Rosa Serra

Unique and redundant roles of Smad3 in TGF-beta-mediated regulation of long bone development in organ culture.

Conditional deletion of the TGF-beta type II receptor in Col2a expressing cells results in defects in the axial skeleton without alterations in chondrocyte differentiation or embryonic development of long bones.

TGF-beta in mammary gland development and breast cancer.

TGF-beta, c-Cbl, and PDGFR-alpha the in mammary stroma.

Mouse models of transforming growth factor beta impact in breast development and cancer.

Transforming growth factor-beta signaling helps specify tumor type in DMBA and hormone-induced mammary cancers.

Tgfbr2 regulates the maintenance of boundaries in the axial skeleton.

Intraflagellar transport is essential for endochondral bone formation.

Development of the post-natal growth plate requires intraflagellar transport proteins.

Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis.

Deletion of Tgfbr2 in Prx1-cre expressing mesenchyme results in defects in development of the long bones and joints.

Wnt5a is required for proper mammary gland development and TGF-beta-mediated inhibition of ductal growth.

Intraflagellar transport in skeletal development.

Transforming growth factor-beta signaling mediates hypoxia-induced pulmonary arterial remodeling and inhibition of alveolar development in newborn mouse lung.

Role for primary cilia in the regulation of mouse ovarian function.

Role of intraflagellar transport and primary cilia in skeletal development.

Cilia involvement in patterning and maintenance of the skeleton.

Loss of TGF-beta or Wnt5a results in an increase in Wnt/beta-catenin activity and redirects mammary tumour phenotype.

TGF-beta promotes Th17 cell development through inhibition of SOCS3.

Tgfbr2 is required for development of the skull vault.

PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development.

Molecular profiling of the developing mouse axial skeleton: a role for Tgfbr2 in the development of the intervertebral disc.

Primary cilia are decreased in breast cancer: analysis of a collection of human breast cancer cell lines and tissues.

Inhibiting breast cancer progression by exploiting TGFbeta signaling.

TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine.

Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type B.

Wnt5a as an effector of TGFβ in mammary development and cancer.

Chondrocyte-specific regulatory activity of Runx2 is essential for survival and skeletal development.

Misexpression of wingless-related MMTV integration site 5A in mouse mammary gland inhibits the milk ejection response and regulates connexin43 phosphorylation.

Depletion of primary cilia in articular chondrocytes results in reduced Gli3 repressor to activator ratio, increased Hedgehog signaling, and symptoms of early osteoarthritis.

PDGF mediates TGFβ-induced migration during development of the spinous process.

Altered responsiveness to TGF-β results in reduced Papss2 expression and alterations in the biomechanical properties of mouse articular cartilage.

Ift88 regulates Hedgehog signaling, Sfrp5 expression, and β-catenin activity in post-natal growth plate.

WNT5A inhibits metastasis and alters splicing of Cd44 in breast cancer cells.

Inactivation of Tgfbr2 in Osterix-Cre expressing dental mesenchyme disrupts molar root formation.

Normal mammary development and function in mice with Ift88 deleted in MMTV- and K14-Cre expressing cells.

Runx2 regulates endochondral ossification through control of chondrocyte proliferation and differentiation.

Function and regulation of primary cilia and intraflagellar transport proteins in the skeleton.

Erg cooperates with TGF-β to control mesenchymal differentiation.

Chondrocyte-specific knockout of Cbfβ reveals the indispensable function of Cbfβ in chondrocyte maturation, growth plate development and trabecular bone formation in mice.

Wnt5a suppresses tumor formation and redirects tumor phenotype in MMTV-Wnt1 tumors.

Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation.

Wnt5a Signals through DVL1 to Repress Ribosomal DNA Transcription by RNA Polymerase I.

SOX9 protein is stabilized by TGF-β and regulates PAPSS2 mRNA expression in chondrocytes.

TGF-β regulates phosphorylation and stabilization of Sox9 protein in chondrocytes through p38 and Smad dependent mechanisms.

Tgfbr2 is required in osterix expressing cells for postnatal skeletal development.

Mechanical loading regulates organization of the actin cytoskeleton and column formation in postnatal growth plate.

IVD Development: Nucleus pulposus development and sclerotome specification.

Prg4 prevents osteoarthritis induced by dominant-negative interference of TGF-ß signaling in mice.

Tgfbr2 is required in Acan-expressing cells for maintenance of the intervertebral and sternocostal joints.

Antagonism of BMP signaling is insufficient to induce fibrous differentiation in primary sclerotome.

Development of the axial skeleton and intervertebral disc.

Scaffoldless tissue-engineered cartilage for studying transforming growth factor beta-mediated cartilage formation.

American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies.

American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies - Secondary Publication.