David L. Spector

The dynamic organization of the perinucleolar compartment in the cell nucleus.

Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity.

Phosphorothioate antisense oligonucleotides induce the formation of nuclear bodies.

The perinucleolar compartment and transcription.

Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo.

Nucleocytoplasmic shuttling: a novel in vivo property of antisense phosphorothioate oligodeoxynucleotides.

Quantitative imaging of pre-mRNA splicing factors in living cells.

Metabolic-energy-dependent movement of PML bodies within the mammalian cell nucleus.

Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing.

A molecular dissection of nuclear function. Conference on the dynamic nucleus: questions and implications.

Sequential entry of components of the gene expression machinery into daughter nuclei.

Nuclear choreography: interpretations from living cells.

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.

The dynamics of chromosome organization and gene regulation.

From silencing to gene expression: real-time analysis in single cells.

Tissue-specific expression and dynamic organization of SR splicing factors in Arabidopsis.

"On the move"ments of nuclear components in living cells.

Spatial and temporal regulation of Condensins I and II in mitotic chromosome assembly in human cells.

Proteomic analysis of interchromatin granule clusters.

Dynamics of single mRNPs in nuclei of living cells.

Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance.

Stopping for FISH and chips along the chromatin fiber superhighway.

Hypophosphorylated SR splicing factors transiently localize around active nucleolar organizing regions in telophase daughter nuclei.

Centromere positioning and dynamics in living Arabidopsis plants.

Regulating gene expression through RNA nuclear retention.

Rapid, diffusional shuttling of poly(A) RNA between nuclear speckles and the nucleoplasm.

Differential regulation of strand-specific transcripts from Arabidopsis centromeric satellite repeats.

PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein.

SnapShot: Cellular bodies.

Eukaryotic regulatory RNAs: an answer to the 'genome complexity' conundrum.

Identification of nuclear dicing bodies containing proteins for microRNA biogenesis in living Arabidopsis plants.

A genetic locus targeted to the nuclear periphery in living cells maintains its transcriptional competence.

Chromatin dynamics and gene positioning.

Live cell dynamics of promyelocytic leukemia nuclear bodies upon entry into and exit from mitosis.

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility.

3' end processing of a long nuclear-retained noncoding RNA yields a tRNA-like cytoplasmic RNA.

MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles.

Nuclear neighborhoods and gene expression.

Long noncoding RNAs: functional surprises from the RNA world.

An unexpected ending: noncanonical 3' end processing mechanisms.

The life of an mRNA in space and time.

Chromatin dynamics.

A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression.

Nonrigid registration of 2-D and 3-D dynamic cell nuclei images for improved classification of subcellular particle motion.

Nuclear organization and dynamics of 7SK RNA in regulating gene expression.

Nuclear speckles.

Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage.

Direct visualization of the co-transcriptional assembly of a nuclear body by noncoding RNAs.

Four amino acids guide the assembly or disassembly of Arabidopsis histone H3.3-containing nucleosomes.

Biogenesis and function of nuclear bodies.

Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation.

The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult.

The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells.

Chromatin organization and transcriptional regulation.

Lamin A/C is expressed in pluripotent mouse embryonic stem cells.

Chromatin meets its organizers.

Receptor-mediated delivery of engineered nucleases for genome modification.

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

Multiple structural maintenance of chromosome complexes at transcriptional regulatory elements.

Long non-coding RNAs: modulators of nuclear structure and function.

Random monoallelic gene expression increases upon embryonic stem cell differentiation.

Identification and initial functional characterization of a human vascular cell-enriched long noncoding RNA.

Random monoallelic expression: regulating gene expression one allele at a time.

Non-rigid multi-frame registration of cell nuclei in live cell fluorescence microscopy image data.

Transient pairing of homologous Oct4 alleles accompanies the onset of embryonic stem cell differentiation.

Regulation of the ESC transcriptome by nuclear long noncoding RNAs.

Quantitative analysis of chromatin interaction changes upon a 4.3 Mb deletion at mouse 4E2.

Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss.

Mammary Tumor-Associated RNAs Impact Tumor Cell Proliferation, Invasion, and Migration.

Identification and Characterization of a Class of MALAT1-like Genomic Loci.

A lncRNA fine tunes the dynamics of a cell state transition involving , and DNA methylation.

Antisense Oligonucleotide-mediated Knockdown in Mammary Tumor Organoids.

Therapeutic Targeting of Long Non-Coding RNAs in Cancer.

POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer.

MALAT1 long non-coding RNA and breast cancer.

Long Non-Coding RNA: Functional Implications.

Comprehensive analysis of structural variants in breast cancer genomes using single-molecule sequencing.

MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression.

: a long non-coding RNA involved in breast cancer progression.

lncRNA regulates Myc translation in hepatocellular carcinoma via sequestering TIAR.

Activating a collaborative innate-adaptive immune response to control metastasis.

Noncoding RNAs: biology and applications-a Keystone Symposia report.

Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics.

Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage.

Simultaneous visualization of RNA transcripts and proteins in whole-mount mouse preimplantation embryos using single-molecule fluorescence hybridization and immunofluorescence microscopy.

Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment.

Testing for Phylogenetic Signal in Single-Cell RNA-Seq Data.

Single Oligonucleotide Capture of RNA And Temperature Elution Series ( ) for Identification of RNA-binding Proteins.