Department of Neurosurgery,
Departments of Ophthalmology,
Oncology and Biomedical Engineering,
Departments of Ophthalmology, Oncology and Biomedical Engineering
Henry Brem has not added Biography.
If you are Henry Brem and would like to personalize this page please email our Author Liaison for assistance.
Biodegradable polymer implants to treat brain tumors.
Journal of controlled release : official journal of the Controlled Release Society Jul, 2001 | Pubmed ID: 11489483
Polymer delivery of camptothecin against 9L gliosarcoma: release, distribution, and efficacy.
Journal of neuro-oncology Feb, 2002 | Pubmed ID: 12061726
Extreme drug resistance in primary brain tumors: in vitro analysis of 64 resection specimens.
Journal of neuro-oncology Jun, 2002 | Pubmed ID: 12164682
Hypertonic saline ameliorates cerebral edema associated with experimental brain tumor.
Journal of neurosurgical anesthesiology Jul, 2002 | Pubmed ID: 12172290
Outcome and cost of craniotomy performed to treat tumors in regional academic referral centers.
Neurosurgery May, 2003 | Pubmed ID: 12699547
The surgical bed after BCNU polymer wafer placement for recurrent glioma: serial assessment on CT and MR imaging.
AJR. American journal of roentgenology May, 2003 | Pubmed ID: 12704070
Polilactofate microspheres for Paclitaxel delivery to central nervous system malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research Aug, 2003 | Pubmed ID: 12960135
Preparing Hopkins medical students for a career in academic neurosurgery.
Surgery Sep, 2003 | Pubmed ID: 14555924
Local delivery of minocycline and systemic BCNU have synergistic activity in the treatment of intracranial glioma.
Journal of neuro-oncology Sep, 2003 | Pubmed ID: 14558595
Recent advances in brain tumor therapy: local intracerebral drug delivery by polymers.
Investigational new drugs Jan, 2004 | Pubmed ID: 14707492
Astroglia induce cytotoxic effects on brain tumors via a nitric oxide-dependent pathway both in vitro and in vivo.
Neurosurgery May, 2004 | Pubmed ID: 15113479
Rhabdoid meningioma occurring in an unrelated resection cavity with leptomeningeal carcinomatosis. Case report.
Journal of neurosurgery Feb, 2005 | Pubmed ID: 15739568
A novel rat model for the study of intraosseous metastatic spine cancer.
Journal of neurosurgery. Spine Mar, 2005 | Pubmed ID: 15796355
Local delivery of antineoplastic agents by controlled-release polymers for the treatment of malignant brain tumours.
Expert opinion on biological therapy Apr, 2005 | Pubmed ID: 15934827
Local delivery of interleukin-2 and adriamycin is synergistic in the treatment of experimental malignant glioma.
Journal of neuro-oncology Sep, 2005 | Pubmed ID: 16193383
Local treatment of malignant brain tumors using implantable chemotherapeutic polymers.
Journal of the National Comprehensive Cancer Network : JNCCN Sep, 2005 | Pubmed ID: 16194460
Local delivery of doxorubicin for the treatment of malignant brain tumors in rats.
Anticancer research Nov-Dec, 2005 | Pubmed ID: 16312042
A novel intramedullary spinal cord tumor model: functional, radiological, and histopathological characterization.
Journal of neurosurgery. Spine Aug, 2005 | Pubmed ID: 16370303
Local delivery of temozolomide by biodegradable polymers is superior to oral administration in a rodent glioma model.
Cancer chemotherapy and pharmacology Oct, 2007 | Pubmed ID: 17256133
Preservation of glial cytoarchitecture from ex vivo human tumor and non-tumor cerebral cortical explants: A human model to study neurological diseases.
Journal of neuroscience methods Aug, 2007 | Pubmed ID: 17580092
Reduction of cerebrospinal fluid rhinorrhea after vestibular schwannoma surgery by reconstruction of the drilled porus acusticus with hydroxyapatite bone cement.
Journal of neurosurgery Aug, 2007 | Pubmed ID: 17695389
Clostridium perfringens enterotoxin as a novel-targeted therapeutic for brain metastasis.
Cancer research Sep, 2007 | Pubmed ID: 17804705
Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells.
Molecular cancer therapeutics Feb, 2009 | Pubmed ID: 19208828
Epirubicin exhibits potent anti-tumor activity in an animal model of malignant glioma when administered via controlled-release polymers.
Journal of neuro-oncology Mar, 2010 | Pubmed ID: 19693439
Gene therapy for malignant brain tumors.
Expert review of neurotherapeutics Sep, 2003 | Pubmed ID: 19810968
A thermal gel depot for local delivery of paclitaxel to treat experimental brain tumors in rats.
Journal of neurosurgery Aug, 2010 | Pubmed ID: 20001591
Combination of intracranial temozolomide with intracranial carmustine improves survival when compared with either treatment alone in a rodent glioma model.
Neurosurgery Mar, 2010 | Pubmed ID: 20173548
Supratentorial glioblastoma multiforme: the role of surgical resection versus biopsy among older patients.
Annals of surgical oncology Jan, 2011 | Pubmed ID: 20697823
Predictors of inpatient death and complications among postoperative elderly patients with metastatic brain tumors.
Annals of surgical oncology Feb, 2011 | Pubmed ID: 20809176
The efficacy of carmustine wafers for older patients with glioblastoma multiforme: prolonging survival.
Neurological research Sep, 2011 | Pubmed ID: 21756557
Delayed onset of paresis in rats with experimental intramedullary spinal cord gliosarcoma following intratumoral administration of the paclitaxel delivery system OncoGel.
Journal of neurosurgery. Spine Jan, 2012 | Pubmed ID: 22208429
Intracranial MEMS based temozolomide delivery in a 9L rat gliosarcoma model.
Biomaterials Aug, 2012 | Pubmed ID: 22591609
Hyperglycemia is independently associated with post-operative function loss in patients with primary eloquent glioblastoma.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia Jul, 2012 | Pubmed ID: 22595358
The impact of bevacizumab on temozolomide concentrations in intracranial U87 gliomas.
Cancer chemotherapy and pharmacology Jul, 2012 | Pubmed ID: 22644796
Suppression of human glioma xenografts with second-generation IL13R-specific chimeric antigen receptor-modified T cells.
Clinical cancer research : an official journal of the American Association for Cancer Research Nov, 2012 | Pubmed ID: 22966020
Growth properties of SF188/V+ human glioma in rats in vivo observed by magnetic resonance imaging.
Journal of neuro-oncology Dec, 2012 | Pubmed ID: 23011120
Combination of paclitaxel thermal gel depot with temozolomide and radiotherapy significantly prolongs survival in an experimental rodent glioma model.
Journal of neuro-oncology Feb, 2013 | Pubmed ID: 23224713
Deep venous thrombosis and pulmonary embolisms in adult patients undergoing craniotomy for brain tumors.
Neurological research Mar, 2013 | Pubmed ID: 23336127
Microdialysis measurement of intratumoral temozolomide concentration after cediranib, a pan-VEGF receptor tyrosine kinase inhibitor, in a U87 glioma model.
Cancer chemotherapy and pharmacology Jul, 2013 | Pubmed ID: 23649683
Increased expression of glutamate transporter GLT-1 in peritumoral tissue associated with prolonged survival and decreases in tumor growth in a rat model of experimental malignant glioma.
Journal of neurosurgery Oct, 2013 | Pubmed ID: 23909244
Combination of anti-VEGF therapy and temozolomide in two experimental human glioma models.
Journal of neuro-oncology Jan, 2014 | Pubmed ID: 24185441
Surgical outcomes of craniocervial junction meningiomas: a series of 22 consecutive patients.
Clinical neurology and neurosurgery Feb, 2014 | Pubmed ID: 24438809
Efficacy of local polymer-based and systemic delivery of the anti-glutamatergic agents riluzole and memantine in rat glioma models.
Journal of neurosurgery Apr, 2014 | Pubmed ID: 24484234
Radiosensitization of malignant gliomas following intracranial delivery of paclitaxel biodegradable polymer microspheres.
Journal of neurosurgery May, 2014 | Pubmed ID: 24605841
Extravascular optical coherence tomography: evaluation of carotid atherosclerosis and pravastatin therapy.
Stroke Apr, 2014 | Pubmed ID: 24627118
Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model.
PloS one , 2014 | Pubmed ID: 25013914
Local delivery of cancer-cell glycolytic inhibitors in high-grade glioma.
Neuro-oncology Jan, 2015 | Pubmed ID: 25053853
Emerging insights into barriers to effective brain tumor therapeutics.
Frontiers in oncology , 2014 | Pubmed ID: 25101239
Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo.
ACS nano Feb, 2015 | Pubmed ID: 25643235
Interstitial chemotherapy for malignant glioma: Future prospects in the era of multimodal therapy.
Surgical neurology international , 2015 | Pubmed ID: 25722936
Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers.
Biomaterials Jun, 2015 | Pubmed ID: 25818456
Delivery of local therapeutics to the brain: working toward advancing treatment for malignant gliomas.
Therapeutic delivery Mar, 2015 | Pubmed ID: 25853310
Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2015 | Pubmed ID: 26195750
MGMT inactivation and clinical response in newly diagnosed GBM patients treated with Gliadel.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia Dec, 2015 | Pubmed ID: 26249244
Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis.
Journal of ophthalmology , 2015 | Pubmed ID: 26491546
Surgical complications following malignant brain tumor surgery: An analysis of 2002-2011 data.
Clinical neurology and neurosurgery Jan, 2016 | Pubmed ID: 26615463
Anticoagulation for Hypercoagulable Patients Associated with Complications after Large Cranioplasty Reconstruction.
Plastic and reconstructive surgery Feb, 2016 | Pubmed ID: 26818296
Time Interval Reduction for Delayed Implant-Based Cranioplasty Reconstruction in the Setting of Previous Bone Flap Osteomyelitis.
Plastic and reconstructive surgery Feb, 2016 | Pubmed ID: 26818330
The Johns Hopkins Hunterian Laboratory Philosophy: Mentoring Students in a Scientific Neurosurgical Research Laboratory.
Academic medicine : journal of the Association of American Medical Colleges 06, 2016 | Pubmed ID: 26934692
Establishment and Biological Characterization of a Panel of Glioblastoma Multiforme (GBM) and GBM Variant Oncosphere Cell Lines.
PloS one , 2016 | Pubmed ID: 27028405
Highlights of Children with Cancer UK's Workshop on Drug Delivery in Paediatric Brain Tumours.
Ecancermedicalscience , 2016 | Pubmed ID: 27110286
Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma.
Journal for immunotherapy of cancer , 2016 | Pubmed ID: 27190629
Non-virally engineered human adipose mesenchymal stem cells produce BMP4, target brain tumors, and extend survival.
Biomaterials 09, 2016 | Pubmed ID: 27240162
Synthesis, characterization, and self-assembly with plasmid DNA of a quaternary ammonium derivative of pectic galactan and its fluorescent labeling for bioimaging applications.
Carbohydrate polymers Oct, 2016 | Pubmed ID: 27312642
Polylactic acid (PLA) controlled delivery carriers for biomedical applications.
Advanced drug delivery reviews 12, 2016 | Pubmed ID: 27426411
Syndrome of the Trephined: A Systematic Review.
Neurosurgery Oct, 2016 | Pubmed ID: 27489166
Defining Glioblastoma Resectability Through the Wisdom of the Crowd: A Proof-of-Principle Study.
Neurosurgery Apr, 2017 | Pubmed ID: 27509070
Discussion on: Usefulness of an Osteotomy Template for Skull Tumorectomy and Simultaneous Skull Reconstruction.
The Journal of craniofacial surgery Sep, 2016 | Pubmed ID: 27526253
Erratum to: Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma.
Journal for immunotherapy of cancer , 2016 | Pubmed ID: 27822377
Anti-PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM.
Science translational medicine 12, 2016 | Pubmed ID: 28003545
Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats.
Journal of controlled release : official journal of the Controlled Release Society Oct, 2017 | Pubmed ID: 28279797
Risk Factors for Preoperative Seizures and Loss of Seizure Control in Patients Undergoing Surgery for Metastatic Brain Tumors.
World neurosurgery Aug, 2017 | Pubmed ID: 28512046
The efficacy of lapatinib and nilotinib in combination with radiation therapy in a model of NF2 associated peripheral schwannoma.
Journal of neuro-oncology Oct, 2017 | Pubmed ID: 28735458
First In-Human Experience With Complete Integration of Neuromodulation Device Within a Customized Cranial Implant.
Operative neurosurgery (Hagerstown, Md.) 07, 2018 | Pubmed ID: 29029236
The Relevance of Simpson Grade Resections in Modern Neurosurgical Treatment of World Health Organization Grade I, II, and III Meningiomas.
World neurosurgery Jan, 2018 | Pubmed ID: 29042332
Neuroplastic Surgery.
The Journal of craniofacial surgery 01, 2018 | Pubmed ID: 29077688
Adult Cranioplasty Reconstruction With Customized Cranial Implants: Preferred Technique, Timing, and Biomaterials.
The Journal of craniofacial surgery Jun, 2018 | Pubmed ID: 29489570
Dendritic cell activation enhances anti-PD-1 mediated immunotherapy against glioblastoma.
Oncotarget Apr, 2018 | Pubmed ID: 29755681
Post-Neurosurgical Temporal Deformities: Various Techniques for Correction and Associated Complications.
The Journal of craniofacial surgery Oct, 2018 | Pubmed ID: 29863558
Ethical Issues and Recommendations in Grateful Patient Fundraising and Philanthropy.
Academic medicine : journal of the Association of American Medical Colleges 11, 2018 | Pubmed ID: 30024472
Expression of LAG-3 and efficacy of combination treatment with anti-LAG-3 and anti-PD-1 monoclonal antibodies in glioblastoma.
International journal of cancer 12, 2018 | Pubmed ID: 30248181
Full-Thickness Skin Grafting for Local Defect Coverage Following Scalp Adjacent Tissue Transfer in the Setting of Cranioplasty.
The Journal of craniofacial surgery Jan, 2019 | Pubmed ID: 30394971
Dural Reconstruction With Autologous Rectus Fascia: A New Technique for Addressing Large-Sized Defects During Cranioplasty.
The Journal of craniofacial surgery Mar/Apr, 2019 | Pubmed ID: 30439737
Deferred Radiotherapy After Debulking of Non-functioning Pituitary Macroadenomas: Clinical Outcomes.
Frontiers in oncology , 2018 | Pubmed ID: 30687636
Risk of Developing Postoperative Deficits Based on Tumor Location after Surgical Resection of an Intracranial Meningioma.
Journal of neurological surgery. Part B, Skull base Feb, 2019 | Pubmed ID: 30733902
First-in-Human Experience With Integration of a Hydrocephalus Shunt Device Within a Customized Cranial Implant.
Operative neurosurgery (Hagerstown, Md.) 12, 2019 | Pubmed ID: 30753624
Transcranioplasty Ultrasound Through a Sonolucent Cranial Implant Made of Polymethyl Methacrylate: Phantom Study Comparing Ultrasound, Computed Tomography, and Magnetic Resonance Imaging.
The Journal of craniofacial surgery Oct, 2019 | Pubmed ID: 31188246
Sonolucent Cranial Implants: Cadaveric Study and Clinical Findings Supporting Diagnostic and Therapeutic Transcranioplasty Ultrasound.
The Journal of craniofacial surgery Jul, 2019 | Pubmed ID: 31299743
Genome-wide investigation of intragenic DNA methylation identifies ZMIZ1 gene as a prognostic marker in glioblastoma and multiple cancer types.
International journal of cancer 12, 2019 | Pubmed ID: 31373686
Nonviral polymeric nanoparticles for gene therapy in pediatric CNS malignancies.
Nanomedicine : nanotechnology, biology, and medicine 01, 2020 | Pubmed ID: 31655205
Multi-layered core-sheath fiber membranes for controlled drug release in the local treatment of brain tumor.
Scientific reports 11, 2019 | Pubmed ID: 31784666
Risk of Complications in Primary Versus Revision-Type Cranioplasty.
The Journal of craniofacial surgery Mar/Apr, 2020 | Pubmed ID: 31917710
First-In-Human Experience With Integration of Wireless Intracranial Pressure Monitoring Device Within a Customized Cranial Implant.
Operative neurosurgery (Hagerstown, Md.) 09, 2020 | Pubmed ID: 31993644
Introducing Medical Students to the Burgeoning Field of Neuroplastic Surgery.
The Journal of craniofacial surgery 06, 2020 | Pubmed ID: 32195837
Educational Program Rankings Are Independently Associated With Residents' Academic Career Trajectory in Neurological Surgery.
Journal of surgical education Sep - Oct, 2020 | Pubmed ID: 32245716
Impact of COVID-19 on an Academic Neurosurgery Department: The Johns Hopkins Experience.
World neurosurgery 07, 2020 | Pubmed ID: 32461176
A systematic review and meta-analysis of supratotal versus gross total resection for glioblastoma.
Journal of neuro-oncology Jul, 2020 | Pubmed ID: 32562247
Repurposing the FDA-Approved Antiviral Drug Ribavirin as Targeted Therapy for Nasopharyngeal Carcinoma.
Molecular cancer therapeutics 09, 2020 | Pubmed ID: 32606016
Predictors of Nonroutine Discharge Disposition Among Patients with Parasagittal/Parafalcine Meningioma.
World neurosurgery 10, 2020 | Pubmed ID: 32652275
Quantifying the utility of a multidisciplinary neuro-oncology tumor board.
Journal of neurosurgery Sep, 2020 | Pubmed ID: 32947258
The Neuroplastic Surgery Fellowship Experience: Where Tradition Meets Innovation.
The Journal of craniofacial surgery Jan-Feb 01, 2021 | Pubmed ID: 33136790
Translucent Customized Cranial Implants Made of Clear Polymethylmethacrylate: An Early Outcome Analysis of 55 Consecutive Cranioplasty Cases.
Annals of plastic surgery 12, 2020 | Pubmed ID: 33170582
Effect of radiation therapy on overall survival following subtotal resection of adult pilocytic astrocytoma.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia Nov, 2020 | Pubmed ID: 33222942
PD-1+ Monocytes Mediate Cerebral Vasospasm Following Subarachnoid Hemorrhage.
Neurosurgery 03, 2021 | Pubmed ID: 33370819
Mebendazole and temozolomide in patients with newly diagnosed high-grade gliomas: results of a phase 1 clinical trial.
Neuro-oncology advances Jan-Dec, 2021 | Pubmed ID: 33506200
Development of new brain metastases in triple negative breast cancer.
Journal of neuro-oncology Apr, 2021 | Pubmed ID: 33512631
P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression.
Nature communications 03, 2021 | Pubmed ID: 33771989
Predictors of Academic Neurosurgical Career Trajectory among International Medical Graduates Training Within the United States.
Neurosurgery 08, 2021 | Pubmed ID: 34114014
Captopril inhibits Matrix Metalloproteinase-2 and extends survival as a temozolomide adjuvant in an intracranial gliosarcoma model.
Clinical neurology and neurosurgery 08, 2021 | Pubmed ID: 34198223
Patient-Specific Factors Drive Intensive Care Unit and Total Hospital Length of Stay in Operative Patients with Brain Tumor.
World neurosurgery 09, 2021 | Pubmed ID: 34217859
The Impact of Hydrocephalus Shunt Devices on Quality of Life.
The Journal of craniofacial surgery Jul-Aug 01, 2021 | Pubmed ID: 34319679
Synergy between glutamate modulation and anti-programmed cell death protein 1 immunotherapy for glioblastoma.
Journal of neurosurgery Feb, 2022 | Pubmed ID: 34388730
The safety and efficacy of dexamethasone in the perioperative management of glioma patients.
Journal of neurosurgery Apr, 2022 | Pubmed ID: 34560653
Disulfiram and copper combination therapy targets NPL4, cancer stem cells and extends survival in a medulloblastoma model.
PloS one , 2021 | Pubmed ID: 34731160
Which medical schools produce the most neurosurgery residents? An analysis of the 2014-2020 cohort.
Journal of neurosurgery Nov, 2021 | Pubmed ID: 34826816
The role of anticoagulation for superior sagittal sinus thrombosis following craniotomy for resection of parasagittal/parafalcine meningiomas.
Journal of neuro-oncology Jan, 2022 | Pubmed ID: 34855096
Predicting High-Value Care Outcomes After Surgery for Non-Skull Base Meningiomas.
World neurosurgery Mar, 2022 | Pubmed ID: 34896348
Clinical features and surgical outcomes of intracranial and spinal cord subependymomas.
Journal of neurosurgery Feb, 2022 | Pubmed ID: 35148513
Automatic detection of cotton balls during brain surgery: Where deep learning meets ultrasound imaging to tackle foreign objects.
Proceedings of SPIE--the International Society for Optical Engineering Feb, 2021 | Pubmed ID: 35233128
Cranioplasty Outcomes From 500 Consecutive Neuroplastic Surgery Patients.
The Journal of craniofacial surgery Mar, 2022 | Pubmed ID: 35245275
Cranioplasty With Customized Craniofacial Implants and Intraoperative Resizing for Single-Stage Reconstruction Following Oncologic Resection of Skull Neoplasms.
The Journal of craniofacial surgery Mar, 2022 | Pubmed ID: 35288504
Safwan Alomari1,
Jayanidhi Kedda1,
Adarsha P. Malla2,3,
Victor Pacis1,
Pavlos Anastasiadis2,3,
Su Xu4,
Emylee McFarland2,3,
Lilia Sukhon1,
Bruno Gallo5,
Jordina Rincon-Torroella1,
Netanel Ben-Shalom1,
Heather M. Ames3,6,
Henry Brem1,7,
Graeme F. Woodworth2,3,
Betty Tyler1
1Department of Neurosurgery, Johns Hopkins University School of Medicine,
2Department of Neurosurgery, University of Maryland School of Medicine,
3Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine,
4Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine,
5, Pontifical Catholic University of Parana,
6Department of Pathology, University of Maryland School of Medicine,
7Departments of Ophthalmology, Oncology and Biomedical Engineering, Johns Hopkins University School of Medicine