Henry Brem

Department of Neurosurgery, Johns Hopkins University School of Medicine

Affiliated withJohns Hopkins University School of Medicine

Research Area

Cancer Research

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2022

Other Publications

Article	Year
Biodegradable polymer implants to treat brain tumors. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 11489483	2001
Polymer delivery of camptothecin against 9L gliosarcoma: release, distribution, and efficacy. Journal of neuro-oncology\| PubMed ID: 12061726	2002
Extreme drug resistance in primary brain tumors: in vitro analysis of 64 resection specimens. Journal of neuro-oncology\| PubMed ID: 12164682	2002
Hypertonic saline ameliorates cerebral edema associated with experimental brain tumor. Journal of neurosurgical anesthesiology\| PubMed ID: 12172290	2002
Outcome and cost of craniotomy performed to treat tumors in regional academic referral centers. Neurosurgery\| PubMed ID: 12699547	2003
The surgical bed after BCNU polymer wafer placement for recurrent glioma: serial assessment on CT and MR imaging. AJR. American journal of roentgenology\| PubMed ID: 12704070	2003
Polilactofate microspheres for Paclitaxel delivery to central nervous system malignancies. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 12960135	2003
Preparing Hopkins medical students for a career in academic neurosurgery. Surgery\| PubMed ID: 14555924	2003
Local delivery of minocycline and systemic BCNU have synergistic activity in the treatment of intracranial glioma. Journal of neuro-oncology\| PubMed ID: 14558595	2003
Recent advances in brain tumor therapy: local intracerebral drug delivery by polymers. Investigational new drugs\| PubMed ID: 14707492	2004
Astroglia induce cytotoxic effects on brain tumors via a nitric oxide-dependent pathway both in vitro and in vivo. Neurosurgery\| PubMed ID: 15113479	2004
Rhabdoid meningioma occurring in an unrelated resection cavity with leptomeningeal carcinomatosis. Case report. Journal of neurosurgery\| PubMed ID: 15739568	2005
A novel rat model for the study of intraosseous metastatic spine cancer. Journal of neurosurgery. Spine\| PubMed ID: 15796355	2005
Local delivery of antineoplastic agents by controlled-release polymers for the treatment of malignant brain tumours. Expert opinion on biological therapy\| PubMed ID: 15934827	2005
Local delivery of interleukin-2 and adriamycin is synergistic in the treatment of experimental malignant glioma. Journal of neuro-oncology\| PubMed ID: 16193383	2005
Local treatment of malignant brain tumors using implantable chemotherapeutic polymers. Journal of the National Comprehensive Cancer Network : JNCCN\| PubMed ID: 16194460	2005
Local delivery of doxorubicin for the treatment of malignant brain tumors in rats. Anticancer research\| PubMed ID: 16312042	2005
A novel intramedullary spinal cord tumor model: functional, radiological, and histopathological characterization. Journal of neurosurgery. Spine\| PubMed ID: 16370303	2005
Local delivery of temozolomide by biodegradable polymers is superior to oral administration in a rodent glioma model. Cancer chemotherapy and pharmacology\| PubMed ID: 17256133	2007
Preservation of glial cytoarchitecture from ex vivo human tumor and non-tumor cerebral cortical explants: A human model to study neurological diseases. Journal of neuroscience methods\| PubMed ID: 17580092	2007
Reduction of cerebrospinal fluid rhinorrhea after vestibular schwannoma surgery by reconstruction of the drilled porus acusticus with hydroxyapatite bone cement. Journal of neurosurgery\| PubMed ID: 17695389	2007
Clostridium perfringens enterotoxin as a novel-targeted therapeutic for brain metastasis. Cancer research\| PubMed ID: 17804705	2007
Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells. Molecular cancer therapeutics\| PubMed ID: 19208828	2009
Epirubicin exhibits potent anti-tumor activity in an animal model of malignant glioma when administered via controlled-release polymers. Journal of neuro-oncology\| PubMed ID: 19693439	2010
Gene therapy for malignant brain tumors. Expert review of neurotherapeutics\| PubMed ID: 19810968	2003
A thermal gel depot for local delivery of paclitaxel to treat experimental brain tumors in rats. Journal of neurosurgery\| PubMed ID: 20001591	2010
Combination of intracranial temozolomide with intracranial carmustine improves survival when compared with either treatment alone in a rodent glioma model. Neurosurgery\| PubMed ID: 20173548	2010
Supratentorial glioblastoma multiforme: the role of surgical resection versus biopsy among older patients. Annals of surgical oncology\| PubMed ID: 20697823	2011
Predictors of inpatient death and complications among postoperative elderly patients with metastatic brain tumors. Annals of surgical oncology\| PubMed ID: 20809176	2011
The efficacy of carmustine wafers for older patients with glioblastoma multiforme: prolonging survival. Neurological research\| PubMed ID: 21756557	2011
Delayed onset of paresis in rats with experimental intramedullary spinal cord gliosarcoma following intratumoral administration of the paclitaxel delivery system OncoGel. Journal of neurosurgery. Spine\| PubMed ID: 22208429	2012
Intracranial MEMS based temozolomide delivery in a 9L rat gliosarcoma model. Biomaterials\| PubMed ID: 22591609	2012
Hyperglycemia is independently associated with post-operative function loss in patients with primary eloquent glioblastoma. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia\| PubMed ID: 22595358	2012
The impact of bevacizumab on temozolomide concentrations in intracranial U87 gliomas. Cancer chemotherapy and pharmacology\| PubMed ID: 22644796	2012
Suppression of human glioma xenografts with second-generation IL13R-specific chimeric antigen receptor-modified T cells. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 22966020	2012
Growth properties of SF188/V+ human glioma in rats in vivo observed by magnetic resonance imaging. Journal of neuro-oncology\| PubMed ID: 23011120	2012
Combination of paclitaxel thermal gel depot with temozolomide and radiotherapy significantly prolongs survival in an experimental rodent glioma model. Journal of neuro-oncology\| PubMed ID: 23224713	2013
Deep venous thrombosis and pulmonary embolisms in adult patients undergoing craniotomy for brain tumors. Neurological research\| PubMed ID: 23336127	2013
Microdialysis measurement of intratumoral temozolomide concentration after cediranib, a pan-VEGF receptor tyrosine kinase inhibitor, in a U87 glioma model. Cancer chemotherapy and pharmacology\| PubMed ID: 23649683	2013
Increased expression of glutamate transporter GLT-1 in peritumoral tissue associated with prolonged survival and decreases in tumor growth in a rat model of experimental malignant glioma. Journal of neurosurgery\| PubMed ID: 23909244	2013
Combination of anti-VEGF therapy and temozolomide in two experimental human glioma models. Journal of neuro-oncology\| PubMed ID: 24185441	2014
Surgical outcomes of craniocervial junction meningiomas: a series of 22 consecutive patients. Clinical neurology and neurosurgery\| PubMed ID: 24438809	2014
Efficacy of local polymer-based and systemic delivery of the anti-glutamatergic agents riluzole and memantine in rat glioma models. Journal of neurosurgery\| PubMed ID: 24484234	2014
Radiosensitization of malignant gliomas following intracranial delivery of paclitaxel biodegradable polymer microspheres. Journal of neurosurgery\| PubMed ID: 24605841	2014
Extravascular optical coherence tomography: evaluation of carotid atherosclerosis and pravastatin therapy. Stroke\| PubMed ID: 24627118	2014
Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model. PloS one\| PubMed ID: 25013914	2014
Local delivery of cancer-cell glycolytic inhibitors in high-grade glioma. Neuro-oncology\| PubMed ID: 25053853	2015
Emerging insights into barriers to effective brain tumor therapeutics. Frontiers in oncology\| PubMed ID: 25101239	2014
Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo. ACS nano\| PubMed ID: 25643235	2015
Interstitial chemotherapy for malignant glioma: Future prospects in the era of multimodal therapy. Surgical neurology international\| PubMed ID: 25722936	2015
Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers. Biomaterials\| PubMed ID: 25818456	2015
Delivery of local therapeutics to the brain: working toward advancing treatment for malignant gliomas. Therapeutic delivery\| PubMed ID: 25853310	2015
Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26195750	2015
MGMT inactivation and clinical response in newly diagnosed GBM patients treated with Gliadel. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia\| PubMed ID: 26249244	2015
Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis. Journal of ophthalmology\| PubMed ID: 26491546	2015
Surgical complications following malignant brain tumor surgery: An analysis of 2002-2011 data. Clinical neurology and neurosurgery\| PubMed ID: 26615463	2016
Anticoagulation for Hypercoagulable Patients Associated with Complications after Large Cranioplasty Reconstruction. Plastic and reconstructive surgery\| PubMed ID: 26818296	2016
Time Interval Reduction for Delayed Implant-Based Cranioplasty Reconstruction in the Setting of Previous Bone Flap Osteomyelitis. Plastic and reconstructive surgery\| PubMed ID: 26818330	2016
The Johns Hopkins Hunterian Laboratory Philosophy: Mentoring Students in a Scientific Neurosurgical Research Laboratory. Academic medicine : journal of the Association of American Medical Colleges\| PubMed ID: 26934692	2016
Establishment and Biological Characterization of a Panel of Glioblastoma Multiforme (GBM) and GBM Variant Oncosphere Cell Lines. PloS one\| PubMed ID: 27028405	2016
Highlights of Children with Cancer UK's Workshop on Drug Delivery in Paediatric Brain Tumours. Ecancermedicalscience\| PubMed ID: 27110286	2016
Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma. Journal for immunotherapy of cancer\| PubMed ID: 27190629	2016
Non-virally engineered human adipose mesenchymal stem cells produce BMP4, target brain tumors, and extend survival. Biomaterials\| PubMed ID: 27240162	2016
Synthesis, characterization, and self-assembly with plasmid DNA of a quaternary ammonium derivative of pectic galactan and its fluorescent labeling for bioimaging applications. Carbohydrate polymers\| PubMed ID: 27312642	2016
Polylactic acid (PLA) controlled delivery carriers for biomedical applications. Advanced drug delivery reviews\| PubMed ID: 27426411	2016
Syndrome of the Trephined: A Systematic Review. Neurosurgery\| PubMed ID: 27489166	2016
Defining Glioblastoma Resectability Through the Wisdom of the Crowd: A Proof-of-Principle Study. Neurosurgery\| PubMed ID: 27509070	2017
Discussion on: Usefulness of an Osteotomy Template for Skull Tumorectomy and Simultaneous Skull Reconstruction. The Journal of craniofacial surgery\| PubMed ID: 27526253	2016
Erratum to: Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma. Journal for immunotherapy of cancer\| PubMed ID: 27822377	2016
Anti-PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM. Science translational medicine\| PubMed ID: 28003545	2016
Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 28279797	2017
Risk Factors for Preoperative Seizures and Loss of Seizure Control in Patients Undergoing Surgery for Metastatic Brain Tumors. World neurosurgery\| PubMed ID: 28512046	2017
The efficacy of lapatinib and nilotinib in combination with radiation therapy in a model of NF2 associated peripheral schwannoma. Journal of neuro-oncology\| PubMed ID: 28735458	2017
First In-Human Experience With Complete Integration of Neuromodulation Device Within a Customized Cranial Implant. Operative neurosurgery (Hagerstown, Md.)\| PubMed ID: 29029236	2018
The Relevance of Simpson Grade Resections in Modern Neurosurgical Treatment of World Health Organization Grade I, II, and III Meningiomas. World neurosurgery\| PubMed ID: 29042332	2018
Neuroplastic Surgery. The Journal of craniofacial surgery\| PubMed ID: 29077688	2018
Adult Cranioplasty Reconstruction With Customized Cranial Implants: Preferred Technique, Timing, and Biomaterials. The Journal of craniofacial surgery\| PubMed ID: 29489570	2018
Dendritic cell activation enhances anti-PD-1 mediated immunotherapy against glioblastoma. Oncotarget\| PubMed ID: 29755681	2018
Post-Neurosurgical Temporal Deformities: Various Techniques for Correction and Associated Complications. The Journal of craniofacial surgery\| PubMed ID: 29863558	2018
Ethical Issues and Recommendations in Grateful Patient Fundraising and Philanthropy. Academic medicine : journal of the Association of American Medical Colleges\| PubMed ID: 30024472	2018
Expression of LAG-3 and efficacy of combination treatment with anti-LAG-3 and anti-PD-1 monoclonal antibodies in glioblastoma. International journal of cancer\| PubMed ID: 30248181	2018
Full-Thickness Skin Grafting for Local Defect Coverage Following Scalp Adjacent Tissue Transfer in the Setting of Cranioplasty. The Journal of craniofacial surgery\| PubMed ID: 30394971	2019
Dural Reconstruction With Autologous Rectus Fascia: A New Technique for Addressing Large-Sized Defects During Cranioplasty. The Journal of craniofacial surgery\| PubMed ID: 30439737	2019
Deferred Radiotherapy After Debulking of Non-functioning Pituitary Macroadenomas: Clinical Outcomes. Frontiers in oncology\| PubMed ID: 30687636	2018
Risk of Developing Postoperative Deficits Based on Tumor Location after Surgical Resection of an Intracranial Meningioma. Journal of neurological surgery. Part B, Skull base\| PubMed ID: 30733902	2019
First-in-Human Experience With Integration of a Hydrocephalus Shunt Device Within a Customized Cranial Implant. Operative neurosurgery (Hagerstown, Md.)\| PubMed ID: 30753624	2019
Transcranioplasty Ultrasound Through a Sonolucent Cranial Implant Made of Polymethyl Methacrylate: Phantom Study Comparing Ultrasound, Computed Tomography, and Magnetic Resonance Imaging. The Journal of craniofacial surgery\| PubMed ID: 31188246	2019
Sonolucent Cranial Implants: Cadaveric Study and Clinical Findings Supporting Diagnostic and Therapeutic Transcranioplasty Ultrasound. The Journal of craniofacial surgery\| PubMed ID: 31299743	2019
Genome-wide investigation of intragenic DNA methylation identifies ZMIZ1 gene as a prognostic marker in glioblastoma and multiple cancer types. International journal of cancer\| PubMed ID: 31373686	2019
Nonviral polymeric nanoparticles for gene therapy in pediatric CNS malignancies. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 31655205	2020
Multi-layered core-sheath fiber membranes for controlled drug release in the local treatment of brain tumor. Scientific reports\| PubMed ID: 31784666	2019
Risk of Complications in Primary Versus Revision-Type Cranioplasty. The Journal of craniofacial surgery\| PubMed ID: 31917710	2020
First-In-Human Experience With Integration of Wireless Intracranial Pressure Monitoring Device Within a Customized Cranial Implant. Operative neurosurgery (Hagerstown, Md.)\| PubMed ID: 31993644	2020
Introducing Medical Students to the Burgeoning Field of Neuroplastic Surgery. The Journal of craniofacial surgery\| PubMed ID: 32195837	2020
Educational Program Rankings Are Independently Associated With Residents' Academic Career Trajectory in Neurological Surgery. Journal of surgical education\| PubMed ID: 32245716	2020
Impact of COVID-19 on an Academic Neurosurgery Department: The Johns Hopkins Experience. World neurosurgery\| PubMed ID: 32461176	2020
A systematic review and meta-analysis of supratotal versus gross total resection for glioblastoma. Journal of neuro-oncology\| PubMed ID: 32562247	2020
Repurposing the FDA-Approved Antiviral Drug Ribavirin as Targeted Therapy for Nasopharyngeal Carcinoma. Molecular cancer therapeutics\| PubMed ID: 32606016	2020
Predictors of Nonroutine Discharge Disposition Among Patients with Parasagittal/Parafalcine Meningioma. World neurosurgery\| PubMed ID: 32652275	2020
Quantifying the utility of a multidisciplinary neuro-oncology tumor board. Journal of neurosurgery\| PubMed ID: 32947258	2020
The Neuroplastic Surgery Fellowship Experience: Where Tradition Meets Innovation. The Journal of craniofacial surgery\| PubMed ID: 33136790	2021
Translucent Customized Cranial Implants Made of Clear Polymethylmethacrylate: An Early Outcome Analysis of 55 Consecutive Cranioplasty Cases. Annals of plastic surgery\| PubMed ID: 33170582	2020
Effect of radiation therapy on overall survival following subtotal resection of adult pilocytic astrocytoma. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia\| PubMed ID: 33222942	2020
PD-1+ Monocytes Mediate Cerebral Vasospasm Following Subarachnoid Hemorrhage. Neurosurgery\| PubMed ID: 33370819	2021
Mebendazole and temozolomide in patients with newly diagnosed high-grade gliomas: results of a phase 1 clinical trial. Neuro-oncology advances\| PubMed ID: 33506200	2021
Development of new brain metastases in triple negative breast cancer. Journal of neuro-oncology\| PubMed ID: 33512631	2021
P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression. Nature communications\| PubMed ID: 33771989	2021
Predictors of Academic Neurosurgical Career Trajectory among International Medical Graduates Training Within the United States. Neurosurgery\| PubMed ID: 34114014	2021
Captopril inhibits Matrix Metalloproteinase-2 and extends survival as a temozolomide adjuvant in an intracranial gliosarcoma model. Clinical neurology and neurosurgery\| PubMed ID: 34198223	2021
Patient-Specific Factors Drive Intensive Care Unit and Total Hospital Length of Stay in Operative Patients with Brain Tumor. World neurosurgery\| PubMed ID: 34217859	2021
The Impact of Hydrocephalus Shunt Devices on Quality of Life. The Journal of craniofacial surgery\| PubMed ID: 34319679	2021
Synergy between glutamate modulation and anti-programmed cell death protein 1 immunotherapy for glioblastoma. Journal of neurosurgery\| PubMed ID: 34388730	2022
The safety and efficacy of dexamethasone in the perioperative management of glioma patients. Journal of neurosurgery\| PubMed ID: 34560653	2022
Disulfiram and copper combination therapy targets NPL4, cancer stem cells and extends survival in a medulloblastoma model. PloS one\| PubMed ID: 34731160	2021
Which medical schools produce the most neurosurgery residents? An analysis of the 2014-2020 cohort. Journal of neurosurgery\| PubMed ID: 34826816	2021
The role of anticoagulation for superior sagittal sinus thrombosis following craniotomy for resection of parasagittal/parafalcine meningiomas. Journal of neuro-oncology\| PubMed ID: 34855096	2022
Predicting High-Value Care Outcomes After Surgery for Non-Skull Base Meningiomas. World neurosurgery\| PubMed ID: 34896348	2022
Clinical features and surgical outcomes of intracranial and spinal cord subependymomas. Journal of neurosurgery\| PubMed ID: 35148513	2022
Automatic detection of cotton balls during brain surgery: Where deep learning meets ultrasound imaging to tackle foreign objects. Proceedings of SPIE--the International Society for Optical Engineering\| PubMed ID: 35233128	2021
Cranioplasty Outcomes From 500 Consecutive Neuroplastic Surgery Patients. The Journal of craniofacial surgery\| PubMed ID: 35245275	2022
Cranioplasty With Customized Craniofacial Implants and Intraoperative Resizing for Single-Stage Reconstruction Following Oncologic Resection of Skull Neoplasms. The Journal of craniofacial surgery\| PubMed ID: 35288504	2022