Kevin W. Plaxco

Equilibrium collapse and the kinetic 'foldability' of proteins.

Residues participating in the protein folding nucleus do not exhibit preferential evolutionary conservation.

How the folding rate constant of simple, single-domain proteins depends on the number of native contacts.

High-efficiency fluorescence quenching of conjugated polymers by proteins.

The backbone conformational entropy of protein folding: experimental measures from atomic force microscopy.

Toward a taxonomy of the denatured state: small angle scattering studies of unfolded proteins.

The topomer search model: A simple, quantitative theory of two-state protein folding kinetics.

Cooperativity, smooth energy landscapes and the origins of topology-dependent protein folding rates.

Beyond superquenching: hyper-efficient energy transfer from conjugated polymers to gold nanoparticles.

Comparison of the folding processes of distantly related proteins. Importance of hydrophobic content in folding.

NMR and temperature-jump measurements of de novo designed proteins demonstrate rapid folding in the absence of explicit selection for kinetics.

Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA.

Contact order revisited: influence of protein size on the folding rate.

Terahertz circular dichroism spectroscopy: a potential approach to the in situ detection of life's metabolic and genetic machinery.

Using protein folding rates to test protein folding theories.

Random-coil behavior and the dimensions of chemically unfolded proteins.

Apparent Debye-Huckel electrostatic effects in the folding of a simple, single domain protein.

Protein folding: defining a "standard" set of experimental conditions and a preliminary kinetic data set of two-state proteins.

The protein folding transition state: what are Phi-values really telling us?

Biosensors based on binding-modulated donor-acceptor distances.

Label-free electronic detection of thrombin in blood serum by using an aptamer-based sensor.

Engineering a signal transduction mechanism for protein-based biosensors.

Site-specific dimensions across a highly denatured protein; a single molecule study.

Is there or isn't there? The case for (and against) residual structure in chemically denatured proteins.

Experimental investigation of the frequency and substitution dependence of negative phi-values in two-state proteins.

A reagentless signal-on architecture for electronic, aptamer-based sensors via target-induced strand displacement.

Absorption spectra of liquid water and aqueous buffers between 0.3 and 3.72 THz.

Differential labeling of closely spaced biosensor electrodes via electrochemical lithography.

On the precision of experimentally determined protein folding rates and phi-values.

An electronic, aptamer-based small-molecule sensor for the rapid, label-free detection of cocaine in adulterated samples and biological fluids.

Rapid, sequence-specific detection of unpurified PCR amplicons via a reusable, electrochemical sensor.

Probing the collective vibrational dynamics of a protein in liquid water by terahertz absorption spectroscopy.

Cooperativity and the origins of rapid, single-exponential kinetics in protein folding.

Sequence-specific, electronic detection of oligonucleotides in blood, soil, and foodstuffs with the reagentless, reusable E-DNA sensor.

Methods for the accurate estimation of confidence intervals on protein folding phi-values.

Excimer-based peptide beacons: a convenient experimental approach for monitoring polypeptide-protein and polypeptide-oligonucleotide interactions.

Single-step electronic detection of femtomolar DNA by target-induced strand displacement in an electrode-bound duplex.

Collective dynamics of lysozyme in water: terahertz absorption spectroscopy and comparison with theory.

Comparison of the signaling and stability of electrochemical DNA sensors fabricated from 6- or 11-carbon self-assembled monolayers.

Aptamer-based electrochemical detection of picomolar platelet-derived growth factor directly in blood serum.

Electrochemical detection of parts-per-billion lead via an electrode-bound DNAzyme assembly.

Increasing the resolution of single pair fluorescence resonance energy transfer measurements in solution via molecular cytometry.

Influence of local and residual structures on the scaling behavior and dimensions of unfolded proteins.

Peptide beacons: a new design for polypeptide-based optical biosensors.

Effect of molecular crowding on the response of an electrochemical DNA sensor.

Label-free electrochemical detection of DNA in blood serum via target-induced resolution of an electrode-bound DNA pseudoknot.

Linear, redox modified DNA probes as electrochemical DNA sensors.

Preparation of electrode-immobilized, redox-modified oligonucleotides for electrochemical DNA and aptamer-based sensing.

Microfluidic device architecture for electrochemical patterning and detection of multiple DNA sequences.

Chimeric peptide beacons: a direct polypeptide analog of DNA molecular beacons.

Some recommendations for the practitioner to improve the precision of experimentally determined protein folding rates and phi values.

Optimization of electrochemical aptamer-based sensors via optimization of probe packing density and surface chemistry.

Optimization of a reusable, DNA pseudoknot-based electrochemical sensor for sequence-specific DNA detection in blood serum.

Improving the stability and sensing of electrochemical biosensors by employing trithiol-anchoring groups in a six-carbon self-assembled monolayer.

Protein complexes: the evolution of symmetry.

Beyond molecular beacons: optical sensors based on the binding-induced folding of proteins and polypeptides.

Reagentless, electrochemical approach for the specific detection of double- and single-stranded DNA binding proteins.

Effects of probe length, probe geometry, and redox-tag placement on the performance of the electrochemical E-DNA sensor.

Continuous, real-time monitoring of cocaine in undiluted blood serum via a microfluidic, electrochemical aptamer-based sensor.

Surface chemistry effects on the performance of an electrochemical DNA sensor.

An electrochemical sensor for the detection of protein-small molecule interactions directly in serum and other complex matrices.

High specificity, electrochemical sandwich assays based on single aptamer sequences and suitable for the direct detection of small-molecule targets in blood and other complex matrices.

Fluorescence detection of single-nucleotide polymorphisms with a single, self-complementary, triple-stem DNA probe.

The length and viscosity dependence of end-to-end collision rates in single-stranded DNA.

Thermodynamic basis for the optimization of binding-induced biomolecular switches and structure-switching biosensors.

Measuring distances within unfolded biopolymers using fluorescence resonance energy transfer: The effect of polymer chain dynamics on the observed fluorescence resonance energy transfer efficiency.

Non-sequence-specific interactions can account for the compaction of proteins unfolded under "native" conditions.

The rate of intramolecular loop formation in DNA and polypeptides: the absence of the diffusion-controlled limit and fractional power-law viscosity dependence.

An electrochemical sensor for single nucleotide polymorphism detection in serum based on a triple-stem DNA probe.

Comparing the properties of electrochemical-based DNA sensors employing different redox tags.

A general electrochemical method for label-free screening of protein-small molecule interactions.

Exploiting binding-induced changes in probe flexibility for the optimization of electrochemical biosensors.

On the binding of cationic, water-soluble conjugated polymers to DNA: electrostatic and hydrophobic interactions.

Sensitive and selective amplified fluorescence DNA detection based on exonuclease III-aided target recycling.

Tracking a molecular motor with a nanoscale optical encoder.

Re-engineering aptamers to support reagentless, self-reporting electrochemical sensors.

Quantitative, reagentless, single-step electrochemical detection of anti-DNA antibodies directly in blood serum.

Folding-based electrochemical biosensors: the case for responsive nucleic acid architectures.

On the Signaling of Electrochemical Aptamer-Based Sensors: Collision- and Folding-Based Mechanisms.

Engineering New Aptamer Geometries for Electrochemical Aptamer-Based Sensors.

Label-free, dual-analyte electrochemical biosensors: a new class of molecular-electronic logic gates.

Colorimetric detection of DNA, small molecules, proteins, and ions using unmodified gold nanoparticles and conjugated polyelectrolytes.

Structure-switching biosensors: inspired by Nature.

Reagentless measurement of aminoglycoside antibiotics in blood serum via an electrochemical, ribonucleic acid aptamer-based biosensor.

Investigation of an anomalously accelerating substitution in the folding of a prototypical two-state protein.

Biomimetic glass nanopores employing aptamer gates responsive to a small molecule.

An electrochemical supersandwich assay for sensitive and selective DNA detection in complex matrices.

Detection of telomerase activity in high concentration of cell lysates using primer-modified gold nanoparticles.

Using Triplex-Forming Oligonucleotide Probes for the Reagentless, Electrochemical Detection of Double-Stranded DNA.

The art of writing science.

A mechanistic study of electron transfer from the distal termini of electrode-bound, single-stranded DNAs.

Switch-based biosensors: a new approach towards real-time, in vivo molecular detection.

Universality in the timescales of internal loop formation in unfolded proteins and single-stranded oligonucleotides.

Dielectric spectroscopy of proteins as a quantitative experimental test of computational models of their low-frequency harmonic motions.

Transcription factor beacons for the quantitative detection of DNA binding activity.

Probe accessibility effects on the performance of electrochemical biosensors employing DNA monolayers.

CheapStat: an open-source, "do-it-yourself" potentiostat for analytical and educational applications.

Electrochemical biosensors employing an internal electrode attachment site and achieving reversible, high gain detection of specific nucleic acid sequences.

Polarity-switching electrochemical sensor for specific detection of single-nucleotide mismatches.

High-precision, in vitro validation of the sequestration mechanism for generating ultrasensitive dose-response curves in regulatory networks.

Two-step, PCR-free telomerase detection by using exonuclease III-aided target recycling.

Wash-free, Electrochemical Platform for the Quantitative, Multiplexed Detection of Specific Antibodies.

Entropic and electrostatic effects on the folding free energy of a surface-attached biomolecule: an experimental and theoretical study.

Engineering biosensors with extended, narrowed, or arbitrarily edited dynamic range.

Quantification of Transcription Factor Binding in Cell Extracts Using an Electrochemical, Structure-Switching Biosensor.

Effects of crowding on the stability of a surface-tethered biopolymer: an experimental study of folding in a highly crowded regime.

Exploiting the conformational-selection mechanism to control the response kinetics of a "smart" DNA hydrogel.

An electrochemical aptamer-based sensor for the rapid and convenient measurement of L-tryptophan.

Seconds-resolved pharmacokinetic measurements of the chemotherapeutic irinotecan in the living body.

Catalytic Interruption Mitigates Edge Effects in the Characterization of Heterogeneous, Insulating Nanoparticles.

Electrochemical Aptamer-Based Sensors: A Platform Approach to High-Frequency Molecular Monitoring In Situ in the Living Body.

Improved calibration of electrochemical aptamer-based sensors.

On the Disinfection of Electrochemical Aptamer-Based Sensors.

Conformational-switch biosensors as novel tools to support continuous, real-time molecular monitoring in lab-on-a-chip devices.

On the Rational Design of Cooperative Receptors.

Efforts toward the continuous monitoring of molecular markers of performance.

A tight squeeze: geometric effects on the performance of three-electrode electrochemical-aptamer based sensors in constrained, placements.