Guri Giaever

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto

Research Area

Biology

Biography

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2011

Other Publications

Article	Year
Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agents. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12077312	2002
Systematic screen for human disease genes in yeast. Nature genetics\| PubMed ID: 12134146	2002
Functional profiling of the Saccharomyces cerevisiae genome. Nature\| PubMed ID: 12140549	2002
"Chemogenomics: tools for protein families" and "Chemical genomics: chemical and biological integration". Pharmacogenomics\| PubMed ID: 12517281	2003
A chemical genomics approach to understanding drug action. Trends in pharmacological sciences\| PubMed ID: 12967766	2003
Chemogenomic profiling: identifying the functional interactions of small molecules in yeast. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14718668	2004
Noise minimization in eukaryotic gene expression. PLoS biology\| PubMed ID: 15124029	2004
Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast. Genetics\| PubMed ID: 15716499	2005
Functional genomic analysis of the rates of protein evolution. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15800036	2005
A latent variable model for chemogenomic profiling. Bioinformatics (Oxford, England)\| PubMed ID: 15919724	2005
Genome-wide requirements for resistance to functionally distinct DNA-damaging agents. PLoS genetics\| PubMed ID: 16121259	2005
A unique and universal molecular barcode array. Nature methods\| PubMed ID: 16862133	2006
Experimental approaches to identify genetic networks. Current opinion in biotechnology\| PubMed ID: 16962766	2006
Chemical genomic profiling for identifying intracellular targets of toxicants producing Parkinson's disease. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 17043098	2007
Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions. Nature genetics\| PubMed ID: 17206143	2007
Accelerating the discovery of biologically active small molecules using a high-throughput yeast halo assay. Journal of natural products\| PubMed ID: 17291044	2007
Identification of genes involved in the toxic response of Saccharomyces cerevisiae against iron and copper overload by parallel analysis of deletion mutants. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 17785683	2008
Examining protein protein interactions using endogenously tagged yeast arrays: the cross-and-capture system. Genome research\| PubMed ID: 17989249	2007
Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures. Nature protocols\| PubMed ID: 18007632	2007
Defining genetic interaction. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18305163	2008
Chemical-genetic approaches for exploring the mode of action of natural products. Progress in drug research. Fortschritte der Arzneimittelforschung. ProgrÃ¨s des recherches pharmaceutiques\| PubMed ID: 18416308	2008
The chemical genomic portrait of yeast: uncovering a phenotype for all genes. Science (New York, N.Y.)\| PubMed ID: 18420932	2008
Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen. PLoS genetics\| PubMed ID: 18454192	2008
The extensive and condition-dependent nature of epistasis among whole-genome duplicates in yeast. Genome research\| PubMed ID: 18463300	2008
An integrated platform of genomic assays reveals small-molecule bioactivities. Nature chemical biology\| PubMed ID: 18622389	2008
Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers. Nature methods\| PubMed ID: 18622398	2008
Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast. PLoS genetics\| PubMed ID: 18688276	2008
Yeast chemical genomics and drug discovery: an update. Trends in pharmacological sciences\| PubMed ID: 18755517	2008
Combination chemical genetics. Nature chemical biology\| PubMed ID: 18936752	2008
Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells. PLoS genetics\| PubMed ID: 19043571	2008
Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis. BMC microbiology\| PubMed ID: 19144191	2009
Knocking sense into regulatory pathways. Nature biotechnology\| PubMed ID: 19204694	2009
Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. PLoS genetics\| PubMed ID: 19300474	2009
Novel insights into iron metabolism by integrating deletome and transcriptome analysis in an iron deficiency model of the yeast Saccharomyces cerevisiae. BMC genomics\| PubMed ID: 19321002	2009
Precise gene-dose alleles for chemical genetics. Genetics\| PubMed ID: 19332878	2009
A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds. Nature biotechnology\| PubMed ID: 19349972	2009
Chemogenomic approaches to elucidation of gene function and genetic pathways. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19521822	2009
Quantitative phenotyping via deep barcode sequencing. Genome research\| PubMed ID: 19622793	2009
A comparative analysis of DNA barcode microarray feature size. BMC genomics\| PubMed ID: 19825181	2009
The genetic landscape of a cell. Science (New York, N.Y.)\| PubMed ID: 20093466	2010
Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action. Genome biology\| PubMed ID: 20226027	2010
Genotype to phenotype: a complex problem. Science (New York, N.Y.)\| PubMed ID: 20413493	2010
Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples. Nucleic acids research\| PubMed ID: 20460461	2010
A universal TagModule collection for parallel genetic analysis of microorganisms. Nucleic acids research\| PubMed ID: 20494978	2010
A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans. Nature chemical biology\| PubMed ID: 20512140	2010
A survey of yeast genomic assays for drug and target discovery. Pharmacology & therapeutics\| PubMed ID: 20546776	2010
Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation. PLoS genetics\| PubMed ID: 20657825	2010
Exploring gene function and drug action using chemogenomic dosage assays. Methods in enzymology\| PubMed ID: 20946813	2010
Gene annotation and drug target discovery in Candida albicans with a tagged transposon mutant collection. PLoS pathogens\| PubMed ID: 20949076	2010
Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection. Nature methods\| PubMed ID: 21217751	2011
Systematic exploration of essential yeast gene function with temperature-sensitive mutants. Nature biotechnology\| PubMed ID: 21441928	2011
The synthetic genetic interaction network reveals small molecules that target specific pathways in Sacchromyces cerevisiae. Molecular bioSystems\| PubMed ID: 21487606	2011
A comprehensive platform for highly multiplexed mammalian functional genetic screens. BMC genomics\| PubMed ID: 21548937	2011
Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell. Nature biotechnology\| PubMed ID: 21572441	2011
Design, synthesis, and characterization of a highly effective Hog1 inhibitor: a powerful tool for analyzing MAP kinase signaling in yeast. PloS one\| PubMed ID: 21655328	2011
Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases. PloS one\| PubMed ID: 21698101	2011
New azole antifungal agents with novel modes of action: synthesis and biological studies of new tridentate ligands based on pyrazole and triazole. European journal of medicinal chemistry\| PubMed ID: 21723647	2011
The automated cell: compound and environment screening system (ACCESS) for chemogenomic screening. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21863492	2011
Displaying chemical information on a biological network using Cytoscape. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21877291	2011
Curcumin inhibits growth of Saccharomyces cerevisiae through iron chelation. Eukaryotic cell\| PubMed ID: 21908599	2011
A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis. PLoS genetics\| PubMed ID: 22028670	2011
Compound prioritization methods increase rates of chemical probe discovery in model organisms. Chemistry & biology\| PubMed ID: 22035796	2011
Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans. Nature chemical biology\| PubMed ID: 22057127	2011
Systematic exploration of synergistic drug pairs. Molecular systems biology\| PubMed ID: 22068327	2011
Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer cell\| PubMed ID: 22094260	2011
Multiple means to the same end: the genetic basis of acquired stress resistance in yeast. PLoS genetics\| PubMed ID: 22102822	2011
Bugs, drugs and chemical genomics. Nature chemical biology\| PubMed ID: 22173359	2012
Mitochondrial electron transport is the cellular target of the oncology drug elesclomol. PloS one\| PubMed ID: 22253786	2012
Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans. Nature chemical biology\| PubMed ID: 22337098	2012
A global perspective of the genetic basis for carbonyl stress resistance. G3 (Bethesda, Md.)\| PubMed ID: 22384333	2011
Identification of yeast genes that confer resistance to chitosan oligosaccharide (COS) using chemogenomics. BMC genomics\| PubMed ID: 22727066	2012
A novel calcineurin-independent activity of cyclosporin A in Saccharomyces cerevisiae. Molecular bioSystems\| PubMed ID: 22751784	2012
Barcode sequencing for understanding drug-gene interactions. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22821592	2012
Comparative chemogenomics to examine the mechanism of action of dna-targeted platinum-acridine anticancer agents. ACS chemical biology\| PubMed ID: 22928710	2012
Global gene deletion analysis exploring yeast filamentous growth. Science (New York, N.Y.)\| PubMed ID: 22984072	2012
An algorithm for chemical genomic profiling that minimizes batch effects: bucket evaluations. BMC bioinformatics\| PubMed ID: 23009392	2012
Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pH(c) in Saccharomyces cerevisiae. Genome biology\| PubMed ID: 23021432	2012
Functional analysis with a barcoder yeast gene overexpression system. G3 (Bethesda, Md.)\| PubMed ID: 23050238	2012
A phenotypic screening platform to identify small molecule modulators of Chlamydomonas reinhardtii growth, motility and photosynthesis. Genome biology\| PubMed ID: 23158586	2012
Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors. The Journal of clinical investigation\| PubMed ID: 23202731	2013
Chromatin is an ancient innovation conserved between Archaea and Eukarya. eLife\| PubMed ID: 23240084	2012
Global analysis of SUMO chain function reveals multiple roles in chromatin regulation. The Journal of cell biology\| PubMed ID: 23547032	2013
DNA-damaging agents in cancer chemotherapy: serendipity and chemical biology. Chemistry & biology\| PubMed ID: 23706631	2013
A high-throughput yeast assay identifies synergistic drug combinations. Assay and drug development technologies\| PubMed ID: 23772551	2013
Miniature short hairpin RNA screens to characterize antiproliferative drugs. G3 (Bethesda, Md.)\| PubMed ID: 23797109	2013
A novel small molecule methyltransferase is important for virulence in Candida albicans. ACS chemical biology\| PubMed ID: 24083538	2013
PITPs as targets for selectively interfering with phosphoinositide signaling in cells. Nature chemical biology\| PubMed ID: 24292071	2014
Large-scale identification and analysis of suppressive drug interactions. Chemistry & biology\| PubMed ID: 24704506	2014
Mapping the cellular response to small molecules using chemogenomic fitness signatures. Science (New York, N.Y.)\| PubMed ID: 24723613	2014
A genome scale overexpression screen to reveal drug activity in human cells. Genome medicine\| PubMed ID: 24944581	2014
Genes required for survival in microgravity revealed by genome-wide yeast deletion collections cultured during spaceflight. BioMed research international\| PubMed ID: 25667933	2015
Caenorhabditis elegans is a useful model for anthelmintic discovery. Nature communications\| PubMed ID: 26108372	2015
Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death. Oncotarget\| PubMed ID: 26353928	2015
Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles. ACS central science\| PubMed ID: 27800551	2016