Jonathan M. Gibbins

Aberrant glycosylation of anti-SARS-CoV-2 IgG is a pro-thrombotic stimulus for platelets.

Platelet endothelial cell adhesion molecule-1 signaling inhibits the activation of human platelets.

Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI.

The negative regulation of platelet function: extending the role of the ITIM.

The role of polyphenolic compounds in the diet as inhibitors of platelet function.

Regulation of glycogen synthase kinase 3 in human platelets: a possible role in platelet function?

Tachykinins regulate the function of platelets.

Platelet adhesion signalling and the regulation of thrombus formation.

Techniques for analysis of proteins by SDS-polyacrylamide gel electrophoresis and Western blotting.

Study of tyrosine kinases and protein tyrosine phosphorylation.

A role for the thiol isomerase protein ERP5 in platelet function.

Platelet PECAM-1 inhibits thrombus formation in vivo.

Extracellular disulfide exchange and the regulation of cellular function.

Ingestion of onion soup high in quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in man: a pilot study.

Nongenomic signaling of the retinoid X receptor through binding and inhibiting Gq in human platelets.

In vivo selection for metastasis promoting genes in the mouse.

Peripheral tachykinins and the neurokinin receptor NK1 are required for platelet thrombus formation.

The neurokinin 1 receptor: a potential new target for anti-platelet therapy?

A dual role for integrin-linked kinase in platelets: regulating integrin function and alpha-granule secretion.

Tweaking the gain on platelet regulation: the tachykinin connection.

A functional proteomic method for the enrichment of peripheral membrane proteins reveals the collagen binding protein Hsp47 is exposed on the surface of activated human platelets.

Proteomic analysis of resting and thrombin-stimulated platelets reveals the translocation and functional relevance of HIP-55 in platelets.

PECAM-1 expression and activity negatively regulate multiple platelet signaling pathways.

Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation.

A structural basis for the inhibition of collagen-stimulated platelet function by quercetin and structurally related flavonoids.

Purification and functional characterisation of rhinocerase, a novel serine protease from the venom of Bitis gabonica rhinoceros.

Platelet-mediated metabolism of the common dietary flavonoid, quercetin.

Purification and functional characterisation of rhiminopeptidase A, a novel aminopeptidase from the venom of Bitis gabonica rhinoceros.

LXR as a novel antithrombotic target.

Evolutionary analysis of novel serine proteases in the venom gland transcriptome of Bitis gabonica rhinoceros.

Regulation of platelet biology by platelet endothelial cell adhesion molecule-1.

Analysis of protein networks in resting and collagen receptor (GPVI)-stimulated platelet sub-proteomes.

Clot retraction.

Endogenous inhibitory mechanisms and the regulation of platelet function.

JAMming the signals.

Gap junctions and connexin hemichannels underpin hemostasis and thrombosis.

Rhinocetin, a venom-derived integrin-specific antagonist inhibits collagen-induced platelet and endothelial cell functions.

Insights into dietary flavonoids as molecular templates for the design of anti-platelet drugs.

Sequence and phylogenetic analysis of viper venom serine proteases.

The integration of proteomics and systems approaches to map regulatory mechanisms underpinning platelet function.

Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice.

Staphylococcus aureus lipoteichoic acid inhibits platelet activation and thrombus formation via the Paf receptor.

Antithrombotic actions of statins involve PECAM-1 signaling.

Connexin40 regulates platelet function.

Flavonoid inhibitory pharmacodynamics on platelet function in physiological environments.

Tangeretin regulates platelet function through inhibition of phosphoinositide 3-kinase and cyclic nucleotide signaling.

Platelets using proteins creatively.

Snakebite and its socio-economic impact on the rural population of Tamil Nadu, India.

Ibuprofen inhibits migration and proliferation of human coronary artery smooth muscle cells by inducing a differentiated phenotype: role of peroxisome proliferator-activated receptor γ.

Platelet endothelial cell adhesion molecule-1 inhibits platelet response to thrombin and von Willebrand factor by regulating the internalization of glycoprotein Ib via AKT/glycogen synthase kinase-3/dynamin and integrin αIIbβ3.

Discovery of novel GPVI receptor antagonists by structure-based repurposing.

EphB2 regulates contact-dependent and contact-independent signaling to control platelet function.

Pharmacological actions of nobiletin in the modulation of platelet function.

Gap junctions and connexin hemichannels in the regulation of haemostasis and thrombosis.

GRID and docking analyses reveal a molecular basis for flavonoid inhibition of Src family kinase activity.

Ibrutinib Inhibits Platelet Integrin αIIbβ3 Outside-In Signaling and Thrombus Stability But Not Adhesion to Collagen.

Syncytiotrophoblast Extracellular Vesicles from Pre-Eclampsia Placentas Differentially Affect Platelet Function.

Regulation of Early Steps of GPVI Signal Transduction by Phosphatases: A Systems Biology Approach.

Platelets stop us leaking.

Intracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol Isomerases.

Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets.

Challenges in diagnosing and treating snakebites in a rural population of Tamil Nadu, India: The views of clinicians.

RXR Ligands Negatively Regulate Thrombosis and Hemostasis.

Evidence for shear-mediated Ca entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line.

Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets.

Lipopolysaccharide potentiates platelet responses via toll-like receptor 4-stimulated Akt-Erk-PLA2 signalling.

Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib.

Modeling thrombosis in silico: Frontiers, challenges, unresolved problems and milestones.

NADPH oxidase 2 (NOX2): A key target of oxidative stress-mediated platelet activation and thrombosis.

Connexins and Pannexins in Vascular Function and Disease.

Talin is a substrate for SUMOylation in migrating cancer cells.

Functional redundancy between RAP1 isoforms in murine platelet production and function.

Screening and High-Throughput Platelet Assays.

Mathematical Techniques for Understanding Platelet Regulation and the Development of New Pharmacological Approaches.

Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction.

The endogenous antimicrobial cathelicidin LL37 induces platelet activation and augments thrombus formation.

Gradient-dependent inhibition of stimulatory signaling from platelet G protein-coupled receptors.

Flow cytometry for near-patient testing in premature neonates reveals variation in platelet function: a novel approach to guide platelet transfusion.

The formyl peptide fMLF primes platelet activation and augments thrombus formation.

The Metabolites of the Dietary Flavonoid Quercetin Possess Potent Antithrombotic Activity, and Interact with Aspirin to Enhance Antiplatelet Effects.

Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation.

Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasis.

Platelet α-granules contribute to organ-specific pathologies in a mouse model of severe malaria.

Ca waves coordinate purinergic receptor-evoked integrin activation and polarization.

Myricetin, the Main Flavonoid in Leaf, Is a Novel Inhibitor of Platelet Thiol Isomerases PDI and ERp5.

Control of Platelet CLEC-2-Mediated Activation by Receptor Clustering and Tyrosine Kinase Signaling.

Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling.

A model of the PI cycle reveals the regulating roles of lipid-binding proteins and pitfalls of using mosaic biological data.

Structural, functional, and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets.

Zafirlukast is a broad-spectrum thiol isomerase inhibitor that inhibits thrombosis without altering bleeding times.

Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring.

Platelet-derived extracellular vesicles express NADPH oxidase-1 (Nox-1), generate superoxide and modulate platelet function.

Targeting platelet inhibition receptors for novel therapies: PECAM-1 and G6b-B.

Protein Disulphide Isomerase and NADPH Oxidase 1 Cooperate to Control Platelet Function and Are Associated with Cardiometabolic Disease Risk Factors.

Mind the gap: connexins and pannexins in platelet function.

Thiol Isomerases Orchestrate Thrombosis and Hemostasis.

The protein disulphide isomerase inhibitor CxxCpep modulates oxidative burst and mitochondrial function in platelets.

The voltage-gated K channel Kv1.3 modulates platelet motility and αβ integrin-dependent adhesion to collagen.

Identification of HSP47 Binding Site on Native Collagen and Its Implications for the Development of HSP47 Inhibitors.

Multi-parameter phenotyping of platelet reactivity for stratification of human cohorts.

G protein-coupled receptor kinase 5 regulates thrombin signaling in platelets via PAR-1.