James N. Sleigh

Department of Neuromuscular Diseases, University College London

Affiliated withUniversity College London

Research Area

Neuroscience

Biography

JoVE Journal Publications

Article Total : 1	Year
Publication title	2021

Other Publications

Article	Year
In vivo imaging of axonal transport in murine motor and sensory neurons. Journal of neuroscience methods\| PubMed ID: 26424507	2016
Vascular Defects and Spinal Cord Hypoxia in Spinal Muscular Atrophy. Annals of neurology\| PubMed ID: 26506088	2016
A simple, step-by-step dissection protocol for the rapid isolation of mouse dorsal root ganglia. BMC research notes\| PubMed ID: 26864470	2016
Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27621445	2016
Methodological advances in imaging intravital axonal transport. F1000Research\| PubMed ID: 28344778	2017
Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by mutations. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28351971	2017
Neuropilin 1 sequestration by neuropathogenic mutant glycyl-tRNA synthetase is permissive to vascular homeostasis. Scientific reports\| PubMed ID: 28835631	2017
Motor Neuron Gene Therapy: Lessons from Spinal Muscular Atrophy for Amyotrophic Lateral Sclerosis. Frontiers in molecular neuroscience\| PubMed ID: 29270111	2017
Aligned electrospun fibers for neural patterning. Biotechnology letters\| PubMed ID: 29313254	2018
Antisense oligonucleotides and other genetic therapies made simple. Practical neurology\| PubMed ID: 29455156
Plexin-Semaphorin Signaling Modifies Neuromuscular Defects in a Model of Peripheral Neuropathy. Frontiers in molecular neuroscience\| PubMed ID: 29520219
UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy. Brain : a journal of neurology\| PubMed ID: 30239612	2018
Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition. The Journal of cell biology\| PubMed ID: 31068376
Axonal transport and neurological disease. Nature reviews. Neurology\| PubMed ID: 31558780	2019
Neuronal over-expression of Oxr1 is protective against ALS-associated mutant TDP-43 mislocalisation in motor neurons and neuromuscular defects in vivo. Human molecular genetics\| PubMed ID: 31642482	2019
The evolution of the axonal transport toolkit. Traffic (Copenhagen, Denmark)\| PubMed ID: 31670447	2020
Loss of BICD2 in muscle drives motor neuron loss in a developmental form of spinal muscular atrophy. Acta neuropathologica communications\| PubMed ID: 32183910	2020
Mice Carrying ALS Mutant TDP-43, but Not Mutant FUS, Display In Vivo Defects in Axonal Transport of Signaling Endosomes. Cell reports\| PubMed ID: 32187538	2020
In Vivo Imaging of Anterograde and Retrograde Axonal Transport in Rodent Peripheral Nerves. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 32524487	2020
Morphological variability is greater at developing than mature mouse neuromuscular junctions. Journal of anatomy\| PubMed ID: 32533580	2020
A video protocol for rapid dissection of mouse dorsal root ganglia from defined spinal levels. BMC research notes\| PubMed ID: 32580748	2020
Developmental demands contribute to early neuromuscular degeneration in CMT2D mice. Cell death & disease\| PubMed ID: 32703932	2020
Intramuscular Delivery of Gene Therapy for Targeting the Nervous System. Frontiers in molecular neuroscience\| PubMed ID: 32765219	2020
Altered Sensory Neuron Development in CMT2D Mice Is Site-Specific and Linked to Increased GlyRS Levels. Frontiers in cellular neuroscience\| PubMed ID: 32848623	2020
NMJ-Analyser identifies subtle early changes in mouse models of neuromuscular disease. Scientific reports\| PubMed ID: 34112844	2021
Dissection, in vivo imaging and analysis of the mouse epitrochleoanconeus muscle. Journal of anatomy\| PubMed ID: 34121181	2021

Article	Year
In vivo imaging of axonal transport in murine motor and sensory neurons. Journal of neuroscience methods\| PubMed ID: 26424507	2016
Vascular Defects and Spinal Cord Hypoxia in Spinal Muscular Atrophy. Annals of neurology\| PubMed ID: 26506088	2016
A simple, step-by-step dissection protocol for the rapid isolation of mouse dorsal root ganglia. BMC research notes\| PubMed ID: 26864470	2016
Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27621445	2016
Methodological advances in imaging intravital axonal transport. F1000Research\| PubMed ID: 28344778	2017
Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by mutations. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28351971	2017
Neuropilin 1 sequestration by neuropathogenic mutant glycyl-tRNA synthetase is permissive to vascular homeostasis. Scientific reports\| PubMed ID: 28835631	2017
Motor Neuron Gene Therapy: Lessons from Spinal Muscular Atrophy for Amyotrophic Lateral Sclerosis. Frontiers in molecular neuroscience\| PubMed ID: 29270111	2017
Aligned electrospun fibers for neural patterning. Biotechnology letters\| PubMed ID: 29313254	2018
Antisense oligonucleotides and other genetic therapies made simple. Practical neurology\| PubMed ID: 29455156
Plexin-Semaphorin Signaling Modifies Neuromuscular Defects in a Model of Peripheral Neuropathy. Frontiers in molecular neuroscience\| PubMed ID: 29520219
UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy. Brain : a journal of neurology\| PubMed ID: 30239612	2018
Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition. The Journal of cell biology\| PubMed ID: 31068376
Axonal transport and neurological disease. Nature reviews. Neurology\| PubMed ID: 31558780	2019
Neuronal over-expression of Oxr1 is protective against ALS-associated mutant TDP-43 mislocalisation in motor neurons and neuromuscular defects in vivo. Human molecular genetics\| PubMed ID: 31642482	2019
The evolution of the axonal transport toolkit. Traffic (Copenhagen, Denmark)\| PubMed ID: 31670447	2020
Loss of BICD2 in muscle drives motor neuron loss in a developmental form of spinal muscular atrophy. Acta neuropathologica communications\| PubMed ID: 32183910	2020
Mice Carrying ALS Mutant TDP-43, but Not Mutant FUS, Display In Vivo Defects in Axonal Transport of Signaling Endosomes. Cell reports\| PubMed ID: 32187538	2020
In Vivo Imaging of Anterograde and Retrograde Axonal Transport in Rodent Peripheral Nerves. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 32524487	2020
Morphological variability is greater at developing than mature mouse neuromuscular junctions. Journal of anatomy\| PubMed ID: 32533580	2020
A video protocol for rapid dissection of mouse dorsal root ganglia from defined spinal levels. BMC research notes\| PubMed ID: 32580748	2020
Developmental demands contribute to early neuromuscular degeneration in CMT2D mice. Cell death & disease\| PubMed ID: 32703932	2020
Intramuscular Delivery of Gene Therapy for Targeting the Nervous System. Frontiers in molecular neuroscience\| PubMed ID: 32765219	2020
Altered Sensory Neuron Development in CMT2D Mice Is Site-Specific and Linked to Increased GlyRS Levels. Frontiers in cellular neuroscience\| PubMed ID: 32848623	2020
NMJ-Analyser identifies subtle early changes in mouse models of neuromuscular disease. Scientific reports\| PubMed ID: 34112844	2021
Dissection, in vivo imaging and analysis of the mouse epitrochleoanconeus muscle. Journal of anatomy\| PubMed ID: 34121181	2021