Zhenghe Wang

High-throughput mutational analysis of the human cancer genome.

Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T.

Epitope tagging of endogenous proteins for genome-wide ChIP-chip studies.

Differential binding modes of the bromodomains of CREB-binding protein (CBP) and p300 with acetylated MyoD.

Tumor-derived extracellular mutations of PTPRT /PTPrho are defective in cell adhesion.

Ugene, a newly identified protein that is commonly overexpressed in cancer and binds uracil DNA glycosylase.

Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns.

Epitope tagging of endogenous proteins for genome-wide chromatin immunoprecipitation analysis.

microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells.

Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T.

Cancer-derived mutations in the fibronectin III repeats of PTPRT/PTPrho inhibit cell-cell aggregation.

Characterization of the adhesive properties of the type IIb subfamily receptor protein tyrosine phosphatases.

CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis.

DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination.

Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes.

Tumour suppressor function of protein tyrosine phosphatase receptor-T.

A mechanism-based potent sirtuin inhibitor containing Nε-thiocarbamoyl-lysine (TuAcK).

Cross-talk between phospho-STAT3 and PLCγ1 plays a critical role in colorectal tumorigenesis.

Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation.

Coupling cellular localization and function of checkpoint kinase 1 (Chk1) in checkpoints and cell viability.

How do alignment programs perform on sequencing data with varying qualities and from repetitive regions?

Identification and functional characterization of p130Cas as a substrate of protein tyrosine phosphatase nonreceptor 14.

Global mutational profiling of formalin-fixed human colon cancers from a pathology archive.

Identifying novel protein complexes in cancer cells using epitope-tagging of endogenous human genes and affinity-purification mass spectrometry.

Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions.

Epithelial to mesenchymal transition promotes breast cancer progression via a fibronectin-dependent STAT3 signaling pathway.

Targeting the protein-protein interaction between IRS1 and mutant p110α for cancer therapy.

CtIP is required for DNA damage-dependent induction of P21.

Phase II trial of imatinib in AIDS-associated Kaposi's sarcoma: AIDS Malignancy Consortium Protocol 042.

Regulation of protein stability of DNA methyltransferase 1 by post-translational modifications.

Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer.

PTPRT regulates high-fat diet-induced obesity and insulin resistance.

Discovery of common sequences absent in the human reference genome using pooled samples from next generation sequencing.

Genetic alterations of protein tyrosine phosphatases in human cancers.

Novel recurrently mutated genes in African American colon cancers.

Cancer driver candidate genes AVL9, DENND5A and NUPL1 contribute to MDCK cystogenesis.

A Protein Interaction between β-Catenin and Dnmt1 Regulates Wnt Signaling and DNA Methylation in Colorectal Cancer Cells.

Reply to Ashktorab et al.: Mutational landscape of colon cancers in African Americans.

TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.

Novel thiourea-based sirtuin inhibitory warheads.

DNMT1-associated long non-coding RNAs regulate global gene expression and DNA methylation in colon cancer.

How do oncoprotein mutations rewire protein-protein interaction networks?

Induction of KIAA1199/CEMIP is associated with colon cancer phenotype and poor patient survival.

STAT3 as a Chemoprevention Target in Carcinogen-Induced Head and Neck Squamous Cell Carcinoma.

Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer.

Regulation of paxillin-p130-PI3K-AKT signaling axis by Src and PTPRT impacts colon tumorigenesis.

Adverse Clinical Outcome Associated With Mutations That Typify African American Colorectal Cancers.

IL-17A-Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis.

Novel all-hydrocarbon stapled p110α[E545K] peptides as blockers of the oncogenic p110α[E545K]-IRS1 interaction.

Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia.

Multiproteomic and Transcriptomic Analysis of Oncogenic β-Catenin Molecular Networks.