Henry Brem

Biodegradable polymer implants to treat brain tumors.

Polymer delivery of camptothecin against 9L gliosarcoma: release, distribution, and efficacy.

Extreme drug resistance in primary brain tumors: in vitro analysis of 64 resection specimens.

Hypertonic saline ameliorates cerebral edema associated with experimental brain tumor.

Outcome and cost of craniotomy performed to treat tumors in regional academic referral centers.

The surgical bed after BCNU polymer wafer placement for recurrent glioma: serial assessment on CT and MR imaging.

Polilactofate microspheres for Paclitaxel delivery to central nervous system malignancies.

Preparing Hopkins medical students for a career in academic neurosurgery.

Local delivery of minocycline and systemic BCNU have synergistic activity in the treatment of intracranial glioma.

Recent advances in brain tumor therapy: local intracerebral drug delivery by polymers.

Astroglia induce cytotoxic effects on brain tumors via a nitric oxide-dependent pathway both in vitro and in vivo.

Rhabdoid meningioma occurring in an unrelated resection cavity with leptomeningeal carcinomatosis. Case report.

A novel rat model for the study of intraosseous metastatic spine cancer.

Local delivery of antineoplastic agents by controlled-release polymers for the treatment of malignant brain tumours.

Local delivery of interleukin-2 and adriamycin is synergistic in the treatment of experimental malignant glioma.

Local treatment of malignant brain tumors using implantable chemotherapeutic polymers.

Local delivery of doxorubicin for the treatment of malignant brain tumors in rats.

A novel intramedullary spinal cord tumor model: functional, radiological, and histopathological characterization.

Local delivery of temozolomide by biodegradable polymers is superior to oral administration in a rodent glioma model.

Preservation of glial cytoarchitecture from ex vivo human tumor and non-tumor cerebral cortical explants: A human model to study neurological diseases.

Reduction of cerebrospinal fluid rhinorrhea after vestibular schwannoma surgery by reconstruction of the drilled porus acusticus with hydroxyapatite bone cement.

Clostridium perfringens enterotoxin as a novel-targeted therapeutic for brain metastasis.

Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells.

Epirubicin exhibits potent anti-tumor activity in an animal model of malignant glioma when administered via controlled-release polymers.

Gene therapy for malignant brain tumors.

A thermal gel depot for local delivery of paclitaxel to treat experimental brain tumors in rats.

Combination of intracranial temozolomide with intracranial carmustine improves survival when compared with either treatment alone in a rodent glioma model.

Supratentorial glioblastoma multiforme: the role of surgical resection versus biopsy among older patients.

Predictors of inpatient death and complications among postoperative elderly patients with metastatic brain tumors.

The efficacy of carmustine wafers for older patients with glioblastoma multiforme: prolonging survival.

Delayed onset of paresis in rats with experimental intramedullary spinal cord gliosarcoma following intratumoral administration of the paclitaxel delivery system OncoGel.

Intracranial MEMS based temozolomide delivery in a 9L rat gliosarcoma model.

Hyperglycemia is independently associated with post-operative function loss in patients with primary eloquent glioblastoma.

The impact of bevacizumab on temozolomide concentrations in intracranial U87 gliomas.

Suppression of human glioma xenografts with second-generation IL13R-specific chimeric antigen receptor-modified T cells.

Growth properties of SF188/V+ human glioma in rats in vivo observed by magnetic resonance imaging.

Combination of paclitaxel thermal gel depot with temozolomide and radiotherapy significantly prolongs survival in an experimental rodent glioma model.

Deep venous thrombosis and pulmonary embolisms in adult patients undergoing craniotomy for brain tumors.

Microdialysis measurement of intratumoral temozolomide concentration after cediranib, a pan-VEGF receptor tyrosine kinase inhibitor, in a U87 glioma model.

Increased expression of glutamate transporter GLT-1 in peritumoral tissue associated with prolonged survival and decreases in tumor growth in a rat model of experimental malignant glioma.

Combination of anti-VEGF therapy and temozolomide in two experimental human glioma models.

Surgical outcomes of craniocervial junction meningiomas: a series of 22 consecutive patients.

Efficacy of local polymer-based and systemic delivery of the anti-glutamatergic agents riluzole and memantine in rat glioma models.

Radiosensitization of malignant gliomas following intracranial delivery of paclitaxel biodegradable polymer microspheres.

Extravascular optical coherence tomography: evaluation of carotid atherosclerosis and pravastatin therapy.

Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model.

Local delivery of cancer-cell glycolytic inhibitors in high-grade glioma.

Emerging insights into barriers to effective brain tumor therapeutics.

Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo.

Interstitial chemotherapy for malignant glioma: Future prospects in the era of multimodal therapy.

Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers.

Delivery of local therapeutics to the brain: working toward advancing treatment for malignant gliomas.

Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord.

MGMT inactivation and clinical response in newly diagnosed GBM patients treated with Gliadel.

Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis.

Surgical complications following malignant brain tumor surgery: An analysis of 2002-2011 data.

Anticoagulation for Hypercoagulable Patients Associated with Complications after Large Cranioplasty Reconstruction.

Time Interval Reduction for Delayed Implant-Based Cranioplasty Reconstruction in the Setting of Previous Bone Flap Osteomyelitis.

The Johns Hopkins Hunterian Laboratory Philosophy: Mentoring Students in a Scientific Neurosurgical Research Laboratory.

Establishment and Biological Characterization of a Panel of Glioblastoma Multiforme (GBM) and GBM Variant Oncosphere Cell Lines.

Highlights of Children with Cancer UK's Workshop on Drug Delivery in Paediatric Brain Tumours.

Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma.

Non-virally engineered human adipose mesenchymal stem cells produce BMP4, target brain tumors, and extend survival.

Synthesis, characterization, and self-assembly with plasmid DNA of a quaternary ammonium derivative of pectic galactan and its fluorescent labeling for bioimaging applications.

Polylactic acid (PLA) controlled delivery carriers for biomedical applications.

Syndrome of the Trephined: A Systematic Review.

Defining Glioblastoma Resectability Through the Wisdom of the Crowd: A Proof-of-Principle Study.

Discussion on: Usefulness of an Osteotomy Template for Skull Tumorectomy and Simultaneous Skull Reconstruction.

Erratum to: Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma.

Anti-PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM.

Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats.

Risk Factors for Preoperative Seizures and Loss of Seizure Control in Patients Undergoing Surgery for Metastatic Brain Tumors.

The efficacy of lapatinib and nilotinib in combination with radiation therapy in a model of NF2 associated peripheral schwannoma.

First In-Human Experience With Complete Integration of Neuromodulation Device Within a Customized Cranial Implant.

The Relevance of Simpson Grade Resections in Modern Neurosurgical Treatment of World Health Organization Grade I, II, and III Meningiomas.

Neuroplastic Surgery.

Adult Cranioplasty Reconstruction With Customized Cranial Implants: Preferred Technique, Timing, and Biomaterials.

Dendritic cell activation enhances anti-PD-1 mediated immunotherapy against glioblastoma.

Post-Neurosurgical Temporal Deformities: Various Techniques for Correction and Associated Complications.

Ethical Issues and Recommendations in Grateful Patient Fundraising and Philanthropy.

Expression of LAG-3 and efficacy of combination treatment with anti-LAG-3 and anti-PD-1 monoclonal antibodies in glioblastoma.

Full-Thickness Skin Grafting for Local Defect Coverage Following Scalp Adjacent Tissue Transfer in the Setting of Cranioplasty.

Dural Reconstruction With Autologous Rectus Fascia: A New Technique for Addressing Large-Sized Defects During Cranioplasty.

Deferred Radiotherapy After Debulking of Non-functioning Pituitary Macroadenomas: Clinical Outcomes.

Risk of Developing Postoperative Deficits Based on Tumor Location after Surgical Resection of an Intracranial Meningioma.

First-in-Human Experience With Integration of a Hydrocephalus Shunt Device Within a Customized Cranial Implant.

Transcranioplasty Ultrasound Through a Sonolucent Cranial Implant Made of Polymethyl Methacrylate: Phantom Study Comparing Ultrasound, Computed Tomography, and Magnetic Resonance Imaging.

Sonolucent Cranial Implants: Cadaveric Study and Clinical Findings Supporting Diagnostic and Therapeutic Transcranioplasty Ultrasound.

Genome-wide investigation of intragenic DNA methylation identifies ZMIZ1 gene as a prognostic marker in glioblastoma and multiple cancer types.

Nonviral polymeric nanoparticles for gene therapy in pediatric CNS malignancies.

Multi-layered core-sheath fiber membranes for controlled drug release in the local treatment of brain tumor.

Risk of Complications in Primary Versus Revision-Type Cranioplasty.

First-In-Human Experience With Integration of Wireless Intracranial Pressure Monitoring Device Within a Customized Cranial Implant.

Introducing Medical Students to the Burgeoning Field of Neuroplastic Surgery.

Educational Program Rankings Are Independently Associated With Residents' Academic Career Trajectory in Neurological Surgery.

Impact of COVID-19 on an Academic Neurosurgery Department: The Johns Hopkins Experience.

A systematic review and meta-analysis of supratotal versus gross total resection for glioblastoma.

Repurposing the FDA-Approved Antiviral Drug Ribavirin as Targeted Therapy for Nasopharyngeal Carcinoma.

Predictors of Nonroutine Discharge Disposition Among Patients with Parasagittal/Parafalcine Meningioma.

Quantifying the utility of a multidisciplinary neuro-oncology tumor board.

The Neuroplastic Surgery Fellowship Experience: Where Tradition Meets Innovation.

Translucent Customized Cranial Implants Made of Clear Polymethylmethacrylate: An Early Outcome Analysis of 55 Consecutive Cranioplasty Cases.

Effect of radiation therapy on overall survival following subtotal resection of adult pilocytic astrocytoma.

PD-1+ Monocytes Mediate Cerebral Vasospasm Following Subarachnoid Hemorrhage.

Mebendazole and temozolomide in patients with newly diagnosed high-grade gliomas: results of a phase 1 clinical trial.

Development of new brain metastases in triple negative breast cancer.

P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression.

Predictors of Academic Neurosurgical Career Trajectory among International Medical Graduates Training Within the United States.

Captopril inhibits Matrix Metalloproteinase-2 and extends survival as a temozolomide adjuvant in an intracranial gliosarcoma model.

Patient-Specific Factors Drive Intensive Care Unit and Total Hospital Length of Stay in Operative Patients with Brain Tumor.

The Impact of Hydrocephalus Shunt Devices on Quality of Life.

Synergy between glutamate modulation and anti-programmed cell death protein 1 immunotherapy for glioblastoma.

The safety and efficacy of dexamethasone in the perioperative management of glioma patients.

Disulfiram and copper combination therapy targets NPL4, cancer stem cells and extends survival in a medulloblastoma model.

Which medical schools produce the most neurosurgery residents? An analysis of the 2014-2020 cohort.

The role of anticoagulation for superior sagittal sinus thrombosis following craniotomy for resection of parasagittal/parafalcine meningiomas.

Predicting High-Value Care Outcomes After Surgery for Non-Skull Base Meningiomas.

Clinical features and surgical outcomes of intracranial and spinal cord subependymomas.

Automatic detection of cotton balls during brain surgery: Where deep learning meets ultrasound imaging to tackle foreign objects.

Cranioplasty Outcomes From 500 Consecutive Neuroplastic Surgery Patients.

Cranioplasty With Customized Craniofacial Implants and Intraoperative Resizing for Single-Stage Reconstruction Following Oncologic Resection of Skull Neoplasms.