Global Drug Discovery
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Effects of heparin-binding protein (CAP37/azurocidin) in a porcine model of Actinobacillus pleuropneumoniae-induced pneumonia.
Pharmacological research : the official journal of the Italian Pharmacological Society Jun, 2005 | Pubmed ID: 15829430
Evaluation of a single dose versus a divided dose regimen of amoxycillin in treatment of Actinobacillus pleuropneumoniae infection in pigs.
Research in veterinary science Aug, 2005 | Pubmed ID: 15894026
Recombinant human factor VIIa and a factor VIIa-analogue reduces heparin and low molecular weight heparin (LMWH)-induced bleeding in rats.
Journal of thrombosis and haemostasis : JTH May, 2008 | Pubmed ID: 18315554
Automated registration of tail bleeding in rats.
Thrombosis and haemostasis May, 2008 | Pubmed ID: 18449428
rFVIIa and a new enhanced rFVIIa-analogue, NN1731, reduce bleeding in clopidogrel-treated and in thrombocytopenic rats.
Journal of thrombosis and haemostasis : JTH Apr, 2009 | Pubmed ID: 19175492
rFVIIa and NN1731 reduce bleeding in hydroxyethyl starch hemodiluted rabbits.
The Journal of trauma Nov, 2010 | Pubmed ID: 20032791
Target-mediated clearance and bio-distribution of a monoclonal antibody against the Kunitz-type protease inhibitor 2 domain of Tissue Factor Pathway Inhibitor.
Thrombosis research Mar, 2014 | Pubmed ID: 24393663
Factor XIII Transglutaminase Supports the Resolution of Mucosal Damage in Experimental Colitis.
PloS one , 2015 | Pubmed ID: 26098308
Recombinant Factor VIIa Reduces Bleeding after Blunt Liver Injury in a Pig Model of Dilutional Coagulopathy under Severe Hypothermia.
PloS one , 2015 | Pubmed ID: 26098426
Administration of recombinant FVIIa (rFVIIa) to concizumab-dosed monkeys is safe, and concizumab does not affect the potency of rFVIIa in hemophilic rabbits.
Journal of thrombosis and haemostasis : JTH 03, 2019 | Pubmed ID: 30614620
Generic immune complex assay for detection of murine anti-drug-antibodies in complex with human IgG.
Biologicals : journal of the International Association of Biological Standardization Jul, 2019 | Pubmed ID: 31200984
An ELISA for detection of complement-bound circulating immune complexes in mice.
Journal of immunotoxicology 12, 2019 | Pubmed ID: 31271074
Concizumab promotes haemostasis via a tissue factor-factor VIIa-dependent mechanism supporting prophylactic treatment of haemophilia: Results from a rabbit haemophilia bleeding model.
Haemophilia : the official journal of the World Federation of Hemophilia Nov, 2019 | Pubmed ID: 31609513
Formation and glomerular deposition of immune complexes in mice administered bovine serum albumin: Evaluation of dose, frequency, and biomarkers.
Journal of immunotoxicology 12, 2019 | Pubmed ID: 31684787
Formation and Glomerular Deposition of Immune Complexes in Mice Administered Human Antibodies: Evaluation of Dose, Frequency, and Biomarkers.
Toxicologic pathology 06, 2020 | Pubmed ID: 32319353
Nonclinical Studies that Support Viral Vector-Delivered Gene Therapies: An EFPIA Gene Therapy Working Group Perspective.
Molecular therapy. Methods & clinical development Dec, 2020 | Pubmed ID: 33024793
Ariadna Carol Illa1,2,
Sarah Baumgarten1,
Dennis Danielsen1,
Karin Larsen3,
Torben Elm1,
Peter B. Johansen4,
Tom Knudsen5,
Brian Lauritzen1,
Mikael Tranholm6,
Carsten D. Ley1
1Global Drug Discovery, Novo Nordisk A/S,
2Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen,
3Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen,
4, Independent consultant,
5, Catalyst Biosciences,
6, Værløse Dyreklinik
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