Stephen R. Holdsworth

Department of Medicine, Monash University

Affiliated withMonash University Monash Health Monash Health

Research Area

Immunology and Infection

Biography

Stephen R. Holdsworth has not added Biography.
If you are Stephen R. Holdsworth and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

Article Total : 2	Year
Publication title	2017
Publication title	2020

Other Publications

Article	Year
The requirement for granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in leukocyte-mediated immune glomerular injury. Journal of the American Society of Nephrology : JASN\| PubMed ID: 11805162	2002
IFN-gamma production by intrinsic renal cells and bone marrow-derived cells is required for full expression of crescentic glomerulonephritis in mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 11937574	2002
Adaptive immunity to nontypeable Haemophilus influenzae. American journal of respiratory and critical care medicine\| PubMed ID: 12433671	2003
Laboratory assessment of immune function in renal transplant patients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 12686675	2003
Plasminogen activator inhibitor-1 is a significant determinant of renal injury in experimental crescentic glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 12761249	2003
T cells in glomerulonephritis. Springer seminars in immunopathology\| PubMed ID: 12778334	2003
Intrinsic renal cells are the major source of tumor necrosis factor contributing to renal injury in murine crescentic glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 12819238	2003
Intrinsic renal cell expression of CD40 directs Th1 effectors inducing experimental crescentic glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 14569091	2003
The role of flow cytometric ANCA detection in screening for acute pauci-immune crescentic glomerulonephritis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 14736960	2004
Contributions of IL-1beta and IL-1alpha to crescentic glomerulonephritis in mice. Journal of the American Society of Nephrology : JASN\| PubMed ID: 15034093	2004
Leukocyte-derived interleukin-1beta interacts with renal interleukin-1 receptor I to promote renal tumor necrosis factor and glomerular injury in murine crescentic glomerulonephritis. The American journal of pathology\| PubMed ID: 15161633	2004
Ex vivo lymphocyte proliferative function is severely inhibited in renal transplant patients on mycophenolate mofetil treatment. Transplant immunology\| PubMed ID: 15203129	2004
An IL-12-independent role for CD40-CD154 in mediating effector responses: studies in cell-mediated glomerulonephritis and dermal delayed-type hypersensitivity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15210767	2004
Experimental autoimmune anti-glomerular basement membrane glomerulonephritis: a protective role for IFN-gamma. Journal of the American Society of Nephrology : JASN\| PubMed ID: 15213264	2004
Fibrin independent proinflammatory effects of tissue factor in experimental crescentic glomerulonephritis. Kidney international\| PubMed ID: 15253718	2004
Endogenous IL-13 limits humoral responses and injury in experimental glomerulonephritis but does not regulate Th1 cell-mediated crescentic glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 15339986	2004
Experimental autoimmune Goodpasture's disease: a pathogenetic role for both effector cells and antibody in injury. Kidney international\| PubMed ID: 15673304	2005
IL-12p40 and IL-18 in crescentic glomerulonephritis: IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 promotes local inflammation and leukocyte recruitment. Journal of the American Society of Nephrology : JASN\| PubMed ID: 15888563	2005
Glomerular expression of CD80 and CD86 is required for leukocyte accumulation and injury in crescentic glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 15944341	2005
CD80 and CD86 costimulatory molecules regulate crescentic glomerulonephritis by different mechanisms. Kidney international\| PubMed ID: 16014035	2005
Leukocyte phenotype and function predicts infection risk in renal transplant recipients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 16030032	2005
Granulocyte macrophage colony-stimulating factor expression by both renal parenchymal and immune cells mediates murine crescentic glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 16033860	2005
A pathogenetic role for mast cells in experimental crescentic glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 16319187	2006
The isolation and purification of biologically active recombinant and native autoantigens for the study of autoimmune disease. Journal of immunological methods\| PubMed ID: 16388818	2006
Inducible co-stimulatory molecule ligand is protective during the induction and effector phases of crescentic glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 16540559	2006
T cells in crescentic glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 16624930	2006
Characterisation of the onset and presenting clinical features of adult bronchiectasis. Respiratory medicine\| PubMed ID: 16650970	2006
Anti-neutrophil cytoplasmic antibodies and effector CD4+ cells play nonredundant roles in anti-myeloperoxidase crescentic glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 16769746	2006
CD100 enhances dendritic cell and CD4+ cell activation leading to pathogenetic humoral responses and immune complex glomerulonephritis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16920982	2006
Outcome in adult bronchiectasis. COPD\| PubMed ID: 17136958	2005
Endogenous myeloperoxidase promotes neutrophil-mediated renal injury, but attenuates T cell immunity inducing crescentic glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 17267745	2007
Microbiologic follow-up study in adult bronchiectasis. Respiratory medicine\| PubMed ID: 17467966	2007
Cytokines in glomerulonephritis. Seminars in nephrology\| PubMed ID: 17533006	2007
Leukocytes in glomerular injury. Seminars in immunopathology\| PubMed ID: 17938927	2007
Intrarenal antigens activate CD4+ cells via co-stimulatory signals from dendritic cells. Journal of the American Society of Nephrology : JASN\| PubMed ID: 18184859	2008
Distinct in vivo roles of CD80 and CD86 in the effector T-cell responses inducing antigen-induced arthritis. Immunology\| PubMed ID: 18217945	2008
T-bet deficiency attenuates renal injury in experimental crescentic glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 18235099	2008
Advances in the pathogenesis of Goodpasture's disease: from epitopes to autoantibodies to effector T cells. Journal of autoimmunity\| PubMed ID: 18502098	2008
Role of mast cells in progressive renal diseases. Journal of the American Society of Nephrology : JASN\| PubMed ID: 18776124	2008
IL-23, not IL-12, directs autoimmunity to the Goodpasture antigen. Journal of the American Society of Nephrology : JASN\| PubMed ID: 19357249	2009
Phenotypes of adult bronchiectasis: onset of productive cough in childhood and adulthood. COPD\| PubMed ID: 19378226	2009
IL-1RI deficiency ameliorates early experimental renal interstitial fibrosis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 19465557	2009
Endogenous CD100 promotes glomerular injury and macrophage recruitment in experimental crescentic glomerulonephritis. Immunology\| PubMed ID: 19689741	2009
Atorvastatin enhances humoral immune responses but does not alter renal injury in experimental crescentic glomerulonephritis. Nephrology (Carlton, Vic.)\| PubMed ID: 19796023	2009
Th1 and Th17 cells induce proliferative glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 19820122	2009
Th17 cells promote autoimmune anti-myeloperoxidase glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 20299361	2010
Review: T helper 17 cells: their role in glomerulonephritis. Nephrology (Carlton, Vic.)\| PubMed ID: 20649870	2010
Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis. Kidney international\| PubMed ID: 20844472	2010
Toll-like receptor 9 enhances nephritogenic immunity and glomerular leukocyte recruitment, exacerbating experimental crescentic glomerulonephritis. The American journal of pathology\| PubMed ID: 20847283	2010
Lung diffusing capacity in adult bronchiectasis: a longitudinal study. Respiratory care\| PubMed ID: 21122177	2010
The Th17-defining transcription factor RORγt promotes glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 21183590	2011
Toll-like receptor 2 induces Th17 myeloperoxidase autoimmunity while Toll-like receptor 9 drives Th1 autoimmunity in murine vasculitis. Arthritis and rheumatism\| PubMed ID: 21190299	2011
Endogenous foxp3(+) T-regulatory cells suppress anti-glomerular basement membrane nephritis. Kidney international\| PubMed ID: 21248715	2011
The IL-27 receptor has biphasic effects in crescentic glomerulonephritis mediated through Th1 responses. The American journal of pathology\| PubMed ID: 21281790	2011
The emergence of TH17 cells as effectors of renal injury. Journal of the American Society of Nephrology : JASN\| PubMed ID: 21289213	2011
Interleukin-17A promotes early but attenuates established disease in crescentic glomerulonephritis in mice. The American journal of pathology\| PubMed ID: 21741931	2011
Tim-1 promotes cisplatin nephrotoxicity. American journal of physiology. Renal physiology\| PubMed ID: 21835770	2011
Mast cells mediate acute kidney injury through the production of TNF. Journal of the American Society of Nephrology : JASN\| PubMed ID: 22021718	2011
Renal dendritic cells adopt a pro-inflammatory phenotype in obstructive uropathy to activate T cells but do not directly contribute to fibrosis. The American journal of pathology\| PubMed ID: 22079432	2012
Endogenous Tim-1 (Kim-1) promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis. Kidney international\| PubMed ID: 22205357	2012
Mast cell activation and degranulation promotes renal fibrosis in experimental unilateral ureteric obstruction. Kidney international\| PubMed ID: 22673890	2012
The immunodominant myeloperoxidase T-cell epitope induces local cell-mediated injury in antimyeloperoxidase glomerulonephritis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22955884	2012
Mast cells contribute to peripheral tolerance and attenuate autoimmune vasculitis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 23138486	2012
Lung T-cell responses to nontypeable Haemophilus influenzae in patients with chronic obstructive pulmonary disease. The Journal of allergy and clinical immunology\| PubMed ID: 23142009	2012
Chest pain and exacerbations of bronchiectasis. International journal of general medicine\| PubMed ID: 23271921	2012
Thymic deletion and regulatory T cells prevent antimyeloperoxidase GN. Journal of the American Society of Nephrology : JASN\| PubMed ID: 23393320	2013
The HLA-DRB1*15:01-restricted Goodpasture's T cell epitope induces GN. Journal of the American Society of Nephrology : JASN\| PubMed ID: 23411782	2013
Reply: To PMID 23142009. The Journal of allergy and clinical immunology\| PubMed ID: 23453686	2013
Neutrophil myeloperoxidase regulates T-cell-driven tissue inflammation in mice by inhibiting dendritic cell function. Blood\| PubMed ID: 23509155	2013
Myeloperoxidase (MPO)-specific CD4+ T cells contribute to MPO-anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis. Cellular immunology\| PubMed ID: 23665205	2013
MicroRNA-155 a new therapeutic target in crescentic GN. Journal of the American Society of Nephrology : JASN\| PubMed ID: 24158984	2013
Histopathologic and clinical predictors of kidney outcomes in ANCA-associated vasculitis. American journal of kidney diseases : the official journal of the National Kidney Foundation\| PubMed ID: 24183110	2014
Innate IL-17A-producing leukocytes promote acute kidney injury via inflammasome and Toll-like receptor activation. The American journal of pathology\| PubMed ID: 24631024	2014
Endogenous myeloperoxidase is a mediator of joint inflammation and damage in experimental arthritis. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 24757143	2014
FcγRIIB regulates T-cell autoreactivity, ANCA production, and neutrophil activation to suppress anti-myeloperoxidase glomerulonephritis. Kidney international\| PubMed ID: 24869670	2014
Glomerulonephritis Induced by Heterologous Anti-GBM Globulin as a Planted Foreign Antigen. Current protocols in immunology\| PubMed ID: 25081909	2014
T cell mediated autoimmune glomerular disease in mice. Current protocols in immunology\| PubMed ID: 25367126	2014
Mouse models of anti-neutrophil cytoplasmic antibody-associated vasculitis. Current pharmaceutical design\| PubMed ID: 25777754	2015
Suppression of Autoimmunity and Renal Disease in Pristane-Induced Lupus by Myeloperoxidase. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 25777776	2015
Nontypeable Haemophilus influenzae induces sustained lung oxidative stress and protease expression. PloS one\| PubMed ID: 25793977	2015
FMS-like tyrosine kinase 3 ligand treatment does not ameliorate experimental rapidly progressive glomerulonephritis. PloS one\| PubMed ID: 25849330	2015
Cytokines: Names and Numbers You Should Care About. Clinical journal of the American Society of Nephrology : CJASN\| PubMed ID: 25941193	2015
Programmed death 1 and its ligands do not limit experimental foreign antigen-induced immune complex glomerulonephritis. Nephrology (Carlton, Vic.)\| PubMed ID: 26043977	2015
Myeloperoxidase Peptide-Based Nasal Tolerance in Experimental ANCA-Associated GN. Journal of the American Society of Nephrology : JASN\| PubMed ID: 26047792	2016
Endogenous Toll-Like Receptor 9 Regulates AKI by Promoting Regulatory T Cell Recruitment. Journal of the American Society of Nephrology : JASN\| PubMed ID: 26116356	2016
Renal participation of myeloperoxidase in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis. Kidney international\| PubMed ID: 26176828	2015
Regulatory T cells in immune-mediated renal disease. Nephrology (Carlton, Vic.)\| PubMed ID: 26206106	2016
Mast Cell Stabilization Ameliorates Autoimmune Anti-Myeloperoxidase Glomerulonephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 26374606	2016
The lung immune response to bacteria in chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine\| PubMed ID: 26426789	2015
Targeting IL-17 and IL-23 in Immune Mediated Renal Disease. Current medicinal chemistry\| PubMed ID: 26521930	2015
Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase. Journal of immunology research\| PubMed ID: 26904693	2016
Biologics for the treatment of autoimmune renal diseases. Nature reviews. Nephrology\| PubMed ID: 26949177	2016
The NLRP3 inflammasome in kidney disease and autoimmunity. Nephrology (Carlton, Vic.)\| PubMed ID: 27011059	2016
CD8+ T Cells Effect Glomerular Injury in Experimental Anti-Myeloperoxidase GN. Journal of the American Society of Nephrology : JASN\| PubMed ID: 27288012	2017
Activated Renal Dendritic Cells Cross Present Intrarenal Antigens After Ischemia-Reperfusion Injury. Transplantation\| PubMed ID: 27495751	2017
Induced regulatory T cells are phenotypically unstable and do not protect mice from rapidly progressive glomerulonephritis. Immunology\| PubMed ID: 27606831	2017
Interleukin-17RA Promotes Humoral Responses and Glomerular Injury in Experimental Rapidly Progressive Glomerulonephritis. Nephron\| PubMed ID: 27941331	2017
T cell receptor assessment in autoimmune disease requires access to the most adjacent immunologically active organ. Journal of autoimmunity\| PubMed ID: 28318808	2017
Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells. Nature\| PubMed ID: 28467828	2017
ANCA-Associated Vasculitis: Pathogenesis, Models, and Preclinical Testing. Seminars in nephrology\| PubMed ID: 28863790	2017
Deoxyribonuclease 1 reduces pathogenic effects of cigarette smoke exposure in the lung. Scientific reports\| PubMed ID: 28935869	2017