Department of Life Science
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Protein glycosylation in Parelaphostrongylus tenuis--first description of the Galalpha1-3Gal sequence in a nematode.
Glycobiology Sep, 2006 | Pubmed ID: 16704967
The highly conserved domain of unknown function 1792 has a distinct glycosyltransferase fold.
Nature communications Jul, 2014 | Pubmed ID: 25023666
Murine and human zona pellucida 3 derived from mouse eggs express identical O-glycans.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2003 | Pubmed ID: 14673092
Mass spectrometric characterisation of Taenia crassiceps metacestode N-glycans.
Molecular and biochemical parasitology Oct, 2005 | Pubmed ID: 16024105
Differential O-glycosylation of a conserved domain expressed in murine and human ZP3.
Biochemistry Jan, 2006 | Pubmed ID: 16401092
Mass spectrometric analysis of N- and O-glycosylation of tissues and cells.
Current opinion in structural biology Oct, 2006 | Pubmed ID: 16938453
Integrated mass spectrometric strategy for characterizing the glycans from glycosphingolipids and glycoproteins: direct identification of sialyl Le(x) in mice.
Glycobiology Jun, 2007 | Pubmed ID: 17341505
Glycomics analysis of Schistosoma mansoni egg and cercarial secretions.
Molecular & cellular proteomics : MCP Sep, 2007 | Pubmed ID: 17550893
The sperm agglutination antigen-1 (SAGA-1) glycoforms of CD52 are O-glycosylated.
Glycobiology Oct, 2007 | Pubmed ID: 17640971
The GlycanBuilder: a fast, intuitive and flexible software tool for building and displaying glycan structures.
Source code for biology and medicine Aug, 2007 | Pubmed ID: 17683623
GlycoWorkbench: a tool for the computer-assisted annotation of mass spectra of glycans.
Journal of proteome research Apr, 2008 | Pubmed ID: 18311910
Comparative efficacy of neutralizing antibodies elicited by recombinant hemagglutinin proteins from avian H5N1 influenza virus.
Journal of virology Jul, 2008 | Pubmed ID: 18417563
Structural characterisation of neutrophil glycans by ultra sensitive mass spectrometric glycomics methodology.
Glycoconjugate journal Nov, 2009 | Pubmed ID: 18587645
Characterizing the glycome of the mammalian immune system.
Immunology and cell biology Oct, 2008 | Pubmed ID: 18725885
The N-glycolyl form of mouse sialyl Lewis X is recognized by selectins but not by HECA-452 and FH6 antibodies that were raised against human cells.
Glycoconjugate journal Jul, 2009 | Pubmed ID: 19089612
Glycoproteomics: past, present and future.
FEBS letters Jun, 2009 | Pubmed ID: 19328791
Glycosyltransferase function in core 2-type protein O glycosylation.
Molecular and cellular biology Jul, 2009 | Pubmed ID: 19349303
Mass spectrometry in the analysis of N-linked and O-linked glycans.
Current opinion in structural biology Oct, 2009 | Pubmed ID: 19577919
DAS181 inhibits H5N1 influenza virus infection of human lung tissues.
Antimicrobial agents and chemotherapy Sep, 2009 | Pubmed ID: 19596886
Regulated and aberrant glycosylation modulate cardiac electrical signaling.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2009 | Pubmed ID: 19666501
Fut2-null mice display an altered glycosylation profile and impaired BabA-mediated Helicobacter pylori adhesion to gastric mucosa.
Glycobiology Dec, 2009 | Pubmed ID: 19706747
Glycomics profiling of Chinese hamster ovary cell glycosylation mutants reveals N-glycans of a novel size and complexity.
The Journal of biological chemistry Feb, 2010 | Pubmed ID: 19951948
Physiological and glycomic characterization of N-acetylglucosaminyltransferase-IVa and -IVb double deficient mice.
Glycobiology Jan, 2010 | Pubmed ID: 20015870
Comparison of methods for profiling O-glycosylation: Human Proteome Organisation Human Disease Glycomics/Proteome Initiative multi-institutional study of IgA1.
Molecular & cellular proteomics : MCP Apr, 2010 | Pubmed ID: 20038609
Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice.
The Journal of clinical investigation May, 2010 | Pubmed ID: 20407205
Glycosylation of {beta}2 subunits regulates GABAA receptor biogenesis and channel gating.
The Journal of biological chemistry Oct, 2010 | Pubmed ID: 20639197
Serum N-glycome biomarker for monitoring development of DENA-induced hepatocellular carcinoma in rat.
Molecular cancer , 2010 | Pubmed ID: 20704698
Glycan analysis and influenza A virus infection of primary swine respiratory epithelial cells: the importance of NeuAc{alpha}2-6 glycans.
The Journal of biological chemistry Oct, 2010 | Pubmed ID: 20724471
Mass spectrometric analysis of mutant mice.
Methods in enzymology , 2010 | Pubmed ID: 20816474
High-sensitivity O-glycomic analysis of mice deficient in core 2 {beta}1,6-N-acetylglucosaminyltransferases.
Glycobiology Jan, 2011 | Pubmed ID: 20855471
The S-layer glycoprotein of the crenarchaeote Sulfolobus acidocaldarius is glycosylated at multiple sites with chitobiose-linked N-glycans.
Archaea (Vancouver, B.C.) Sep, 2010 | Pubmed ID: 20936123
Simian immunodeficiency virus from the sooty mangabey and rhesus macaque is modified with O-linked carbohydrate.
Journal of virology Jan, 2011 | Pubmed ID: 20962077
EUROCarbDB: An open-access platform for glycoinformatics.
Glycobiology Apr, 2011 | Pubmed ID: 21106561
G6PC3 mutations are associated with a major defect of glycosylation: a novel mechanism for neutrophil dysfunction.
Glycobiology Jul, 2011 | Pubmed ID: 21385794
Peracetylated 4-fluoro-glucosamine reduces the content and repertoire of N- and O-glycans without direct incorporation.
The Journal of biological chemistry Jun, 2011 | Pubmed ID: 21493714
Glycomic analysis of human mast cells, eosinophils and basophils.
Glycobiology Jan, 2012 | Pubmed ID: 21725073
Early murine T-lymphocyte activation is accompanied by a switch from N-Glycolyl- to N-acetyl-neuraminic acid and generation of ligands for siglec-E.
The Journal of biological chemistry Oct, 2011 | Pubmed ID: 21835922
Human sperm binding is mediated by the sialyl-Lewis(x) oligosaccharide on the zona pellucida.
Science (New York, N.Y.) Sep, 2011 | Pubmed ID: 21852454
A novel type of macrothrombocytopenia associated with a defect in α2,3-sialylation.
The American journal of pathology Oct, 2011 | Pubmed ID: 21864493
Mannosidase 2, alpha 1 deficiency is associated with ricin resistance in embryonic stem (ES) cells.
PloS one , 2011 | Pubmed ID: 21886775
Histo-blood group antigens act as attachment factors of rabbit hemorrhagic disease virus infection in a virus strain-dependent manner.
PLoS pathogens Aug, 2011 | Pubmed ID: 21901093
Glycosylation of mouse and human immune cells: insights emerging from N-glycomics analyses.
Biochemical Society transactions Oct, 2011 | Pubmed ID: 21936811
Tumor biomarker glycoproteins in the seminal plasma of healthy human males are endogenous ligands for DC-SIGN.
Molecular & cellular proteomics : MCP Jan, 2012 | Pubmed ID: 21986992
The antifungal drug itraconazole inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells.
The Journal of biological chemistry Dec, 2011 | Pubmed ID: 22025615
Sulfoquinovose synthase - an important enzyme in the N-glycosylation pathway of Sulfolobus acidocaldarius.
Molecular microbiology Dec, 2011 | Pubmed ID: 22059775
Glycoproteomic characterization of recombinant mouse α-dystroglycan.
Glycobiology May, 2012 | Pubmed ID: 22241827
Loss of effector function of human cytolytic T lymphocytes is accompanied by major alterations in N- and O-glycosylation.
The Journal of biological chemistry Mar, 2012 | Pubmed ID: 22334653
Glycoengineering approach to half-life extension of recombinant biotherapeutics.
Bioconjugate chemistry Aug, 2012 | Pubmed ID: 22681552
The GlycanBuilder and GlycoWorkbench glycoinformatics tools: updates and new developments.
Biological chemistry Nov, 2012 | Pubmed ID: 23109548
Polylactosaminoglycan glycomics: enhancing the detection of high-molecular-weight N-glycans in matrix-assisted laser desorption ionization time-of-flight profiles by matched filtering.
Molecular & cellular proteomics : MCP Apr, 2013 | Pubmed ID: 23325768
The Minimum Information Required for a Glycomics Experiment (MIRAGE) Project: Improving the Standards for Reporting Mass-spectrometry-based Glycoanalytic Data.
Molecular & cellular proteomics : MCP Apr, 2013 | Pubmed ID: 23378518
Glycomic analysis of human respiratory tract tissues and correlation with influenza virus infection.
PLoS pathogens Mar, 2013 | Pubmed ID: 23516363
Competition between core-2 GlcNAc-transferase and ST6GalNAc-transferase regulates the synthesis of the leukocyte selectin ligand on human P-selectin glycoprotein ligand-1.
The Journal of biological chemistry May, 2013 | Pubmed ID: 23548905
The use of sialidase therapy for respiratory viral infections.
Antiviral research Jun, 2013 | Pubmed ID: 23602850
Infection of swine ex vivo tissues with avian viruses including H7N9 and correlation with glycomic analysis.
Influenza and other respiratory viruses Nov, 2013 | Pubmed ID: 24001121
Synthesis of biologically active N- and O-linked glycans with multisialylated poly-N-acetyllactosamine extensions using P. damsela α2-6 sialyltransferase.
Journal of the American Chemical Society Dec, 2013 | Pubmed ID: 24256304
Novel expression of Haemonchus contortus vaccine candidate aminopeptidase H11 using the free-living nematode Caenorhabditis elegans.
Veterinary research Dec, 2013 | Pubmed ID: 24289031
Profiling of glycan receptors for minute virus of mice in permissive cell lines towards understanding the mechanism of cell recognition.
PloS one , 2014 | Pubmed ID: 24475195
An in vivo functional screen identifies ST6GalNAc2 sialyltransferase as a breast cancer metastasis suppressor.
Cancer discovery Mar, 2014 | Pubmed ID: 24520024
Towards controlling the glycoform: a model framework linking extracellular metabolites to antibody glycosylation.
International journal of molecular sciences Mar, 2014 | Pubmed ID: 24637934
MIRAGE: the minimum information required for a glycomics experiment.
Glycobiology May, 2014 | Pubmed ID: 24653214
Hypomorphic homozygous mutations in phosphoglucomutase 3 (PGM3) impair immunity and increase serum IgE levels.
The Journal of allergy and clinical immunology May, 2014 | Pubmed ID: 24698316
Methylated glycans as conserved targets of animal and fungal innate defense.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2014 | Pubmed ID: 24879441
JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia.
Nature genetics Sep, 2014 | Pubmed ID: 25129144
Glycomic characterization of respiratory tract tissues of ferrets: implications for its use in influenza virus infection studies.
The Journal of biological chemistry Oct, 2014 | Pubmed ID: 25135641
Systemic blockade of sialylation in mice with a global inhibitor of sialyltransferases.
The Journal of biological chemistry Dec, 2014 | Pubmed ID: 25368325
ST3Gal-4 is the primary sialyltransferase regulating the synthesis of E-, P-, and L-selectin ligands on human myeloid leukocytes.
Blood Jan, 2015 | Pubmed ID: 25498912
Annotation of glycomics MS and MS/MS spectra using the GlycoWorkbench software tool.
Methods in molecular biology (Clifton, N.J.) , 2015 | Pubmed ID: 25753699
MKAN27435 is required for the biosynthesis of higher subclasses of lipooligosaccharides in Mycobacterium kansasii.
PloS one , 2015 | Pubmed ID: 25893968
Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease.
The Journal of clinical investigation Jun, 2015 | Pubmed ID: 25915583
Gp120 on HIV-1 Virions Lacks O-Linked Carbohydrate.
PloS one , 2015 | Pubmed ID: 25915761
The Cytotoxicity of Elderberry Ribosome-Inactivating Proteins Is Not Solely Determined by Their Protein Translation Inhibition Activity.
PloS one , 2015 | Pubmed ID: 26148207
Enhanced Aromatic Sequons Increase Oligosaccharyltransferase Glycosylation Efficiency and Glycan Homogeneity.
Chemistry & biology Aug, 2015 | Pubmed ID: 26190824
GlyTouCan 1.0--The international glycan structure repository.
Nucleic acids research Jan, 2016 | Pubmed ID: 26476458
XBP1s Links the Unfolded Protein Response to the Molecular Architecture of Mature N-Glycans.
Chemistry & biology Oct, 2015 | Pubmed ID: 26496683
Global N-linked Glycosylation is Not Significantly Impaired in Myoblasts in Congenital Myasthenic Syndromes Caused by Defective Glutamine-Fructose-6-Phosphate Transaminase 1 (GFPT1).
Biomolecules Oct, 2015 | Pubmed ID: 26501342
Cellular O-Glycome Reporter/Amplification to explore O-glycans of living cells.
Nature methods Jan, 2016 | Pubmed ID: 26619014
Bovine Herpesvirus 4 Modulates Its β-1,6-N-Acetylglucosaminyltransferase Activity through Alternative Splicing.
Journal of virology 02, 2016 | Pubmed ID: 26656682
Glycoproteomic studies of IgE from a novel hyper IgE syndrome linked to PGM3 mutation.
Glycoconjugate journal 06, 2016 | Pubmed ID: 26687240
Glycosphingolipids on Human Myeloid Cells Stabilize E-Selectin-Dependent Rolling in the Multistep Leukocyte Adhesion Cascade.
Arteriosclerosis, thrombosis, and vascular biology Apr, 2016 | Pubmed ID: 26868209
Evidence for Differential Glycosylation of Trophoblast Cell Types.
Molecular & cellular proteomics : MCP 06, 2016 | Pubmed ID: 26929217
Characterization of the N-glycans of female Angiostrongylus cantonensis worms.
Experimental parasitology Jul, 2016 | Pubmed ID: 27107931
Golgi self-correction generates bioequivalent glycans to preserve cellular homeostasis.
eLife 06, 2016 | Pubmed ID: 27269286
The human fetoembryonic defense system hypothesis: Twenty years on.
Molecular aspects of medicine 10, 2016 | Pubmed ID: 27349751
New Helical Binding Domain Mediates a Glycosyltransferase Activity of a Bifunctional Protein.
The Journal of biological chemistry Oct, 2016 | Pubmed ID: 27539847
Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding.
Scientific reports 09, 2016 | Pubmed ID: 27604319
The minimum information required for a glycomics experiment (MIRAGE) project: sample preparation guidelines for reliable reporting of glycomics datasets.
Glycobiology 09, 2016 | Pubmed ID: 27654115
The minimum information required for a glycomics experiment (MIRAGE) project: improving the standards for reporting glycan microarray-based data.
Glycobiology 04, 2017 | Pubmed ID: 27993942
Engineering and Dissecting the Glycosylation Pathway of a Streptococcal Serine-rich Repeat Adhesin.
The Journal of biological chemistry 12, 2016 | Pubmed ID: 28039332
Partial correction of neutrophil dysfunction by oral galactose therapy in glycogen storage disease type Ib.
International immunopharmacology Mar, 2017 | Pubmed ID: 28126686
Characterization of H type 1 and type 1 -acetyllactosamine glycan epitopes on ovarian cancer specifically recognized by the anti-glycan monoclonal antibody mAb-A4.
The Journal of biological chemistry 04, 2017 | Pubmed ID: 28167527
The redefinition of Helicobacter pylori lipopolysaccharide O-antigen and core-oligosaccharide domains.
PLoS pathogens 03, 2017 | Pubmed ID: 28306723
Effects of altered sialic acid biosynthesis on -linked glycan branching and cell surface interactions.
The Journal of biological chemistry 06, 2017 | Pubmed ID: 28424265
HEK293T cell lines defective for O-linked glycosylation.
PloS one , 2017 | Pubmed ID: 28654657
Insights from the redefinition of lipopolysaccharide O-antigen and core-oligosaccharide domains.
Microbial cell (Graz, Austria) Apr, 2017 | Pubmed ID: 28685143
Human Immunodeficiency Virus and Simian Immunodeficiency Virus Maintain High Levels of Infectivity in the Complete Absence of Mucin-Type O-Glycosylation.
Journal of virology 10, 2017 | Pubmed ID: 28747495
Towards automation of glycomic profiling of complex biological materials.
Glycoconjugate journal 06, 2018 | Pubmed ID: 29909447
Photoactivable Glycolipid Antigens Generate Stable Conjugates with CD1d for Invariant Natural Killer T Cell Activation.
Bioconjugate chemistry 09, 2018 | Pubmed ID: 30085659
Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans.
Nature communications 08, 2018 | Pubmed ID: 30120234
Loss of GCNT2/I-branched glycans enhances melanoma growth and survival.
Nature communications 08, 2018 | Pubmed ID: 30135430
XBP1s activation can globally remodel N-glycan structure distribution patterns.
Proceedings of the National Academy of Sciences of the United States of America 10, 2018 | Pubmed ID: 30305426
The mucinous domain of pancreatic carboxyl-ester lipase (CEL) contains core 1/core 2 glycans that can be modified by ABO blood group determinants.
The Journal of biological chemistry 12, 2018 | Pubmed ID: 30315106
Thioglycosides Are Efficient Metabolic Decoys of Glycosylation that Reduce Selectin Dependent Leukocyte Adhesion.
Cell chemical biology 12, 2018 | Pubmed ID: 30344053
Host and viral determinants of influenza A virus species specificity.
Nature reviews. Microbiology 01, 2019 | Pubmed ID: 30487536
Publisher Correction: Host and viral determinants of influenza A virus species specificity.
Nature reviews. Microbiology Jan, 2019 | Pubmed ID: 30560932
Human B Cell Differentiation Is Characterized by Progressive Remodeling of O-Linked Glycans.
Frontiers in immunology , 2018 | Pubmed ID: 30619255
Serum IgA1 shows increased levels of 2,6-linked sialic acid in breast cancer.
Interface focus Apr, 2019 | Pubmed ID: 30842877
Site-specific glycoproteomic characterization of ES-62: The major secreted product of the parasitic worm Acanthocheilonema viteae.
Glycobiology 07, 2019 | Pubmed ID: 31094418
East-Asian Helicobacter pylori strains synthesize heptan-deficient lipopolysaccharide.
PLoS genetics 11, 2019 | Pubmed ID: 31747390
Glycan biomarkers for Alzheimer disease correlate with T-tau and P-tau in cerebrospinal fluid in subjective cognitive impairment.
The FEBS journal 08, 2020 | Pubmed ID: 31889402
Exteriorisation of Mannoses on Human Erythrocyte Membrane Skeleton Provides 'Eat Me' Signals for Oxidatively Damaged Cells to be Cleared By Macrophages: A Pathway Mediating Hemolysis in Sickle Cell Disease.
Blood Dec, 2017 | Pubmed ID: 31909782
Insights into the hyperglycosylation of human chorionic gonadotropin revealed by glycomics analysis.
PloS one , 2020 | Pubmed ID: 32045434
Discovery of O-Linked Carbohydrate on HIV-1 Envelope and Its Role in Shielding against One Category of Broadly Neutralizing Antibodies.
Cell reports 02, 2020 | Pubmed ID: 32049016
Altered glycosylation of glycodelin in endometrial carcinoma.
Laboratory investigation; a journal of technical methods and pathology 07, 2020 | Pubmed ID: 32205858
Glycan characterization of pregnancy-specific glycoprotein 1 and its identification as a novel Galectin-1 ligand.
Glycobiology 10, 2020 | Pubmed ID: 32280962
Analysis of N- and O-Linked Glycosylation: Differential Glycosylation after Rat Spinal Cord Injury.
Journal of neurotrauma 09, 2020 | Pubmed ID: 32316850
Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB).
Seminars in immunopathology 08, 2020 | Pubmed ID: 32601855
The glycomic sialylation profile of GNE Myopathy muscle cells does not point to consistent hyposialylation of individual glycoconjugates.
Neuromuscular disorders : NMD 08, 2020 | Pubmed ID: 32736841
Site-specific characterization of SARS-CoV-2 spike glycoprotein receptor-binding domain.
Glycobiology 04, 2021 | Pubmed ID: 32886791
Metabolic precision labeling enables selective probing of O-linked -acetylgalactosamine glycosylation.
Proceedings of the National Academy of Sciences of the United States of America 10, 2020 | Pubmed ID: 32989128
Glycosylation of Trypanosoma cruzi TcI antigen reveals recognition by chagasic sera.
Scientific reports 10, 2020 | Pubmed ID: 33009443
Vulpeculin: a novel and abundant lipocalin in the urine of the common brushtail possum, .
Open biology 10, 2020 | Pubmed ID: 33022194
Efficient inhibition of O-glycan biosynthesis using the hexosamine analog AcGalNTGc.
Cell chemical biology 05, 2021 | Pubmed ID: 33609441
Glycoengineering Chinese hamster ovary cells: a short history.
Biochemical Society transactions 04, 2021 | Pubmed ID: 33704400
Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance.
Nature communications 03, 2021 | Pubmed ID: 33741926
Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis.
Nature communications 04, 2021 | Pubmed ID: 33879788
A mutation in SLC37A4 causes a dominantly inherited congenital disorder of glycosylation characterized by liver dysfunction.
American journal of human genetics 06, 2021 | Pubmed ID: 33964207
Proteome-wide prediction of bacterial carbohydrate-binding proteins as a tool for understanding commensal and pathogen colonisation of the vaginal microbiome.
NPJ biofilms and microbiomes 06, 2021 | Pubmed ID: 34131152
Major differences in glycosylation and fucosyltransferase expression in low-grade versus high-grade bladder cancer cell lines.
Glycobiology 12, 2021 | Pubmed ID: 34350945
Rapid Antibody Glycoengineering in CHO Cells Via RNA Interference and CGE-LIF N-Glycomics.
Methods in molecular biology (Clifton, N.J.) , 2022 | Pubmed ID: 34611868
Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis.
Nature methods 11, 2021 | Pubmed ID: 34725484
Author Correction: Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis.
Nature methods Jan, 2022 | Pubmed ID: 34893784
Strategies to control therapeutic antibody glycosylation during bioprocessing: Synthesis and separation.
Biotechnology and bioengineering Jun, 2022 | Pubmed ID: 35182428
Activation of regulatory T cells triggers specific changes in glycosylation associated with Siglec-1-dependent inflammatory responses.
Wellcome open research , 2021 | Pubmed ID: 35224210
Measurement of erythrocyte membrane mannoses to assess splenic function.
British journal of haematology Apr, 2022 | Pubmed ID: 35411940
The Tip of O-Polysaccharide Is a Potent Epitope in Response to Brucellosis Infection and Enables Short Synthetic Antigens to Be Superior Diagnostic Reagents.
Microorganisms Mar, 2022 | Pubmed ID: 35456759
Masue Marbiah*,1,2,
Pavlos Kotidis*,1,3,
Roberto Donini1,4,
Itzcóatl A. Gómez5,
Ioscani Jimenez del Val5,
Stuart M. Haslam4,
Karen M. Polizzi1,2,
Cleo Kontoravdi1
1Department of Chemical Engineering, Imperial College London,
2Imperial College Centre for Synthetic Biology, Imperial College London,
3BioPharm Process Research, GlaxoSmithKline Research and Development,
4Department of Life Science, Imperial College London,
5School of Chemical & Bioprocess Engineering, University College Dublin
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