Ie-Ming Shih

Department of Obstetrics and Gynecology, Johns Hopkins University School of Medicine

Affiliated withJohns Hopkins University School of Medicine Johns Hopkins University

Research Area

Cancer Research

Biography

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2023

Other Publications

Article	Year
HLA-G immunoreactivity is specific for intermediate trophoblast in gestational trophoblastic disease and can serve as a useful marker in differential diagnosis. The American journal of surgical pathology\| PubMed ID: 12131159	2002
Detection of allelic imbalance in ascitic supernatant by digital single nucleotide polymorphism analysis. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 12171887	2002
Molecular genetic analysis of placental site trophoblastic tumors and epithelioid trophoblastic tumors confirms their trophoblastic origin. The American journal of pathology\| PubMed ID: 12213732	2002
Genotype analysis using human hair shaft. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 12223440	2002
The Role of E-cadherin in the Motility and Invasion of Implantation Site Intermediate Trophoblast. Placenta\| PubMed ID: 12398810	2002
Assessment of plasma DNA levels, allelic imbalance, and CA 125 as diagnostic tests for cancer. Journal of the National Cancer Institute\| PubMed ID: 12441325	2002
Proteomic approaches to tumor marker discovery. Archives of pathology & laboratory medicine\| PubMed ID: 12456215	2002
Mutational analysis of K-ras segregates ovarian serous carcinomas into two types: invasive MPSC (low-grade tumor) and conventional serous carcinoma (high-grade tumor). International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists\| PubMed ID: 12496696	2003
Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma. Journal of the National Cancer Institute\| PubMed ID: 12644542	2003
Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis. The American journal of pathology\| PubMed ID: 15111296	2004
Digital single-nucleotide polymorphism analysis for allelic imbalance. Methods in molecular medicine\| PubMed ID: 15542903	2005
Patterns of p53 mutations separate ovarian serous borderline tumors and low- and high-grade carcinomas and provide support for a new model of ovarian carcinogenesis: a mutational analysis wi... The American journal of surgical pathology\| PubMed ID: 15644779	2005
HLA-G upregulation in pre-malignant and malignant lesions of the gastrointestinal tract. International journal of gastrointestinal cancer\| PubMed ID: 15722570	2005
Differential expression of L-selectin ligand in the endometrium during the menstrual cycle. Fertility and sterility\| PubMed ID: 15831305	2005
Activation of mitogen-activated protein kinase is required for migration and invasion of placental site trophoblastic tumor. The American journal of pathology\| PubMed ID: 16127165	2005
Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16172393	2005
Expression of L-selectin ligands in human endometrium during the implantation window after controlled ovarian stimulation for oocyte donation. Fertility and sterility\| PubMed ID: 16500358	2006
Effect of luteal-phase support on endometrial L-selectin ligand expression after recombinant follicle-stimulating hormone and ganirelix acetate for in vitro fertilization. The Journal of clinical endocrinology and metabolism\| PubMed ID: 16868054	2006
Immunological localization of syndecan-1 in human endometrium throughout the menstrual cycle. Fertility and sterility\| PubMed ID: 17113089	2007
Application of human leukocyte antigen-G expression in the diagnosis of human cancer. Human immunology\| PubMed ID: 17400063	2007
Trophogram, an immunohistochemistry-based algorithmic approach, in the differential diagnosis of trophoblastic tumors and tumorlike lesions. Annals of diagnostic pathology\| PubMed ID: 17498600	2007
Knowledge-guided multi-scale independent component analysis for biomarker identification. BMC bioinformatics\| PubMed ID: 18837990	2008
Cystic and adenofibromatous clear cell carcinomas of the ovary: distinctive tumors that differ in their pathogenesis and behavior: a clinicopathologic analysis of 122 cases. The American journal of surgical pathology\| PubMed ID: 19342944	2009
Analysis of DNA copy number alterations in ovarian serous tumors identifies new molecular genetic changes in low-grade and high-grade carcinomas. Cancer research\| PubMed ID: 19383911	2009
p53 autoantibodies, cytokine levels and ovarian carcinogenesis. Gynecologic oncology\| PubMed ID: 19398128	2009
Defining the cut point between low-grade and high-grade ovarian serous carcinomas: a clinicopathologic and molecular genetic analysis. The American journal of surgical pathology\| PubMed ID: 19461510	2009
Utility of p16 expression for distinction of uterine serous carcinomas from endometrial endometrioid and endocervical adenocarcinomas: immunohistochemical analysis of 201 cases. The American journal of surgical pathology\| PubMed ID: 19623034	2009
Ovarian low-grade and high-grade serous carcinoma: pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems. Advances in anatomic pathology\| PubMed ID: 19700937	2009
Pathogenesis of ovarian cancer: clues from selected overexpressed genes. Future oncology (London, England)\| PubMed ID: 20001801	2009
The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory. The American journal of surgical pathology\| PubMed ID: 20154587	2010
Lack of a y-chromosomal complement in the majority of gestational trophoblastic neoplasms. Journal of oncology\| PubMed ID: 20182630	2010
DNA copy numbers profiles in affinity-purified ovarian clear cell carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 20233889	2010
Precursor lesions of high-grade serous ovarian carcinoma: morphological and molecular characteristics. Journal of oncology\| PubMed ID: 20445756	2010
Are all pelvic (nonuterine) serous carcinomas of tubal origin? The American journal of surgical pathology\| PubMed ID: 20861711	2010
ARID1A mutations in endometriosis-associated ovarian carcinomas. The New England journal of medicine\| PubMed ID: 20942669	2010
Distinct DNA methylation profiles in ovarian serous neoplasms and their implications in ovarian carcinogenesis. American journal of obstetrics and gynecology\| PubMed ID: 20965493	2010
PUGSVM: a caBIGâ„¢ analytical tool for multiclass gene selection and predictive classification. Bioinformatics (Oxford, England)\| PubMed ID: 21186245	2011
DDN: a caBIGÂ® analytical tool for differential network analysis. Bioinformatics (Oxford, England)\| PubMed ID: 21296752	2011
Mutation and loss of expression of ARID1A in uterine low-grade endometrioid carcinoma. The American journal of surgical pathology\| PubMed ID: 21412130	2011
Mutation of PPP2R1A: a new clue in unveiling the pathogenesis of uterine serous carcinoma. The Journal of pathology\| PubMed ID: 21432855	2011
BACOM: in silico detection of genomic deletion types and correction of normal cell contamination in copy number data. Bioinformatics (Oxford, England)\| PubMed ID: 21498400	2011
Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer--shifting the paradigm. Human pathology\| PubMed ID: 21683865	2011
Comparison of candidate serologic markers for type I and type II ovarian cancer. Gynecologic oncology\| PubMed ID: 21704359	2011
Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes. The American journal of pathology\| PubMed ID: 21888887	2011
ARID1A, a factor that promotes formation of SWI/SNF-mediated chromatin remodeling, is a tumor suppressor in gynecologic cancers. Cancer research\| PubMed ID: 21900401	2011
Mapping DNA Quantity into Electrophoretic Mobility through Quantum Dot Nanotethers for High-Resolution Genetic and Epigenetic Analysis. ACS nano\| PubMed ID: 22136600	2012
Mutant BRAF induces DNA strand breaks, activates DNA damage response pathway, and up-regulates glucose transporter-1 in nontransformed epithelial cells. The American journal of pathology\| PubMed ID: 22227015	2012
Validation of an algorithm for the diagnosis of serous tubal intraepithelial carcinoma. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists\| PubMed ID: 22498942	2012
Genome-wide identification of significant aberrations in cancer genome. BMC genomics\| PubMed ID: 22839576	2012
The diagnostic and biological implications of laminin expression in serous tubal intraepithelial carcinoma. The American journal of surgical pathology\| PubMed ID: 22892598	2012
Pathogenesis and new therapeutic targets of ovarian cancer. Journal of oncology\| PubMed ID: 22969800	2012
Functional analysis of in-frame indel ARID1A mutations reveals new regulatory mechanisms of its tumor suppressor functions. Neoplasia (New York, N.Y.)\| PubMed ID: 23097632	2012
High level of chromosomal aberration in ovarian cancer genome correlates with poor clinical outcome. Gynecologic oncology\| PubMed ID: 23200914	2013
Polysialic acid enhances the migration and invasion of human cytotrophoblasts. Glycobiology\| PubMed ID: 23208007	2013
Fallopian tube precursors of ovarian low- and high-grade serous neoplasms. Histopathology\| PubMed ID: 23240669	2013
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23530248	2013
Identification of the NAC1-regulated genes in ovarian cancer. The American journal of pathology\| PubMed ID: 24200849	2014
Establishing isogenic inducible cell lines using founder reporter lines and recombinase-mediated cassette exchange. BioTechniques\| PubMed ID: 24215638	2013
AISAIC: a software suite for accurate identification of significant aberrations in cancers. Bioinformatics (Oxford, England)\| PubMed ID: 24292941	2014
Mutational analysis of BRAF and KRAS in ovarian serous borderline (atypical proliferative) tumours and associated peritoneal implants. The Journal of pathology\| PubMed ID: 24307542	2014
Dedifferentiated endometrioid adenocarcinoma: An under-recognized but aggressive tumor? Gynecologic oncology case reports\| PubMed ID: 24371688	2013
Evaluation of microinvasion and lymph node involvement in ovarian serous borderline/atypical proliferative serous tumors: a morphologic and immunohistochemical analysis of 37 cases. The American journal of surgical pathology\| PubMed ID: 24441661	2014
Long interspersed element-1 protein expression is a hallmark of many human cancers. The American journal of pathology\| PubMed ID: 24607009	2014
The emerging roles of ARID1A in tumor suppression. Cancer biology & therapy\| PubMed ID: 24618703	2014
Roles of deletion of Arid1a, a tumor suppressor, in mouse ovarian tumorigenesis. Journal of the National Cancer Institute\| PubMed ID: 24899687	2014
BRAF mutation is associated with a specific cell type with features suggestive of senescence in ovarian serous borderline (atypical proliferative) tumors. The American journal of surgical pathology\| PubMed ID: 25188864	2014
GATA-3 expression in trophoblastic tissues: an immunohistochemical study of 445 cases, including diagnostic utility. The American journal of surgical pathology\| PubMed ID: 25188865	2015
Precursors of ovarian cancer in the fallopian tube: serous tubal intraepithelial carcinoma--an update. The journal of obstetrics and gynaecology research\| PubMed ID: 25330822	2015
Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. PLoS genetics\| PubMed ID: 25356737	2014
Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules. Cancer cell\| PubMed ID: 26096845	2015
Molecular Alterations of TP53 are a Defining Feature of Ovarian High-Grade Serous Carcinoma: A Rereview of Cases Lacking TP53 Mutations in The Cancer Genome Atlas Ovarian Study. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists\| PubMed ID: 26166714	2016
Laminin C1 expression by uterine carcinoma cells is associated with tumor progression. Gynecologic oncology\| PubMed ID: 26343160	2015
Seromucinous Tumors of the Ovary. What's in a Name? International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists\| PubMed ID: 26598986	2016
Inactivating ARID1A Tumor Suppressor Enhances TERT Transcription and Maintains Telomere Length in Cancer Cells. The Journal of biological chemistry\| PubMed ID: 26953344	2016
Rationale for Developing a Specimen Bank to Study the Pathogenesis of High-Grade Serous Carcinoma: A Review of the Evidence. Cancer prevention research (Philadelphia, Pa.)\| PubMed ID: 27221539	2016
Adenocarcinoma of Mullerian origin: review of pathogenesis, molecular biology, and emerging treatment paradigms. Gynecologic oncology research and practice\| PubMed ID: 27231561	2015
PD-L1 Expression in Human Placentas and Gestational Trophoblastic Diseases. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists\| PubMed ID: 27362903	2017
Human transposon insertion profiling: Analysis, visualization and identification of somatic LINE-1 insertions in ovarian cancer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28096347	2017
Mutation of NRAS is a rare genetic event in ovarian low-grade serous carcinoma. Human pathology\| PubMed ID: 28873354	2017
High grade serous ovarian carcinomas originate in the fallopian tube. Nature communications\| PubMed ID: 29061967	2017
CINdex: A Bioconductor Package for Analysis of Chromosome Instability in DNA Copy Number Data. Cancer informatics\| PubMed ID: 29343938	2017
International Society of Gynecological Pathologists (ISGyP) Endometrial Cancer Project: Guidelines From the Special Techniques and Ancillary Studies Group. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists\| PubMed ID: 29521846	2019
Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers. Science translational medicine\| PubMed ID: 29563323	2018
Methylomic Analysis of Ovarian Cancers Identifies Tumor-Specific Alterations Readily Detectable in Early Precursor Lesions. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 30108103	2018
Loss of ARID1A expression in endometrial samplings is associated with the risk of endometrial carcinoma. Gynecologic oncology\| PubMed ID: 30126589	2018
Fallopian Tube Lesions in Women at High Risk for Ovarian Cancer: A Multicenter Study. Cancer prevention research (Philadelphia, Pa.)\| PubMed ID: 30232083	2018
Long Interspersed Nuclear Element 1 Retrotransposons Become Deregulated during the Development of Ovarian Cancer Precursor Lesions. The American journal of pathology\| PubMed ID: 30553834	2019
PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8 T-cell Function. Cancer immunology research\| PubMed ID: 30659054	2019
Molecular Classification and Emerging Targeted Therapy in Endometrial Cancer. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists\| PubMed ID: 30741844	2020
Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment. Nature communications\| PubMed ID: 30760718	2019
Follicular fluid has more to offer: Insulin-like growth factor axis on ovarian carcinogenesis. EBioMedicine\| PubMed ID: 30797714	2019
Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference. Cancer\| PubMed ID: 30835824	2019
Cytomorphologic and molecular analyses of fallopian tube fimbrial brushings for diagnosis of serous tubal intraepithelial carcinoma. Cancer cytopathology\| PubMed ID: 30861338	2019
Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 31196855	2019
Clinicopathologic and Molecular Features of Paired Cases of Metachronous Ovarian Serous Borderline Tumor and Subsequent Serous Carcinoma. The American journal of surgical pathology\| PubMed ID: 31343420	2019
The Origin and Pathogenesis of Endometriosis. Annual review of pathology\| PubMed ID: 31479615	2020
Spleen tyrosine kinase activity regulates epidermal growth factor receptor signaling pathway in ovarian cancer. EBioMedicine\| PubMed ID: 31492560	2019
Oncogenic BRAF and KRAS mutations in endosalpingiosis. The Journal of pathology\| PubMed ID: 31576556	2020
-mutated ovarian serous borderline tumors are at relatively low risk for progression to serous carcinoma. Oncotarget\| PubMed ID: 31839880	2019
Not All Peritoneal Implants Are Created Equal. Gynecologic oncology\| PubMed ID: 31954499	2020
Low-grade serous ovarian cancer: State of the science. Gynecologic oncology\| PubMed ID: 31969252	2020
Epithelial Cells in Endometriosis and Adenomyosis Upregulate STING Expression. Reproductive sciences (Thousand Oaks, Calif.)\| PubMed ID: 32046461	2020
Assessing aneuploidy with repetitive element sequencing. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32075918	2020
Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming. Nature communications\| PubMed ID: 32483112	2020
Methylomic Landscapes of Ovarian Cancer Precursor Lesions. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 32817081	2020
Inhibition of the MYC-Regulated Glutaminase Metabolic Axis Is an Effective Synthetic Lethal Approach for Treating Chemoresistant Ovarian Cancers. Cancer research\| PubMed ID: 32859605	2020
The Origin of Ovarian Cancer Species and Precancerous Landscape. The American journal of pathology\| PubMed ID: 33011111	2021
Pathology and Pathogenesis of Adenomyosis. Seminars in reproductive medicine\| PubMed ID: 33080632	2020
Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis. Cell reports\| PubMed ID: 33296650	2020
Correction: -mutated ovarian serous borderline tumors are at relatively low risk for progression to serous carcinoma. Oncotarget\| PubMed ID: 34194631	2021
Uterine serous carcinoma: key advances and novel treatment approaches. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society\| PubMed ID: 34210768	2021
A novel human endometrial epithelial cell line for modeling gynecological diseases and for drug screening. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 34376780	2021
Mutation and methylation profiles of ectopic and eutopic endometrial tissues. The Journal of pathology\| PubMed ID: 34396532	2021
Combination ATR and PARP Inhibitor (CAPRI): A phase 2 study of ceralasertib plus olaparib in patients with recurrent, platinum-resistant epithelial ovarian cancer. Gynecologic oncology\| PubMed ID: 34620496	2021
Development of small molecule inhibitors targeting PBX1 transcription signaling as a novel cancer therapeutic strategy. iScience\| PubMed ID: 34816098	2021
Current and Emerging Methods for Ovarian Cancer Screening and Diagnostics: A Comprehensive Review. Cancers\| PubMed ID: 35740550	2022
Serous tubal intra-epithelial carcinoma: what do we really know at this point? Histopathology\| PubMed ID: 35859323	2022
Treating ARID1A mutated cancers by harnessing synthetic lethality and DNA damage response. Journal of biomedical science\| PubMed ID: 36123603	2022
Targeting glutamine metabolism enhances responses to platinum-based chemotherapy in triple-negative breast cancers (TNBC). Genes & diseases\| PubMed ID: 36157486	2022
Spatial Transcriptomic Analysis of Ovarian Cancer Precursors Reveals Reactivation of IGFBP2 during Pathogenesis. Cancer research\| PubMed ID: 36206311	2022
Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. bioRxiv : the preprint server for biology\| PubMed ID: 36747644	2023
A novel human endometrial epithelial cell line for modeling gynecological diseases and for drug screening. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 36775477	2021