Lawrence E. Heisler

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto

Research Area

Biology

Biography

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2011

Other Publications

Article	Year
CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome. Nucleic acids research\| PubMed ID: 15911630	2005
Genomic DNA functions as a universal external standard in quantitative real-time PCR. Nucleic acids research\| PubMed ID: 16840529	2006
Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers. Nature methods\| PubMed ID: 18622398	2008
Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast. PLoS genetics\| PubMed ID: 18688276	2008
Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells. PLoS genetics\| PubMed ID: 19043571	2008
Quantitative phenotyping via deep barcode sequencing. Genome research\| PubMed ID: 19622793	2009
A comparative analysis of DNA barcode microarray feature size. BMC genomics\| PubMed ID: 19825181	2009
Genotype to phenotype: a complex problem. Science (New York, N.Y.)\| PubMed ID: 20413493	2010
Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples. Nucleic acids research\| PubMed ID: 20460461	2010
A comprehensive platform for highly multiplexed mammalian functional genetic screens. BMC genomics\| PubMed ID: 21548937	2011
Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell. Nature biotechnology\| PubMed ID: 21572441	2011
Compound prioritization methods increase rates of chemical probe discovery in model organisms. Chemistry & biology\| PubMed ID: 22035796	2011
Multiple means to the same end: the genetic basis of acquired stress resistance in yeast. PLoS genetics\| PubMed ID: 22102822	2011
Identification of yeast genes that confer resistance to chitosan oligosaccharide (COS) using chemogenomics. BMC genomics\| PubMed ID: 22727066	2012
Comparative chemogenomics to examine the mechanism of action of dna-targeted platinum-acridine anticancer agents. ACS chemical biology\| PubMed ID: 22928710	2012
Functional analysis with a barcoder yeast gene overexpression system. G3 (Bethesda, Md.)\| PubMed ID: 23050238	2012
Effects of the Paf1 complex and histone modifications on snoRNA 3'-end formation reveal broad and locus-specific regulation. Molecular and cellular biology\| PubMed ID: 23109428	2013
Miniature short hairpin RNA screens to characterize antiproliferative drugs. G3 (Bethesda, Md.)\| PubMed ID: 23797109	2013
CHIP-MYTH: a novel interactive proteomics method for the assessment of agonist-dependent interactions of the human β₂-adrenergic receptor. Biochemical and biophysical research communications\| PubMed ID: 24561123	2014
Mapping the cellular response to small molecules using chemogenomic fitness signatures. Science (New York, N.Y.)\| PubMed ID: 24723613	2014
A genome scale overexpression screen to reveal drug activity in human cells. Genome medicine\| PubMed ID: 24944581	2014
A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing. Nature communications\| PubMed ID: 26647970	2015
Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories. Nature communications\| PubMed ID: 28067867	2017
Genomic hallmarks of localized, non-indolent prostate cancer. Nature\| PubMed ID: 28068672	2017
Mitochondrial mutations drive prostate cancer aggression. Nature communications\| PubMed ID: 28939825	2017
The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression. Cell\| PubMed ID: 29681457	2018