Department of Chemistry and Biochemistry,
Program in BioMolecular Science and Engineering,
Department of Chemistry and Biochemistry, Program in BioMolecular Science and Engineering
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Equilibrium collapse and the kinetic 'foldability' of proteins.
Biochemistry Jan, 2002 | Pubmed ID: 11772031
Residues participating in the protein folding nucleus do not exhibit preferential evolutionary conservation.
Journal of molecular biology Feb, 2002 | Pubmed ID: 11851333
How the folding rate constant of simple, single-domain proteins depends on the number of native contacts.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2002 | Pubmed ID: 11904417
High-efficiency fluorescence quenching of conjugated polymers by proteins.
Journal of the American Chemical Society May, 2002 | Pubmed ID: 12010029
The backbone conformational entropy of protein folding: experimental measures from atomic force microscopy.
Journal of molecular biology Sep, 2002 | Pubmed ID: 12225756
Toward a taxonomy of the denatured state: small angle scattering studies of unfolded proteins.
Advances in protein chemistry , 2002 | Pubmed ID: 12418105
The topomer search model: A simple, quantitative theory of two-state protein folding kinetics.
Protein science : a publication of the Protein Society Jan, 2003 | Pubmed ID: 12493824
Cooperativity, smooth energy landscapes and the origins of topology-dependent protein folding rates.
Journal of molecular biology Feb, 2003 | Pubmed ID: 12547206
Beyond superquenching: hyper-efficient energy transfer from conjugated polymers to gold nanoparticles.
Proceedings of the National Academy of Sciences of the United States of America May, 2003 | Pubmed ID: 12750470
Comparison of the folding processes of distantly related proteins. Importance of hydrophobic content in folding.
Journal of molecular biology Jul, 2003 | Pubmed ID: 12842473
NMR and temperature-jump measurements of de novo designed proteins demonstrate rapid folding in the absence of explicit selection for kinetics.
Journal of molecular biology Jul, 2003 | Pubmed ID: 12850149
Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2003 | Pubmed ID: 12867594
Contact order revisited: influence of protein size on the folding rate.
Protein science : a publication of the Protein Society Sep, 2003 | Pubmed ID: 12931003
Terahertz circular dichroism spectroscopy: a potential approach to the in situ detection of life's metabolic and genetic machinery.
Astrobiology , 2003 | Pubmed ID: 14678660
Using protein folding rates to test protein folding theories.
Annual review of biochemistry , 2004 | Pubmed ID: 15189160
Random-coil behavior and the dimensions of chemically unfolded proteins.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2004 | Pubmed ID: 15314214
Apparent Debye-Huckel electrostatic effects in the folding of a simple, single domain protein.
Biochemistry Feb, 2005 | Pubmed ID: 15667218
Protein folding: defining a "standard" set of experimental conditions and a preliminary kinetic data set of two-state proteins.
Protein science : a publication of the Protein Society Mar, 2005 | Pubmed ID: 15689503
The protein folding transition state: what are Phi-values really telling us?
Protein and peptide letters Feb, 2005 | Pubmed ID: 15723637
Biosensors based on binding-modulated donor-acceptor distances.
Trends in biotechnology Apr, 2005 | Pubmed ID: 15780710
Label-free electronic detection of thrombin in blood serum by using an aptamer-based sensor.
Angewandte Chemie (International ed. in English) Aug, 2005 | Pubmed ID: 16044476
Engineering a signal transduction mechanism for protein-based biosensors.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2005 | Pubmed ID: 16046542
Site-specific dimensions across a highly denatured protein; a single molecule study.
Journal of molecular biology Sep, 2005 | Pubmed ID: 16095607
Is there or isn't there? The case for (and against) residual structure in chemically denatured proteins.
Critical reviews in biochemistry and molecular biology Jul-Aug, 2005 | Pubmed ID: 16126485
Experimental investigation of the frequency and substitution dependence of negative phi-values in two-state proteins.
Biochemistry Sep, 2005 | Pubmed ID: 16142914
A reagentless signal-on architecture for electronic, aptamer-based sensors via target-induced strand displacement.
Journal of the American Chemical Society Dec, 2005 | Pubmed ID: 16366535
Absorption spectra of liquid water and aqueous buffers between 0.3 and 3.72 THz.
The Journal of chemical physics Jan, 2006 | Pubmed ID: 16438614
Differential labeling of closely spaced biosensor electrodes via electrochemical lithography.
Langmuir : the ACS journal of surfaces and colloids Feb, 2006 | Pubmed ID: 16460130
On the precision of experimentally determined protein folding rates and phi-values.
Protein science : a publication of the Protein Society Mar, 2006 | Pubmed ID: 16501226
An electronic, aptamer-based small-molecule sensor for the rapid, label-free detection of cocaine in adulterated samples and biological fluids.
Journal of the American Chemical Society Mar, 2006 | Pubmed ID: 16522082
Rapid, sequence-specific detection of unpurified PCR amplicons via a reusable, electrochemical sensor.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2006 | Pubmed ID: 16537478
Probing the collective vibrational dynamics of a protein in liquid water by terahertz absorption spectroscopy.
Protein science : a publication of the Protein Society May, 2006 | Pubmed ID: 16641490
Cooperativity and the origins of rapid, single-exponential kinetics in protein folding.
Protein science : a publication of the Protein Society Jul, 2006 | Pubmed ID: 16815915
Sequence-specific, electronic detection of oligonucleotides in blood, soil, and foodstuffs with the reagentless, reusable E-DNA sensor.
Analytical chemistry Aug, 2006 | Pubmed ID: 16906710
Methods for the accurate estimation of confidence intervals on protein folding phi-values.
Protein science : a publication of the Protein Society Oct, 2006 | Pubmed ID: 17008714
Excimer-based peptide beacons: a convenient experimental approach for monitoring polypeptide-protein and polypeptide-oligonucleotide interactions.
Journal of the American Chemical Society Nov, 2006 | Pubmed ID: 17061871
Single-step electronic detection of femtomolar DNA by target-induced strand displacement in an electrode-bound duplex.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2006 | Pubmed ID: 17065320
Collective dynamics of lysozyme in water: terahertz absorption spectroscopy and comparison with theory.
The journal of physical chemistry. B Nov, 2006 | Pubmed ID: 17125398
Comparison of the signaling and stability of electrochemical DNA sensors fabricated from 6- or 11-carbon self-assembled monolayers.
Langmuir : the ACS journal of surfaces and colloids Dec, 2006 | Pubmed ID: 17129062
Aptamer-based electrochemical detection of picomolar platelet-derived growth factor directly in blood serum.
Analytical chemistry Jan, 2007 | Pubmed ID: 17194144
Electrochemical detection of parts-per-billion lead via an electrode-bound DNAzyme assembly.
Journal of the American Chemical Society Jan, 2007 | Pubmed ID: 17212391
Increasing the resolution of single pair fluorescence resonance energy transfer measurements in solution via molecular cytometry.
Analytical chemistry May, 2007 | Pubmed ID: 17385843
Influence of local and residual structures on the scaling behavior and dimensions of unfolded proteins.
Biopolymers Jul, 2007 | Pubmed ID: 17450572
Peptide beacons: a new design for polypeptide-based optical biosensors.
Bioconjugate chemistry May-Jun, 2007 | Pubmed ID: 17461545
Effect of molecular crowding on the response of an electrochemical DNA sensor.
Langmuir : the ACS journal of surfaces and colloids Jun, 2007 | Pubmed ID: 17488132
Label-free electrochemical detection of DNA in blood serum via target-induced resolution of an electrode-bound DNA pseudoknot.
Journal of the American Chemical Society Oct, 2007 | Pubmed ID: 17850085
Linear, redox modified DNA probes as electrochemical DNA sensors.
Chemical communications (Cambridge, England) Sep, 2007 | Pubmed ID: 17851622
Preparation of electrode-immobilized, redox-modified oligonucleotides for electrochemical DNA and aptamer-based sensing.
Nature protocols , 2007 | Pubmed ID: 18007622
Microfluidic device architecture for electrochemical patterning and detection of multiple DNA sequences.
Langmuir : the ACS journal of surfaces and colloids Feb, 2008 | Pubmed ID: 18181654
Chimeric peptide beacons: a direct polypeptide analog of DNA molecular beacons.
Chemical communications (Cambridge, England) Dec, 2007 | Pubmed ID: 18361352
Some recommendations for the practitioner to improve the precision of experimentally determined protein folding rates and phi values.
Proteins Feb, 2009 | Pubmed ID: 18655053
Optimization of electrochemical aptamer-based sensors via optimization of probe packing density and surface chemistry.
Langmuir : the ACS journal of surfaces and colloids Sep, 2008 | Pubmed ID: 18690727
Optimization of a reusable, DNA pseudoknot-based electrochemical sensor for sequence-specific DNA detection in blood serum.
Analytical chemistry Jan, 2009 | Pubmed ID: 19093760
Improving the stability and sensing of electrochemical biosensors by employing trithiol-anchoring groups in a six-carbon self-assembled monolayer.
Analytical chemistry Feb, 2009 | Pubmed ID: 19133790
Protein complexes: the evolution of symmetry.
Current biology : CB Jan, 2009 | Pubmed ID: 19138586
Beyond molecular beacons: optical sensors based on the binding-induced folding of proteins and polypeptides.
Chemistry (Weinheim an der Bergstrasse, Germany) , 2009 | Pubmed ID: 19191230
Reagentless, electrochemical approach for the specific detection of double- and single-stranded DNA binding proteins.
Analytical chemistry Feb, 2009 | Pubmed ID: 19199570
Effects of probe length, probe geometry, and redox-tag placement on the performance of the electrochemical E-DNA sensor.
Analytical chemistry Mar, 2009 | Pubmed ID: 19215066
Continuous, real-time monitoring of cocaine in undiluted blood serum via a microfluidic, electrochemical aptamer-based sensor.
Journal of the American Chemical Society Apr, 2009 | Pubmed ID: 19271708
Surface chemistry effects on the performance of an electrochemical DNA sensor.
Bioelectrochemistry (Amsterdam, Netherlands) Sep, 2009 | Pubmed ID: 19362061
An electrochemical sensor for the detection of protein-small molecule interactions directly in serum and other complex matrices.
Journal of the American Chemical Society May, 2009 | Pubmed ID: 19413316
High specificity, electrochemical sandwich assays based on single aptamer sequences and suitable for the direct detection of small-molecule targets in blood and other complex matrices.
Journal of the American Chemical Society May, 2009 | Pubmed ID: 19419171
Fluorescence detection of single-nucleotide polymorphisms with a single, self-complementary, triple-stem DNA probe.
Angewandte Chemie (International ed. in English) , 2009 | Pubmed ID: 19431180
The length and viscosity dependence of end-to-end collision rates in single-stranded DNA.
Biophysical journal Jul, 2009 | Pubmed ID: 19580758
Thermodynamic basis for the optimization of binding-induced biomolecular switches and structure-switching biosensors.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2009 | Pubmed ID: 19666496
Measuring distances within unfolded biopolymers using fluorescence resonance energy transfer: The effect of polymer chain dynamics on the observed fluorescence resonance energy transfer efficiency.
The Journal of chemical physics Aug, 2009 | Pubmed ID: 19725638
Non-sequence-specific interactions can account for the compaction of proteins unfolded under "native" conditions.
Journal of molecular biology Nov, 2009 | Pubmed ID: 19751743
The rate of intramolecular loop formation in DNA and polypeptides: the absence of the diffusion-controlled limit and fractional power-law viscosity dependence.
The journal of physical chemistry. B Oct, 2009 | Pubmed ID: 19780594
An electrochemical sensor for single nucleotide polymorphism detection in serum based on a triple-stem DNA probe.
Journal of the American Chemical Society Oct, 2009 | Pubmed ID: 19807078
Comparing the properties of electrochemical-based DNA sensors employing different redox tags.
Analytical chemistry Nov, 2009 | Pubmed ID: 19810694
A general electrochemical method for label-free screening of protein-small molecule interactions.
Chemical communications (Cambridge, England) Nov, 2009 | Pubmed ID: 19826675
Exploiting binding-induced changes in probe flexibility for the optimization of electrochemical biosensors.
Analytical chemistry Jan, 2010 | Pubmed ID: 20000457
On the binding of cationic, water-soluble conjugated polymers to DNA: electrostatic and hydrophobic interactions.
Journal of the American Chemical Society Feb, 2010 | Pubmed ID: 20058862
Sensitive and selective amplified fluorescence DNA detection based on exonuclease III-aided target recycling.
Journal of the American Chemical Society Feb, 2010 | Pubmed ID: 20092337
Tracking a molecular motor with a nanoscale optical encoder.
Nano letters Mar, 2010 | Pubmed ID: 20121107
Re-engineering aptamers to support reagentless, self-reporting electrochemical sensors.
The Analyst Mar, 2010 | Pubmed ID: 20174715
Quantitative, reagentless, single-step electrochemical detection of anti-DNA antibodies directly in blood serum.
Chemical communications (Cambridge, England) Mar, 2010 | Pubmed ID: 20177635
Folding-based electrochemical biosensors: the case for responsive nucleic acid architectures.
Accounts of chemical research Apr, 2010 | Pubmed ID: 20201486
On the Signaling of Electrochemical Aptamer-Based Sensors: Collision- and Folding-Based Mechanisms.
Electroanalysis Jun, 2009 | Pubmed ID: 20436787
Engineering New Aptamer Geometries for Electrochemical Aptamer-Based Sensors.
Proceedings - Society of Photo-Optical Instrumentation Engineers , 2009 | Pubmed ID: 20436792
Label-free, dual-analyte electrochemical biosensors: a new class of molecular-electronic logic gates.
Journal of the American Chemical Society Jun, 2010 | Pubmed ID: 20527878
Colorimetric detection of DNA, small molecules, proteins, and ions using unmodified gold nanoparticles and conjugated polyelectrolytes.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2010 | Pubmed ID: 20534499
Structure-switching biosensors: inspired by Nature.
Current opinion in structural biology Aug, 2010 | Pubmed ID: 20627702
Reagentless measurement of aminoglycoside antibiotics in blood serum via an electrochemical, ribonucleic acid aptamer-based biosensor.
Analytical chemistry Sep, 2010 | Pubmed ID: 20687587
Investigation of an anomalously accelerating substitution in the folding of a prototypical two-state protein.
Journal of molecular biology Oct, 2010 | Pubmed ID: 20816985
Biomimetic glass nanopores employing aptamer gates responsive to a small molecule.
Chemical communications (Cambridge, England) Nov, 2010 | Pubmed ID: 20865192
An electrochemical supersandwich assay for sensitive and selective DNA detection in complex matrices.
Journal of the American Chemical Society Oct, 2010 | Pubmed ID: 20873767
Detection of telomerase activity in high concentration of cell lysates using primer-modified gold nanoparticles.
Journal of the American Chemical Society Nov, 2010 | Pubmed ID: 20932008
Using Triplex-Forming Oligonucleotide Probes for the Reagentless, Electrochemical Detection of Double-Stranded DNA.
Analytical chemistry Oct, 2010 | Pubmed ID: 20936782
The art of writing science.
Protein science : a publication of the Protein Society Dec, 2010 | Pubmed ID: 20954234
A mechanistic study of electron transfer from the distal termini of electrode-bound, single-stranded DNAs.
Journal of the American Chemical Society Nov, 2010 | Pubmed ID: 20964337
Switch-based biosensors: a new approach towards real-time, in vivo molecular detection.
Trends in biotechnology Jan, 2011 | Pubmed ID: 21106266
Universality in the timescales of internal loop formation in unfolded proteins and single-stranded oligonucleotides.
Biophysical journal Dec, 2010 | Pubmed ID: 21156138
Dielectric spectroscopy of proteins as a quantitative experimental test of computational models of their low-frequency harmonic motions.
Journal of the American Chemical Society Jun, 2011 | Pubmed ID: 21542634
Transcription factor beacons for the quantitative detection of DNA binding activity.
Journal of the American Chemical Society Sep, 2011 | Pubmed ID: 21815647
Probe accessibility effects on the performance of electrochemical biosensors employing DNA monolayers.
Analytical and bioanalytical chemistry Jan, 2012 | Pubmed ID: 21928081
CheapStat: an open-source, "do-it-yourself" potentiostat for analytical and educational applications.
PloS one , 2011 | Pubmed ID: 21931613
Electrochemical biosensors employing an internal electrode attachment site and achieving reversible, high gain detection of specific nucleic acid sequences.
Analytical chemistry Dec, 2011 | Pubmed ID: 21975121
Polarity-switching electrochemical sensor for specific detection of single-nucleotide mismatches.
Angewandte Chemie (International ed. in English) Nov, 2011 | Pubmed ID: 21976312
High-precision, in vitro validation of the sequestration mechanism for generating ultrasensitive dose-response curves in regulatory networks.
PLoS computational biology Oct, 2011 | Pubmed ID: 21998566
Two-step, PCR-free telomerase detection by using exonuclease III-aided target recycling.
Chembiochem : a European journal of chemical biology Dec, 2011 | Pubmed ID: 22125097
Wash-free, Electrochemical Platform for the Quantitative, Multiplexed Detection of Specific Antibodies.
Analytical chemistry Jan, 2012 | Pubmed ID: 22145706
Entropic and electrostatic effects on the folding free energy of a surface-attached biomolecule: an experimental and theoretical study.
Journal of the American Chemical Society Feb, 2012 | Pubmed ID: 22239220
Engineering biosensors with extended, narrowed, or arbitrarily edited dynamic range.
Journal of the American Chemical Society Feb, 2012 | Pubmed ID: 22239688
Quantification of Transcription Factor Binding in Cell Extracts Using an Electrochemical, Structure-Switching Biosensor.
Journal of the American Chemical Society Feb, 2012 | Pubmed ID: 22313286
Effects of crowding on the stability of a surface-tethered biopolymer: an experimental study of folding in a highly crowded regime.
Journal of the American Chemical Society Jun, 2014 | Pubmed ID: 24919057
Exploiting the conformational-selection mechanism to control the response kinetics of a "smart" DNA hydrogel.
The Analyst May, 2018 | Pubmed ID: 29713702
An electrochemical aptamer-based sensor for the rapid and convenient measurement of L-tryptophan.
Analytical and bioanalytical chemistry Jul, 2019 | Pubmed ID: 30796485
Seconds-resolved pharmacokinetic measurements of the chemotherapeutic irinotecan in the living body.
Chemical science Sep, 2019 | Pubmed ID: 31673321
Catalytic Interruption Mitigates Edge Effects in the Characterization of Heterogeneous, Insulating Nanoparticles.
Journal of the American Chemical Society Nov, 2021 | Pubmed ID: 34735140
Electrochemical Aptamer-Based Sensors: A Platform Approach to High-Frequency Molecular Monitoring In Situ in the Living Body.
Methods in molecular biology (Clifton, N.J.) , 2022 | Pubmed ID: 34837195
Improved calibration of electrochemical aptamer-based sensors.
Scientific reports Apr, 2022 | Pubmed ID: 35365672
On the Disinfection of Electrochemical Aptamer-Based Sensors.
ECS sensors plus Mar, 2022 | Pubmed ID: 36452064
Conformational-switch biosensors as novel tools to support continuous, real-time molecular monitoring in lab-on-a-chip devices.
Lab on a chip Mar, 2023 | Pubmed ID: 36655710
On the Rational Design of Cooperative Receptors.
Annual review of biophysics May, 2023 | Pubmed ID: 36737603
Efforts toward the continuous monitoring of molecular markers of performance.
Journal of science and medicine in sport Jun, 2023 | Pubmed ID: 36841706
A tight squeeze: geometric effects on the performance of three-electrode electrochemical-aptamer based sensors in constrained, placements.
The Analyst Mar, 2023 | Pubmed ID: 36891771
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