Graduate School of Brain Science
Yasuo Ihara has not added Biography.
If you are Yasuo Ihara and would like to personalize this page please email our Author Liaison for assistance.
Curcumin improves tau-induced neuronal dysfunction of nematodes.
Neurobiology of aging Mar, 2016 | Pubmed ID: 26923403
[Overview on Alzheimer's disease].
Rinsho shinkeigaku = Clinical neurology Nov, 2007 | Pubmed ID: 18210830
GAB2 is not associated with late-onset Alzheimer's disease in Japanese.
European journal of human genetics : EJHG May, 2009 | Pubmed ID: 18854865
gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2009 | Pubmed ID: 19828817
Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction.
Genes to cells : devoted to molecular & cellular mechanisms Jun, 2011 | Pubmed ID: 21554501
The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease.
Cold Spring Harbor perspectives in medicine Aug, 2012 | Pubmed ID: 22908190
Suspected limited efficacy of γ-secretase modulators.
Neurobiology of aging Apr, 2013 | Pubmed ID: 23058852
SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.
PloS one , 2013 | Pubmed ID: 23565137
Modulation of lipid kinase PI4KIIα activity and lipid raft association of presenilin 1 underlies γ-secretase inhibition by ginsenoside (20S)-Rg3.
The Journal of biological chemistry Jul, 2013 | Pubmed ID: 23723072
Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase.
Nature communications , 2013 | Pubmed ID: 24108142
γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment.
The Journal of biological chemistry Feb, 2014 | Pubmed ID: 24375443
The homologous carboxyl-terminal domains of microtubule-associated protein 2 and TAU induce neuronal dysfunction and have differential fates in the evolution of neurofibrillary tangles.
PloS one , 2014 | Pubmed ID: 24587039
Lack of genetic association between TREM2 and late-onset Alzheimer's disease in a Japanese population.
Journal of Alzheimer's disease : JAD , 2014 | Pubmed ID: 24762945
Immunostaining of oxidized DJ-1 in human and mouse brains.
Journal of neuropathology and experimental neurology Jul, 2014 | Pubmed ID: 24918637
Identification of key amino acids responsible for the distinct aggregation properties of microtubule-associated protein 2 and tau.
Journal of neurochemistry Oct, 2015 | Pubmed ID: 26134402
The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells.
Acta neuropathologica communications Nov, 2015 | Pubmed ID: 26531305
Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups.
Nature communications Dec, 2015 | Pubmed ID: 26671725
Alanine substitutions in the GXXXG motif alter C99 cleavage by γ-secretase but not its dimerization.
Journal of neurochemistry 03, 2017 | Pubmed ID: 28032911
Semagacestat Is a Pseudo-Inhibitor of γ-Secretase.
Cell reports Oct, 2017 | Pubmed ID: 28978478
Distinct deposition of amyloid-β species in brains with Alzheimer's disease pathology visualized with MALDI imaging mass spectrometry.
Acta neuropathologica communications 10, 2017 | Pubmed ID: 29037261
Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in Models of Tauopathy.
Frontiers in neuroscience , 2018 | Pubmed ID: 29973863
JoVE 소개
Copyright © 2024 MyJoVE Corporation. 판권 소유