Masahito Ikawa

Laboratory of Reproductive Systems Biology, The University of Tokyo

Affiliated withThe University of Tokyo Osaka University the university of tokyo

Research Area

Developmental Biology

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2022

Other Publications

Article	Year
Innate versus learned odour processing in the mouse olfactory bulb. Nature\| PubMed ID: 17989651	2007
Liver-specific γ-glutamyl carboxylase-deficient mice display bleeding diathesis and short life span. PloS one\| PubMed ID: 24520408	2014
Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies. Experimental animals\| PubMed ID: 26822934	2016
Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis. Nature communications\| PubMed ID: 27389782	2016
Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization. Nature communications\| PubMed ID: 27416963	2016
TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28630322	2017
Genome Editing in Mouse Zygotes and Embryonic Stem Cells by Introducing SgRNA/Cas9 Expressing Plasmids. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 28643250	2017
Placenta-specific gene manipulation using lentiviral vector and its application. Placenta\| PubMed ID: 28988726	2017
Human Globozoospermia-Related Gene Spata16 Is Required for Sperm Formation Revealed by CRISPR/Cas9-Mediated Mouse Models. International journal of molecular sciences\| PubMed ID: 29065458	2017
Factors controlling sperm migration through the oviduct revealed by gene-modified mouse models. Experimental animals\| PubMed ID: 29353867	2018
Sperm-borne phospholipase C zeta-1 ensures monospermic fertilization in mice. Scientific reports\| PubMed ID: 29358633	2018
Chimeric analysis with newly established EGFP/DsRed2-tagged ES cells identify HYDIN as essential for spermiogenesis in mice. Experimental animals\| PubMed ID: 30089752	2019
Engineered CRISPR-Cas9 nuclease with expanded targeting space. Science (New York, N.Y.)\| PubMed ID: 30166441	2018
New Insights into the Molecular Events of Mammalian Fertilization. Trends in biochemical sciences\| PubMed ID: 30170889	2018
RSPH6A is required for sperm flagellum formation and male fertility in mice. Journal of cell science\| PubMed ID: 30185526	2018
Co-expression of sperm membrane proteins CMTM2A and CMTM2B is essential for ADAM3 localization and male fertility in mice. Journal of cell science\| PubMed ID: 30209135	2018
PTBP1 contributes to spermatogenesis through regulation of proliferation in spermatogonia. The Journal of reproduction and development\| PubMed ID: 30416150	2019
Seminal vesicle secretory protein 7, PATE4, is not required for sperm function but for copulatory plug formation to ensure fecundity†. Biology of reproduction\| PubMed ID: 30452524	2019
An azoospermic factor gene, Ddx3y and its paralog, Ddx3x are dispensable in germ cells for male fertility. The Journal of reproduction and development\| PubMed ID: 30613052	2019
Glycerol kinase 2 is essential for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during mouse spermatogenesis. The Journal of reproduction and development\| PubMed ID: 30662012	2019
Lvrn expression is not critical for mouse placentation. The Journal of reproduction and development\| PubMed ID: 30745494	2019
CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†. Biology of reproduction\| PubMed ID: 31201419	2019
Calaxin is required for cilia-driven determination of vertebrate laterality. Communications biology\| PubMed ID: 31240264	2019
Erratum: Publisher Correction: Calaxin is required for cilia-driven determination of vertebrate laterality. Communications biology\| PubMed ID: 31286071	2019
Physiological function of seminal vesicle secretions on male fecundity. Reproductive medicine and biology\| PubMed ID: 31312102	2019
The testis-specific serine proteases PRSS44, PRSS46, and PRSS54 are dispensable for male mouse fertility†. Biology of reproduction\| PubMed ID: 31403672	2020
Identification of multiple male reproductive tract-specific proteins that regulate sperm migration through the oviduct in mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31455729	2019
Male mice, caged in the International Space Station for 35 days, sire healthy offspring. Scientific reports\| PubMed ID: 31551430	2019
Genetic mutation of Frem3 does not causeFraser syndrome in mice. Experimental animals\| PubMed ID: 31554749	2020
Tesmin, Metallothionein-Like 5, is Required for Spermatogenesis in Mice†. Biology of reproduction\| PubMed ID: 31916570	2020
Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice. PLoS genetics\| PubMed ID: 31961863	2020
Testis-enriched kinesin KIF9 is important for progressive motility in mouse spermatozoa. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 32072696	2020
CRISPR/Cas9-Mediated Genome Editing Reveals Family Genes are Dispensable for Female Fertility in Mice. Cells\| PubMed ID: 32231122	2020
Structural insights into tetraspanin CD9 function. Nature communications\| PubMed ID: 32231207	2020
Spermatozoa lacking Fertilization Influencing Membrane Protein (FIMP) fail to fuse with oocytes in mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32295885	2020
Prss55 but not Prss51 is required for male fertility in mice†. Biology of reproduction\| PubMed ID: 32301961	2020
Knockout of serine-rich single-pass membrane protein 1 (Ssmem1) causes globozoospermia and sterility in male mice†. Biology of reproduction\| PubMed ID: 32301969	2020
Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32393636	2020
CIB4 is essential for the haploid phase of spermatogenesis in mice†. Biology of reproduction\| PubMed ID: 32430498	2020
NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility. Science (New York, N.Y.)\| PubMed ID: 32499443	2020
Tmprss12 is required for sperm motility and uterotubal junction migration in mice†. Biology of reproduction\| PubMed ID: 32529245	2020
Analysis of the sperm flagellar axoneme using gene-modified mice. Experimental animals\| PubMed ID: 32554934	2020
CRISPR/Cas9-mediated genome-edited mice reveal 10 testis-enriched genes are dispensable for male fecundity. Biology of reproduction\| PubMed ID: 32561905	2020
CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or epididymis-enriched genes individually dispensable for male reproduction†. Biology of reproduction\| PubMed ID: 32588039	2020
Knockout of family with sequence similarity 170 member A (Fam170a) causes male subfertility, while Fam170b is dispensable in mice†. Biology of reproduction\| PubMed ID: 32588889	2020
Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility. American journal of human genetics\| PubMed ID: 32619401	2020
RNA-binding protein Ptbp1 regulates alternative splicing and transcriptome in spermatogonia and maintains spermatogenesis in concert with Nanos3. The Journal of reproduction and development\| PubMed ID: 32624547	2020
PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis. Cell reports\| PubMed ID: 32726616	2020
CRISPR/CAS9-mediated amino acid substitution reveals phosphorylation residues of RSPH6A are not essential for male fertility in mice†. Biology of reproduction\| PubMed ID: 32901808	2020
Astrocytic cAMP modulates memory via synaptic plasticity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33452135	2021
Protocol for isolation of spermatids from mouse testes. STAR protocols\| PubMed ID: 33490974	2021
ARMC12 regulates spatiotemporal mitochondrial dynamics during spermiogenesis and is required for male fertility. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33536340	2021
KCTD19 and its associated protein ZFP541 are independently essential for meiosis in male mice. PLoS genetics\| PubMed ID: 33961623	2021
Precise CAG repeat contraction in a Huntington's Disease mouse model is enabled by gene editing with SpCas9-NG. Communications biology\| PubMed ID: 34163001	2021
CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice. Asian journal of andrology\| PubMed ID: 34290169	2022
Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function. PLoS genetics\| PubMed ID: 34351902	2021
Uterine Epithelial LIF Receptors Contribute to Implantation Chamber Formation in Blastocyst Attachment. Endocrinology\| PubMed ID: 34402888	2021
A sublethal ATP11A mutation associated with neurological deterioration causes aberrant phosphatidylcholine flipping in plasma membranes. The Journal of clinical investigation\| PubMed ID: 34403372	2021
SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 34446558	2021
The motor domain of testis-enriched kinesin KIF9 is essential for its localization in the mouse flagellum. Experimental animals\| PubMed ID: 34526446	2022
The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 34556579	2021
LRRC23 is a conserved component of the radial spoke that is necessary for sperm motility and male fertility in mice. Journal of cell science\| PubMed ID: 34585727	2021
FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice. Development (Cambridge, England)\| PubMed ID: 34714330	2021
Sperm IZUMO1 Is Required for Binding Preceding Fusion With Oolemma in Mice and Rats. Frontiers in cell and developmental biology\| PubMed ID: 35096839	2021
Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis. Nature communications\| PubMed ID: 35228556	2022
Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish. Communications biology\| PubMed ID: 35393517	2022
Proteolysis in Reproduction: Lessons From Gene-Modified Organism Studies. Frontiers in endocrinology\| PubMed ID: 35600599	2022
IRGC1, a testis-enriched immunity related GTPase, is important for fibrous sheath integrity and sperm motility in mice. Developmental biology\| PubMed ID: 35618043	2022
TULP2 deletion mice exhibit abnormal outer dense fiber structure and male infertility. Reproductive medicine and biology\| PubMed ID: 35619658	2022
Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice. PLoS genetics\| PubMed ID: 35648791	2022