Prem Kumar Govindappa

Department of Orthopaedics and Rehabilitation,
Center for Orthopaedics and Translational Science,
Center for Orthopaedic Research and Translational Science (CORTS),
Department of Orthopaedics and Rehabilitation, Center for Orthopaedics and Translational Science,
Department of Orthopaedics and Rehabilitation, Center for Orthopaedic Research and Translational Science (CORTS)

The Pennsylvania State University College of Medicine

BIOGRAPHY

Prem Kumar Govindappa is a Researcher in the Center for Orthopaedic Research and Translational Science (CORTS), College of Medicine, The Pennsylvania State University, Hershey, USA.

As a self-motivated and accomplished veterinary research scientist, Dr.Prem has a comprehensive experience in in-vivo animal models and in-vitro cell culture techniques to understand the pathophysiological complexities of cardiac, neural, skeletal, and cancer diseases. Dr.Prem also has a preclinical industrial research experience in Good Laboratory Practice (GLP), AAALAC, and US-FDA certified drug discovery laboratory.

Dr.Prem's current research focused on investigating the repurposing therapeutic effect of FDA-approved drugs on the peripheral nervous system and their associated target organs, muscle, bone, and intestine.

PUBLICATIONS

Toxicity evaluation of 6-mercaptopurine-Chitosan nanoparticles in rats.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society Jan, 2020 | Pubmed ID: 31933529

An effective erythropoietin dose regimen protects against severe nerve injury-induced pathophysiological changes with improved neural gene expression and enhances functional recovery.

International immunopharmacology Mar, 2020 | Pubmed ID: 32143001

Obligatory role of Schwann cell-specific erythropoietin receptors in erythropoietin-induced functional recovery and neurogenic muscle atrophy after nerve injury.

Muscle & nerve 02, 2021 | Pubmed ID: 33205838

A novel nerve transection and repair method in mice: histomorphometric analysis of nerves, blood vessels, and muscles with functional recovery.

Scientific reports 12, 2020 | Pubmed ID: 33303798

Novel Real-time Digital Pressure Sensor Reveals Wide Variations in Current Nerve Crush Injury Models.

Military medicine 01, 2021 | Pubmed ID: 33499447

Purposeful Misalignment of Severed Nerve Stumps in a Standardized Transection Model Reveals Persistent Functional Deficit With Aberrant Neurofilament Distribution.

Military medicine 01, 2021 | Pubmed ID: 33499508

(4-Aminopyridine)-PLGA-PEG as a Novel Thermosensitive and Locally Injectable Treatment for Acute Peripheral Nerve Injury.

ACS applied bio materials 05, 2021 | Pubmed ID: 34142019

Altered gut microbiota composition with antibiotic treatment impairs functional recovery after traumatic peripheral nerve crush injury in mice: effects of probiotics with butyrate producing bacteria.

BMC research notes Feb, 2022 | Pubmed ID: 35197129

Erythropoietin promotes M2 macrophage phagocytosis of Schwann cells in peripheral nerve injury.

Cell death & disease Mar, 2022 | Pubmed ID: 35296651

INSTITUTIONS

The Pennsylvania State University College of Medicine

JOVE ARTICLES

Traumatic Peripheral Nerve Injury in Mice

Jung Il Lee^*,1,

Prem Kumar Govindappa^*,2,

Grant D. Wandling²,

John C. Elfar²

¹Department of Orthopaedic Surgery, Korea University Guro Hospital,

²Department of Orthopaedics and Rehabilitation, Center for Orthopaedics and Translational Science, The Pennsylvania State University College of Medicine

Neuroscience

Isolation, Culture, and Characterization of Primary Schwann Cells, Keratinocytes, and Fibroblasts from Human Foreskin

Mashanipalya G. Jagadeeshaprasad¹,

Prem Kumar Govindappa¹,

Amanda M. Nelson²,

John C. Elfar¹

¹Department of Orthopaedics and Rehabilitation, Center for Orthopaedic Research and Translational Science (CORTS), The Pennsylvania State University College of Medicine,

²Department of Dermatology, The Pennsylvania State University College of Medicine

Neuroscience

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