David L. Kaplan

Enhancing annulus fibrosus tissue formation in porous silk scaffolds.

In vitro 3D model for human vascularized adipose tissue.

Human mesenchymal stem cell grafts engineered to release adenosine reduce chronic seizures in a mouse model of CA3-selective epileptogenesis.

Emulsan-alginate beads for protein adsorption.

Dynamic culture conditions to generate silk-based tissue-engineered vascular grafts.

Stabilization of enzymes in silk films.

Preadipocytes stimulate ductal morphogenesis and functional differentiation of human mammary epithelial cells on 3D silk scaffolds.

Role of electrospun fibre diameter and corresponding specific surface area (SSA) on cell attachment.

Delayed transplantation of human marrow stromal cell-seeded scaffolds increases transcallosal neural fiber length, angiogenesis, and hippocampal neuronal survival and improves functional outcome after traumatic brain injury in rats.

Comparative chondrogenesis of human cell sources in 3D scaffolds.

Treatment of traumatic brain injury in mice with bone marrow stromal cell-impregnated collagen scaffolds.

Antiepileptic effects of silk-polymer based adenosine release in kindled rats.

Vascularization strategies for tissue engineering.

Mandibular repair in rats with premineralized silk scaffolds and BMP-2-modified bMSCs.

Apatite-coated silk fibroin scaffolds to healing mandibular border defects in canines.

Stem cell- and scaffold-based tissue engineering approaches to osteochondral regenerative medicine.

Role of membrane potential in the regulation of cell proliferation and differentiation.

Bioengineered silk protein-based gene delivery systems.

Surface modification of silk fibroin with poly(ethylene glycol) for antiadhesion and antithrombotic applications.

Electrospun silk biomaterial scaffolds for regenerative medicine.

In vitro model of mesenchymal condensation during chondrogenic development.

Silk fibroin processing and thrombogenic responses.

Relationships between mechanical properties and extracellular matrix constituents of the cervical stroma during pregnancy.

Vortex-induced injectable silk fibroin hydrogels.

Water-insoluble silk films with silk I structure.

Ultra-sensitive vibrational spectroscopy of protein monolayers with plasmonic nanoantenna arrays.

Role of polyalanine domains in beta-sheet formation in spider silk block copolymers.

Soft tissue augmentation using silk gels: an in vitro and in vivo study.

Insoluble and flexible silk films containing glycerol.

Green process to prepare silk fibroin/gelatin biomaterial scaffolds.

Expression, cross-linking, and characterization of recombinant chitin binding resilin.

The use of sulfonated silk fibroin derivatives to control binding, delivery and potency of FGF-2 in tissue regeneration.

Silk nanospheres and microspheres from silk/pva blend films for drug delivery.

Spectral analysis of induced color change on periodically nanopatterned silk films.

Non-equilibrium silk fibroin adhesives.

Bone marrow osteoblastic niche: a new model to study physiological regulation of megakaryopoiesis.

Mechanism of enzymatic degradation of beta-sheet crystals.

Can tissue engineering concepts advance tumor biology research?

Bioactive "self-sensing" optical systems.

Erratum: "Silicon electronics on silk as a path to bioresorbable, implantable devices" [Appl. Phys. Lett. 95, 133701 (2009)].

Effect of hydration on silk film material properties.

Electrospun silk material systems for wound healing.

Cervical tissue engineering using silk scaffolds and human cervical cells.

Silk fibroin encapsulated powder reservoirs for sustained release of adenosine.

The consolidation behavior of silk hydrogels.

Effects of hyperinsulinemia on lipolytic function of three-dimensional adipocyte/endothelial co-cultures.

Silicon electronics on silk as a path to bioresorbable, implantable devices.

Biomedical applications of chemically-modified silk fibroin.

Reinforcing silk scaffolds with silk particles.

Adipose tissue engineering for soft tissue regeneration.

A complex 3D human tissue culture system based on mammary stromal cells and silk scaffolds for modeling breast morphogenesis and function.

Mechanisms of enzymatic degradation of amyloid Beta microfibrils generating nanofilaments and nanospheres related to cytotoxicity.

Macromol. Biosci. 3/2010.

Bio-microfluidics: biomaterials and biomimetic designs.

Electrogelation for protein adhesives.

Stabilization and release of enzymes from silk films.

Controlling silk fibroin particle features for drug delivery.

Silk-based delivery systems of bioactive molecules.

Response of human corneal fibroblasts on silk film surface patterns.

Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics.

Two-photon microscopy for non-invasive, quantitative monitoring of stem cell differentiation.

Gene delivery mediated by recombinant silk proteins containing cationic and cell binding motifs.

Tissue-engineered three-dimensional in vitro models for normal and diseased kidney.

Rapid nanoimprinting of silk fibroin films for biophotonic applications.

Simple modular bioreactors for tissue engineering: a system for characterization of oxygen gradients, human mesenchymal stem cell differentiation, and prevascularization.

Smart biomaterials - regulating cell behavior through signaling molecules.

Relationships between degradability of silk scaffolds and osteogenesis.

Spatial and spectral detection of protein monolayers with deterministic aperiodic arrays of metal nanoparticles.

SnapShot: Silk biomaterials.

Ingrowth of human mesenchymal stem cells into porous silk particle reinforced silk composite scaffolds: An in vitro study.

Novel in vivo-degradable cellulose-chitin copolymer from metabolically engineered Gluconacetobacter xylinus.

Native-sized recombinant spider silk protein produced in metabolically engineered Escherichia coli results in a strong fiber.

Metamaterial silk composites at terahertz frequencies.

New opportunities for an ancient material.

Hypoxia and amino acid supplementation synergistically promote the osteogenesis of human mesenchymal stem cells on silk protein scaffolds.

Biomaterials derived from silk-tropoelastin protein systems.

A silk platform that enables electrophysiology and targeted drug delivery in brain astroglial cells.

A model for the stretch-mediated enzymatic degradation of silk fibers.

BioDome regenerative sleeve for biochemical and biophysical stimulation of tissue regeneration.

Modular elastic patches: mechanical and biological effects.

Silk hydrogel for cartilage tissue engineering.

Helicoidal multi-lamellar features of RGD-functionalized silk biomaterials for corneal tissue engineering.

Mechanically robust, rapidly actuating, and biologically functionalized macroporous poly(N-isopropylacrylamide)/silk hybrid hydrogels.

Osteoinductive silk-silica composite biomaterials for bone regeneration.

Functionalization of silk fibroin with NeutrAvidin and biotin.

Synthetic adipose tissue models for studying mammary gland development and breast tissue engineering.

Rapid nanoimprinting of doped silk films for enhanced fluorescent emission.

Development of an in vitro model to study the impact of BMP-2 on metastasis to bone.

Multilayered silk scaffolds for meniscus tissue engineering.

Biomaterials from Ultrasonication-Induced Silk Fibroin-Hyaluronic Acid Hydrogels.

Silk-Based Gene Carriers with Cell Membrane Destabilizing Peptides.

Chondrogenesis in perfusion bioreactors using porous silk scaffolds and hESC-derived MSCs.

Incorporation of proteinase inhibitors into silk-based delivery devices for enhanced control of degradation and drug release.

Evaluation of gel spun silk-based biomaterials in a murine model of bladder augmentation.

Waterproof AlInGaP optoelectronics on stretchable substrates with applications in biomedicine and robotics.

Differences in cytotoxicity of β-sheet peptides originated from silk and amyloid β.

Nanofibrous architecture of silk fibroin scaffolds prepared with a mild self-assembly process.

Nanoscale control of silica particle formation via silk-silica fusion proteins for bone regeneration.

Tissue response and biodegradation of composite scaffolds prepared from Thai silk fibroin, gelatin and hydroxyapatite.

pH-Sensitive ionomeric particles obtained via chemical conjugation of silk with poly(amino acid)s.

The treatment of TBI with human marrow stromal cells impregnated into collagen scaffold: functional outcome and gene expression profile.

Adipogenic differentiation of human adipose-derived stem cells on 3D silk scaffolds.

Co-cross-linking silk matrices with silica nanostructures for robust ultrathin nanocomposites.

Quantifying osteogenic cell degradation of silk biomaterials.

Human bone marrow-derived MSCs can home to orthotopic breast cancer tumors and promote bone metastasis.

Thin film assembly of spider silk-like block copolymers.

Lyophilized silk fibroin hydrogels for the sustained local delivery of therapeutic monoclonal antibodies.

Tubular silk scaffolds for small diameter vascular grafts.

Protein-based block copolymers.

Lipolytic function of adipocyte/endothelial cocultures.

Mechanisms of controlled release from silk fibroin films.

Nucleation and growth of mineralized bone matrix on silk-hydroxyapatite composite scaffolds.

Silk fibroin conduits: a cellular and functional assessment of peripheral nerve repair.

Osteoblastic differentiation and stress response of human mesenchymal stem cells exposed to alternating current electric fields.

An ectopic study of apatite-coated silk fibroin scaffolds seeded with AdBMP-2-modified canine bMSCs.

Bioreactor system using noninvasive imaging and mechanical stretch for biomaterial screening.

Single honeybee silk protein mimics properties of multi-protein silk.

Silk fibroin electrogelation mechanisms.

BMP-2 gene modified canine bMSCs promote ectopic bone formation mediated by a nonviral PEI derivative.

Degradation mechanism and control of silk fibroin.

AFM study of morphology and mechanical properties of a chimeric spider silk and bone sialoprotein protein for bone regeneration.

Surface immobilization of antibody on silk fibroin through conformational transition.

Calcium phosphate combination biomaterials as human mesenchymal stem cell delivery vehicles for bone repair.

Regulation of silk material structure by temperature-controlled water vapor annealing.

Tunable silk: using microfluidics to fabricate silk fibers with controllable properties.

Rapid transfer-based micropatterning and dry etching of silk microstructures.

Silk fibroin biomaterials for controlled release drug delivery.

Antimicrobial functionalized genetically engineered spider silk.

Human dental pulp progenitor cell behavior on aqueous and hexafluoroisopropanol based silk scaffolds.

Critical-size calvarial bone defects healing in a mouse model with silk scaffolds and SATB2-modified iPSCs.

Clay enriched silk biomaterials for bone formation.

Concise review: Mesenchymal stem cell tumor-homing: detection methods in disease model systems.

A 3D cartilage - inflammatory cell culture system for the modeling of human osteoarthritis.

A 3D aligned microfibrous myocardial tissue construct cultured under transient perfusion.

Heparin stimulates elastogenesis: application to silk-based vascular grafts.

Potential of 3-D tissue constructs engineered from bovine chondrocytes/silk fibroin-chitosan for in vitro cartilage tissue engineering.

Metamaterials on paper as a sensing platform.

N-acetylglucosamine 6-phosphate deacetylase (nagA) is required for N-acetyl glucosamine assimilation in Gluconacetobacter xylinus.

Silk fibroin and polyethylene glycol-based biocompatible tissue adhesives.

Stem cell-based meniscus tissue engineering.

Production, structure and in vitro degradation of electrospun honeybee silk nanofibers.

Effect of processing on silk-based biomaterials: reproducibility and biocompatibility.

Hierarchical Assembly of Collagen-Like Peptides in vitro Provides Structural Causes of Osteogenesis Imperfecta.

Spatially controlled delivery of neurotrophic factors in silk fibroin-based nerve conduits for peripheral nerve repair.

Silk-fibrin/hyaluronic acid composite gels for nucleus pulposus tissue regeneration.

Spider silk-based gene carriers for tumor cell-specific delivery.

The effect of manipulation of silk scaffold fabrication parameters on matrix performance in a murine model of bladder augmentation.

Mechanical improvements to reinforced porous silk scaffolds.

Biomaterials for the development of peripheral nerve guidance conduits.

生肌和向成骨细胞分化的丝绸弹性蛋白生物材料上的单元格对弹性和表面粗糙度的影响。

The use of injectable sonication-induced silk hydrogel for VEGF(165) and BMP-2 delivery for elevation of the maxillary sinus floor.

Three-dimensional system for the in vitro study of megakaryocytes and functional platelet production using silk-based vascular tubes.

Intervertebral disk tissue engineering using biphasic silk composite scaffolds.

Oxygen tension and formation of cervical-like tissue in two-dimensional and three-dimensional culture.

Tunable self-assembly of genetically engineered silk--elastin-like protein polymers.

Materials fabrication from Bombyx mori silk fibroin.

Recombinant exon-encoded resilins for elastomeric biomaterials.

A Review of the Responses of Two- and Three-Dimensional Engineered Tissues to Electric Fields.

Robust and responsive silk ionomer microcapsules.

Silk-based nanocomplexes with tumor-homing peptides for tumor-specific gene delivery.

Natural and Genetically Engineered Proteins for Tissue Engineering.

Impact of processing parameters on the haemocompatibility of Bombyx mori silk films.

Silk-hyaluronan-based composite hydrogels: A novel, securable vehicle for drug delivery.

Effect of β-sheet crystalline content on mass transfer in silk films.

Combinatorial library of lipidoids for in vitro DNA delivery.

Bioinspired silicification of silica-binding peptide-silk protein chimeras: comparison of chemically and genetically produced proteins.

Silk-based conformal, adhesive, edible food sensors.

Review physical and chemical aspects of stabilization of compounds in silk.

Mechanisms and control of silk-based electrospinning.

Hormone-responsive 3D multicellular culture model of human breast tissue.

Annulus fibrosus tissue engineering using lamellar silk scaffolds.

Silk-silica composites from genetically engineered chimeric proteins: materials properties correlate with silica condensation rate and colloidal stability of the proteins in aqueous solution.

Silk self-assembly mechanisms and control from thermodynamics to kinetics.

Isolation and maintenance-free culture of contractile myotubes from Manduca sexta embryos.

Sodium dodecyl sulfate-induced rapid gelation of silk fibroin.

Development of silk-based scaffolds for tissue engineering of bone from human adipose-derived stem cells.

Silks: Properties and uses of natural and designed variants.

Spider webs: Damage control.

Graphene-based wireless bacteria detection on tooth enamel.

Preparation of uniaxial multichannel silk fibroin scaffolds for guiding primary neurons.

Biological responses to spider silk-antibiotic fusion protein.

Silk constructs for delivery of musculoskeletal therapeutics.

Characterization of natural, decellularized and reseeded porcine tooth bud matrices.

High-strength silk protein scaffolds for bone repair.

Silk materials--a road to sustainable high technology.

Characterization of metabolic changes associated with the functional development of 3D engineered tissues by non-invasive, dynamic measurement of individual cell redox ratios.

Flexibility regeneration of silk fibroin in vitro.

Stabilization of organophosphorus hydrolase by entrapment in silk fibroin: formation of a robust enzymatic material suitable for surface coatings.

A silk hydrogel-based delivery system of bone morphogenetic protein for the treatment of large bone defects.

Silk layering as studied with neutron reflectivity.

Human corneal limbal epithelial cell response to varying silk film geometric topography in vitro.

Structure and Biodegradation Mechanism of Milled Bombyx mori Silk Particles.

Enhanced function of pancreatic islets co-encapsulated with ECM proteins and mesenchymal stromal cells in a silk hydrogel.

Stabilization of vaccines and antibiotics in silk and eliminating the cold chain.

Ion Electrodiffusion Governs Silk Electrogelation.

Silk ionomers for encapsulation and differentiation of human MSCs.

Permeability and Micromechanical Properties of Silk Ionomer Microcapsules.

Purification and cytotoxicity of tag-free bioengineered spider silk proteins.

In Vitro Model of Metastasis to Bone Marrow Mediates Prostate Cancer Castration Resistant Growth through Paracrine and Extracellular Matrix Factors.

Cationic polymers and their therapeutic potential.

Seamless, axially aligned, fiber tubes, meshes, microbundles and gradient biomaterial constructs.

Mechanism of resilin elasticity.

Doxorubicin-loaded silk films: Drug-silk interactions and in vivo performance in human orthotopic breast cancer.

A review of combined experimental and computational procedures for assessing biopolymer structure-process-property relationships.

The regulation of cystogenesis in a tissue engineered kidney disease system by abnormal matrix interactions.

Direct Transfer of Subwavelength Plasmonic Nanostructures on Bioactive Silk Films.

Enhanced cellular adhesion on titanium by silk functionalized with titanium binding and RGD peptides.

Clues for biomimetics from natural composite materials.

A statistical algorithm for assessing cellular alignment.

Elasticity maps of living neurons measured by combined fluorescence and atomic force microscopy.

Salt-Leached Silk Scaffolds with Tunable Mechanical Properties.

A physically transient form of silicon electronics.

基于芯片的机械刺激下人类骨髓和脂肪组织源性间充质干细胞的成骨的比较。

A silk-based scaffold platform with tunable architecture for engineering critically-sized tissue constructs.

Patterned Silk Film Scaffolds for Aligned Lamellar Bone Tissue Engineering.

The influence of specific binding of collagen-silk chimeras to silk biomaterials on hMSC behavior.

Stem Cell Implants for Cancer Therapy: TRAIL-Expressing Mesenchymal Stem Cells Target Cancer Cells In Situ.