Britta Engelhardt

Mini-review: Transendothelial migration of leukocytes: through the front door or around the side of the house?

P-selectin glycoprotein ligand 1 is not required for the development of experimental autoimmune encephalomyelitis in SJL and C57BL/6 mice.

The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms.

VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF.

Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity.

Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1.

Lack of junctional adhesion molecule (JAM)-B ameliorates experimental autoimmune encephalomyelitis.

Claudin-3-deficient C57BL/6J mice display intact brain barriers.

The Genetic Background of Mice Influences the Effects of Cigarette Smoke on Onset and Severity of Experimental Autoimmune Encephalomyelitis.

Gene and protein expression profiling of the microvascular compartment in experimental autoimmune encephalomyelitis in C57Bl/6 and SJL mice.

Importance of integrin LFA-1 deactivation for the generation of immune responses.

Therapeutic targeting of alpha 4-integrins in chronic inflammatory diseases: tipping the scales of risk towards benefit?

The circumventricular organs participate in the immunopathogenesis of experimental autoimmune encephalomyelitis.

Regulation of immune cell entry into the central nervous system.

E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice.

Natalizumab: targeting alpha4-integrins in multiple sclerosis.

Therapeutic targeting of leukocyte trafficking across the blood-brain barrier.

Inducible endothelial cell-specific gene expression in transgenic mouse embryos and adult mice.

Effect of interferon-beta and atorvastatin on Th1/Th2 cytokines in multiple sclerosis.

Immune cell entry into the central nervous system: involvement of adhesion molecules and chemokines.

Distinct molecular composition of blood and lymphatic vascular endothelial cell junctions establishes specific functional barriers within the peripheral lymph node.

L-Selectin-deficient SJL and C57BL/6 mice are not resistant to experimental autoimmune encephalomyelitis.

The blood-central nervous system barriers actively control immune cell entry into the central nervous system.

Flotillins interact with PSGL-1 in neutrophils and, upon stimulation, rapidly organize into membrane domains subsequently accumulating in the uropod.

Cutting edge: Natalizumab blocks adhesion but not initial contact of human T cells to the blood-brain barrier in vivo in an animal model of multiple sclerosis.

Culture-induced changes in blood-brain barrier transcriptome: implications for amino-acid transporters in vivo.

The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction.

Preclinical testing of strategies for therapeutic targeting of human T-cell trafficking in vivo.

Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing.

Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis.

Comparison of immortalized bEnd5 and primary mouse brain microvascular endothelial cells as in vitro blood-brain barrier models for the study of T cell extravasation.

Differential roles for endothelial ICAM-1, ICAM-2, and VCAM-1 in shear-resistant T cell arrest, polarization, and directed crawling on blood-brain barrier endothelium.

PSGL-1 is dispensible for the development of active experimental autoimmune encephalomyelitis in SJL/J mice.

Tight junctions in brain barriers during central nervous system inflammation.

TET inducible expression of the α4β7-integrin ligand MAdCAM-1 on the blood-brain barrier does not influence the immunopathogenesis of experimental autoimmune encephalomyelitis.

Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle.

Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy.

β1-integrin/matrix interactions support blood-brain barrier integrity.

Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis.

Neuroscience. Blood-brain barrier differentiation.

Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation.

Capture, crawl, cross: the T cell code to breach the blood-brain barriers.

Going against the tide--how encephalitogenic T cells breach the blood-brain barrier.

Junctional adhesion molecule (JAM)-C deficient C57BL/6 mice develop a severe hydrocephalus.

Immunologic privilege in the central nervous system and the blood-brain barrier.

The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury.

Live cell imaging techniques to study T cell trafficking across the blood-brain barrier in vitro and in vivo.

Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro.

Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells.

β2 integrin-mediated crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood-brain barrier.

Novel insights into the development and maintenance of the blood-brain barrier.

DARC shuttles inflammatory chemokines across the blood-brain barrier during autoimmune central nervous system inflammation.

PSGL-1 and E/P-selectins are essential for T-cell rolling in inflamed CNS microvessels but dispensable for initiation of EAE.

Novel oxazolo-oxazole derivatives of FTY720 reduce endothelial cell permeability, immune cell chemotaxis and symptoms of experimental autoimmune encephalomyelitis in mice.

A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells.

Neutrophils mediate blood-spinal cord barrier disruption in demyelinating neuroinflammatory diseases.

The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions.

Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier.

Investigation of leptomeningeal enhancement in MS: a postcontrast FLAIR MRI study.

Mode of action of claudin peptidomimetics in the transient opening of cellular tight junction barriers.

Brain barriers: Crosstalk between complex tight junctions and adherens junctions.

Wiring the Vascular Network with Neural Cues: A CNS Perspective.

Migration of encephalitogenic CD8 T cells into the central nervous system is dependent on the α4β1-integrin.

Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis.

Leptomeningeal contrast enhancement and blood-CSF barrier dysfunction in aseptic meningitis.

Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke.

Sphingosine kinase 2 deficient mice exhibit reduced experimental autoimmune encephalomyelitis: Resistance to FTY720 but not ST-968 treatments.

Lung ICAM-1 and ICAM-2 support spontaneous intravascular effector lymphocyte entrapment but are not required for neutrophil entrapment or emigration inside endotoxin-inflamed lungs.

Modeling immune functions of the mouse blood-cerebrospinal fluid barrier in vitro: primary rather than immortalized mouse choroid plexus epithelial cells are suited to study immune cell migration across this brain barrier.

Postarrest stalling rather than crawling favors CD8(+) over CD4(+) T-cell migration across the blood-brain barrier under flow in vitro.

Current multiple sclerosis treatments have improved our understanding of MS autoimmune pathogenesis.

Refined clinical scoring in comparative EAE studies does not enhance the chance to observe statistically significant differences.

Vascular, glial, and lymphatic immune gateways of the central nervous system.

Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis.

Non-invasive near-infrared fluorescence imaging of the neutrophil response in a mouse model of transient cerebral ischaemia.

Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis.

The movers and shapers in immune privilege of the CNS.

How Does the Immune System Enter the Brain?

ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood-brain barrier.

A Novel Cervical Spinal Cord Window Preparation Allows for Two-Photon Imaging of T-Cell Interactions with the Cervical Spinal Cord Microvasculature during Experimental Autoimmune Encephalomyelitis.

The choroid plexus is a key cerebral invasion route for T cells after stroke.

ICAMs support B cell interactions with T follicular helper cells and promote clonal selection.

Guidelines for the use of flow cytometry and cell sorting in immunological studies.

Impaired T-cell migration to the CNS under fingolimod and dimethyl fumarate.

TNFα blockade mediates bone protection in antigen-induced arthritis by reducing osteoclast precursor supply.

Immunosenescence in persons with spinal cord injury in relation to urinary tract infections -a cross-sectional study.

Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease.

Cluster: barriers of the central nervous system.

ICAM-1 C57BL/6 Mice Are Not Protected from Experimental Ischemic Stroke.

Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke.

Frequency and clinical characteristics of Multiple Sclerosis rebounds after withdrawal of Fingolimod.

Ischemia-reperfusion injury in stroke: impact of the brain barriers and brain immune privilege on neutrophil function.

A silicon nanomembrane platform for the visualization of immune cell trafficking across the human blood-brain barrier under flow.

PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation.

CD49d/CD29-integrin controls the accumulation of plasmacytoid dendritic cells into the CNS during neuroinflammation.

Publisher Correction: Claudin-3-deficient C57BL/6J mice display intact brain barriers.

Claudin-12 is not required for blood-brain barrier tight junction function.

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).

Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers.

Distinct migratory pattern of naive and effector T cells through the blood-CSF barrier following Echovirus 30 infection.

Sleep enhances numbers and function of monocytes and improves bacterial infection outcome in mice.

Functional relevance of the multi-drug transporter abcg2 on teriflunomide therapy in an animal model of multiple sclerosis.

Intercellular Adhesion Molecule-1 (ICAM-1) and ICAM-2 Differentially Contribute to Peripheral Activation and CNS Entry of Autoaggressive Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis.

Human CD4 T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro.

Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS.

CD31 (PECAM-1) Serves as the Endothelial Cell-Specific Receptor of Clostridium perfringens β-Toxin.

Oligomeric Forms of Human Amyloid-Beta(1-42) Inhibit Antigen Presentation.

Contribution of brain pericytes in blood-brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells.

Advancing brain barriers RNA sequencing: guidelines from experimental design to publication.

Morpholino Analogues of Fingolimod as Novel and Selective S1P Ligands with In Vivo Efficacy in a Mouse Model of Experimental Antigen-Induced Encephalomyelitis.

Immune cell trafficking across the blood-brain barrier in the absence and presence of neuroinflammation.

Microglia Get a Little Help from "Th"-eir Friends.

Advancing human induced pluripotent stem cell-derived blood-brain barrier models for studying immune cell interactions.

Innovative high-resolution microCT imaging of animal brain vasculature.

Brain Barriers and Multiple Sclerosis: Novel Treatment Approaches from a Brain Barriers Perspective.

T Cell-Mediated Transport of Polymer Nanoparticles across the Blood-Brain Barrier.

Maternal Infection Impairs Fetal Brain Development via Choroid Plexus Inflammation.

Novel compounds with dual S1P receptor agonist and histamine H receptor antagonist activities act protective in a mouse model of multiple sclerosis.

Biotin-NeutrAvidin Mediated Immobilization of Polymer Micro- and Nanoparticles on T Lymphocytes.

Histone deacetylase 1 controls CD4 T cell trafficking in autoinflammatory diseases.

Selective Endocannabinoid Reuptake Inhibitor WOBE437 Reduces Disease Progression in a Mouse Model of Multiple Sclerosis.

Loss of Claudin-3 Impairs Hepatic Metabolism, Biliary Barrier Function, and Cell Proliferation in the Murine Liver.

Brain endothelial tricellular junctions as novel sites for T cell diapedesis across the blood-brain barrier.

Pro-resolving lipid mediator lipoxin A attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome.

Differentiation of human pluripotent stem cells to brain microvascular endothelial cell-like cells suitable to study immune cell interactions.

Covalent and Noncovalent Conjugation of Degradable Polymer Nanoparticles to T Lymphocytes.

ACKR1 favors transcellular over paracellular T-cell diapedesis across the blood-brain barrier in neuroinflammation in vitro.

Wnt signaling mediates acquisition of blood-brain barrier properties in naïve endothelium derived from human pluripotent stem cells.

The blood-CSF-brain route of neurological disease: The indirect pathway into the brain.

Nano-scale architecture of blood-brain barrier tight-junctions.

Intrinsic blood-brain barrier dysfunction contributes to multiple sclerosis pathogenesis.

Central nervous system zoning: How brain barriers establish subdivisions for CNS immune privilege and immune surveillance.

Brain barriers virtual: an interim solution or future opportunity?

COVID-19 and the Vasculature: Current Aspects and Long-Term Consequences.

Multiple sclerosis: Immunopathological heterogeneity and its implications.

Autoimmune neuroinflammation triggers mitochondrial oxidation in oligodendrocytes.

Full spectrum of vitamin D immunomodulation in multiple sclerosis: mechanisms and therapeutic implications.

The Modular µSiM: A Mass Produced, Rapidly Assembled, and Reconfigurable Platform for the Study of Barrier Tissue Models In Vitro.

Connexins orchestrate progression of breast cancer metastasis to the brain by promoting FAK activation.

A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature.

Perivascular spaces and their role in neuroinflammation.

Bovine neutrophil chemotaxis to Listeria monocytogenes in neurolisteriosis depends on microglia-released rather than bacterial factors.

Modeling Brain Vasculature Immune Interactions In Vitro.

Macrophages clear the way for CNS fluid flow.

Insulin-like growth factor-1 receptor controls the function of CNS-resident macrophages and their contribution to neuroinflammation.

Open pathways for cerebrospinal fluid outflow at the cribriform plate along the olfactory nerves.

Blockade of VEGFR3 signaling leads to functional impairment of dural lymphatic vessels without affecting autoimmune neuroinflammation.

Effects of a Small-Molecule Perforin Inhibitor in a Mouse Model of CD8 T Cell-Mediated Neuroinflammation.

High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4 T cell arrest on the inflamed BBB under flow in vitro.

Antigen recognition detains CD8 T cells at the blood-brain barrier and contributes to its breakdown.

The choroid plexus acts as an immune cell reservoir and brain entry site in experimental autoimmune encephalomyelitis.

Integration of immune cells in organs-on-chips: a tutorial.

Correction to: The choroid plexus acts as an immune cell reservoir and brain entry site in experimental autoimmune encephalomyelitis.

VE-cadherin in arachnoid and pia mater cells serves as a suitable landmark for in vivo imaging of CNS immune surveillance and inflammation.

Molecular anatomy of adult mouse leptomeninges.

A20 regulates lymphocyte adhesion in murine neuroinflammation by restricting endothelial ICOSL expression in the CNS.

SARS-CoV-2 infects epithelial cells of the blood-cerebrospinal fluid barrier rather than endothelial cells or pericytes of the blood-brain barrier.

Compromised Blood-Brain Barrier Junctions Enhance Melanoma Cell Intercalation and Extravasation.