Department of Genetics and Genome Sciences,
Case Comprehensive Cancer Center
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High-throughput mutational analysis of the human cancer genome.
Pharmacogenomics Jun, 2006 | Pubmed ID: 16753007
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2007 | Pubmed ID: 17360477
Epitope tagging of endogenous proteins for genome-wide ChIP-chip studies.
Nature methods Feb, 2008 | Pubmed ID: 18176569
Differential binding modes of the bromodomains of CREB-binding protein (CBP) and p300 with acetylated MyoD.
Biochemical and biophysical research communications Apr, 2008 | Pubmed ID: 18222173
Tumor-derived extracellular mutations of PTPRT /PTPrho are defective in cell adhesion.
Molecular cancer research : MCR Jul, 2008 | Pubmed ID: 18644975
Ugene, a newly identified protein that is commonly overexpressed in cancer and binds uracil DNA glycosylase.
Cancer research Aug, 2008 | Pubmed ID: 18676834
Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns.
Genome research Apr, 2009 | Pubmed ID: 19251738
Epitope tagging of endogenous proteins for genome-wide chromatin immunoprecipitation analysis.
Methods in molecular biology (Clifton, N.J.) , 2009 | Pubmed ID: 19588087
microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells.
Cancer research Oct, 2009 | Pubmed ID: 19826040
Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2010 | Pubmed ID: 20133777
Cancer-derived mutations in the fibronectin III repeats of PTPRT/PTPrho inhibit cell-cell aggregation.
Cell communication & adhesion Dec, 2009 | Pubmed ID: 20230342
Characterization of the adhesive properties of the type IIb subfamily receptor protein tyrosine phosphatases.
Cell communication & adhesion Apr, 2010 | Pubmed ID: 20521994
CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis.
Human molecular genetics Sep, 2010 | Pubmed ID: 20591827
DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination.
Science signaling Nov, 2010 | Pubmed ID: 21045206
Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2010 | Pubmed ID: 21098664
Tumour suppressor function of protein tyrosine phosphatase receptor-T.
Bioscience reports Oct, 2011 | Pubmed ID: 21517784
A mechanism-based potent sirtuin inhibitor containing Nε-thiocarbamoyl-lysine (TuAcK).
Bioorganic & medicinal chemistry letters Aug, 2011 | Pubmed ID: 21752644
Cross-talk between phospho-STAT3 and PLCγ1 plays a critical role in colorectal tumorigenesis.
Molecular cancer research : MCR Oct, 2011 | Pubmed ID: 21840932
Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation.
Proceedings of the National Academy of Sciences of the United States of America May, 2012 | Pubmed ID: 22547799
Coupling cellular localization and function of checkpoint kinase 1 (Chk1) in checkpoints and cell viability.
The Journal of biological chemistry Jul, 2012 | Pubmed ID: 22692200
How do alignment programs perform on sequencing data with varying qualities and from repetitive regions?
BioData mining , 2012 | Pubmed ID: 22709551
Identification and functional characterization of p130Cas as a substrate of protein tyrosine phosphatase nonreceptor 14.
Oncogene Apr, 2013 | Pubmed ID: 22710723
Global mutational profiling of formalin-fixed human colon cancers from a pathology archive.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc Aug, 2012 | Pubmed ID: 22878650
Identifying novel protein complexes in cancer cells using epitope-tagging of endogenous human genes and affinity-purification mass spectrometry.
Journal of proteome research Dec, 2012 | Pubmed ID: 23106643
Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions.
Cancer cell May, 2013 | Pubmed ID: 23643389
Epithelial to mesenchymal transition promotes breast cancer progression via a fibronectin-dependent STAT3 signaling pathway.
The Journal of biological chemistry Jun, 2013 | Pubmed ID: 23653350
Targeting the protein-protein interaction between IRS1 and mutant p110α for cancer therapy.
Toxicologic pathology Jan, 2014 | Pubmed ID: 24178578
CtIP is required for DNA damage-dependent induction of P21.
Cell cycle (Georgetown, Tex.) , 2014 | Pubmed ID: 24196441
Phase II trial of imatinib in AIDS-associated Kaposi's sarcoma: AIDS Malignancy Consortium Protocol 042.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology Feb, 2014 | Pubmed ID: 24378417
Regulation of protein stability of DNA methyltransferase 1 by post-translational modifications.
Acta biochimica et biophysica Sinica Mar, 2014 | Pubmed ID: 24389641
Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2014 | Pubmed ID: 24395800
PTPRT regulates high-fat diet-induced obesity and insulin resistance.
PloS one , 2014 | Pubmed ID: 24949727
Discovery of common sequences absent in the human reference genome using pooled samples from next generation sequencing.
BMC genomics Aug, 2014 | Pubmed ID: 25129063
Genetic alterations of protein tyrosine phosphatases in human cancers.
Oncogene Jul, 2015 | Pubmed ID: 25263441
Novel recurrently mutated genes in African American colon cancers.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2015 | Pubmed ID: 25583493
Cancer driver candidate genes AVL9, DENND5A and NUPL1 contribute to MDCK cystogenesis.
Oncoscience , 2014 | Pubmed ID: 25621300
A Protein Interaction between β-Catenin and Dnmt1 Regulates Wnt Signaling and DNA Methylation in Colorectal Cancer Cells.
Molecular cancer research : MCR Jun, 2015 | Pubmed ID: 25753001
Reply to Ashktorab et al.: Mutational landscape of colon cancers in African Americans.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2015 | Pubmed ID: 25941411
TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.
Science (New York, N.Y.) Jun, 2015 | Pubmed ID: 26068857
Novel thiourea-based sirtuin inhibitory warheads.
Bioorganic & medicinal chemistry letters Aug, 2015 | Pubmed ID: 26081291
DNMT1-associated long non-coding RNAs regulate global gene expression and DNA methylation in colon cancer.
Human molecular genetics Nov, 2015 | Pubmed ID: 26307088
How do oncoprotein mutations rewire protein-protein interaction networks?
Expert review of proteomics , 2015 | Pubmed ID: 26325016
Induction of KIAA1199/CEMIP is associated with colon cancer phenotype and poor patient survival.
Oncotarget Oct, 2015 | Pubmed ID: 26437221
STAT3 as a Chemoprevention Target in Carcinogen-Induced Head and Neck Squamous Cell Carcinoma.
Cancer prevention research (Philadelphia, Pa.) Aug, 2016 | Pubmed ID: 27267892
Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer.
Nature communications 06, 2016 | Pubmed ID: 27321283
Regulation of paxillin-p130-PI3K-AKT signaling axis by Src and PTPRT impacts colon tumorigenesis.
Oncotarget Jul, 2017 | Pubmed ID: 27447856
Adverse Clinical Outcome Associated With Mutations That Typify African American Colorectal Cancers.
Journal of the National Cancer Institute Dec, 2016 | Pubmed ID: 27582379
IL-17A-Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis.
Journal of immunology (Baltimore, Md. : 1950) 12, 2017 | Pubmed ID: 29070673
Novel all-hydrocarbon stapled p110α[E545K] peptides as blockers of the oncogenic p110α[E545K]-IRS1 interaction.
Bioorganic & medicinal chemistry letters 12, 2017 | Pubmed ID: 29138025
Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia.
eLife 12, 2017 | Pubmed ID: 29256392
Multiproteomic and Transcriptomic Analysis of Oncogenic β-Catenin Molecular Networks.
Journal of proteome research Jun, 2018 | Pubmed ID: 29747501
1Department of Genetics and Genome Sciences, Case Western Reserve University,
2Department of Endocrinology, Dongfang Hospital of Beijing University of Chinese Medicine,
3Case Comprehensive Cancer Center, Case Western Reserve University,
4Center for RNA Science and Therapeutics, Case Western Reserve University
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