Section on Integrative Physiology and Metabolism,
Research Division,
Joslin Diabetes Center,
Section on Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center
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Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.
Proceedings of the National Academy of Sciences of the United States of America Dec, 1999 | Pubmed ID: 10611312
Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.
Molecular and cellular biology Feb, 2002 | Pubmed ID: 11784871
Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin.
The Journal of biological chemistry Aug, 2002 | Pubmed ID: 12082100
Differential roles of insulin receptor substrates in brown adipocyte differentiation.
Molecular and cellular biology Mar, 2004 | Pubmed ID: 14966273
Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2004 | Pubmed ID: 15240880
Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin.
Nature cell biology Jun, 2005 | Pubmed ID: 15895078
Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes.
Cell Aug, 2005 | Pubmed ID: 16096055
Developmental origin of fat: tracking obesity to its source.
Cell Oct, 2007 | Pubmed ID: 17956727
Rad GTPase deficiency leads to cardiac hypertrophy.
Circulation Dec, 2007 | Pubmed ID: 18056528
Dissection of the insulin signaling pathway via quantitative phosphoproteomics.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2008 | Pubmed ID: 18268350
Substance P as a novel anti-obesity target.
Gastroenterology Mar, 2008 | Pubmed ID: 18325388
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure.
Nature Aug, 2008 | Pubmed ID: 18719589
Identification and importance of brown adipose tissue in adult humans.
The New England journal of medicine Apr, 2009 | Pubmed ID: 19357406
Adipose tissue expression and genetic variants of the bone morphogenetic protein receptor 1A gene (BMPR1A) are associated with human obesity.
Diabetes Sep, 2009 | Pubmed ID: 19502417
Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism.
Cytokine & growth factor reviews , 2009 | Pubmed ID: 19896888
Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription.
The Journal of biological chemistry May, 2010 | Pubmed ID: 20360006
Cellular bioenergetics as a target for obesity therapy.
Nature reviews. Drug discovery Jun, 2010 | Pubmed ID: 20514071
Cross talk between insulin and bone morphogenetic protein signaling systems in brown adipogenesis.
Molecular and cellular biology Sep, 2010 | Pubmed ID: 20584981
Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2011 | Pubmed ID: 21173238
Genetic and evolutionary analyses of the human bone morphogenetic protein receptor 2 (BMPR2) in the pathophysiology of obesity.
PloS one Feb, 2011 | Pubmed ID: 21311592
Insulin/IGF-I regulation of necdin and brown adipocyte differentiation via CREB- and FoxO1-associated pathways.
Endocrinology Oct, 2011 | Pubmed ID: 21862615
Necdin controls proliferation of white adipocyte progenitor cells.
PloS one , 2012 | Pubmed ID: 22292082
Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology May, 2012 | Pubmed ID: 22331196
Intrinsic differences in adipocyte precursor cells from different white fat depots.
Diabetes Jul, 2012 | Pubmed ID: 22596050
Increased mitochondrial activity in BMP7-treated brown adipocytes, due to increased CPT1- and CD36-mediated fatty acid uptake.
Antioxidants & redox signaling Jul, 2013 | Pubmed ID: 22938691
Brown adipose tissue regulates glucose homeostasis and insulin sensitivity.
The Journal of clinical investigation Jan, 2013 | Pubmed ID: 23221344
p62 links β-adrenergic input to mitochondrial function and thermogenesis.
The Journal of clinical investigation Jan, 2013 | Pubmed ID: 23257354
Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance.
Nature medicine Feb, 2013 | Pubmed ID: 23291629
Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat.
Nature Mar, 2013 | Pubmed ID: 23485971
Anti-melanin-concentrating hormone treatment attenuates chronic experimental colitis and fibrosis.
American journal of physiology. Gastrointestinal and liver physiology May, 2013 | Pubmed ID: 23538494
Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat.
Nature medicine May, 2013 | Pubmed ID: 23603815
Brown adipose tissue: Recent insights into development, metabolic function and therapeutic potential.
Adipocyte Jan, 2012 | Pubmed ID: 23700507
Brown adipose tissue: development, metabolism and beyond.
The Biochemical journal Jul, 2013 | Pubmed ID: 23805974
Quantification of human and rodent brown adipose tissue function using 99mTc-methoxyisobutylisonitrile SPECT/CT and 18F-FDG PET/CT.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Nov, 2013 | Pubmed ID: 24071505
Systemic control of brown fat thermogenesis: integration of peripheral and central signals.
Annals of the New York Academy of Sciences Oct, 2013 | Pubmed ID: 24111913
Brown fat fuel utilization and thermogenesis.
Trends in endocrinology and metabolism: TEM Apr, 2014 | Pubmed ID: 24389130
Glial cell line-derived neurotrophic factor protects against high-fat diet-induced obesity.
American journal of physiology. Gastrointestinal and liver physiology Mar, 2014 | Pubmed ID: 24458024
Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis.
Cell Jan, 2014 | Pubmed ID: 24485453
Isolation of progenitors that exhibit myogenic/osteogenic bipotency in vitro by fluorescence-activated cell sorting from human fetal muscle.
Stem cell reports Jan, 2014 | Pubmed ID: 24678452
IRF4 is a key thermogenic transcriptional partner of PGC-1α.
Cell Jul, 2014 | Pubmed ID: 24995979
ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes.
Science translational medicine Jul, 2014 | Pubmed ID: 25080478
Unwiring the transcriptional heat circuit.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2014 | Pubmed ID: 25261553
A novel role for subcutaneous adipose tissue in exercise-induced improvements in glucose homeostasis.
Diabetes Jun, 2015 | Pubmed ID: 25605808
Disruption of insulin signaling in Myf5-expressing progenitors leads to marked paucity of brown fat but normal muscle development.
Endocrinology May, 2015 | Pubmed ID: 25625589
Genetic and functional characterization of clonally derived adult human brown adipocytes.
Nature medicine Apr, 2015 | Pubmed ID: 25774848
Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes.
Nature medicine Jul, 2015 | Pubmed ID: 26076036
Curcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browning.
Scientific reports Aug, 2015 | Pubmed ID: 26269357
MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1α signaling network.
EMBO reports Oct, 2015 | Pubmed ID: 26303948
The Thermogenic Circuit: Regulators of Thermogenic Competency and Differentiation.
Genes & diseases Jun, 2015 | Pubmed ID: 26491708
3D brown adipogenesis to create "Brown-Fat-in-Microstrands".
Biomaterials Jan, 2016 | Pubmed ID: 26496384
Tribbles 3 inhibits brown adipocyte differentiation and function by suppressing insulin signaling.
Biochemical and biophysical research communications Feb, 2016 | Pubmed ID: 26801556
Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance.
Diabetologia Aug, 2016 | Pubmed ID: 27209464
Monoacylglycerol Analysis Using MS/MS(ALL) Quadruple Time of Flight Mass Spectrometry.
Metabolites Aug, 2016 | Pubmed ID: 27548241
Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals.
Cell metabolism 09, 2016 | Pubmed ID: 27626200
Protocols for Generation of Immortalized Human Brown and White Preadipocyte Cell Lines.
Methods in molecular biology (Clifton, N.J.) , 2017 | Pubmed ID: 28244042
The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.
Nature medicine May, 2017 | Pubmed ID: 28346411
Optical visualisation of thermogenesis in stimulated single-cell brown adipocytes.
Scientific reports May, 2017 | Pubmed ID: 28469146
Identification and characterization of a supraclavicular brown adipose tissue in mice.
JCI insight Jun, 2017 | Pubmed ID: 28570265
Ca-associated triphasic pH changes in mitochondria during brown adipocyte activation.
Molecular metabolism Aug, 2017 | Pubmed ID: 28752044
Deciphering adipose tissue heterogeneity.
Annals of the New York Academy of Sciences Jan, 2018 | Pubmed ID: 28763833
NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program.
Nature cell biology Sep, 2017 | Pubmed ID: 28812581
MicroRNA Regulation of Brown Adipogenesis and Thermogenic Energy Expenditure.
Frontiers in endocrinology , 2017 | Pubmed ID: 28878735
Reestablishment of Energy Balance in a Male Mouse Model With POMC Neuron Deletion of BMPR1A.
Endocrinology 12, 2017 | Pubmed ID: 29040444
Integrating Extracellular Flux Measurements and Genome-Scale Modeling Reveals Differences between Brown and White Adipocytes.
Cell reports Dec, 2017 | Pubmed ID: 29241534
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.
Nature medicine Mar, 2018 | Pubmed ID: 29400713
Adapted MS/MS Shotgun Lipidomics Approach for Analysis of Cardiolipin Molecular Species.
Lipids Jan, 2018 | Pubmed ID: 29488636
12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake.
Cell metabolism May, 2018 | Pubmed ID: 29719226
Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis.
Cell metabolism Jul, 2018 | Pubmed ID: 29861389
RGB-Color Intensiometric Indicators to Visualize Spatiotemporal Dynamics of ATP in Single Cells.
Angewandte Chemie (International ed. in English) Aug, 2018 | Pubmed ID: 29952110
Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism.
Cell reports Jul, 2018 | Pubmed ID: 30021173
Shades of brown: an introduction for the special focus issue of Adipocyte on "brown and beige/brite adipocytes".
Adipocyte Apr, 2016 | Pubmed ID: 30168365
Insulin receptor-mediated signaling regulates pluripotency markers and lineage differentiation.
Molecular metabolism 12, 2018 | Pubmed ID: 30316806
TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism.
Nature metabolism Feb, 2019 | Pubmed ID: 31032475
ComBATing aging-does increased brown adipose tissue activity confer longevity?
GeroScience Jun, 2019 | Pubmed ID: 31230192
Afadin is a scaffold protein repressing insulin action via HDAC6 in adipose tissue.
EMBO reports Aug, 2019 | Pubmed ID: 31264358
12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat.
Cell metabolism Oct, 2019 | Pubmed ID: 31353262
Lipokines and Thermogenesis.
Endocrinology Oct, 2019 | Pubmed ID: 31504387
Cell-autonomous light sensitivity via Opsin3 regulates fuel utilization in brown adipocytes.
PLoS biology Feb, 2020 | Pubmed ID: 32040503
FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis.
Nature communications Mar, 2020 | Pubmed ID: 32184391
Analyzing Mitochondrial Function in Brown Adipocytes with a Bioenergetic Analyzer.
Methods in molecular biology (Clifton, N.J.) , 2020 | Pubmed ID: 32219757
Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice.
The Journal of clinical investigation May, 2020 | Pubmed ID: 32250344
Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity.
Nature communications Apr, 2020 | Pubmed ID: 32355218
The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis.
Nature communications May, 2020 | Pubmed ID: 32457326
Commentary on: "The Presence of Active Brown Adipose Tissue Determines Cold-Induced Energy Expenditure and Oxylipin Profiles in Humans".
The Journal of clinical endocrinology and metabolism Aug, 2020 | Pubmed ID: 32559764
Integrated metabolomics reveals altered lipid metabolism in adipose tissue in a model of extreme longevity.
GeroScience Dec, 2020 | Pubmed ID: 32632845
Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells.
Cell Aug, 2020 | Pubmed ID: 32679029
The Heating Microenvironment: Intercellular Cross Talk Within Thermogenic Adipose Tissue.
Diabetes Aug, 2020 | Pubmed ID: 32690661
The Link between Stress and IL-6 Is Heating Up.
Cell metabolism Aug, 2020 | Pubmed ID: 32755607
Lipidomics of brown and white adipose tissue: Implications for energy metabolism.
Biochimica et biophysica acta. Molecular and cell biology of lipids Oct, 2020 | Pubmed ID: 32763428
CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice.
Science translational medicine Aug, 2020 | Pubmed ID: 32848096
Brown Fat-Activating Lipokine 12,13-diHOME in Human Milk Is Associated With Infant Adiposity.
The Journal of clinical endocrinology and metabolism Jan, 2021 | Pubmed ID: 33135728
The involvement of neuroimmune cells in adipose innervation.
Molecular medicine (Cambridge, Mass.) 12, 2020 | Pubmed ID: 33297933
Adipocyte Microenvironment: Everybody in the Neighborhood Talks about the Temperature.
Cell metabolism Jan, 2021 | Pubmed ID: 33406404
Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution.
Cell reports Jan, 2021 | Pubmed ID: 33440156
Vascular smooth muscle-derived Trpv1 progenitors are a source of cold-induced thermogenic adipocytes.
Nature metabolism Apr, 2021 | Pubmed ID: 33846638
Defining the lineage of thermogenic perivascular adipose tissue.
Nature metabolism Apr, 2021 | Pubmed ID: 33846639
Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application.
Molecular metabolism Sep, 2021 | Pubmed ID: 33878401
Cold-induction of afadin in brown fat supports its thermogenic capacity.
Scientific reports May, 2021 | Pubmed ID: 33963248
Narrating the story ARC of adipose tissue aging.
Developmental cell May, 2021 | Pubmed ID: 34004148
β3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis.
JCI insight Jun, 2021 | Pubmed ID: 34100382
N-butylidenephthalide ameliorates high-fat diet-induced obesity in mice and promotes browning through adrenergic response/AMPK activation in mouse beige adipocytes.
Biochimica et biophysica acta. Molecular and cell biology of lipids Dec, 2021 | Pubmed ID: 34487913
The evolving view of thermogenic adipocytes - ontogeny, niche and function.
Nature reviews. Endocrinology Dec, 2021 | Pubmed ID: 34625737
Characterization of transcript enrichment and detection bias in single-nucleus RNA-seq for mapping of distinct human adipocyte lineages.
Genome research Feb, 2022 | Pubmed ID: 35042723
Signaling Lipidomic Analysis of Thermogenic Adipocytes.
Methods in molecular biology (Clifton, N.J.) , 2022 | Pubmed ID: 35167102
Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue.
Cell metabolism Apr, 2022 | Pubmed ID: 35305295
Telomerase Reverse Transcriptase Expression Marks a Population of Rare Adipose Tissue Stem Cells.
Stem cells (Dayton, Ohio) 03, 2022 | Pubmed ID: 35511869
Transplantation of Brown Adipose Tissue with the Ability of Converting Omega-6 to Omega-3 Polyunsaturated Fatty Acids Counteracts High-Fat-Induced Metabolic Abnormalities in Mice.
International journal of molecular sciences May, 2022 | Pubmed ID: 35628137
Endothelial Cells Induced Progenitors Into Brown Fat to Reduce Atherosclerosis.
Circulation research Jul, 2022 | Pubmed ID: 35642564
Silk Hydrogel-Mediated Delivery of Bone Morphogenetic Protein 7 Directly to Subcutaneous White Adipose Tissue Increases Browning and Energy Expenditure.
Frontiers in bioengineering and biotechnology , 2022 | Pubmed ID: 35646839
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation.
Nature metabolism Jun, 2022 | Pubmed ID: 35760872
Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling.
Nature communications Oct, 2022 | Pubmed ID: 36241662
Architecture of the outbred brown fat proteome defines regulators of metabolic physiology.
Cell Nov, 2022 | Pubmed ID: 36334589
ADRA1A-Gα signalling potentiates adipocyte thermogenesis through CKB and TNAP.
Nature metabolism Nov, 2022 | Pubmed ID: 36344764
Adipose tissue in communication: within and without.
Nature reviews. Endocrinology Feb, 2023 | Pubmed ID: 36526875
Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity.
Nature metabolism Dec, 2022 | Pubmed ID: 36536132
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