Molecular Medicine
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Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells.
Nature protocols Mar, 2015 | Pubmed ID: 25654755
Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia.
NPJ genomic medicine , | Pubmed ID: 28649446
SLC6A14, an amino acid transporter, modifies the primary CF defect in fluid secretion.
eLife , | Pubmed ID: 30004386
VacA generates a protective intracellular reservoir for Helicobacter pylori that is eliminated by activation of the lysosomal calcium channel TRPML1.
Nature microbiology 08, 2019 | Pubmed ID: 31110360
Augmentation of Cystic Fibrosis Transmembrane Conductance Regulator Function in Human Bronchial Epithelial Cells via SLC6A14-Dependent Amino Acid Uptake. Implications for Treatment of Cystic Fibrosis.
American journal of respiratory cell and molecular biology , | Pubmed ID: 31189070
Conversion of human and mouse fibroblasts into lung-like epithelial cells.
Scientific reports , | Pubmed ID: 31227724
ORKAMBI-Mediated Rescue of Mucociliary Clearance in Cystic Fibrosis Primary Respiratory Cultures Is Enhanced by Arginine Uptake, Arginase Inhibition, and Promotion of Nitric Oxide Signaling to the Cystic Fibrosis Transmembrane Conductance Regulator Channel.
Molecular pharmacology , | Pubmed ID: 31427400
An organoid model to assay the role of CFTR in the human epididymis epithelium.
Cell and tissue research , | Pubmed ID: 32377875
A new platform for high-throughput therapy testing on iPSC-derived lung progenitor cells from cystic fibrosis patients.
Stem cell reports 11, 2021 | Pubmed ID: 34678210
Perspectives on the translation of in-vitro studies to precision medicine in Cystic Fibrosis.
EBioMedicine Nov, 2021 | Pubmed ID: 34740114
Generation of functional ciliated cholangiocytes from human pluripotent stem cells.
Nature communications 11, 2021 | Pubmed ID: 34764255
High-Throughput Functional Analysis of CFTR and Other Apically Localized Proteins in iPSC-Derived Human Intestinal Organoids.
Cells 12, 2021 | Pubmed ID: 34943927
Stage-Specific Generation of Human Pluripotent Stem Cell Derived Lung Models to Measure CFTR Function.
Current protocols Jan, 2022 | Pubmed ID: 35025140
Hospital for Sick Children
University of Toronto
Sunny Xia1,3,
Michelle Di Paola3,
Nicola L. Jones2,4,5,
Christine E. Bear1,3,5
1Molecular Medicine, Hospital for Sick Children,
2Cell Biology, Hospital for Sick Children,
3Department of Physiology, University of Toronto,
4Department of Paediatrics, University of Toronto,
5Department of Biochemistry, University of Toronto
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