Karen M. Dobos

Proteomic approaches to antigen discovery.

A limited antigen-specific cellular response is sufficient for the early control of Mycobacterium tuberculosis in the lung but is insufficient for long-term survival.

Continued proteomic analysis of Mycobacterium leprae subcellular fractions.

Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling.

Demonstration of components of antigen 85 complex in cerebrospinal fluid of tuberculous meningitis patients.

Conserved mycobacterial lipoglycoproteins activate TLR2 but also require glycosylation for MHC class II-restricted T cell activation.

Deciphering the proteomic profile of Mycobacterium leprae cell envelope.

A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis.

Descriptive proteomic analysis shows protein variability between closely related clinical isolates of Mycobacterium tuberculosis.

Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories.

Proteomic analysis identifies highly antigenic proteins in exosomes from M. tuberculosis-infected and culture filtrate protein-treated macrophages.

Proteomic definition of the cell wall of Mycobacterium tuberculosis.

Portrait of a pathogen: the Mycobacterium tuberculosis proteome in vivo.

The non-clonality of drug resistance in Beijing-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South Africa.

Three protein cocktails mediate delayed-type hypersensitivity responses indistinguishable from that elicited by purified protein derivative in the guinea pig model of Mycobacterium tuberculosis infection.

Prospective on Mycobacterium tuberculosis proteomics.

Deciphering the proteome of the in vivo diagnostic reagent "purified protein derivative" from Mycobacterium tuberculosis.

Purified protein derivatives of tuberculin--past, present, and future.

HspX-mediated protection against tuberculosis depends on its chaperoning of a mycobacterial molecule.

Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation.

A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis.

Antigen 85 variation across lineages of Mycobacterium tuberculosis-implications for vaccine and biomarker success.

O-mannosylation of the Mycobacterium tuberculosis adhesin Apa is crucial for T cell antigenicity during infection but is expendable for protection.

HspX vaccination and role in virulence in the guinea pig model of tuberculosis.

The human antibody response to the surface of Mycobacterium tuberculosis.

Detection of Mycobacterium tuberculosis peptides in the exosomes of patients with active and latent M. tuberculosis infection using MRM-MS.

Deciphering the role of exosomes in tuberculosis.

Fractionation and analysis of mycobacterial proteins.

Analysis of the metabolome of Anopheles gambiae mosquito after exposure to Mycobacterium ulcerans.

Pathogenic nontuberculous mycobacteria resist and inactivate cathelicidin: implication of a novel role for polar mycobacterial lipids.

RP105 Engages Phosphatidylinositol 3-Kinase p110δ To Facilitate the Trafficking and Secretion of Cytokines in Macrophages during Mycobacterial Infection.

Comparing isogenic strains of Beijing genotype Mycobacterium tuberculosis after acquisition of Isoniazid resistance: A proteomics approach.

Longitudinal whole genome analysis of pre and post drug treatment Mycobacterium tuberculosis isolates reveals progressive steps to drug resistance.

Boosting BCG-primed responses with a subunit Apa vaccine during the waning phase improves immunity and imparts protection against Mycobacterium tuberculosis.

A Subset of Protective γ9δ2 T Cells Is Activated by Novel Mycobacterial Glycolipid Components.

Virulence of Mycobacterium tuberculosis after Acquisition of Isoniazid Resistance: Individual Nature of katG Mutants and the Possible Role of AhpC.

Changes in the Membrane-Associated Proteins of Exosomes Released from Human Macrophages after Mycobacterium tuberculosis Infection.

Second generation multiple reaction monitoring assays for enhanced detection of ultra-low abundancepeptides in human serum.

HLA-E Presents Glycopeptides from the Mycobacterium tuberculosis Protein MPT32 to Human CD8T cells.

The N-terminal peptide moiety of the Mycobacterium tuberculosis 19 kDa lipoprotein harbors RP105-agonistic properties.

Cytokine-Mediated Systemic Adverse Drug Reactions in a Drug-Drug Interaction Study of Dolutegravir with Once-Weekly Isoniazid and Rifapentine.

Structural determinants in a glucose-containing lipopolysaccharide from critical for inducing a subset of protective T cells.

Biochemical Characterization of Isoniazid-resistant Can the Analysis of Clonal Strains Reveal Novel Targetable Pathways?

Moving toward Tuberculosis Elimination. Critical Issues for Research in Diagnostics and Therapeutics for Tuberculosis Infection.

Deciphering the molecular basis of mycobacteria and lipoglycan recognition by the C-type lectin Dectin-2.

Mycobacteria and their sweet proteins: An overview of protein glycosylation and lipoglycosylation in M. tuberculosis.

Protein profile of different cellular fractions from strains after exposure to isoniazid.

Nontuberculous Mycobacteria Show Differential Infectivity and Use Phospholipids to Antagonize LL-37.

Identification of Mycobacterium tuberculosis Peptides in Serum Extracellular Vesicles from Persons with Latent Tuberculosis Infection.

Towards a method for cryopreservation of mosquito vectors of human pathogens.

Reuse of Disposable Isolation Gowns in Rodent Facilities during a Pandemic.

Culturing Mycobacteria.

Extraction and Separation of Mycobacterial Proteins.

Methods for Proteomic Analyses of Mycobacteria.

Structural implications of lipoarabinomannan glycans from global clinical isolates in diagnosis of Mycobacterium tuberculosis infection.

Sub-Lineage Specific Phenolic Glycolipid Patterns in the Complex Lineage 1.