Yu-Hua Tseng

Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.

Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.

Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin.

Differential roles of insulin receptor substrates in brown adipocyte differentiation.

Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse.

Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin.

Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes.

Developmental origin of fat: tracking obesity to its source.

Rad GTPase deficiency leads to cardiac hypertrophy.

Dissection of the insulin signaling pathway via quantitative phosphoproteomics.

Substance P as a novel anti-obesity target.

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure.

Identification and importance of brown adipose tissue in adult humans.

Adipose tissue expression and genetic variants of the bone morphogenetic protein receptor 1A gene (BMPR1A) are associated with human obesity.

Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism.

Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription.

Cellular bioenergetics as a target for obesity therapy.

Cross talk between insulin and bone morphogenetic protein signaling systems in brown adipogenesis.

Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat.

Genetic and evolutionary analyses of the human bone morphogenetic protein receptor 2 (BMPR2) in the pathophysiology of obesity.

Insulin/IGF-I regulation of necdin and brown adipocyte differentiation via CREB- and FoxO1-associated pathways.

Necdin controls proliferation of white adipocyte progenitor cells.

Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway.

Intrinsic differences in adipocyte precursor cells from different white fat depots.

Increased mitochondrial activity in BMP7-treated brown adipocytes, due to increased CPT1- and CD36-mediated fatty acid uptake.

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity.

p62 links β-adrenergic input to mitochondrial function and thermogenesis.

Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance.

Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat.

Anti-melanin-concentrating hormone treatment attenuates chronic experimental colitis and fibrosis.

Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat.

Brown adipose tissue: Recent insights into development, metabolic function and therapeutic potential.

Brown adipose tissue: development, metabolism and beyond.

Quantification of human and rodent brown adipose tissue function using 99mTc-methoxyisobutylisonitrile SPECT/CT and 18F-FDG PET/CT.

Systemic control of brown fat thermogenesis: integration of peripheral and central signals.

Brown fat fuel utilization and thermogenesis.

Glial cell line-derived neurotrophic factor protects against high-fat diet-induced obesity.

Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis.

Isolation of progenitors that exhibit myogenic/osteogenic bipotency in vitro by fluorescence-activated cell sorting from human fetal muscle.

IRF4 is a key thermogenic transcriptional partner of PGC-1α.

ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes.

Unwiring the transcriptional heat circuit.

A novel role for subcutaneous adipose tissue in exercise-induced improvements in glucose homeostasis.

Disruption of insulin signaling in Myf5-expressing progenitors leads to marked paucity of brown fat but normal muscle development.

Genetic and functional characterization of clonally derived adult human brown adipocytes.

Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes.

Curcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browning.

MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1α signaling network.

The Thermogenic Circuit: Regulators of Thermogenic Competency and Differentiation.

3D brown adipogenesis to create "Brown-Fat-in-Microstrands".

Tribbles 3 inhibits brown adipocyte differentiation and function by suppressing insulin signaling.

Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance.

Monoacylglycerol Analysis Using MS/MS(ALL) Quadruple Time of Flight Mass Spectrometry.

Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals.

Protocols for Generation of Immortalized Human Brown and White Preadipocyte Cell Lines.

The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.

Optical visualisation of thermogenesis in stimulated single-cell brown adipocytes.

Identification and characterization of a supraclavicular brown adipose tissue in mice.

Ca-associated triphasic pH changes in mitochondria during brown adipocyte activation.

Deciphering adipose tissue heterogeneity.

NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program.

MicroRNA Regulation of Brown Adipogenesis and Thermogenic Energy Expenditure.

Reestablishment of Energy Balance in a Male Mouse Model With POMC Neuron Deletion of BMPR1A.

Integrating Extracellular Flux Measurements and Genome-Scale Modeling Reveals Differences between Brown and White Adipocytes.

Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.

Adapted MS/MS Shotgun Lipidomics Approach for Analysis of Cardiolipin Molecular Species.

12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake.

Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis.

RGB-Color Intensiometric Indicators to Visualize Spatiotemporal Dynamics of ATP in Single Cells.

Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism.

Shades of brown: an introduction for the special focus issue of Adipocyte on "brown and beige/brite adipocytes".

Insulin receptor-mediated signaling regulates pluripotency markers and lineage differentiation.

TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism.

ComBATing aging-does increased brown adipose tissue activity confer longevity?

Afadin is a scaffold protein repressing insulin action via HDAC6 in adipose tissue.

12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat.

Lipokines and Thermogenesis.

Cell-autonomous light sensitivity via Opsin3 regulates fuel utilization in brown adipocytes.

FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis.

Analyzing Mitochondrial Function in Brown Adipocytes with a Bioenergetic Analyzer.

Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice.

Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity.

The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis.

Commentary on: "The Presence of Active Brown Adipose Tissue Determines Cold-Induced Energy Expenditure and Oxylipin Profiles in Humans".

Integrated metabolomics reveals altered lipid metabolism in adipose tissue in a model of extreme longevity.

Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells.

The Heating Microenvironment: Intercellular Cross Talk Within Thermogenic Adipose Tissue.

The Link between Stress and IL-6 Is Heating Up.

Lipidomics of brown and white adipose tissue: Implications for energy metabolism.

CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice.

Brown Fat-Activating Lipokine 12,13-diHOME in Human Milk Is Associated With Infant Adiposity.

The involvement of neuroimmune cells in adipose innervation.

Adipocyte Microenvironment: Everybody in the Neighborhood Talks about the Temperature.

Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution.

Vascular smooth muscle-derived Trpv1 progenitors are a source of cold-induced thermogenic adipocytes.

Defining the lineage of thermogenic perivascular adipose tissue.

Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application.

Cold-induction of afadin in brown fat supports its thermogenic capacity.

Narrating the story ARC of adipose tissue aging.

β3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis.

N-butylidenephthalide ameliorates high-fat diet-induced obesity in mice and promotes browning through adrenergic response/AMPK activation in mouse beige adipocytes.

The evolving view of thermogenic adipocytes - ontogeny, niche and function.

Characterization of transcript enrichment and detection bias in single-nucleus RNA-seq for mapping of distinct human adipocyte lineages.

Signaling Lipidomic Analysis of Thermogenic Adipocytes.

Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue.

Telomerase Reverse Transcriptase Expression Marks a Population of Rare Adipose Tissue Stem Cells.

Transplantation of Brown Adipose Tissue with the Ability of Converting Omega-6 to Omega-3 Polyunsaturated Fatty Acids Counteracts High-Fat-Induced Metabolic Abnormalities in Mice.

Endothelial Cells Induced Progenitors Into Brown Fat to Reduce Atherosclerosis.

Silk Hydrogel-Mediated Delivery of Bone Morphogenetic Protein 7 Directly to Subcutaneous White Adipose Tissue Increases Browning and Energy Expenditure.

Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation.

Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling.

Architecture of the outbred brown fat proteome defines regulators of metabolic physiology.

ADRA1A-Gα signalling potentiates adipocyte thermogenesis through CKB and TNAP.

Adipose tissue in communication: within and without.

Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity.