Zhiguo Chen

Cell Therapy Center, Ministry of Education

Affiliated withMinistry of Education Beijing Institute for Brain Disorders University of Texas Southwestern Medical Center at Dallas

Research Area

Developmental BiologyNeuroscience

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title	2019
Publication title	2023
Publication title	2025

Other Publications

Article	Year
Upregulation of myosin Va by Snail is involved in cancer cell migration and metastasis. International journal of cancer\| PubMed ID: 19521958	2010
Cancer/testis antigens and clinical risk factors for liver metastasis of colorectal cancer: a predictive panel. Diseases of the colon and rectum\| PubMed ID: 20010347	2010
Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors. Cell research\| PubMed ID: 22064700	2012
Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural progenitors. Cell research\| PubMed ID: 22370632	2012
Differential roles of TNFR1 and TNFR2 signaling in adult hippocampal neurogenesis. Brain, behavior, and immunity\| PubMed ID: 23402793	2013
Autologous transplantation of GDNF-expressing mesenchymal stem cells protects against MPTP-induced damage in cynomolgus monkeys. Scientific reports\| PubMed ID: 24071770	2013
MicroRNA-181a promotes tumor growth and liver metastasis in colorectal cancer by targeting the tumor suppressor WIF-1. Molecular cancer\| PubMed ID: 24755295	2014
Introduction to the special topic "stem cells and regenerative medicine". Science China. Life sciences\| PubMed ID: 24849512	2014
Lmx1a enhances the effect of iNSCs in a PD model. Stem cell research\| PubMed ID: 25460246	2015
Cell therapy for macular degeneration--first phase I/II pluripotent stem cell-based clinical trial shows promise. Science China. Life sciences\| PubMed ID: 25528254	2015
Comparison of intracerebral transplantation effects of different stem cells on rodent stroke models. Cell biochemistry and function\| PubMed ID: 25914321	2015
Cell Therapy for Parkinson's Disease: New Hope from Reprogramming Technologies. Aging and disease\| PubMed ID: 26618051	2015
PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype. Nature communications\| PubMed ID: 26632666	2015
Conversion of adult human peripheral blood mononuclear cells into induced neural stem cell by using episomal vectors. Stem cell research\| PubMed ID: 26826927	2016
Aberrant trafficking of a Leu89Pro connexin32 mutant associated with X-linked dominant Charcot-Marie-Tooth disease. Neurological research\| PubMed ID: 27367520	2016
Autologous iPSC-derived dopamine neuron transplantation in a nonhuman primate Parkinson's disease model. Cell discovery\| PubMed ID: 27462412	2015
Accelerated generation of oligodendrocyte progenitor cells from human induced pluripotent stem cells by forced expression of Sox10 and Olig2. Science China. Life sciences\| PubMed ID: 27785726	2016
MRI tracking of autologous pancreatic progenitor-derived insulin-producing cells in monkeys. Scientific reports\| PubMed ID: 28566744	2017
SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature\| PubMed ID: 30135584	2018
Differentiation of Glial Cells From hiPSCs: Potential Applications in Neurological Diseases and Cell Replacement Therapy. Frontiers in cellular neuroscience\| PubMed ID: 30140204	2018
Ectopic hTERT expression facilitates reprograming of fibroblasts derived from patients with Werner syndrome as a WS cellular model. Cell death & disease\| PubMed ID: 30206203	2018
Culture of pyramidal neural precursors, neural stem cells, and fibroblasts on various biomaterials. Journal of biomaterials science. Polymer edition\| PubMed ID: 30261158	2018
Dopaminergic precursors differentiated from human blood-derived induced neural stem cells improve symptoms of a mouse Parkinson's disease model. Theranostics\| PubMed ID: 30279731	2018
Intravenous Transplantation of Mesenchymal Stem Cells Reduces the Number of Infiltrated Ly6C Cells but Enhances the Proportions Positive for BDNF, TNF-1, and IL-1 in the Infarct Cortices of ... Stem cells international\| PubMed ID: 30405724	2018
Melatonin Treatment Alleviates Spinal Cord Injury-Induced Gut Dysbiosis in Mice. Journal of neurotrauma\| PubMed ID: 30693824	2019
Employing Endogenous NSCs to Promote Recovery of Spinal Cord Injury. Stem cells international\| PubMed ID: 31191666	2019
BET bromodomain inhibition triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors through Bim induction. Cell reports\| PubMed ID: 24373973	2014
Overcoming BET Inhibitor Resistance in Malignant Peripheral Nerve Sheath Tumors. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 30796033	2019
Treatment with Humanized Selective CD19CAR-T Cells Shows Efficacy in Highly Treated B-ALL Patients Who Have Relapsed after Receiving Murine-Based CD19CAR-T Therapies. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 31300451	2019
The Effect of Human Umbilical Cord Mesenchymal Stromal Cells in Protection of Dopaminergic Neurons from Apoptosis by Reducing Oxidative Stress in the Early Stage of a 6-OHDA-Induced Parkinso... Cell transplantation\| PubMed ID: 31775521	2019
Proteostasis of α-Synuclein and Its Role in the Pathogenesis of Parkinson's Disease. Frontiers in cellular neuroscience\| PubMed ID: 32210767	2020
Mesenchymal Stem/Stromal Cell-Mediated Mitochondrial Transfer and the Therapeutic Potential in Treatment of Neurological Diseases. Stem cells international\| PubMed ID: 32724315	2020
Peripheral Circulation and Astrocytes Contribute to the MSC-Mediated Increase in IGF-1 Levels in the Infarct Cortex in a dMCAO Rat Model. Stem cells international\| PubMed ID: 32952570	2020
Unusual electrophysiological findings in a Chinese ALS 4 family with SETX-L389S mutation: a three-year follow-up. Journal of neurology\| PubMed ID: 32997296	2021
Case Report: Humanized Selective CD19CAR-T Treatment Induces MRD-Negative Remission in a Pediatric B-ALL Patient With Primary Resistance to Murine-Based CD19CAR-T Therapy. Frontiers in immunology\| PubMed ID: 33424835	2020
Effect of fecal microbiota transplantation on neurological restoration in a spinal cord injury mouse model: involvement of brain-gut axis. Microbiome\| PubMed ID: 33678185	2021
Astrocytes constitute the major TNF-α-producing cell population in the infarct cortex in dMCAO rats receiving intravenous MSC infusion. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie\| PubMed ID: 34343893	2021
Fecal Microbiota Transplantation Exerts Neuroprotective Effects in a Mouse Spinal Cord Injury Model by Modulating the Microenvironment at the Lesion Site. Microbiology spectrum\| PubMed ID: 35467388	2022
Induced neural stem cells from Macaca fascicularis show potential of dopaminergic neuron specification and efficacy in a mouse Parkinson's disease model. Acta histochemica\| PubMed ID: 35792494	2022
Long-Term Safety and Efficacy of CD19 Humanized Selective CAR-T Therapy in B-ALL Patients Who Have Previously Received Murine-Based CD19 CAR-T Therapy. Frontiers in oncology\| PubMed ID: 35800047	2022
Neuroprotective effects of human umbilical cord mesenchymal stromal cells in PD mice via centrally and peripherally suppressing NLRP3 inflammasome-mediated inflammatory responses. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie\| PubMed ID: 36076517	2022
Characterization of Human-Induced Neural Stem Cells and Derivatives following Transplantation into the Central Nervous System of a Nonhuman Primate and Rats. Stem cells international\| PubMed ID: 36618021	2022
Probiotic Formulation VSL#3 Interacts with Mesenchymal Stromal Cells To Protect Dopaminergic Neurons via Centrally and Peripherally Suppressing NOD-Like Receptor Protein 3 Inflammasome-Media... Microbiology spectrum\| PubMed ID: 36728426	2023
GD2 CAR-T cells in combination with Nivolumab exhibit enhanced antitumor efficacy. Translational oncology\| PubMed ID: 36966611	2023
MicroRNAs of extracellular vesicles derived from mesenchymal stromal cells alleviate inflammation in dry eye disease by targeting the IRAK1/TAB2/NF-κB pathway. The ocular surface\| PubMed ID: 36990276	2023
Human iPSC-derived midbrain organoids functionally integrate into striatum circuits and restore motor function in a mouse model of Parkinson's disease. Theranostics\| PubMed ID: 37215566	2023
Suppression of TGFβR-Smad3 pathway alleviates the syrinx induced by syringomyelia. Cell & bioscience\| PubMed ID: 37248485	2023
Therapeutic effects against high-grade glioblastoma mediated by engineered induced neural stem cells combined with GD2-specific CAR-NK. Cellular oncology (Dordrecht, Netherlands)\| PubMed ID: 37420122	2023
Human iPSC-derived endothelial cells promote CNS remyelination via BDNF and mTORC1 pathway. Glia\| PubMed ID: 37675625	2024
A C2C3 hinge region enhances the cytotoxicity of anti-CD5 CAR-T cells targeting T cell acute lymphoblastic leukemia. International immunopharmacology\| PubMed ID: 37690234	2023
Human midbrain dopaminergic progenitors. Cell proliferation\| PubMed ID: 37881164	2024
First-in-human transplantation of autologous induced neural stem cell-derived dopaminergic precursors to treat Parkinson's disease. Science bulletin\| PubMed ID: 37919161	2023
Spinal cord injury-induced gut dysbiosis influences neurological recovery partly through short-chain fatty acids. NPJ biofilms and microbiomes\| PubMed ID: 38092763	2023
In vitro differentiation of human CD45 CD34 induced hematopoietic progenitor cells from iPSCs using a monolayer system. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis\| PubMed ID: 38182435	2024
Grafted human-induced pluripotent stem cells-derived oligodendrocyte progenitor cells combined with human umbilical vein endothelial cells contribute to functional recovery following spinal ... Stem cell research & therapy\| PubMed ID: 38321505	2024
Treatment of Syringomyelia Characterized by Focal Dilatation of the Central Canal Using Mesenchymal Stem Cells and Neural Stem Cells. Tissue engineering and regenerative medicine\| PubMed ID: 38578425	2024
Human induced pluripotent stem cell/embryonic stem cell-derived pyramidal neuronal precursors show safety and efficacy in a rat spinal cord injury model. Cellular and molecular life sciences : CMLS\| PubMed ID: 39073571	2024
Immune Cells Promote BDNF Expression by Infiltrated Macrophages via Interleukin 4 in the Cerebral Ischemia of Male Rats. Journal of neuroscience research\| PubMed ID: 39235282	2024
Modulation of human induced neural stem cell-derived dopaminergic neurons by DREADD reveals therapeutic effects on a mouse model of Parkinson's disease. Stem cell research & therapy\| PubMed ID: 39256801	2024
The isoflavone puerarin promotes generation of human iPSC-derived pre-oligodendrocytes and enhances endogenous remyelination in rodent models. Journal of neurochemistry\| PubMed ID: 39424593	2025
Robot-Assisted Stereotactic Microinjection Method for Precision Cell Transplantation in Rat and Canine Models. Cell transplantation\| PubMed ID: 40103182	2025