery Research Laboratories, University Health Network

Affiliated withUniversity Health Network University of Toronto University Health Network

Research Area

MedicineUnit 1UnitBioengineering

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title	2017
Publication title	2019
Publication title	2023

Other Publications

Article	Year
Evaluation of the inhibition potential of plumbagin against cytochrome P450 using LC-MS/MS and cocktail approach. Scientific reports\| PubMed ID: 27329697	2016
Differential proteomic analysis of bronchoalveolar lavage fluid from lung transplant patients with and without chronic graft dysfunction. Clinical biochemistry\| PubMed ID: 22206736	2012
Caffeic acid 3,4-dihydroxy-phenethyl ester suppresses receptor activator of NF-κB ligand–induced osteoclastogenesis and prevents ovariectomy-induced bone loss through inhibition of mitogen-a... Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 22337253	2012
Comparative study of regulatory T cells expanded ex vivo from cord blood and adult peripheral blood. Immunology\| PubMed ID: 22348606	2012
Src tyrosine kinase inhibition prevents pulmonary ischemia-reperfusion-induced acute lung injury. Intensive care medicine\| PubMed ID: 22349424	2012
Synthesis and biological evaluation of heterocyclic ring-fused betulinic acid derivatives as novel inhibitors of osteoclast differentiation and bone resorption. Journal of medicinal chemistry\| PubMed ID: 22435650	2012
Pulmonary bacterial communities in surgically resected noncystic fibrosis bronchiectasis lungs are similar to those in cystic fibrosis. Pulmonary medicine\| PubMed ID: 22448327	2012
Ex vivo adenoviral vector gene delivery results in decreased vector-associated inflammation pre- and post-lung transplantation in the pig. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22453765	2012
Molecular binding of self-assembling peptide EAK16-II with anticancer agent EPT and its implication in cancer cell inhibition. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 22465389	2012
Usnic acid inhibits breast tumor angiogenesis and growth by suppressing VEGFR2-mediated AKT and ERK1/2 signaling pathways. Angiogenesis\| PubMed ID: 22669534	2012
Claudin 1 mediates TNFα-induced gene expression and cell migration in human lung carcinoma cells. PloS one\| PubMed ID: 22675434	2012
KiSS1 and its G-protein-coupled receptor GPR54 in cancer development and metastasis. Cancer metastasis reviews\| PubMed ID: 22692479	2012
Knowledge translation: airway epithelial cell migration and respiratory diseases. Cellular and molecular life sciences : CMLS\| PubMed ID: 22718093	2012
Protective effects of long pentraxin PTX3 on lung injury in a severe acute respiratory syndrome model in mice. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 22732935	2012
MEK/ERK pathway mediates PKC activation-induced recruitment of PKCζ and MMP-9 to podosomes. Journal of cellular physiology\| PubMed ID: 22740332	2013
XB130 as an independent prognostic factor in human esophageal squamous cell carcinoma. Annals of surgical oncology\| PubMed ID: 22805860	2013
Cucurbitacin E inhibits breast tumor metastasis by suppressing cell migration and invasion. Breast cancer research and treatment\| PubMed ID: 22842972	2012
XB130 mediates cancer cell proliferation and survival through multiple signaling events downstream of Akt. PloS one\| PubMed ID: 22928011	2012
Physiologic assessment of the ex vivo donor lung for transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 22975103	2012
Therapeutic effects of inhaling aerosolized surfactant alone or with dexamethasone generated by a novel noninvasive apparatus on acute lung injury in rats. The journal of trauma and acute care surgery\| PubMed ID: 22976417	2012
Norcantharidin facilitates LPS-mediated immune responses by up-regulation of AKT/NF-κB signaling in macrophages. PloS one\| PubMed ID: 22984593	2012
Microarray meta-analysis identifies acute lung injury biomarkers in donor lungs that predict development of primary graft failure in recipients. PloS one\| PubMed ID: 23071521	2012
Atypical protein kinase C in cell motility. Cellular and molecular life sciences : CMLS\| PubMed ID: 23096778	2013
MiR-93 enhances angiogenesis and metastasis by targeting LATS2. Cell cycle (Georgetown, Tex.)\| PubMed ID: 23111389	2012
Inhibition of breast cancer metastases by a novel inhibitor of TGFβ receptor 1. Journal of the National Cancer Institute\| PubMed ID: 23178439	2013
A natural small molecule harmine inhibits angiogenesis and suppresses tumour growth through activation of p53 in endothelial cells. PloS one\| PubMed ID: 23300602	2012
Rejection of tracheal allograft by intrapulmonary lymphoid neogenesis in the absence of secondary lymphoid organs. Transplantation\| PubMed ID: 23318304	2012
Aqp5 is a new transcriptional target of Dot1a and a regulator of Aqp2. PloS one\| PubMed ID: 23326416	2013
Lgr4 gene deficiency increases susceptibility and severity of dextran sodium sulfate-induced inflammatory bowel disease in mice. The Journal of biological chemistry\| PubMed ID: 23393138	2013
FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation. Cell research\| PubMed ID: 23507969	2013
XB130, a new adaptor protein, regulates expression of tumor suppressive microRNAs in cancer cells. PloS one\| PubMed ID: 23527086	2013
Lgr4-mediated Wnt/β-catenin signaling in peritubular myoid cells is essential for spermatogenesis. Development (Cambridge, England)\| PubMed ID: 23533175	2013
Lgr4/Gpr48 negatively regulates TLR2/4-associated pattern recognition and innate immunity by targeting CD14 expression. The Journal of biological chemistry\| PubMed ID: 23589304	2013
High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases. Nucleic acids research\| PubMed ID: 23630316	2013
PKC activation induces inflammatory response and cell death in human bronchial epithelial cells. PloS one\| PubMed ID: 23691166	2013
Lgr4 Regulates Mammary Gland Development and Stem Cell Activity through the Pluripotency Transcription Factor Sox2. Stem cells (Dayton, Ohio)\| PubMed ID: 23712846	2013
Lgr4 in ocular development and glaucoma. Journal of ophthalmology\| PubMed ID: 23840940	2013
Lgr4 is a key regulator of prostate development and prostate stem cell differentiation. Stem cells (Dayton, Ohio)\| PubMed ID: 23897697	2013
Heritable gene targeting in the mouse and rat using a CRISPR-Cas system. Nature biotechnology\| PubMed ID: 23929336	2013
GPR116, an adhesion G-protein-coupled receptor, promotes breast cancer metastasis via the Gαq-p63RhoGEF-Rho GTPase pathway. Cancer research\| PubMed ID: 24008316	2013
Zebrafish cancer and metastasis models for in vivo drug discovery. Drug discovery today. Technologies\| PubMed ID: 24050234	2013
Efficient gene delivery to pig airway epithelia and submucosal glands using helper-dependent adenoviral vectors. Molecular therapy. Nucleic acids\| PubMed ID: 24104599	2013
Inhibitory effects of celastrol on rat liver cytochrome P450 1A2, 2C11, 2D6, 2E1 and 3A2 activity. Fitoterapia\| PubMed ID: 24144799	2014
Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch. Nature cell biology\| PubMed ID: 24212090	2013
Solid phase microextraction fills the gap in tissue sampling protocols. Analytica chimica acta\| PubMed ID: 24216199	2013
Evaluating the pharmacological mechanism of Chinese medicine Si-Wu-Tang through multi-level data integration. PloS one\| PubMed ID: 24223693	2013
Modified in vivo lung perfusion allows for prolonged perfusion without acute lung injury. The Journal of thoracic and cardiovascular surgery\| PubMed ID: 24290703	2014
LGR4 acts as a link between the peripheral circadian clock and lipid metabolism in liver. Journal of molecular endocrinology\| PubMed ID: 24353284	2014
Biological effects of Tat cell-penetrating peptide: a multifunctional Trojan horse? Nanomedicine (London, England)\| PubMed ID: 24354809	2014
α1-Antitrypsin inhibits ischemia reperfusion-induced lung injury by reducing inflammatory response and cell death. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 24365768	2014
Chimeric anti-IL-17 full-length monoclonal antibody is a novel potential candidate for the treatment of rheumatoid arthritis. International journal of molecular medicine\| PubMed ID: 24378614	2014
Synthesis and biological evaluation of novel tetrahydro-β-carboline derivatives as antitumor growth and metastasis agents through inhibiting the transforming growth factor-β signaling pathwa... Journal of medicinal chemistry\| PubMed ID: 24417479	2014
Protein kinase C mediates enterohemorrhagic Escherichia coli O157:H7-induced attaching and effacing lesions. Infection and immunity\| PubMed ID: 24491575	2014
LGR4/GPR48 inactivation leads to aniridia-genitourinary anomalies-mental retardation syndrome defects. The Journal of biological chemistry\| PubMed ID: 24519938	2014
Metabolomic heterogeneity of pulmonary arterial hypertension. PloS one\| PubMed ID: 24533144	2014
PKA turnover by the REGγ-proteasome modulates FoxO1 cellular activity and VEGF-induced angiogenesis. Journal of molecular and cellular cardiology\| PubMed ID: 24560667	2014
Soluble platelet-endothelial cell adhesion molecule-1, a biomarker of ventilator-induced lung injury. Critical care (London, England)\| PubMed ID: 24588994	2014
Gpr48 deficiency induces polycystic kidney lesions and renal fibrosis in mice by activating Wnt signal pathway. PloS one\| PubMed ID: 24595031	2014
Low invasive in vivo tissue sampling for monitoring biomarkers and drugs during surgery. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 24687119	2014
Optimization of 2-(3-(arylalkyl amino carbonyl) phenyl)-3-(2-methoxyphenyl)-4-thiazolidinone derivatives as potent antitumor growth and metastasis agents. European journal of medicinal chemistry\| PubMed ID: 24794770	2014
Structure of the human P2Y₁₂ receptor in complex with an antithrombotic drug. Science China. Life sciences\| PubMed ID: 24801571	2014
History and current status of evidence-based korean medicine. Evidence-based complementary and alternative medicine : eCAM\| PubMed ID: 24839452	2014
Lgr4 gene regulates corpus luteum maturation through modulation of the WNT-mediated EGFR-ERK signaling pathway. Endocrinology\| PubMed ID: 24877628	2014
Measurement error of surface-mounted fiber Bragg grating temperature sensor. The Review of scientific instruments\| PubMed ID: 24985840	2014
XB130-A Novel Adaptor Protein: Gene, Function, and Roles in Tumorigenesis. Scientifica\| PubMed ID: 24995146	2014
A note on CYP2J2-mediated terfenadine hydroxylation in human liver microsomes. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association\| PubMed ID: 24997310	2014
Lgr4 protein deficiency induces ataxia-like phenotype in mice and impairs long term depression at cerebellar parallel fiber-Purkinje cell synapses. The Journal of biological chemistry\| PubMed ID: 25063812	2014
Enhancement of the pharmacological efficacy of FGF-21 by genetic modification and PEGylation. Current pharmaceutical biotechnology\| PubMed ID: 25106652	2013
Total synthesis and biological studies of cryptocin and derivatives of equisetin and fusarisetin A. Organic & biomolecular chemistry\| PubMed ID: 25139438	2014
GPR126 protein regulates developmental and pathological angiogenesis through modulation of VEGFR2 receptor signaling. The Journal of biological chemistry\| PubMed ID: 25217645	2014
Antitumor action of a novel histone deacetylase inhibitor, YF479, in breast cancer. Neoplasia (New York, N.Y.)\| PubMed ID: 25220594	2014
Toll-like receptor-triggered calcium mobilization protects mice against bacterial infection through extracellular ATP release. Infection and immunity\| PubMed ID: 25245808	2014
Effects of cucurbitacin e, a tetracyclic triterpene compound from Cucurbitaceae, on the pharmacokinetics and pharmacodynamics of warfarin in rats. Basic & clinical pharmacology & toxicology\| PubMed ID: 25250504	2015
CRISPR/Cas-mediated genome editing in the rat via direct injection of one-cell embryos. Nature protocols\| PubMed ID: 25255092	2014
Extracellular UDP and P2Y6 function as a danger signal to protect mice from vesicular stomatitis virus infection through an increase in IFN-β production. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25261483	2014
XB130 deficiency affects tracheal epithelial differentiation during airway repair. PloS one\| PubMed ID: 25272040	2014
Small molecule 1'-acetoxychavicol acetate suppresses breast tumor metastasis by regulating the SHP-1/STAT3/MMPs signaling pathway. Breast cancer research and treatment\| PubMed ID: 25301089	2014
A novel synthetic small molecule YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. Journal of cellular and molecular medicine\| PubMed ID: 25351103	2015
The antiparasitic drug, potassium antimony tartrate, inhibits tumor angiogenesis and tumor growth in nonsmall-cell lung cancer. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 25352499	2015
Design and optimization of novel hydroxamate-based histone deacetylase inhibitors of Bis-substituted aromatic amides bearing potent activities against tumor growth and metastasis. Journal of medicinal chemistry\| PubMed ID: 25360834	2014
Protein expression profiling predicts graft performance in clinical ex vivo lung perfusion. Annals of surgery\| PubMed ID: 25371129	2015
De novo synthesize of bile acids in pulmonary arterial hypertension lung. Metabolomics : Official journal of the Metabolomic Society\| PubMed ID: 25374487	2014
PubAngioGen: a database and knowledge for angiogenesis and related diseases. Nucleic acids research\| PubMed ID: 25392416	2015
Generation of site-specific mutations in the rat genome via CRISPR/Cas9. Methods in enzymology\| PubMed ID: 25398346	2014
Inhibition of tumor growth by polyarginine-fused mutant cytosine deaminase. Applied biochemistry and biotechnology\| PubMed ID: 25416477	2015
New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors. Annals of the New York Academy of Sciences\| PubMed ID: 25424900	2014
Development of a validated LC-MS/MS method for the determination of ailanthone in rat plasma with application to pharmacokinetic study. Journal of pharmaceutical and biomedical analysis\| PubMed ID: 25433911	2015
Evaluation of enzyme inhibition kinetics in drug-drug interactions. Chemico-biological interactions\| PubMed ID: 25451570	2014
Long-acting hypoglycemic effects of PEGylated FGF21 and insulin glargine in mice with type 1 diabetes. Journal of diabetes and its complications\| PubMed ID: 25456819	2015
Crystal structure of LGR4-Rspo1 complex: insights into the divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors (LGRs). The Journal of biological chemistry\| PubMed ID: 25480784	2015
Oridonin inhibits tumor growth and metastasis through anti-angiogenesis by blocking the Notch signaling. PloS one\| PubMed ID: 25485753	2014
Claudin 1 mediates tumor necrosis factor alpha-induced cell migration in human gastric cancer cells. World journal of gastroenterology\| PubMed ID: 25548484	2014
PKCδ-iPLA2-PGE2-PPARγ signaling cascade mediates TNF-α induced Claudin 1 expression in human lung carcinoma cells. Cellular signalling\| PubMed ID: 25562426	2015
Investigation of cytochrome P450 inhibitory properties of maslinic acid, a bioactive compound from Olea europaea L., and its structure-activity relationship. Phytomedicine : international journal of phytotherapy and phytopharmacology\| PubMed ID: 25636872	2015
Chemokine receptors and their therapeutic opportunities in diseased lung: far beyond leukocyte trafficking. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 25637606	2015
Targeted deletion of the murine Lgr4 gene decreases lens epithelial cell resistance to oxidative stress and induces age-related cataract formation. PloS one\| PubMed ID: 25811370	2015
Inhibition of breast cancer progression by a novel histone deacetylase inhibitor, LW479, by down-regulating EGFR expression. British journal of pharmacology\| PubMed ID: 25884486	2015
Design and optimization of hybrid of 2,4-diaminopyrimidine and arylthiazole scaffold as anticancer cell proliferation and migration agents. European journal of medicinal chemistry\| PubMed ID: 25899332	2015
The role of the endothelin-1 pathway as a biomarker for donor lung assessment in clinical ex vivo lung perfusion. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 25907141	2015
Lycorine is a novel inhibitor of the growth and metastasis of hormone-refractory prostate cancer. Oncotarget\| PubMed ID: 25915156	2015
TAT cell-penetrating peptide modulates inflammatory response and apoptosis in human lung epithelial cells. Drug delivery and translational research\| PubMed ID: 25916485	2015
The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation. Molecular cell\| PubMed ID: 25936802	2015
Mechanical Stress and the Induction of Lung Fibrosis via the Midkine Signaling Pathway. American journal of respiratory and critical care medicine\| PubMed ID: 25945397	2015
5-Fluoruracil blocked giant cell tumor progression by suppressing osteoclastogenesis through NF-kappaB signals and blocking angiogenesis. Bone\| PubMed ID: 25956534	2015
XB130 translocation to microfilamentous structures mediates NNK-induced migration of human bronchial epithelial cells. Oncotarget\| PubMed ID: 25980441	2015
Long-Term Administration of Fibroblast Growth Factor 21 Prevents Chemically-Induced Hepatocarcinogenesis in Mice. Digestive diseases and sciences\| PubMed ID: 26003555	2015
Repression of Mammalian Target of Rapamycin Complex 1 Inhibits Intestinal Regeneration in Acute Inflammatory Bowel Disease Models. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 26026060	2015
Phenotypic diversity within a Pseudomonas aeruginosa population infecting an adult with cystic fibrosis. Scientific reports\| PubMed ID: 26047320	2015
Amino Acid-Dependent Attenuation of Toll-like Receptor Signaling by Peptide-Gold Nanoparticle Hybrids. ACS nano\| PubMed ID: 26083966	2015
In vivo selection for spine-derived highly metastatic lung cancer cells is associated with increased migration, inflammation and decreased adhesion. Oncotarget\| PubMed ID: 26090868	2015
Effective delivery of a rationally designed intracellular peptide drug with gold nanoparticle-peptide hybrids. Nanoscale\| PubMed ID: 26151444	2015
A Novel TGR5 Activator WB403 Promotes GLP-1 Secretion and Preserves Pancreatic β-Cells in Type 2 Diabetic Mice. PloS one\| PubMed ID: 26208278	2015
Extension of donor lung preservation with hypothermic storage after normothermic ex vivo lung perfusion. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 26227444	2016
Chromosome Condensation 1-Like (Chc1L) Is a Novel Tumor Suppressor Involved in Development of Histiocyte-Rich Neoplasms. PloS one\| PubMed ID: 26291700	2015
Altered Profile of Circulating Endothelial-Derived Microparticles in Ventilator-Induced Lung Injury. Critical care medicine\| PubMed ID: 26308427	2015
Low-dose computed tomography volumetry for subtyping chronic lung allograft dysfunction. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 26342441	2016
In vitro and in vivo evaluation of cucurbitacin E on rat hepatic CYP2C11 expression and activity using LC-MS/MS. Science China. Life sciences\| PubMed ID: 26354504	2017
XB130 promotes bronchioalveolar stem cell and Club cell proliferation in airway epithelial repair and regeneration. Oncotarget\| PubMed ID: 26360608	2015
LG308, a Novel Synthetic Compound with Antimicrotubule Activity in Prostate Cancer Cells, Exerts Effective Antitumor Activity. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 26377911	2015
A Fiber Bragg Grating Sensing Based Triaxial Vibration Sensor. Sensors (Basel, Switzerland)\| PubMed ID: 26393616	2015
XB130/Tks5 scaffold protein interaction regulates Src-mediated cell proliferation and survival. Molecular biology of the cell\| PubMed ID: 26446840	2015
The greedy nature of mutant RAS: a boon for drug discovery targeting cancer metabolism? Acta biochimica et biophysica Sinica\| PubMed ID: 26487443	2016
Hierarchically micro-patterned nanofibrous scaffolds with a nanosized bio-glass surface for accelerating wound healing. Nanoscale\| PubMed ID: 26503372	2015
Using the inherent chemistry of the endothelin-1 peptide to develop a rapid assay for pre-transplant donor lung assessment. The Analyst\| PubMed ID: 26548776	2015
Fibroblast growth factor 21 attenuates hepatic fibrogenesis through TGF-β/smad2/3 and NF-κB signaling pathways. Toxicology and applied pharmacology\| PubMed ID: 26592322	2016
Design, synthesis and anticancer activities of novel otobain derivatives. Organic & biomolecular chemistry\| PubMed ID: 26593226	2016
Fractal circuit sensors enable rapid quantification of biomarkers for donor lung assessment for transplantation. Science advances\| PubMed ID: 26601233	2015
Insulin sensitizes FGF21 in glucose and lipid metabolisms via activating common AKT pathway. Endocrine\| PubMed ID: 26607153	2016
Inhibition of Osteoclastogenesis and Bone Resorption in vitro and in vivo by a prenylflavonoid xanthohumol from hops. Scientific reports\| PubMed ID: 26620037	2015
Large genomic fragment deletion and functional gene cassette knock-in via Cas9 protein mediated genome editing in one-cell rodent embryos. Scientific reports\| PubMed ID: 26620761	2015
Meet Our Associate Editor. Current molecular medicine\| PubMed ID: 26634985	2015
Annexin V homodimer protects against ischemia reperfusion-induced acute lung injury in lung transplantation. The Journal of thoracic and cardiovascular surgery\| PubMed ID: 26725713	2016
A hybrid of thiazolidinone with the hydroxamate scaffold for developing novel histone deacetylase inhibitors with antitumor activities. Organic & biomolecular chemistry\| PubMed ID: 26732459	2016
TLR-Activated Gap Junction Channels Protect Mice against Bacterial Infection through Extracellular UDP Release. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 26783339	2016
Halofuginone treatment reduces interleukin-17A and ameliorates features of chronic lung allograft dysfunction in a mouse orthotopic lung transplant model. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 26787621	2016
Circulating Cell Death Biomarkers May Predict Survival in Human Lung Transplantation. American journal of respiratory and critical care medicine\| PubMed ID: 26796350	2016
Bortezomib Inhibits Giant Cell Tumor of Bone through Induction of Cell Apoptosis and Inhibition of Osteoclast Recruitment, Giant Cell Formation, and Bone Resorption. Molecular cancer therapeutics\| PubMed ID: 26861247	2016
New insights into the androgen biotransformation in prostate cancer: A regulatory network among androgen, androgen receptors and UGTs. Pharmacological research\| PubMed ID: 26926093	2016
Characterization of novel cytochrome P450 2E1 knockout rat model generated by CRISPR/Cas9. Biochemical pharmacology\| PubMed ID: 26947455	2016
Modified In Vivo Lung Perfusion for Local Chemotherapy: A Preclinical Study With Doxorubicin. The Annals of thoracic surgery\| PubMed ID: 26952295	2016
CRISPR/Cas9-mediated somatic correction of a novel coagulator factor IX gene mutation ameliorates hemophilia in mouse. EMBO molecular medicine\| PubMed ID: 26964564	2016
Preparation of copper-containing bioactive glass/eggshell membrane nanocomposites for improving angiogenesis, antibacterial activity and wound healing. Acta biomaterialia\| PubMed ID: 26965395	2016
XB130 deficiency enhances lipopolysaccharide-induced septic response and acute lung injury. Oncotarget\| PubMed ID: 27029000	2016
β-Lapachone Induces NAD(P)H:Quinone Oxidoreductase-1- and Oxidative Stress-Dependent Heat Shock Protein 90 Cleavage and Inhibits Tumor Growth and Angiogenesis. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 27048660	2016
Measurement of Rhodamine 123 in Three-Dimensional Organoids: A Novel Model for P-Glycoprotein Inhibitor Screening. Basic & clinical pharmacology & toxicology\| PubMed ID: 27060462	2016
LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption. Nature medicine\| PubMed ID: 27064449	2016
Gpr97 is dispensable for metabolic syndrome but is involved in macrophage inflammation in high-fat diet-induced obesity in mice. Scientific reports\| PubMed ID: 27089991	2016
Human α1-antitrypsin improves early post-transplant lung function: Pre-clinical studies in a pig lung transplant model. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 27095003	2016
Importance of left atrial pressure during ex vivo lung perfusion. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 27160496	2016
Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK. Nature communications\| PubMed ID: 27193833	2016
Generation of obese rat model by transcription activator-like effector nucleases targeting the leptin receptor gene. Science China. Life sciences\| PubMed ID: 27225180	2017
Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors. The Journal of biological chemistry\| PubMed ID: 27226600	2016
Ccndbp1 is a new positive regulator of skeletal myogenesis. Journal of cell science\| PubMed ID: 27235421	2016
Inhibiting cytoplasmic accumulation of HuR synergizes genotoxic agents in urothelial carcinoma of the bladder. Oncotarget\| PubMed ID: 27303922	2016
Linifanib (ABT-869) Potentiates the Efficacy of Chemotherapeutic Agents through the Suppression of Receptor Tyrosine Kinase-Mediated AKT/mTOR Signaling Pathways in Gastric Cancer. Scientific reports\| PubMed ID: 27387652	2016
Mesenchymal stem cell treatment is associated with decreased perfusate concentration of interleukin-8 during ex vivo perfusion of donor lungs after 18-hour preservation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 27444694	2016
Defeat mutant KRAS with synthetic lethality. Small GTPases\| PubMed ID: 27463838	2016
Identification of Genes Involved in Breast Cancer Metastasis by Integrating Protein-Protein Interaction Information with Expression Data. Journal of computational biology : a journal of computational molecular cell biology\| PubMed ID: 27508455	2017
Efficient liver repopulation of transplanted hepatocyte prevents cirrhosis in a rat model of hereditary tyrosinemia type I. Scientific reports\| PubMed ID: 27510266	2016
Formulation of hydrophobic therapeutics with self-assembling peptide and amino acid: A new platform for intravenous drug delivery. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 27586187	2016
A Novel Model of P-Glycoprotein Inhibitor Screening Using Human Small Intestinal Organoids. Basic & clinical pharmacology & toxicology\| PubMed ID: 27657920	2017
A Self-restricted CRISPR System to Reduce Off-target Effects. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 27687135	2016
Lgr4 is crucial for skin carcinogenesis by regulating MEK/ERK and Wnt/β-catenin signaling pathways. Cancer letters\| PubMed ID: 27693558	2016
Effects of Melanocortin 3 and 4 Receptor Deficiency on Energy Homeostasis in Rats. Scientific reports\| PubMed ID: 27713523	2016
3D printing of biomaterials with mussel-inspired nanostructures for tumor therapy and tissue regeneration. Biomaterials\| PubMed ID: 27728813	2016
Endosomal pH modulation by peptide-gold nanoparticle hybrids enables potent anti-inflammatory activity in phagocytic immune cells. Biomaterials\| PubMed ID: 27728817	2016
A combination therapy for KRAS-mutant lung cancer by targeting synthetic lethal partners of mutant KRAS. Chinese journal of cancer\| PubMed ID: 27793187	2016
Stimulus-dependent dissociation between XB130 and Tks5 scaffold proteins promotes airway epithelial cell migration. Oncotarget\| PubMed ID: 27835612	2016
Design and Fabrication of a Dual-Photoelectrode Fuel Cell towards Cost-Effective Electricity Production from Biomass. ChemSusChem\| PubMed ID: 27860457	2017
Extracellular ADP facilitates monocyte recruitment in bacterial infection via ERK signaling. Cellular & molecular immunology\| PubMed ID: 27867196	2016
Prevention of Muscle Wasting by CRISPR/Cas9-mediated Disruption of Myostatin In Vivo. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 27916995	2016
Heritable expansion of the genetic code in mouse and zebrafish. Cell research\| PubMed ID: 27934867	2017
Proteome-Scale Investigation of Protein Allosteric Regulation Perturbed by Somatic Mutations in 7,000 Cancer Genomes. American journal of human genetics\| PubMed ID: 27939638	2017
Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer. Nature communications\| PubMed ID: 27959342	2016
A betulinic acid derivative SH479 inhibits collagen-induced arthritis by modulating T cell differentiation and cytokine balance. Biochemical pharmacology\| PubMed ID: 27965071	2017
Lung Lavage and Surfactant Replacement During Ex Vivo Lung Perfusion for Treatment of Gastric Acid Aspiration-Induced Donor Lung Injury. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 28041954	2017
Safety and Efficacy of Ex Vivo Donor Lung Adenoviral IL-10 Gene Therapy in a Large Animal Lung Transplant Survival Model. Human gene therapy\| PubMed ID: 28052693	2017
Exploration and analysis of drug modes of action through feature integration. Molecular bioSystems\| PubMed ID: 28092388	2017
Sevoflurane Attenuates Ischemia-Reperfusion Injury in a Rat Lung Transplantation Model. The Annals of thoracic surgery\| PubMed ID: 28190546	2017
A novel synthetic small molecule YF-452 inhibits tumor growth through antiangiogenesis by suppressing VEGF receptor 2 signaling. Science China. Life sciences\| PubMed ID: 28194552	2017
SH479, a Betulinic Acid Derivative, Ameliorates Experimental Autoimmune Encephalomyelitis by Regulating the T Helper 17/Regulatory T Cell Balance. Molecular pharmacology\| PubMed ID: 28213589	2017
Ten years of achievements in biological and medical sciences. Science China. Life sciences\| PubMed ID: 28215028	2017
CRISPR knockout rat cytochrome P450 3A1/2 model for advancing drug metabolism and pharmacokinetics research. Scientific reports\| PubMed ID: 28218310	2017
Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and... Journal of medicinal chemistry\| PubMed ID: 28218840	2017
Ailanthone: a new potential drug for castration-resistant prostate cancer. Chinese journal of cancer\| PubMed ID: 28257652	2017
Comprehensive assessment of Cucurbitacin E related hepatotoxicity and drug-drug interactions involving CYP3A and P-glycoprotein. Phytomedicine : international journal of phytotherapy and phytopharmacology\| PubMed ID: 28257659	2017
Synthesis of heterocyclic ring-fused tricyclic diterpene analogs as novel inhibitors of RANKL-induced osteoclastogenesis and bone resorption. European journal of medicinal chemistry\| PubMed ID: 28288319	2017
Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress. International journal of cancer\| PubMed ID: 28316092	2017
Novel hemostatic agents based on gelatin-microbial transglutaminase mix. Science China. Life sciences\| PubMed ID: 28321657	2017
Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis. eLife\| PubMed ID: 28440748	2017
Elimination of GPR146-mediated antiviral function through IRF3/HES1-signalling pathway. Immunology\| PubMed ID: 28464285	2017
CRISPR/Cas9 system: a powerful technology for in vivo and ex vivo gene therapy. Science China. Life sciences\| PubMed ID: 28534255	2017
Virus-Triggered ATP Release Limits Viral Replication through Facilitating IFN-β Production in a P2X7-Dependent Manner. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 28687662	2017
Higher M30 and high mobility group box 1 protein levels in ex vivo lung perfusate are associated with primary graft dysfunction after human lung transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 28689646	2017
A conducive bioceramic/polymer composite biomaterial for diabetic wound healing. Acta biomaterialia\| PubMed ID: 28713016	2017
Cytochrome P450 3A selectively affects the pharmacokinetic interaction between erlotinib and docetaxel in rats. Biochemical pharmacology\| PubMed ID: 28716728	2017
Inhibition of histone deacetylases sensitizes EGF receptor-TK inhibitor-resistant non-small-cell lung cancer cells to erlotinib in vitro and in vivo. British journal of pharmacology\| PubMed ID: 28749535	2017
Leucine-rich repeat-containing G protein coupled receptor 4 (Lgr4) is necessary for prostate cancer metastasis via epithelial-mesenchymal transition. The Journal of biological chemistry\| PubMed ID: 28768769	2017
Leucine-rich repeat-containing G protein-coupled receptor 4 facilitates vesicular stomatitis virus infection by binding vesicular stomatitis virus glycoprotein. The Journal of biological chemistry\| PubMed ID: 28842478	2017
Donor bronchial wash bile acid and suitability of donor lungs for transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 28888765	2017
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Transcriptomic investigation reveals donor-specific gene signatures in human lung transplants. The European respiratory journal\| PubMed ID: 33122335	2021
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Proteomics, brain death, and organ transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 35016814	2022
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Evaluation of 10°C as the optimal storage temperature for aspiration-injured donor lungs in a large animal transplant model. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 36216693	2022
Determining the impact of ex-vivo lung perfusion on hospital costs for lung transplantation: A retrospective cohort study. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 36411188	2023
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Defining and targeting tumor-associated macrophages in malignant mesothelioma. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 36821580	2023
Alpha-1-antitrypsin safely promotes rapid recovery of pigs after lung transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 37004914	2023
Evaluating the Impact of Ex Vivo Lung Perfusion on Organ Transplantation: A Retrospective Cohort Study. Annals of surgery\| PubMed ID: 37073734	2023
Immunomodulation of the donor lung with CRISPR-mediated activation of IL-10 expression. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 37315746	2023
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A cell-free tissue-engineered tracheal substitute with sequential cytokine release maintained airway opening in a rabbit tracheal full circumferential defect model. Biomaterials\| PubMed ID: 37352607	2023
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Time to extubation for lung transplant recipients represents a pragmatic end-point to guide the development of prognostic tests. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 37406839	2023
Identification of regional variation in gene expression and inflammatory proteins in donor lung tissue and ex vivo lung perfusate. The Journal of thoracic and cardiovascular surgery\| PubMed ID: 37482240	2023
A machine-learning approach to human ex vivo lung perfusion predicts transplantation outcomes and promotes organ utilization. Nature communications\| PubMed ID: 37558674	2023
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Donor IL-17 receptor A regulates LPS-potentiated acute and chronic murine lung allograft rejection. JCI insight\| PubMed ID: 37937643	2023