Sean G. Rudd

Sean G. Rudd

Science for Life Laboratory, Karolinska Institutet

Affiliated withKarolinska Institutet

Research Area

Biochemistry

Biography

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2021

Other Publications

Article	Year
PrimPol-A new polymerase on the block. Molecular & cellular oncology\| PubMed ID: 27308331	2014
Pathways controlling dNTP pools to maintain genome stability. DNA repair\| PubMed ID: 27311542	2016
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies. Nature medicine\| PubMed ID: 28067901	2017
SAMHD1 is a barrier to antimetabolite-based cancer therapies. Molecular & cellular oncology\| PubMed ID: 28401188	2017
SAMHD1 protects cancer cells from various nucleoside-based antimetabolites. Cell cycle (Georgetown, Tex.)\| PubMed ID: 28436707	2017
With me or against me: Tumor suppressor and drug resistance activities of SAMHD1. Experimental hematology\| PubMed ID: 28502830	2017
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. Nature communications\| PubMed ID: 29343827	2018
Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism. Cancers\| PubMed ID: 30041457	2018
Low-level expression of SAMHD1 in acute myeloid leukemia (AML) blasts correlates with improved outcome upon consolidation chemotherapy with high-dose cytarabine-based regimens. Blood cancer journal\| PubMed ID: 30341277	2018
Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. Nature communications\| PubMed ID: 31676755	2019
Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy. EMBO molecular medicine\| PubMed ID: 31950591	2020
Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics. Molecular & cellular proteomics : MCP\| PubMed ID: 32051232	2020
MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG. Cancer research\| PubMed ID: 32312836	2020
Development of a chemical probe against NUDT15. Nature chemical biology\| PubMed ID: 32690945	2020
Drug synergy scoring using minimal dose response matrices. BMC research notes\| PubMed ID: 33468238	2021
Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity. The Journal of biological chemistry\| PubMed ID: 33753169	2021