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Department of Integrative Biology and Pharmacology
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Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors.
The Journal of biological chemistry May, 2005 | Pubmed ID: 15710623
Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels.
Journal of neurochemistry Sep, 2006 | Pubmed ID: 16771827
Characterization of three types of ATP-activated current in relation to P2X subunits in rat trigeminal ganglion neurons.
Brain research Oct, 2006 | Pubmed ID: 16934235
Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthase.
Molecular pharmacology May, 2007 | Pubmed ID: 17299028
Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents.
Biochemical and biophysical research communications Sep, 2007 | Pubmed ID: 17655827
Promising anti-Alzheimer's dimer bis(7)-tacrine reduces beta-amyloid generation by directly inhibiting BACE-1 activity.
Biochemical and biophysical research communications Feb, 2008 | Pubmed ID: 18039469
Mecamylamine prevents neuronal apoptosis induced by glutamate and low potassium via differential anticholinergic-independent mechanisms.
Neuropharmacology Mar, 2008 | Pubmed ID: 18222492
Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently.
European journal of pharmacology Nov, 2009 | Pubmed ID: 19765582
Role of voltage-gated potassium channels in the fate determination of embryonic stem cells.
Journal of cellular physiology Jul, 2010 | Pubmed ID: 20333647
Pathologically activated neuroprotection via uncompetitive blockade of N-methyl-D-aspartate receptors with fast off-rate by novel multifunctional dimer bis(propyl)-cognitin.
The Journal of biological chemistry Jun, 2010 | Pubmed ID: 20404346
Effects of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blockers on the proliferation and cell cycle progression of embryonic stem cells.
Pflügers Archiv : European journal of physiology Jan, 2011 | Pubmed ID: 21110038
Preventing Hâ‚‚Oâ‚‚-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone.
Brain research Jun, 2011 | Pubmed ID: 21315693
Neuroprotection against excitotoxic and ischemic insults by bis(12)-hupyridone, a novel anti-acetylcholinesterase dimer, possibly via acting on multiple targets.
Brain research Nov, 2011 | Pubmed ID: 21978549
NaHS relaxes rat cerebral artery in vitro via inhibition of l-type voltage-sensitive Ca(2+) channel.
Pharmacological research : the official journal of the Italian Pharmacological Society Feb, 2012 | Pubmed ID: 22133671
The University of Texas Health Science Center at Houston
Jialie Luo1,
Yingmin Zhu1,
Michael X. Zhu1,
Hongzhen Hu1
1Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston
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