Eric B. Kmiec

Targeted gene repair and its application to neurodegenerative disorders.

Strand bias in targeted gene repair is influenced by transcriptional activity.

The 'biased' evolution of targeted gene repair.

Rad51p and Rad54p, but not Rad52p, elevate gene repair in Saccharomyces cerevisiae directed by modified single-stranded oligonucleotide vectors.

Targeted nucleotide exchange in Saccharomyces cerevisiae directed by short oligonucleotides containing locked nucleic acids.

Nucleotide replacement at two sites can be directed by modified single-stranded oligonucleotides in vitro and in vivo.

DNA pairing is an important step in the process of targeted nucleotide exchange.

Efficiency of chimeraplast gene targeting by direct nuclear injection using a GFP recovery assay.

The synaptic complex of RecA protein participates in hybridization and inverse strand exchange reactions.

Targeted nucleotide repair of cyc1 mutations in Saccharomyces cerevisiae directed by modified single-stranded DNA oligonucleotides.

The development and regulation of gene repair.

Targeted gene repair -- in the arena.

Targeted nucleotide exchange in the CAG repeat region of the human HD gene.

Nuclease activity of Saccharomyces cerevisiae Mre11 functions in targeted nucleotide alteration.

Reduction of Htt inclusion formation in strains of Saccharomyces cerevisiae deficient in certain DNA repair functions: a statistical analysis of phenotype.

Fluorescent detection and isolation of DNA variants using stabilized RecA-coated oligonucleotides.

The effect of hydroxyurea and trichostatin a on targeted nucleotide exchange in yeast and Mammalian cells.

Enhancement of in vivo targeted nucleotide exchange by nonspecific carrier DNA.

Genetic re-engineering of Saccharomyces cerevisiae RAD51 leads to a significant increase in the frequency of gene repair in vivo.

DNA replication and transcription direct a DNA strand bias in the process of targeted gene repair in mammalian cells.

Enhanced oligonucleotide-directed gene targeting in mammalian cells following treatment with DNA damaging agents.

Modified single-stranded oligonucleotides inhibit aggregate formation and toxicity induced by expanded polyglutamine.

Camptothecin enhances the frequency of oligonucleotide-directed gene repair in mammalian cells by inducing DNA damage and activating homologous recombination.

Double displacement loops (double d-loops) are templates for oligonucleotide-directed mutagenesis and gene repair.

Gene repair in mammalian cells is stimulated by the elongation of S phase and transient stalling of replication forks.

Reaction parameters of targeted gene repair in mammalian cells.

A tolerance of DNA heterology in the mammalian targeted gene repair reaction.

Targeted gene repair activates Chk1 and Chk2 and stalls replication in corrected cells.

Multiple roles for MSH2 in the repair of a deletion mutation directed by modified single-stranded oligonucleotides.

Reduction of gene repair by selenomethionine with the use of single-stranded oligonucleotides.

Manipulation of cell cycle progression can counteract the apparent loss of correction frequency following oligonucleotide-directed gene repair.

Recovery of cell cycle delay following targeted gene repair by oligonucleotides.

Genetic conversion of an SMN2 gene to SMN1: a novel approach to the treatment of spinal muscular atrophy.

G-rich oligonucleotides alter cell cycle progression and induce apoptosis specifically in OE19 esophageal tumor cells.

DNA replication, cell cycle progression and the targeted gene repair reaction.

DNA breakage and induction of DNA damage response proteins precede the appearance of visible mutant huntingtin aggregates.

Regulation of targeted gene repair by intrinsic cellular processes.

DNA breakage associated with targeted gene alteration directed by DNA oligonucleotides.

A stable G-quartet binds to a huntingtin protein fragment containing expanded polyglutamine tracks.

Fluorescent detection and isolation of DNA variants using stabilized RecA-coated oligonucleotides.

Gene editing activity on extrachromosomal arrays in C. elegans transgenics.

Strand bias influences the mechanism of gene editing directed by single-stranded DNA oligonucleotides.

Modifications of p53 and the DNA damage response in cells expressing mutant form of the protein huntingtin.

Oligonucleotide delivery by nucleofection does not rescue the reduced proliferation phenotype of gene-edited cells.

Proliferation of genetically modified human cells on electrospun nanofiber scaffolds.

DNA damage response pathway and replication fork stress during oligonucleotide directed gene editing.

Electrospun fiber membranes enable proliferation of genetically modified cells.

Combinatorial gene editing in mammalian cells using ssODNs and TALENs.

Enrichment of breast cancer stem-like cells by growth on electrospun polycaprolactone-chitosan nanofiber scaffolds.

The position of DNA cleavage by TALENs and cell synchronization influences the frequency of gene editing directed by single-stranded oligonucleotides.

Is the age of genetic surgery finally upon us?

Regulation of Gene Editing Activity Directed by Single-Stranded Oligonucleotides and CRISPR/Cas9 Systems.

Genetic spell-checking: gene editing using single-stranded DNA oligonucleotides.

Analyses of point mutation repair and allelic heterogeneity generated by CRISPR/Cas9 and single-stranded DNA oligonucleotides.

Insertional Mutagenesis by CRISPR/Cas9 Ribonucleoprotein Gene Editing in Cells Targeted for Point Mutation Repair Directed by Short Single-Stranded DNA Oligonucleotides.

To cleave or not to cleave: therapeutic gene editing with and without programmable nucleases.

CRISPR/Cas9-Directed Reassignment of the GATA1 Initiation Codon in K562 Cells to Recapitulate AML in Down Syndrome.