Irina A. Okkelman

Tissue Engineering and Biomaterials Group,
Department of Human Structure and Repair,
Faculty of Medical and Health Sciences,
Tissue Engineering and Biomaterials Group, Department of Human Structure and Repair, Faculty of Medical and Health Sciences,
Faculty of Medicine and Health Sciences,
Ghent Light Microscopy Core,
Tissue Engineering and Biomaterials Group, Department of Human Structure and Repair, Faculty of Medicine and Health Sciences

Ghent University

BIOGRAPHY

Irina A. Okkelman is a post-doctoral researcher in the Laboratory of Tissue Engineering and Biomaterials, in the Department of Human Structure and Repair, Ghent University (Belgium). She received her undergraduate with honors degree from Kazan State University of the Republic of Tatarstan (2007), and a Ph.D. from the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences in Moscow (2014).

During her postdoctoral training in the Laboratory of Biophysics and Bioanalysis at the School of Biochemistry and Cell Biology, University College Cork, Ireland (2014 – 2020), she gained an experience in analysis of cell metabolism and oxygenation of 3D cell and tissue cultures (spheroids, organoids, ex vivo tissues), using F(P)LIM live microscopy approaches. She developed some innovative FLIM-based methods for quantitative analysis of oxygenation (2017), mitochondrial polarization (2020), cell proliferation and duration of S phase (2016) in the intestinal organoids. Since 2020, she continues her research in imaging assisted tissue engineering at the laboratory of Prof. Dmitriev, Ghent University.

PUBLICATIONS

Extracellular Ca-Sensing Fluorescent Protein Biosensor Based on a Collagen-Binding Domain.

ACS applied bio materials Aug, 2020 | Pubmed ID: 35021705

Balance between the cell viability and death in 3D.

Seminars in cell & developmental biology Jul, 2023 | Pubmed ID: 36117019

Fluorescence Intensity and Fluorescence Lifetime Imaging Microscopies (FLIM) of Cell Differentiation in the Small Intestinal Organoids Using Cholera Toxin.

Methods in molecular biology (Clifton, N.J.) , 2023 | Pubmed ID: 37310632

Live Microscopy of Multicellular Spheroids with the Multimodal Near-Infrared Nanoparticles Reveals Differences in Oxygenation Gradients.

ACS nano May, 2024 | Pubmed ID: 38687976

INSTITUTIONS

Ghent University

JOVE ARTICLES

Affordable Oxygen Microscopy-Assisted Biofabrication of Multicellular Spheroids

Irina A. Okkelman^*,1,

Chris Vercruysse^*,1,

Alina V. Kondrashina²,

Sergey M. Borisov³,

Ruslan I. Dmitriev¹

¹Tissue Engineering and Biomaterials Group, Department of Human Structure and Repair, Faculty of Medical and Health Sciences, Ghent University,

²Health and Happiness (H&H) Group, National Food Innovation Hub,

³Institute of Analytical Chemistry and Food Chemistry, Graz University of Technology

Bioengineering

Production and Multi-Parameter Live Cell Fluorescence Lifetime Imaging Microscopy (FLIM) of Multicellular Spheroids

Angela C. Debruyne^*,1,

Gabriele Ferrari^*,1,

Hang Zhou^*,1,

Nore Van Loon¹,

Nina Heymans¹,

Irina A. Okkelman^1,2,

Ruslan I. Dmitriev^1,2

¹Tissue Engineering and Biomaterials Group, Department of Human Structure and Repair, Faculty of Medicine and Health Sciences, Ghent University,

²Ghent Light Microscopy Core, Ghent University

Bioengineering

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