Stephen R. Holdsworth

The requirement for granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in leukocyte-mediated immune glomerular injury.

IFN-gamma production by intrinsic renal cells and bone marrow-derived cells is required for full expression of crescentic glomerulonephritis in mice.

Adaptive immunity to nontypeable Haemophilus influenzae.

Laboratory assessment of immune function in renal transplant patients.

Plasminogen activator inhibitor-1 is a significant determinant of renal injury in experimental crescentic glomerulonephritis.

T cells in glomerulonephritis.

Intrinsic renal cells are the major source of tumor necrosis factor contributing to renal injury in murine crescentic glomerulonephritis.

Intrinsic renal cell expression of CD40 directs Th1 effectors inducing experimental crescentic glomerulonephritis.

The role of flow cytometric ANCA detection in screening for acute pauci-immune crescentic glomerulonephritis.

Contributions of IL-1beta and IL-1alpha to crescentic glomerulonephritis in mice.

Leukocyte-derived interleukin-1beta interacts with renal interleukin-1 receptor I to promote renal tumor necrosis factor and glomerular injury in murine crescentic glomerulonephritis.

Ex vivo lymphocyte proliferative function is severely inhibited in renal transplant patients on mycophenolate mofetil treatment.

An IL-12-independent role for CD40-CD154 in mediating effector responses: studies in cell-mediated glomerulonephritis and dermal delayed-type hypersensitivity.

Experimental autoimmune anti-glomerular basement membrane glomerulonephritis: a protective role for IFN-gamma.

Fibrin independent proinflammatory effects of tissue factor in experimental crescentic glomerulonephritis.

Endogenous IL-13 limits humoral responses and injury in experimental glomerulonephritis but does not regulate Th1 cell-mediated crescentic glomerulonephritis.

Experimental autoimmune Goodpasture's disease: a pathogenetic role for both effector cells and antibody in injury.

IL-12p40 and IL-18 in crescentic glomerulonephritis: IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 promotes local inflammation and leukocyte recruitment.

Glomerular expression of CD80 and CD86 is required for leukocyte accumulation and injury in crescentic glomerulonephritis.

CD80 and CD86 costimulatory molecules regulate crescentic glomerulonephritis by different mechanisms.

Leukocyte phenotype and function predicts infection risk in renal transplant recipients.

Granulocyte macrophage colony-stimulating factor expression by both renal parenchymal and immune cells mediates murine crescentic glomerulonephritis.

A pathogenetic role for mast cells in experimental crescentic glomerulonephritis.

The isolation and purification of biologically active recombinant and native autoantigens for the study of autoimmune disease.

Inducible co-stimulatory molecule ligand is protective during the induction and effector phases of crescentic glomerulonephritis.

T cells in crescentic glomerulonephritis.

Characterisation of the onset and presenting clinical features of adult bronchiectasis.

Anti-neutrophil cytoplasmic antibodies and effector CD4+ cells play nonredundant roles in anti-myeloperoxidase crescentic glomerulonephritis.

CD100 enhances dendritic cell and CD4+ cell activation leading to pathogenetic humoral responses and immune complex glomerulonephritis.

Outcome in adult bronchiectasis.

Endogenous myeloperoxidase promotes neutrophil-mediated renal injury, but attenuates T cell immunity inducing crescentic glomerulonephritis.

Microbiologic follow-up study in adult bronchiectasis.

Cytokines in glomerulonephritis.

Leukocytes in glomerular injury.

Intrarenal antigens activate CD4+ cells via co-stimulatory signals from dendritic cells.

Distinct in vivo roles of CD80 and CD86 in the effector T-cell responses inducing antigen-induced arthritis.

T-bet deficiency attenuates renal injury in experimental crescentic glomerulonephritis.

Advances in the pathogenesis of Goodpasture's disease: from epitopes to autoantibodies to effector T cells.

Role of mast cells in progressive renal diseases.

IL-23, not IL-12, directs autoimmunity to the Goodpasture antigen.

Phenotypes of adult bronchiectasis: onset of productive cough in childhood and adulthood.

IL-1RI deficiency ameliorates early experimental renal interstitial fibrosis.

Endogenous CD100 promotes glomerular injury and macrophage recruitment in experimental crescentic glomerulonephritis.

Atorvastatin enhances humoral immune responses but does not alter renal injury in experimental crescentic glomerulonephritis.

Th1 and Th17 cells induce proliferative glomerulonephritis.

Th17 cells promote autoimmune anti-myeloperoxidase glomerulonephritis.

Review: T helper 17 cells: their role in glomerulonephritis.

Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis.

Toll-like receptor 9 enhances nephritogenic immunity and glomerular leukocyte recruitment, exacerbating experimental crescentic glomerulonephritis.

Lung diffusing capacity in adult bronchiectasis: a longitudinal study.

The Th17-defining transcription factor RORγt promotes glomerulonephritis.

Toll-like receptor 2 induces Th17 myeloperoxidase autoimmunity while Toll-like receptor 9 drives Th1 autoimmunity in murine vasculitis.

Endogenous foxp3(+) T-regulatory cells suppress anti-glomerular basement membrane nephritis.

The IL-27 receptor has biphasic effects in crescentic glomerulonephritis mediated through Th1 responses.

The emergence of TH17 cells as effectors of renal injury.

Interleukin-17A promotes early but attenuates established disease in crescentic glomerulonephritis in mice.

Tim-1 promotes cisplatin nephrotoxicity.

Mast cells mediate acute kidney injury through the production of TNF.

Renal dendritic cells adopt a pro-inflammatory phenotype in obstructive uropathy to activate T cells but do not directly contribute to fibrosis.

Endogenous Tim-1 (Kim-1) promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis.

Mast cell activation and degranulation promotes renal fibrosis in experimental unilateral ureteric obstruction.

The immunodominant myeloperoxidase T-cell epitope induces local cell-mediated injury in antimyeloperoxidase glomerulonephritis.

Mast cells contribute to peripheral tolerance and attenuate autoimmune vasculitis.

Lung T-cell responses to nontypeable Haemophilus influenzae in patients with chronic obstructive pulmonary disease.

Chest pain and exacerbations of bronchiectasis.

Thymic deletion and regulatory T cells prevent antimyeloperoxidase GN.

The HLA-DRB1*15:01-restricted Goodpasture's T cell epitope induces GN.

Reply: To PMID 23142009.

Neutrophil myeloperoxidase regulates T-cell-driven tissue inflammation in mice by inhibiting dendritic cell function.

Myeloperoxidase (MPO)-specific CD4+ T cells contribute to MPO-anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis.

MicroRNA-155 a new therapeutic target in crescentic GN.

Histopathologic and clinical predictors of kidney outcomes in ANCA-associated vasculitis.

Innate IL-17A-producing leukocytes promote acute kidney injury via inflammasome and Toll-like receptor activation.

Endogenous myeloperoxidase is a mediator of joint inflammation and damage in experimental arthritis.

FcγRIIB regulates T-cell autoreactivity, ANCA production, and neutrophil activation to suppress anti-myeloperoxidase glomerulonephritis.

Glomerulonephritis Induced by Heterologous Anti-GBM Globulin as a Planted Foreign Antigen.

T cell mediated autoimmune glomerular disease in mice.

Mouse models of anti-neutrophil cytoplasmic antibody-associated vasculitis.

Suppression of Autoimmunity and Renal Disease in Pristane-Induced Lupus by Myeloperoxidase.

Nontypeable Haemophilus influenzae induces sustained lung oxidative stress and protease expression.

FMS-like tyrosine kinase 3 ligand treatment does not ameliorate experimental rapidly progressive glomerulonephritis.

Cytokines: Names and Numbers You Should Care About.

Programmed death 1 and its ligands do not limit experimental foreign antigen-induced immune complex glomerulonephritis.

Myeloperoxidase Peptide-Based Nasal Tolerance in Experimental ANCA-Associated GN.

Endogenous Toll-Like Receptor 9 Regulates AKI by Promoting Regulatory T Cell Recruitment.

Renal participation of myeloperoxidase in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis.

Regulatory T cells in immune-mediated renal disease.

Mast Cell Stabilization Ameliorates Autoimmune Anti-Myeloperoxidase Glomerulonephritis.

The lung immune response to bacteria in chronic obstructive pulmonary disease.

Targeting IL-17 and IL-23 in Immune Mediated Renal Disease.

Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase.

Biologics for the treatment of autoimmune renal diseases.

The NLRP3 inflammasome in kidney disease and autoimmunity.

CD8+ T Cells Effect Glomerular Injury in Experimental Anti-Myeloperoxidase GN.

Activated Renal Dendritic Cells Cross Present Intrarenal Antigens After Ischemia-Reperfusion Injury.

Induced regulatory T cells are phenotypically unstable and do not protect mice from rapidly progressive glomerulonephritis.

Interleukin-17RA Promotes Humoral Responses and Glomerular Injury in Experimental Rapidly Progressive Glomerulonephritis.

T cell receptor assessment in autoimmune disease requires access to the most adjacent immunologically active organ.

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.

ANCA-Associated Vasculitis: Pathogenesis, Models, and Preclinical Testing.

Deoxyribonuclease 1 reduces pathogenic effects of cigarette smoke exposure in the lung.