David A. Tuveson

SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia.

SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice.

Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma.

Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment.

The RAS and YAP1 dance, who is leading?

Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy.

p53 mutations change phosphatidylinositol acyl chain composition.

Organoid models of human and mouse ductal pancreatic cancer.

Identification of novel vascular projections with cellular trafficking abilities on the microvasculature of pancreatic ductal adenocarcinoma.

BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model.

ADAM8 as a drug target in pancreatic cancer.

Stromal biology and therapy in pancreatic cancer: a changing paradigm.

A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules.

The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1.

Mouse Models of Pancreatic Ductal Adenocarcinoma.

MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model.

Pre-clinical Models of Pancreatic Ductal Adenocarcinoma.

BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages.

Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus.

Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis.

Modeling pancreatic cancer with organoids.

Pancreatic cancer.

Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic.

Model organoids provide new research opportunities for ductal pancreatic cancer.

NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer.

ROS in translation: Chink in the armor.

Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors.

Cancer: Double trouble for tumours.

Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization.

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer.

Untangling the genetics from the epigenetics in pancreatic cancer metastasis.

Challenges and Opportunities in Modeling Pancreatic Cancer.

ROS in Cancer: The Burning Question.

Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma.

Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis.

Transcriptional Regulation by Nrf2.

Soils and Seeds That Initiate Pancreatic Cancer Metastasis.

Successful creation of pancreatic cancer organoids by means of EUS-guided fine-needle biopsy sampling for personalized cancer treatment.

Macrophage-Derived Granulin Drives Resistance to Immune Checkpoint Inhibition in Metastatic Pancreatic Cancer.

Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer.

Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine.

Stromal biology and therapy in pancreatic cancer: ready for clinical translation?

IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma.

Generation and Culture of Human Pancreatic Ductal Adenocarcinoma Organoids from Resected Tumor Specimens.

Generation and Culture of Tumor and Metastatic Organoids from Murine Models of Pancreatic Ductal Adenocarcinoma.

TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma.

Deciphering cancer fibroblasts.

Organoid models for translational pancreatic cancer research.

A FATal Combination: Fibroblast-Derived Lipids and Cancer-Derived Autotaxin Promote Pancreatic Cancer Growth.

Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy.

Cancer modeling meets human organoid technology.

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts.

The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice.

Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer.

Perspectives on the role of Wnt biology in cancer.

Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells.

Identification of Resistance Pathways Specific to Malignancy Using Organoid Models of Pancreatic Cancer.

Bioactivation of Napabucasin Triggers Reactive Oxygen Species-Mediated Cancer Cell Death.

Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism.

Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution.

A framework for advancing our understanding of cancer-associated fibroblasts.

Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer.

Cancer Cell-Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma.

Author Correction: Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution.

ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity.

Single-Pass vs 2-Pass Endoscopic Ultrasound-Guided Fine-Needle Biopsy Sample Collection for Creation of Pancreatic Adenocarcinoma Organoids.

Roadmap for the Emerging Field of Cancer Neuroscience.

Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation.

The Era of COVID-19 and the Rise of Science Collectivism in Cancer Research.

SIRT1-NOX4 signaling axis regulates cancer cachexia.

Diversity and Biology of Cancer-Associated Fibroblasts.

Famotidine use and quantitative symptom tracking for COVID-19 in non-hospitalised patients: a case series.

SOAT1 promotes mevalonate pathway dependency in pancreatic cancer.

Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma.

Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer.

Intraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes.

Pancreatic cancer SLUGged.

KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice.

Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer.

Vestigial-like 1 is a shared targetable cancer-placenta antigen expressed by pancreatic and basal-like breast cancers.

Detection of Chemotherapy-resistant Pancreatic Cancer Using a Glycan Biomarker, sTRA.

Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer.

Fighting the Sixth Decade of the Cancer War with Better Cancer Models.

Oncogenic KRAS engages an RSK1/NF1 pathway to inhibit wild-type RAS signaling in pancreatic cancer.

Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade.