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Program in Molecular Medicine
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Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2014 | Pubmed ID: 25422458
Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer.
PLoS pathogens Mar, 2015 | Pubmed ID: 25807248
Origins of a Vaccine-Induced, Human Anti-HIV-1 Antibody.
EBioMedicine Jul, 2015 | Pubmed ID: 26288832
Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2015 | Pubmed ID: 26372963
EspP, an Extracellular Serine Protease from Enterohemorrhagic E. coli, Reduces Coagulation Factor Activities, Reduces Clot Strength, and Promotes Clot Lysis.
PloS one , 2016 | Pubmed ID: 26934472
HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.
Science (New York, N.Y.) Mar, 2016 | Pubmed ID: 27013733
Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.
PLoS pathogens Aug, 2016 | Pubmed ID: 27560183
Discrete TCR Binding Kinetics Control Invariant NKT Cell Selection and Central Priming.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2016 | Pubmed ID: 27798168
Key Residues at Third CDR3β Position Impact Structure and Antigen Recognition of Human Invariant NK TCRs.
Journal of immunology (Baltimore, Md. : 1950) 02, 2017 | Pubmed ID: 28003379
Molecular basis of human CD22 function and therapeutic targeting.
Nature communications 10, 2017 | Pubmed ID: 28970495
Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.
Nature communications Nov, 2017 | Pubmed ID: 29146922
Rare PfCSP C-terminal antibodies induced by live sporozoite vaccination are ineffective against malaria infection.
The Journal of experimental medicine Jan, 2018 | Pubmed ID: 29167197
Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies.
Immunity 12, 2017 | Pubmed ID: 29195810
Structural Basis of Enhanced Crystallizability Induced by a Molecular Chaperone for Antibody Antigen-Binding Fragments.
Journal of molecular biology Feb, 2018 | Pubmed ID: 29277294
Molecular Basis of Unusually High Neutralization Resistance in Tier 3 HIV-1 Strain 253-11.
Journal of virology 07, 2018 | Pubmed ID: 29618644
Peek-Peak-Pique: Repeating Motifs of Subtle Variance Are Targets for Potent Malaria Antibodies.
Immunity May, 2018 | Pubmed ID: 29768173
Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope.
Science (New York, N.Y.) 06, 2018 | Pubmed ID: 29880723
The Hospital for Sick Children Research Institute
University of Toronto
June Ereño-Orbea*,1,
Taylor Sicard*,1,2,
Hong Cui1,
Indira Akula1,
Jean-Philippe Julien1,2,3
1Program in Molecular Medicine, The Hospital for Sick Children Research Institute,
2Department of Biochemistry, University of Toronto,
3Department of Immunology, University of Toronto
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