Hisaysohi Hayashi

[Effects of green tea extract on galactosamine-induced hepatic injury in rats].

Properties of active magnesium flux across the small intestine of the guinea pig.

Studies on absorption, distribution, excretion and metabolism of ginseng saponins. V. The decomposition products of ginsenoside Rb2 in the large intestine of rats.

[Effect of shakuyaku-extract on electrical stimulation induced contraction of guinea pig ileum].

Decreased density of alpha 2-adrenoceptors in medulla oblongata of spontaneously hypertensive rats.

Basolateral Cl-/HCO3- exchange in epithelial cells from guinea pig distal colon.

Transmural potential changes associated with the in vitro absorption of theanine in the guinea pig intestine.

Abnormality in plasma catecholamines and myocardial adrenoceptors in cardiomyopathic BIO 53.58 Syrian hamsters and improvement by metoprolol treatment.

Low-dose irradiation induces expression of heat shock protein 70 mRNA and thermo- and radio-resistance in myeloid leukemia cell line.

Regulation of intracellular pH during H+-coupled oligopeptide absorption in enterocytes from guinea-pig ileum.

Brain distribution of 6-mercaptopurine is regulated by the efflux transport system in the blood-brain barrier.

Na+-dependent recovery of intracellular pH from acid loading in mouse colonic crypt cells.

Improved brain delivery of a nonsteroidal anti-inflammatory drug with a synthetic glyceride ester: a preliminary attempt at a CNS drug delivery system for the therapy of Alzheimer's disease.

Studies of the constituents of Uruguayan propolis.

Cholinergic inhibition of electrogenic sodium absorption in the guinea pig distal colon.

Rhythmical contractions in pulmonary arteries of monocrotaline-induced pulmonary hypertensive rats.

Biphasic response of cutaneous blood flow induced by passive cutaneous anaphylaxis in rats.

Identification of metabolites in plasma and urine of Uruguayan propolis-treated rats.

Association of paracellin-1 with ZO-1 augments the reabsorption of divalent cations in renal epithelial cells.

Formulation study and drug release mechanism of a new theophylline sustained-release preparation.

Design and synthesis of artificial phospholipid for selective cleavage of integral membrane protein.

Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine.

Phosphorylation of paracellin-1 at Ser217 by protein kinase A is essential for localization in tight junctions.

Functional characterization of Cl-/HCO3- exchange in villous cells of the mouse ileum.

Propionate absorption associated with bicarbonate secretion in vitro in the mouse cecum.

Genetic polymorphism of C452T (T127I) in human gamma-glutamyl hydrolase in a Japanese population.

Identification of cell proliferation-associated epitope on CD98 oncoprotein using phage display random peptide library.

Expression of the short-chain fatty acid receptor, GPR43, in the human colon.

pH stat studies on bicarbonate secretion in the isolated mouse ileum.

Exclusion of actin-binding protein p57/coronin-1 from bacteria-containing phagosomes in macrophages infected with Legionella.

Application of fluorescence polarization immunoassay for determination of methotrexate-polyglutamates in rheumatoid arthritis patients.

Elevated production of Legionella-specific immunoglobulin A in A/J mice is accompanied by T-helper 1-type polarization.

Antibody epitope peptides as potential inducers of IgG antibodies against CD98 oncoprotein.

Effect of VKORC1-1639 G>A polymorphism, body weight, age, and serum albumin alterations on warfarin response in Japanese patients.

Plasma total homocysteine level and methylenetetrahydrofolate reductase 677C>T genetic polymorphism in Japanese patients with rheumatoid arthritis.

Regulation of intestinal Cl-/HCO3- exchanger SLC26A3 by intracellular pH.

Generation of a recombinant single-chain variable fragment (scFv) targeting 5-methyl-2'-deoxycytidine.

Genetic polymorphisms in folate pathway enzymes as a possible marker for predicting the outcome of methotrexate therapy in Japanese patients with rheumatoid arthritis.

Proteinase-activated receptors-1 and 2 induce electrogenic Cl- secretion in the mouse cecum by distinct mechanisms.

Proteomic analysis of growth phase-dependent expression of Legionella pneumophila proteins which involves regulation of bacterial virulence traits.

Dihydrofolate reductase gene intronic 19-bp deletion polymorphisms in a Japanese population.

Generation of AcGFP fusion with single-chain Fv selected from a phage display library constructed from mice hyperimmunized against 5-methyl 2'-deoxycytidine.

[Recurrent education for pharmacists to support regional medicine].

Enhancement of cell-cell contact by claudin-4 in renal epithelial Madin-Darby canine kidney cells.

An artifact derived from a pseudogene led to the discovery of microRNA binding site polymorphism in the 3'-untranslated region of the human dihydrofolate reductase gene.

Genotype distributions and allele frequencies of possible major depressive disorder-associated single nucleotide polymorphisms, cyclic adenosine monophosphate response element binding protein 1 rs4675690 and Piccolo rs2522833, in a Japanese population.

Expression of β-adrenergic-like octopamine receptors during Drosophila development.

Subepithelial trypsin induces enteric nerve-mediated anion secretion by activating proteinase-activated receptor 1 in the mouse cecum.

Effect of menstrual cycle phase on the ventilatory response to rising body temperature during exercise.

Influence of CYP4F2 polymorphisms and plasma vitamin K levels on warfarin sensitivity in Japanese pediatric patients.

A single nucleotide polymorphism of reduced folate carrier 1 predicts methotrexate efficacy in Japanese patients with rheumatoid arthritis.

Polymorphisms of the UDP-glucuronosyl transferase 1A genes are associated with adverse events in cancer patients receiving irinotecan-based chemotherapy.

Association of ABCB1 polymorphisms with the antiemetic efficacy of granisetron plus dexamethasone in breast cancer patients.

Ezrin is required for the functional regulation of the epithelial sodium proton exchanger, NHE3.

A case study on the association of variation of bitter-taste receptor gene TAS2R38 with the height, weight and energy intake in Japanese female college students.

Hyperosmolarity-induced up-regulation of claudin-4 mediated by NADPH oxidase-dependent H2O2 production and Sp1/c-Jun cooperation.

[Personalized drug therapy-directed clinical pharmacology research based on genetic polymorphisms and pharmacokinetics analysis].

The JFFMA assessment of flavoring substances structurally related to menthol and uniquely used in Japan.

Simultaneous microdetermination of bosentan, ambrisentan, sildenafil, and tadalafil in plasma using liquid chromatography/tandem mass spectrometry for pediatric patients with pulmonary arterial hypertension.

Masked function of amino acid sensors on pancreatic hormone secretion in ventromedial hypothalamic (VMH) lesioned rats with marked hyperinsulinemia.

Cell proliferation in ventromedial hypothalamic lesioned rats inhibits acute gastric mucosal lesions.

Ventromedial hypothalamic lesions enhance small intestinal cell proliferation in mice.

Activation of focal adhesion kinase via M1 muscarinic acetylcholine receptor is required in restitution of intestinal barrier function after epithelial injury.

Influence of uridine diphosphate glucuronosyltransferase 2B7 -161C>T polymorphism on the concentration of valproic acid in pediatric epilepsy patients.

Bladder endothelin-1 receptor binding of bosentan and ambrisentan.

Luminal trypsin induces enteric nerve-mediated anion secretion in the mouse cecum.

Identification of anti-CD98 antibody mimotopes for inducing antibodies with antitumor activity by mimotope immunization.

Endothelin-1 receptors in rat tissues: characterization by bosentan, ambrisentan and CI-1020.

Effect of the STAT3 inhibitor STX-0119 on the proliferation of a temozolomide-resistant glioblastoma cell line.

Effect of postprandial thermogenesis on the cutaneous vasodilatory response during exercise.

4217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy.

Retrospective analysis of severe neutropenia in patients receiving concomitant administration of docetaxel and clarithromycin.

A novel immunochromatographic system for easy-to-use detection of group 1 avian influenza viruses with acquired human-type receptor binding specificity.

Autocrine regulation of ecdysone synthesis by β3-octopamine receptor in the prothoracic gland is essential for Drosophila metamorphosis.

Muscarinic cholinoceptor-mediated activation of JNK negatively regulates intestinal secretion in mice.

Plasma vitamin K concentrations depend on CYP4F2 polymorphism and influence on anticoagulation in Japanese patients with warfarin therapy.

Hyperosmolarity-Induced Down-Regulation of Claudin-2 Mediated by Decrease in PKCβ-Dependent GATA-2 in MDCK Cells.

Relationship between ABCB1 gene polymorphisms and severe neutropenia in patients with breast cancer treated with doxorubicin/cyclophosphamide chemotherapy.

Reduced folate carrier 1 gene expression levels are correlated with methotrexate efficacy in Japanese patients with rheumatoid arthritis.

JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for the detection of genotoxic carcinogens: I. Summary of pre-validation study results.

JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for detection of genotoxic carcinogens: II. Summary of definitive validation study results.

Production and Purification of Secretory Simian Cytidine Monophosphate-N-acetylneuraminic Acid Hydroxylase Using Baculovirus-Protein Expression System.

Simultaneous and rapid determination of gefitinib, erlotinib and afatinib plasma levels using liquid chromatography/tandem mass spectrometry in patients with non-small-cell lung cancer.

Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization.

Bioanalysis of bevacizumab and infliximab by high-temperature reversed-phase liquid chromatography with fluorescence detection after immunoaffinity magnetic purification.

Characteristics of hyperthermia-induced hyperventilation in humans.

Influence of ABCB1 and ABCG2 polymorphisms on the antiemetic efficacy in patients with cancer receiving cisplatin-based chemotherapy: a TRIPLE pharmacogenomics study.

Combination of a STAT3 Inhibitor and an mTOR Inhibitor Against a Temozolomide-resistant Glioblastoma Cell Line.

Signal-transducing adaptor protein-2 promotes generation of functional long-term memory CD8+ T cells by preventing terminal effector differentiation.

Japan Flavour and Fragrance Materials Association's (JFFMA) safety assessment of food-flavouring substances uniquely used in Japan that belong to the class of aliphatic primary alcohols, aldehydes, carboxylic acids, acetals and esters containing additional oxygenated functional groups.

Overexpression of KCNJ2 in induced pluripotent stem cell-derived cardiomyocytes for the assessment of QT-prolonging drugs.

A clustering approach to identify and characterize the asthma and chronic obstructive pulmonary disease overlap phenotype.

The anti-tumor activity of the STAT3 inhibitor STX-0119 occurs via promotion of tumor-infiltrating lymphocyte accumulation in temozolomide-resistant glioblastoma cell line.

Up-regulation of claudin-2 expression by aldosterone in colonic epithelial cells of mice fed with NaCl-depleted diets.

Genetic risk factors for chemotherapy-induced nausea and vomiting in patients with cancer receiving cisplatin-based chemotherapy.

Concomitant alteration in number and affinity of PX and muscarinic receptors are associated with bladder dysfunction in early stage of diabetic rats.

Time-Dependent Decline in Serum Phenytoin Concentration With Heightened Convulsive Seizure Risk by Prolonged Administration of Fosphenytoin in Japanese: A Retrospective Study.

Effect of food intake on the ventilatory response to increasing core temperature during exercise.

Luminal Na homeostasis has an important role in intestinal peptide absorption in vivo.

Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance.

High-Throughput Bioanalysis of Bevacizumab in Human Plasma Based on Enzyme-Linked Aptamer Assay Using Anti-Idiotype DNA Aptamer.

Anti-Idiotype DNA Aptamer Affinity Purification⁻High-Temperature Reversed-Phase Liquid Chromatography: A Simple, Accurate, and Selective Bioanalysis of Bevacizumab.

Effect of food intake on respiratory chemosensitivity to CO in young adults.

Probabilistic exposure assessment of aggregate rates of dermal exposure of Japanese women and children to parabens in personal care products.

Kinetics-Based Structural Requirements of Human Immunoglobulin G Binding Peptides.

Impact of combination therapy with anti-PD-1 blockade and a STAT3 inhibitor on the tumor-infiltrating lymphocyte status.

Na-Coupled Nutrient Cotransport Induced Luminal Negative Potential and Claudin-15 Play an Important Role in Paracellular Na Recycling in Mouse Small Intestine.

Theanine, the Main Amino Acid in Tea, Prevents Stress-Induced Brain Atrophy by Modifying Early Stress Responses.

Upregulation of Claudin-7 Expression by Angiotensin II in Colonic Epithelial Cells of Mice Fed with NaCl-Depleted Diets.

Discovery of a Potent Anticancer Agent PVHD303 with Activity.

Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer.

Angulin-2/ILDR1, a tricellular tight junction protein, does not affect water transport in the mouse large intestine.

Proteolytic cleavage of Podocin by Matriptase exacerbates podocyte injury.

Effect of therapeutic plasma exchange on phenytoin plasma concentration in patients receiving intravenous fosphenytoin therapy.

Inverse regulation of claudin-2 and -7 expression by p53 and hepatocyte nuclear factor 4α in colonic MCE301 cells.

Segmental differences in Slc26a3-dependent Cl absorption and HCO secretion in the mouse large intestine in vitro in Ussing chambers.

Acute effect of green tea catechins on uric acid metabolism after alcohol ingestion in Japanese men.

A novel cooling method using carbon dioxide-rich water after passive heating.

Design of synthetic polymer nanoparticles that inhibit glucose absorption from the intestine.