Anna Szlachcic

Department of Protein Engineering,
Faculty of Biotechnology,
Department of Protein Engineering, Faculty of Biotechnology

University of Wroclaw

BIOGRAPHY

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PUBLICATIONS

Structure of a highly stable mutant of human fibroblast growth factor 1.

Acta crystallographica. Section D, Biological crystallography Jan, 2009 | Pubmed ID: 19153468

Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.

The Journal of biological chemistry Sep, 2009 | Pubmed ID: 19574212

The structural basis of tail-anchored membrane protein recognition by Get3.

Nature Sep, 2009 | Pubmed ID: 19675567

Two pentadehydropeptides with different configurations of the DeltaPhe residues.

Acta crystallographica. Section C, Crystal structure communications Mar, 2010 | Pubmed ID: 20203407

Longer action means better drug: tuning up protein therapeutics.

Biotechnology advances Jul-Aug, 2011 | Pubmed ID: 21443940

Tailoring small proteins towards biomedical applications.

Current pharmaceutical biotechnology Nov, 2011 | Pubmed ID: 21902634

FGF1-gold nanoparticle conjugates targeting FGFR efficiently decrease cell viability upon NIR irradiation.

International journal of nanomedicine , 2012 | Pubmed ID: 23226697

Design and characteristics of cytotoxic fibroblast growth factor 1 conjugate for fibroblast growth factor receptor-targeted cancer therapy.

Drug design, development and therapy , 2016 | Pubmed ID: 27563235

Site-specific conjugation of fibroblast growth factor 2 (FGF2) based on incorporation of alkyne-reactive unnatural amino acid.

Bioorganic & medicinal chemistry 07, 2017 | Pubmed ID: 28522266

High-Yield Site-Specific Conjugation of Fibroblast Growth Factor 1 with Monomethylauristatin E via Cysteine Flanked by Basic Residues.

Bioconjugate chemistry 07, 2017 | Pubmed ID: 28598150

FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and α-Amanitin Displays a Cytotoxic Effect towards Cancer Cells Overproducing FGF Receptor 1.

International journal of molecular sciences Jul, 2018 | Pubmed ID: 30029518

Specific Antibody Fragment Ligand Traps Blocking FGF1 Activity.

International journal of molecular sciences Aug, 2018 | Pubmed ID: 30134556

Identification of a peptide antagonist of the FGF1-FGFR1 signaling axis by phage display selection.

FEBS open bio 05, 2019 | Pubmed ID: 30968602

Low Stability of Integrin-Binding Deficient Mutant of FGF1 Restricts Its Biological Activity.

Cells 08, 2019 | Pubmed ID: 31443196

FGF2-Derived PeptibodyF2-MMAE Conjugate for Targeted Delivery of Cytotoxic Drugs into Cancer Cells Overexpressing FGFR1.

Cancers Oct, 2020 | Pubmed ID: 33076489

INSTITUTIONS

University of Wroclaw

JOVE ARTICLES

Preparation of Site-Specific Cytotoxic Protein Conjugates via Maleimide-thiol Chemistry and Sortase A-Mediated Ligation

Mateusz Adam Krzyscik^1,2,

Aleksandra Sokolowska-Wedzina¹,

Karolina Jendryczko¹,

Marta Pozniak¹,

Daria Nawrocka¹,

Natalia Porebska¹,

Malgorzata Zakrzewska¹,

Jacek Otlewski¹,

Anna Szlachcic¹,

Lukasz Opalinski¹

¹Department of Protein Engineering, Faculty of Biotechnology, University of Wroclaw,

²Department of Protein Biotechnology, Faculty of Biotechnology, University of Wroclaw

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Anna Szlachcic

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Department of Protein Engineering,Faculty of Biotechnology,Department of Protein Engineering, Faculty of Biotechnology

University of Wroclaw

Preparation of Site-Specific Cytotoxic Protein Conjugates via Maleimide-thiol Chemistry and Sortase A-Mediated Ligation

Department of Protein Engineering,
Faculty of Biotechnology,
Department of Protein Engineering, Faculty of Biotechnology