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SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia.
The Journal of clinical investigation Nov, 2011 | Pubmed ID: 21965329
SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice.
Gut Jun, 2014 | Pubmed ID: 24067278
Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma.
OncoTargets and therapy Dec, 2013 | Pubmed ID: 24379681
Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment.
BioMed research international , 2014 | Pubmed ID: 25147816
The RAS and YAP1 dance, who is leading?
The EMBO journal Nov, 2014 | Pubmed ID: 25257311
Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy.
Cell Sep, 2014 | Pubmed ID: 25259922
p53 mutations change phosphatidylinositol acyl chain composition.
Cell reports Jan, 2015 | Pubmed ID: 25543136
Organoid models of human and mouse ductal pancreatic cancer.
Cell Jan, 2015 | Pubmed ID: 25557080
Identification of novel vascular projections with cellular trafficking abilities on the microvasculature of pancreatic ductal adenocarcinoma.
The Journal of pathology Jun, 2015 | Pubmed ID: 25561062
BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2015 | Pubmed ID: 25624498
ADAM8 as a drug target in pancreatic cancer.
Nature communications Jan, 2015 | Pubmed ID: 25629724
Stromal biology and therapy in pancreatic cancer: a changing paradigm.
Gut Sep, 2015 | Pubmed ID: 25994217
A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules.
Scientific reports Jun, 2015 | Pubmed ID: 26046460
The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1.
Cell Jul, 2015 | Pubmed ID: 26144316
Mouse Models of Pancreatic Ductal Adenocarcinoma.
Hematology/oncology clinics of North America Aug, 2015 | Pubmed ID: 26226900
MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model.
Gut Mar, 2016 | Pubmed ID: 26347531
Pre-clinical Models of Pancreatic Ductal Adenocarcinoma.
The Journal of pathology Sep, 2015 | Pubmed ID: 26419819
BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages.
Nature communications Nov, 2015 | Pubmed ID: 26522614
Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus.
Clinical cancer research : an official journal of the American Association for Cancer Research Apr, 2016 | Pubmed ID: 26573598
Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis.
Nature cell biology 05, 2016 | Pubmed ID: 27088855
Modeling pancreatic cancer with organoids.
Trends in cancer Apr, 2016 | Pubmed ID: 27135056
Pancreatic cancer.
Nature reviews. Disease primers 04, 2016 | Pubmed ID: 27158978
Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic.
Oncotarget Jun, 2016 | Pubmed ID: 27244881
Model organoids provide new research opportunities for ductal pancreatic cancer.
Molecular & cellular oncology Jan, 2016 | Pubmed ID: 27308531
NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer.
Cell Aug, 2016 | Pubmed ID: 27477511
ROS in translation: Chink in the armor.
Cell cycle (Georgetown, Tex.) 02, 2017 | Pubmed ID: 27636545
Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors.
Cancer research 12, 2016 | Pubmed ID: 27742686
Cancer: Double trouble for tumours.
Nature 02, 2017 | Pubmed ID: 28099410
Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization.
Nature communications 02, 2017 | Pubmed ID: 28224990
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer.
The Journal of experimental medicine 03, 2017 | Pubmed ID: 28232471
Untangling the genetics from the epigenetics in pancreatic cancer metastasis.
Nature genetics Feb, 2017 | Pubmed ID: 28232730
Challenges and Opportunities in Modeling Pancreatic Cancer.
Cold Spring Harbor symposia on quantitative biology , 2016 | Pubmed ID: 28289164
ROS in Cancer: The Burning Question.
Trends in molecular medicine 05, 2017 | Pubmed ID: 28427863
Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma.
Nature genetics Jun, 2017 | Pubmed ID: 28481342
Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis.
Cell Aug, 2017 | Pubmed ID: 28757253
Transcriptional Regulation by Nrf2.
Antioxidants & redox signaling 12, 2018 | Pubmed ID: 28899199
Soils and Seeds That Initiate Pancreatic Cancer Metastasis.
Cancer discovery 10, 2017 | Pubmed ID: 28974531
Successful creation of pancreatic cancer organoids by means of EUS-guided fine-needle biopsy sampling for personalized cancer treatment.
Gastrointestinal endoscopy Jun, 2018 | Pubmed ID: 29325707
Macrophage-Derived Granulin Drives Resistance to Immune Checkpoint Inhibition in Metastatic Pancreatic Cancer.
Cancer research 08, 2018 | Pubmed ID: 29789416
Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer.
Cancer discovery 09, 2018 | Pubmed ID: 29853643
Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine.
Cancer discovery 09, 2018 | Pubmed ID: 29903880
Stromal biology and therapy in pancreatic cancer: ready for clinical translation?
Gut 01, 2019 | Pubmed ID: 30177543
IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma.
Cancer discovery 02, 2019 | Pubmed ID: 30366930
Generation and Culture of Human Pancreatic Ductal Adenocarcinoma Organoids from Resected Tumor Specimens.
Methods in molecular biology (Clifton, N.J.) , 2019 | Pubmed ID: 30378047
Generation and Culture of Tumor and Metastatic Organoids from Murine Models of Pancreatic Ductal Adenocarcinoma.
Methods in molecular biology (Clifton, N.J.) , 2019 | Pubmed ID: 30378048
TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma.
Cell reports 11, 2018 | Pubmed ID: 30428345
Deciphering cancer fibroblasts.
The Journal of experimental medicine 12, 2018 | Pubmed ID: 30470718
Organoid models for translational pancreatic cancer research.
Current opinion in genetics & development 02, 2019 | Pubmed ID: 30844513
A FATal Combination: Fibroblast-Derived Lipids and Cancer-Derived Autotaxin Promote Pancreatic Cancer Growth.
Cancer discovery May, 2019 | Pubmed ID: 31043410
Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy.
Cancer discovery 07, 2019 | Pubmed ID: 31053628
Cancer modeling meets human organoid technology.
Science (New York, N.Y.) Jun, 2019 | Pubmed ID: 31171691
Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts.
Cancer discovery 08, 2019 | Pubmed ID: 31197017
The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice.
Science (New York, N.Y.) 06, 2019 | Pubmed ID: 31221853
Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer.
Cancer discovery 09, 2019 | Pubmed ID: 31263025
Perspectives on the role of Wnt biology in cancer.
Science signaling 07, 2019 | Pubmed ID: 31289213
Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells.
Proceedings of the National Academy of Sciences of the United States of America 09, 2019 | Pubmed ID: 31484774
Identification of Resistance Pathways Specific to Malignancy Using Organoid Models of Pancreatic Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 11, 2019 | Pubmed ID: 31492749
Bioactivation of Napabucasin Triggers Reactive Oxygen Species-Mediated Cancer Cell Death.
Clinical cancer research : an official journal of the American Association for Cancer Research 12, 2019 | Pubmed ID: 31527169
Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism.
Cell reports Oct, 2019 | Pubmed ID: 31665640
Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution.
Nature genetics 02, 2020 | Pubmed ID: 31932696
A framework for advancing our understanding of cancer-associated fibroblasts.
Nature reviews. Cancer 03, 2020 | Pubmed ID: 31980749
Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer.
Cancer cell 02, 2020 | Pubmed ID: 31983610
Cancer Cell-Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma.
Cancer research 04, 2020 | Pubmed ID: 32029550
Author Correction: Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution.
Nature genetics Apr, 2020 | Pubmed ID: 32051610
ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity.
Nature 03, 2020 | Pubmed ID: 32076273
Single-Pass vs 2-Pass Endoscopic Ultrasound-Guided Fine-Needle Biopsy Sample Collection for Creation of Pancreatic Adenocarcinoma Organoids.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 04, 2021 | Pubmed ID: 32119924
Roadmap for the Emerging Field of Cancer Neuroscience.
Cell 04, 2020 | Pubmed ID: 32302564
Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation.
eLife 04, 2020 | Pubmed ID: 32329713
The Era of COVID-19 and the Rise of Science Collectivism in Cancer Research.
Cancer discovery 07, 2020 | Pubmed ID: 32404307
SIRT1-NOX4 signaling axis regulates cancer cachexia.
The Journal of experimental medicine 07, 2020 | Pubmed ID: 32441762
Diversity and Biology of Cancer-Associated Fibroblasts.
Physiological reviews 01, 2021 | Pubmed ID: 32466724
Famotidine use and quantitative symptom tracking for COVID-19 in non-hospitalised patients: a case series.
Gut 09, 2020 | Pubmed ID: 32499303
SOAT1 promotes mevalonate pathway dependency in pancreatic cancer.
The Journal of experimental medicine 09, 2020 | Pubmed ID: 32633781
Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma.
eLife 07, 2020 | Pubmed ID: 32648540
Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer.
Annals of surgery 09, 2020 | Pubmed ID: 32657929
Intraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes.
Cancer discovery 10, 2020 | Pubmed ID: 32703770
Pancreatic cancer SLUGged.
The Journal of experimental medicine 09, 2020 | Pubmed ID: 32813872
KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice.
JCI insight 11, 2020 | Pubmed ID: 32990679
Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer.
Gastroenterology 01, 2021 | Pubmed ID: 33039466
Vestigial-like 1 is a shared targetable cancer-placenta antigen expressed by pancreatic and basal-like breast cancers.
Nature communications 10, 2020 | Pubmed ID: 33087697
Detection of Chemotherapy-resistant Pancreatic Cancer Using a Glycan Biomarker, sTRA.
Clinical cancer research : an official journal of the American Association for Cancer Research 01, 2021 | Pubmed ID: 33093149
Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 04, 2021 | Pubmed ID: 33495315
Fighting the Sixth Decade of the Cancer War with Better Cancer Models.
Cancer discovery 04, 2021 | Pubmed ID: 33811115
Oncogenic KRAS engages an RSK1/NF1 pathway to inhibit wild-type RAS signaling in pancreatic cancer.
Proceedings of the National Academy of Sciences of the United States of America 05, 2021 | Pubmed ID: 34021083
Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade.
Nature communications 06, 2021 | Pubmed ID: 34099731
Laura Maiorino*,1,2,3,
Margaret Shevik*,1,4,5,
José M. Adrover1,
Xiao Han1,6,
Elias Georgas7,8,
John Erby Wilkinson9,
Harrison Seidner1,
Leonie Foerschner1,
David A. Tuveson1,
Yi-Xian Qin8,
Mikala Egeblad1
1, Cold Spring Harbor Laboratory,
2, Cold Spring Harbor Laboratory School of Biological Sciences,
3Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology,
4Medical Scientist Training Program, School of Medicine, Stony Brook University,
5Graduate Program in Pharmacology, Stony Brook University,
6Graduate Program in Genetics, Stony Brook University,
7Graduate Program in Biomedical Engineering, Stony Brook University,
8Department of Biomedical Engineering, Stony Brook University,
9Department of Pathology, University of Michigan
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