Biological and Environmental Sciences and Engineering Division
Pierre J. Magistretti received his MD in 1979 from the University of Geneva and his Ph.D. in Biology in 1982 from UCSD. His laboratory has discovered some of the cellular and molecular mechanisms that underlie the coupling between neuronal activity and energy consumption by revealing the key role that glial cells, in particular, astrocytes, play in this physiological process. These findings are particularly relevant for understanding the origin of the signals detected by functional brain imaging and are revealing the role of astrocytes in neuronal plasticity and neuroprotection. He is strongly engaged in the public understanding of neuroscience.
Genes involved in the astrocyte-neuron lactate shuttle (ANLS) are specifically regulated in cortical astrocytes following sleep deprivation in mice.
Sleep Oct, 2013 | Pubmed ID: 24082304
Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2014 | Pubmed ID: 25071212
Control of mitochondrial pH by uncoupling protein 4 in astrocytes promotes neuronal survival.
The Journal of biological chemistry Nov, 2014 | Pubmed ID: 25237189
Sustained sleep fragmentation induces sleep homeostasis in mice.
Sleep Apr, 2015 | Pubmed ID: 25325477
Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect.
Frontiers in physiology , 2014 | Pubmed ID: 25642192
Methylglyoxal, the dark side of glycolysis.
Frontiers in neuroscience , 2015 | Pubmed ID: 25709564
Multi-timescale modeling of activity-dependent metabolic coupling in the neuron-glia-vasculature ensemble.
PLoS computational biology Feb, 2015 | Pubmed ID: 25719367
Impact of HSD11B1 polymorphisms on BMI and components of the metabolic syndrome in patients receiving psychotropic treatments.
Pharmacogenetics and genomics May, 2015 | Pubmed ID: 25751397
Neuroenergetic Response to Prolonged Cerebral Glucose Depletion after Severe Brain Injury and the Role of Lactate.
Journal of neurotrauma Oct, 2015 | Pubmed ID: 25790152
A cellular perspective on brain energy metabolism and functional imaging.
Neuron May, 2015 | Pubmed ID: 25996133
Embodied memory: unconscious smiling modulates emotional evaluation of episodic memories.
Frontiers in psychology , 2015 | Pubmed ID: 26074833
Three-dimensional immersive virtual reality for studying cellular compartments in 3D models from EM preparations of neural tissues.
The Journal of comparative neurology Jan, 2016 | Pubmed ID: 26179415
Complex regulation of CREB-binding protein by homeodomain-interacting protein kinase 2.
Cellular signalling Nov, 2015 | Pubmed ID: 26247811
Improvement of Neuroenergetics by Hypertonic Lactate Therapy in Patients with Traumatic Brain Injury Is Dependent on Baseline Cerebral Lactate/Pyruvate Ratio.
Journal of neurotrauma Apr, 2016 | Pubmed ID: 26421521
Goals in Nutrition Science 2015-2020.
Frontiers in nutrition , 2015 | Pubmed ID: 26442272
Learning-Induced Gene Expression in the Hippocampus Reveals a Role of Neuron -Astrocyte Metabolic Coupling in Long Term Memory.
PloS one , 2015 | Pubmed ID: 26513352
In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons.
Cell metabolism Jan, 2016 | Pubmed ID: 26698914
Regulation of neuron-astrocyte metabolic coupling across the sleep-wake cycle.
Neuroscience May, 2016 | Pubmed ID: 26704637
The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression.
Neuropharmacology 08, 2016 | Pubmed ID: 26970016
Sodium signaling and astrocyte energy metabolism.
Glia 10, 2016 | Pubmed ID: 27027636
Sleep fragmentation alters brain energy metabolism without modifying hippocampal electrophysiological response to novelty exposure.
Journal of sleep research 10, 2016 | Pubmed ID: 27136914
A Role for Lactate in the Consolidation of Drug-Related Associative Memories.
Biological psychiatry 06, 2016 | Pubmed ID: 27198521
Imaging brain aerobic glycolysis as a marker of synaptic plasticity.
Proceedings of the National Academy of Sciences of the United States of America 06, 2016 | Pubmed ID: 27317739
Astrocytic β2-adrenergic receptors mediate hippocampal long-term memory consolidation.
Proceedings of the National Academy of Sciences of the United States of America 07, 2016 | Pubmed ID: 27402767
Lactate release from astrocytes to neurons contributes to cocaine memory formation.
BioEssays : news and reviews in molecular, cellular and developmental biology 12, 2016 | Pubmed ID: 27699812
Role of MCT1 and CAII in skeletal muscle pH homeostasis, energetics, and function: insights from MCT1 haploinsufficient mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 06, 2017 | Pubmed ID: 28254758
A preclinical model for identifying rats at risk of alcohol use disorder.
Scientific reports 08, 2017 | Pubmed ID: 28842608
Gender-specific alteration of energy balance and circadian locomotor activity in the Crtc1 knockout mouse model of depression.
Translational psychiatry 12, 2017 | Pubmed ID: 29217834
Inadequate brain glycogen or sleep increases spreading depression susceptibility.
Annals of neurology 01, 2018 | Pubmed ID: 29244233
Lactate in the brain: from metabolic end-product to signalling molecule.
Nature reviews. Neuroscience 04, 2018 | Pubmed ID: 29515192
Impact of MCT1 Haploinsufficiency on the Mouse Retina.
Advances in experimental medicine and biology , 2018 | Pubmed ID: 29721966
Hypertonic Lactate to Improve Cerebral Perfusion and Glucose Availability After Acute Brain Injury.
Critical care medicine 10, 2018 | Pubmed ID: 29923931
At the Heart of Genome Editing and Cardiovascular Diseases.
Circulation research 07, 2018 | Pubmed ID: 29976689
Norepinephrine stimulates glycogenolysis in astrocytes to fuel neurons with lactate.
PLoS computational biology 08, 2018 | Pubmed ID: 30161133
Dual action of L-Lactate on the activity of NR2B-containing NMDA receptors: from potentiation to neuroprotection.
Scientific reports Sep, 2018 | Pubmed ID: 30194439
A Process for Digitizing and Simulating Biologically Realistic Oligocellular Networks Demonstrated for the Neuro-Glio-Vascular Ensemble.
Frontiers in neuroscience , 2018 | Pubmed ID: 30319342
L-Lactate Regulates the Expression of Synaptic Plasticity and Neuroprotection Genes in Cortical Neurons: A Transcriptome Analysis.
Frontiers in molecular neuroscience , 2018 | Pubmed ID: 30364173
The Epistemological Foundations of Freud's Energetics Model.
Frontiers in psychology , 2018 | Pubmed ID: 30364323
The Strategic Location of Glycogen and Lactate: From Body Energy Reserve to Brain Plasticity.
Frontiers in cellular neuroscience , 2019 | Pubmed ID: 30894801
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.
Nature genetics Aug, 2019 | Pubmed ID: 31308545
Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction.
Cell research Aug, 2019 | Pubmed ID: 31444470
Gangliosides: Treatment Avenues in Neurodegenerative Disease.
Frontiers in neurology , 2019 | Pubmed ID: 31447771
Lactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling.
Cell death & disease Sep, 2019 | Pubmed ID: 31506428
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