Gene Editing Institute,
Helen F. Graham Cancer Center and Research Institute,
Gene Editing Institute, Helen F. Graham Cancer Center and Research Institute
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Targeted gene repair and its application to neurodegenerative disorders.
Neuron Feb, 2002 | Pubmed ID: 11856524
Strand bias in targeted gene repair is influenced by transcriptional activity.
Molecular and cellular biology Jun, 2002 | Pubmed ID: 11997519
The 'biased' evolution of targeted gene repair.
Current opinion in molecular therapeutics Apr, 2002 | Pubmed ID: 12044039
Rad51p and Rad54p, but not Rad52p, elevate gene repair in Saccharomyces cerevisiae directed by modified single-stranded oligonucleotide vectors.
Nucleic acids research Jul, 2002 | Pubmed ID: 12087156
Targeted nucleotide exchange in Saccharomyces cerevisiae directed by short oligonucleotides containing locked nucleic acids.
Chemistry & biology Oct, 2002 | Pubmed ID: 12401492
Nucleotide replacement at two sites can be directed by modified single-stranded oligonucleotides in vitro and in vivo.
Biomolecular engineering Jan, 2003 | Pubmed ID: 12485680
DNA pairing is an important step in the process of targeted nucleotide exchange.
Nucleic acids research Feb, 2003 | Pubmed ID: 12560486
Efficiency of chimeraplast gene targeting by direct nuclear injection using a GFP recovery assay.
Molecular therapy : the journal of the American Society of Gene Therapy Feb, 2003 | Pubmed ID: 12597913
The synaptic complex of RecA protein participates in hybridization and inverse strand exchange reactions.
Biochemistry Mar, 2003 | Pubmed ID: 12614159
Targeted nucleotide repair of cyc1 mutations in Saccharomyces cerevisiae directed by modified single-stranded DNA oligonucleotides.
Genetics Feb, 2003 | Pubmed ID: 12618392
The development and regulation of gene repair.
Nature reviews. Genetics Sep, 2003 | Pubmed ID: 12951569
Targeted gene repair -- in the arena.
The Journal of clinical investigation Sep, 2003 | Pubmed ID: 12952907
Targeted nucleotide exchange in the CAG repeat region of the human HD gene.
Biochemical and biophysical research communications Oct, 2003 | Pubmed ID: 14521962
Nuclease activity of Saccharomyces cerevisiae Mre11 functions in targeted nucleotide alteration.
Applied and environmental microbiology Oct, 2003 | Pubmed ID: 14532083
Reduction of Htt inclusion formation in strains of Saccharomyces cerevisiae deficient in certain DNA repair functions: a statistical analysis of phenotype.
Experimental cell research Nov, 2003 | Pubmed ID: 14597407
Fluorescent detection and isolation of DNA variants using stabilized RecA-coated oligonucleotides.
Genome research Jan, 2004 | Pubmed ID: 14672976
The effect of hydroxyurea and trichostatin a on targeted nucleotide exchange in yeast and Mammalian cells.
Annals of the New York Academy of Sciences Dec, 2003 | Pubmed ID: 14751821
Enhancement of in vivo targeted nucleotide exchange by nonspecific carrier DNA.
Methods in molecular biology (Clifton, N.J.) , 2004 | Pubmed ID: 14769964
Genetic re-engineering of Saccharomyces cerevisiae RAD51 leads to a significant increase in the frequency of gene repair in vivo.
Nucleic acids research , 2004 | Pubmed ID: 15087488
DNA replication and transcription direct a DNA strand bias in the process of targeted gene repair in mammalian cells.
Journal of cell science Aug, 2004 | Pubmed ID: 15265980
Enhanced oligonucleotide-directed gene targeting in mammalian cells following treatment with DNA damaging agents.
Experimental cell research Oct, 2004 | Pubmed ID: 15383324
Modified single-stranded oligonucleotides inhibit aggregate formation and toxicity induced by expanded polyglutamine.
Journal of molecular neuroscience : MN , 2004 | Pubmed ID: 15456939
Camptothecin enhances the frequency of oligonucleotide-directed gene repair in mammalian cells by inducing DNA damage and activating homologous recombination.
Nucleic acids research , 2004 | Pubmed ID: 15466591
Double displacement loops (double d-loops) are templates for oligonucleotide-directed mutagenesis and gene repair.
Oligonucleotides , 2004 | Pubmed ID: 15665595
Gene repair in mammalian cells is stimulated by the elongation of S phase and transient stalling of replication forks.
DNA repair Apr, 2005 | Pubmed ID: 15725625
Reaction parameters of targeted gene repair in mammalian cells.
Molecular biotechnology Mar, 2005 | Pubmed ID: 15767697
A tolerance of DNA heterology in the mammalian targeted gene repair reaction.
Oligonucleotides , 2005 | Pubmed ID: 16201904
Targeted gene repair activates Chk1 and Chk2 and stalls replication in corrected cells.
DNA repair Apr, 2006 | Pubmed ID: 16414312
Multiple roles for MSH2 in the repair of a deletion mutation directed by modified single-stranded oligonucleotides.
Gene Jan, 2007 | Pubmed ID: 17113727
Reduction of gene repair by selenomethionine with the use of single-stranded oligonucleotides.
BMC molecular biology Jan, 2007 | Pubmed ID: 17257432
Manipulation of cell cycle progression can counteract the apparent loss of correction frequency following oligonucleotide-directed gene repair.
BMC molecular biology Feb, 2007 | Pubmed ID: 17284323
Recovery of cell cycle delay following targeted gene repair by oligonucleotides.
DNA repair Oct, 2007 | Pubmed ID: 17560837
Genetic conversion of an SMN2 gene to SMN1: a novel approach to the treatment of spinal muscular atrophy.
Experimental cell research Feb, 2008 | Pubmed ID: 18078930
G-rich oligonucleotides alter cell cycle progression and induce apoptosis specifically in OE19 esophageal tumor cells.
Oligonucleotides , 2008 | Pubmed ID: 18321162
DNA replication, cell cycle progression and the targeted gene repair reaction.
Cell cycle (Georgetown, Tex.) May, 2008 | Pubmed ID: 18424915
DNA breakage and induction of DNA damage response proteins precede the appearance of visible mutant huntingtin aggregates.
Journal of neuroscience research Feb, 2009 | Pubmed ID: 18831068
Regulation of targeted gene repair by intrinsic cellular processes.
BioEssays : news and reviews in molecular, cellular and developmental biology Feb, 2009 | Pubmed ID: 19204988
DNA breakage associated with targeted gene alteration directed by DNA oligonucleotides.
Mutation research Oct, 2009 | Pubmed ID: 19463835
A stable G-quartet binds to a huntingtin protein fragment containing expanded polyglutamine tracks.
Journal of neuroscience research Feb, 2010 | Pubmed ID: 19705452
Fluorescent detection and isolation of DNA variants using stabilized RecA-coated oligonucleotides.
Discovery medicine Apr, 2004 | Pubmed ID: 20705000
Gene editing activity on extrachromosomal arrays in C. elegans transgenics.
Gene Apr, 2011 | Pubmed ID: 21241788
Strand bias influences the mechanism of gene editing directed by single-stranded DNA oligonucleotides.
Nucleic acids research Jun, 2011 | Pubmed ID: 21343181
Modifications of p53 and the DNA damage response in cells expressing mutant form of the protein huntingtin.
Journal of molecular neuroscience : MN Oct, 2011 | Pubmed ID: 21465263
Oligonucleotide delivery by nucleofection does not rescue the reduced proliferation phenotype of gene-edited cells.
Nucleic acid therapeutics Dec, 2012 | Pubmed ID: 23072627
Proliferation of genetically modified human cells on electrospun nanofiber scaffolds.
Molecular therapy. Nucleic acids , 2012 | Pubmed ID: 23212298
DNA damage response pathway and replication fork stress during oligonucleotide directed gene editing.
Molecular therapy. Nucleic acids Apr, 2012 | Pubmed ID: 23343929
Electrospun fiber membranes enable proliferation of genetically modified cells.
International journal of nanomedicine , 2013 | Pubmed ID: 23467983
Combinatorial gene editing in mammalian cells using ssODNs and TALENs.
Scientific reports Jan, 2014 | Pubmed ID: 24445749
Enrichment of breast cancer stem-like cells by growth on electrospun polycaprolactone-chitosan nanofiber scaffolds.
International journal of nanomedicine , 2014 | Pubmed ID: 24570583
The position of DNA cleavage by TALENs and cell synchronization influences the frequency of gene editing directed by single-stranded oligonucleotides.
PloS one , 2014 | Pubmed ID: 24788536
Is the age of genetic surgery finally upon us?
Surgical oncology Jun, 2015 | Pubmed ID: 25936245
Regulation of Gene Editing Activity Directed by Single-Stranded Oligonucleotides and CRISPR/Cas9 Systems.
PloS one , 2015 | Pubmed ID: 26053390
Genetic spell-checking: gene editing using single-stranded DNA oligonucleotides.
Plant biotechnology journal Feb, 2016 | Pubmed ID: 26402400
Analyses of point mutation repair and allelic heterogeneity generated by CRISPR/Cas9 and single-stranded DNA oligonucleotides.
Scientific reports Sep, 2016 | Pubmed ID: 27609304
Insertional Mutagenesis by CRISPR/Cas9 Ribonucleoprotein Gene Editing in Cells Targeted for Point Mutation Repair Directed by Short Single-Stranded DNA Oligonucleotides.
PloS one , 2017 | Pubmed ID: 28052104
To cleave or not to cleave: therapeutic gene editing with and without programmable nucleases.
Nature reviews. Drug discovery Apr, 2017 | Pubmed ID: 28303022
CRISPR/Cas9-Directed Reassignment of the GATA1 Initiation Codon in K562 Cells to Recapitulate AML in Down Syndrome.
Molecular therapy. Nucleic acids Jun, 2017 | Pubmed ID: 28624204
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