Graduate School of Brain Science
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Curcumin improves tau-induced neuronal dysfunction of nematodes.
Neurobiology of aging Mar, 2016 | Pubmed ID: 26923403
[Overview on Alzheimer's disease].
Rinsho shinkeigaku = Clinical neurology Nov, 2007 | Pubmed ID: 18210830
GAB2 is not associated with late-onset Alzheimer's disease in Japanese.
European journal of human genetics : EJHG May, 2009 | Pubmed ID: 18854865
gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2009 | Pubmed ID: 19828817
Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction.
Genes to cells : devoted to molecular & cellular mechanisms Jun, 2011 | Pubmed ID: 21554501
The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease.
Cold Spring Harbor perspectives in medicine Aug, 2012 | Pubmed ID: 22908190
Suspected limited efficacy of γ-secretase modulators.
Neurobiology of aging Apr, 2013 | Pubmed ID: 23058852
SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.
PloS one , 2013 | Pubmed ID: 23565137
Modulation of lipid kinase PI4KIIα activity and lipid raft association of presenilin 1 underlies γ-secretase inhibition by ginsenoside (20S)-Rg3.
The Journal of biological chemistry Jul, 2013 | Pubmed ID: 23723072
Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase.
Nature communications , 2013 | Pubmed ID: 24108142
γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment.
The Journal of biological chemistry Feb, 2014 | Pubmed ID: 24375443
The homologous carboxyl-terminal domains of microtubule-associated protein 2 and TAU induce neuronal dysfunction and have differential fates in the evolution of neurofibrillary tangles.
PloS one , 2014 | Pubmed ID: 24587039
Lack of genetic association between TREM2 and late-onset Alzheimer's disease in a Japanese population.
Journal of Alzheimer's disease : JAD , 2014 | Pubmed ID: 24762945
Immunostaining of oxidized DJ-1 in human and mouse brains.
Journal of neuropathology and experimental neurology Jul, 2014 | Pubmed ID: 24918637
Identification of key amino acids responsible for the distinct aggregation properties of microtubule-associated protein 2 and tau.
Journal of neurochemistry Oct, 2015 | Pubmed ID: 26134402
The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells.
Acta neuropathologica communications Nov, 2015 | Pubmed ID: 26531305
Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups.
Nature communications Dec, 2015 | Pubmed ID: 26671725
Alanine substitutions in the GXXXG motif alter C99 cleavage by γ-secretase but not its dimerization.
Journal of neurochemistry 03, 2017 | Pubmed ID: 28032911
Semagacestat Is a Pseudo-Inhibitor of γ-Secretase.
Cell reports Oct, 2017 | Pubmed ID: 28978478
Distinct deposition of amyloid-β species in brains with Alzheimer's disease pathology visualized with MALDI imaging mass spectrometry.
Acta neuropathologica communications 10, 2017 | Pubmed ID: 29037261
Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in Models of Tauopathy.
Frontiers in neuroscience , 2018 | Pubmed ID: 29973863
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