Thomas Seidel
Institute of Cellular and Molecular Physiology
Friedrich-Alexander University Erlangen-Nürnberg
Thomas Seidel is a senior researcher and lecturer at the Institute of Cellular and Molecular Physiology, Friedrich-Alexander University (FAU) in Erlangen, Germany. He received his MD/PhD degree from the University of Leipzig, Germany, for his work on computational modeling of cardiac electrophysiology with Stefan Dhein.
During Dr. Seidel’s postdoctoral training at the Cardiovascular Research and Training Institute, University of Utah, USA, he developed a focus on cardiac excitation-contraction coupling and its pathological alterations in heart failure and on 3D microscopy and image analysis techniques under the guidance of Frank Sachse. He then moved to Erlangen, where he started researching cellular and molecular mechanisms of t-system remodeling in human heart failure together with Tilmann Volk.
Dr. Seidel is especially interested in translational cardiac research, for which methods of cell isolation, cell culture and tissue culture of human myocardium are essential.
Sheet-Like Remodeling of the Transverse Tubular System in Human Heart Failure Impairs Excitation-Contraction Coupling and Functional Recovery by Mechanical Unloading.
Circulation Apr, 2017 | Pubmed ID: 28073805
Remodeling of the transverse tubular system after myocardial infarction in rabbit correlates with local fibrosis: A potential role of biomechanics.
Progress in biophysics and molecular biology 11, 2017 | Pubmed ID: 28709857
Pelvic orthosis effects on posterior pelvis kinematics An in-vitro biomechanical study.
Scientific reports 10, 2018 | Pubmed ID: 30374032
Physiological in vitro sacroiliac joint motion: a study on three-dimensional posterior pelvic ring kinematics.
Journal of anatomy 03, 2019 | Pubmed ID: 30536830
Long-term functional and structural preservation of precision-cut human myocardium under continuous electromechanical stimulation in vitro.
Nature communications 01, 2019 | Pubmed ID: 30631059
Publisher Correction: Long-term functional and structural preservation of precision-cut human myocardium under continuous electromechanical stimulation in vitro.
Nature communications 01, 2019 | Pubmed ID: 30692546
Glucocorticoids preserve the t-tubular system in ventricular cardiomyocytes by upregulation of autophagic flux.
Basic research in cardiology 10, 2019 | Pubmed ID: 31673803
The Degree of t-System Remodeling Predicts Negative Force-Frequency Relationship and Prolonged Relaxation Time in Failing Human Myocardium.
Frontiers in physiology , 2020 | Pubmed ID: 32231589
Severe T-System Remodeling in Pediatric Viral Myocarditis.
Frontiers in cardiovascular medicine , 2020 | Pubmed ID: 33537349
Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart.
NPJ aging and mechanisms of disease May, 2021 | Pubmed ID: 34050186
Long-Term Cultivation of Human Atrial Myocardium.
Frontiers in physiology , 2022 | Pubmed ID: 35283779
Preparation of Human Myocardial Tissue for Long-Term Cultivation
Jules Hamers1,2,
Payel Sen1,2,
Daphne Merkus1,2,3,
Thomas Seidel4,5,
Kun Lu1,6,
Andreas Dendorfer1,2
1Walter-Brendel-Centre of Experimental Medicine, University Hospital, LMU Munich,
2, German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich Heart Alliance (MHA),
3Division of Experimental Cardiology, Department of Cardiology, Erasmus MC, University Medical Center Rotterdam,
4Institute of Cellular and Molecular Physiology, Friedrich-Alexander-Universität Erlangen-Nürnberg,
5Muscle Research Center Erlangen (MURCE), Friedrich-Alexander-Universität Erlangen-Nürnberg,
6Department of Cardiac Surgery, University Hospital, LMU Munich