Victoria Lucia Alonso

Área Parasitología,
Facultad de Ciencias Bioquímicas y Farmacéuticas,
Área Parasitología, Facultad de Ciencias Bioquímicas y Farmacéuticas,
Area Parasitología,
Area Parasitología, Facultad de Ciencias Bioquímicas y Farmacéuticas

Universidad Nacional de Rosario (UNR)

BIOGRAPHY

Victoria Lucia Alonso has a Bachelor degree in Biotechnology from the School of Biochemical and Pharmaceutical Sciences (FCByF) of the National University of Rosario, completed her doctorate at the Institute of Molecular and Cellular Biology of Rosario (IBR-CONICET) of the same School under the direction of Dr. Esteban Serra. She did a posdoc in medicinal chemistry at the Research Institute for the Discovery of Pharmaceuticals of Rosario (IIDEFAR-UNR) under the direction of Dr. Ricardo Furlan. She is currently an Assistant Researcher at CONICET and Assistant Professor in the Parasitology Department of the FCByF. Within Dr. Serra's group, her work focuses on studying the role of α-tubulin acetylation in the dynamics of the cytoskeleton in the flagellate protozoan Trypansoma cruzi, particularly in the characterization of the enzymes responsible for this post-transcriptional modification. These are potential target mechanisms for the development of new trypanosidal drugs.

PUBLICATIONS

Effect directed synthesis of a new tyrosinase inhibitor with anti-browning activity.

Food chemistry Mar, 2021 | Pubmed ID: 33039744

Trypanosoma cruzi bromodomain factor 3 binds acetylated α-tubulin and concentrates in the flagellum during metacyclogenesis.

Eukaryotic cell Jun, 2014 | Pubmed ID: 24747213

Glycosomal bromodomain factor 1 from Trypanosoma cruzi enhances trypomastigote cell infection and intracellular amastigote growth.

The Biochemical journal Jan, 2016 | Pubmed ID: 26500280

Overexpression of bromodomain factor 3 in Trypanosoma cruzi (TcBDF3) affects differentiation of the parasite and protects it against bromodomain inhibitors.

The FEBS journal Jun, 2016 | Pubmed ID: 27007774

Aim for the Readers! Bromodomains As New Targets Against Chagas' Disease.

Current medicinal chemistry , 2019 | Pubmed ID: 30378479

Overexpression of Trypanosoma cruzi High Mobility Group B protein (TcHMGB) alters the nuclear structure, impairs cytokinesis and reduces the parasite infectivity.

Scientific reports 01, 2019 | Pubmed ID: 30655631

Alpha-Tubulin Acetylation in : A Dynamic Instability of Microtubules Is Required for Replication and Cell Cycle Progression.

Frontiers in cellular and infection microbiology , 2021 | Pubmed ID: 33777851

Update on the Biological Relevance of Lysine Acetylation as a Novel Drug Target in Trypanosomatids.

Current medicinal chemistry , 2022 | Pubmed ID: 34825865

Ultrastructure Expansion Microscopy (U-ExM) in Trypanosoma cruzi: localization of tubulin isoforms and isotypes.

Parasitology research Oct, 2022 | Pubmed ID: 35941325

INSTITUTIONS

Universidad Nacional de Rosario (UNR)

CONICET

JOVE ARTICLES

In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase

Victoria Lucia Alonso^1,2,

Romina Manarin¹,

Virginia Perdomo¹,

Ernesto Gulin³,

Esteban Serra^1,2,

Pamela Cribb^1,2

¹Área Parasitología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario (UNR),

²Instituto de Biología Molecular y Celular de Rosario (IBR), CONICET,

³Instituto de Investigaciones Biomédicas (INBIOMED), Universidad de Buenos Aires (UBA) Facultad de Medicina, CONICET

Biochemistry

Ultrastructural Expansion Microscopy in Three In Vitro Life Cycle Stages of Trypanosoma cruzi

María Azul de Hernández^*,1,

Gonzalo Martinez Peralta^*,1,2,

Rodrigo Vena^1,4,

Victoria Lucia Alonso^1,3,4

¹Instituto de Biología Molecular y Celular de Rosario (IBR), CONICET,

²Area Biología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario (UNR),

³Area Parasitología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario (UNR),

⁴Unidad de Microscopía, Instituto de Biología Molecular y Celular de Rosario (IBR), CONICET

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