Qingjie Li
Division of Gastroenterology,
Department of Internal Medicine,
Division of Gastroenterology, Department of Internal Medicine
University of texas Medical Branch at Galveston
Dr. Li is an Associate Professor in the Division of Gastroenetrology, Department of Internal Medicine, the University of Texas Medical Branch at Galveston. He received
his Master’s Degree in Organic Chemistry from Guangxi Normal University, and a PhD in Biochemistry and Molecular Biology from Central South University, China.
He received his postdoctoral training in Dr. Roderick Dashwood's laboratory at the Linus Pauling Institute, Oregon State University, where he worked on molecular mechanisms and chemoprevention of colorectal cancer. He joined UTMB as a faculty member in 2006.
Dr. Li’s research interests lie in inflammatory bowel disease (IBD), a complex GI disease associated with lifelong medical attention, poor quality of life and huge economic burden, as well as in IBD-associated disorders, including colitis-associated cancer and IBD-induced cardiovascular diseases. Decades of research suggests that the pathogenesis of IBD, including Crohn’s disease and ulcerative colitis, involves abnormal gut microbiota, immune response dysregulation, environmental factors and genetic susceptibility. Specifically, Dr. Li’s research interests include:
• Epigenetic and bacterial contributions to the development of IBD and colitis-associated cancer (CAC);
• Molecular mechanisms underlying IBD-associated cardiovascular disorders;
• Identification of biomarkers and therapeutic targets in IBD and CAC;
• Development of small molecule drugs targeting TRAF6 and MMP7 in inflammatory diseases;
• Phytochemicals as chemopreventive agents against IBD and extraintestinal manifestations of IBD.
Nuclear myosin II regulates the assembly of preinitiation complex for ICAM-1 gene transcription.
Gastroenterology , | Pubmed ID: 19328794
Chronic stress targets posttranscriptional mechanisms to rapidly upregulate α1C-subunit of Cav1.2b calcium channels in colonic smooth muscle cells.
American journal of physiology. Gastrointestinal and liver physiology , | Pubmed ID: 21051529
Activator protein-2α functions as a master regulator of multiple transcription factors in the mouse liver.
Hepatology research : the official journal of the Japan Society of Hepatology , | Pubmed ID: 21682828
Nitric oxide modifies chromatin to suppress ICAM-1 expression during colonic inflammation.
American journal of physiology. Gastrointestinal and liver physiology , | Pubmed ID: 22517771
Paradoxical regulation of ChAT and nNOS expression in animal models of Crohn's colitis and ulcerative colitis.
American journal of physiology. Gastrointestinal and liver physiology , | Pubmed ID: 23681475
Developmental origins of colon smooth muscle dysfunction in IBS-like rats.
American journal of physiology. Gastrointestinal and liver physiology , | Pubmed ID: 23886858
Chronic prenatal stress epigenetically modifies spinal cord BDNF expression to induce sex-specific visceral hypersensitivity in offspring.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society , | Pubmed ID: 24588943
Traumatic brain injury dysregulates microRNAs to modulate cell signaling in rat hippocampus.
PloS one , | Pubmed ID: 25089700
A novel function of nuclear nonmuscle myosin regulatory light chain in promotion of xanthine oxidase transcription after myocardial ischemia/reperfusion.
Free radical biology & medicine Jun, 2015 | Pubmed ID: 25701432
Noninflammatory upregulation of nerve growth factor underlies gastric hypersensitivity induced by neonatal colon inflammation.
American journal of physiology. Regulatory, integrative and comparative physiology , | Pubmed ID: 26608656
Neonatal Colonic Inflammation Epigenetically Aggravates Epithelial Inflammatory Responses to Injury in Adult Life.
Cellular and molecular gastroenterology and hepatology , | Pubmed ID: 29928672
Inhibition of Phosphoglycerate Mutase 5 Reduces Necroptosis in Rat Hearts Following Ischemia/Reperfusion Through Suppression of Dynamin-Related Protein 1.
Cardiovascular drugs and therapy , | Pubmed ID: 30637549
Neonatal Injury Increases Gut Permeability by Epigenetically Suppressing E-Cadherin in Adulthood.
Journal of immunology (Baltimore, Md. : 1950) , | Pubmed ID: 31889022
Chronic colitis upregulates microRNAs suppressing brain-derived neurotrophic factor in the adult heart.
PloS one , 2021 | Pubmed ID: 34543287
Exosomal miR-29b of Gut Origin in Patients With Ulcerative Colitis Suppresses Heart Brain-Derived Neurotrophic Factor.
Frontiers in molecular biosciences , 2022 | Pubmed ID: 35274002
ABOUT JoVE
Copyright © 2024 MyJoVE Corporation. All rights reserved