Anaesthesia,
Pain,
and Critical Care Sciences,
School of Physiology,
Pharmacology,
& Neuroscience,
Anaesthesia, Pain, and Critical Care Sciences, School of Physiology, Pharmacology, & Neuroscience
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Activation of Brainstem Pro-opiomelanocortin Neurons Produces Opioidergic Analgesia, Bradycardia and Bradypnoea.
PloS one , 2016 | Pubmed ID: 27077912
The nucleus of the solitary tract: an integrating station for nociceptive and cardiorespiratory afferents.
Experimental physiology Mar, 2002 | Pubmed ID: 11856972
Investigation of systemic bupivacaine toxicity using the in situ perfused working heart-brainstem preparation of the rat.
Anesthesiology Dec, 2002 | Pubmed ID: 12459684
Nociception attenuates parasympathetic but not sympathetic baroreflex via NK1 receptors in the rat nucleus tractus solitarii.
The Journal of physiology Sep, 2003 | Pubmed ID: 12813142
Targeting brain stem centers of cardiovascular control using adenoviral vectors: impact of promoters on transgene expression.
Physiological genomics Jan, 2005 | Pubmed ID: 15561757
A decerebrate, artificially-perfused in situ preparation of rat: utility for the study of autonomic and nociceptive processing.
Journal of neuroscience methods Sep, 2006 | Pubmed ID: 16499970
Disinhibition of the cardiac limb of the arterial baroreflex in rat: a role for metabotropic glutamate receptors in the nucleus tractus solitarii.
The Journal of physiology Sep, 2006 | Pubmed ID: 16809369
Hierarchical recruitment of the sympathetic and parasympathetic limbs of the baroreflex in normotensive and spontaneously hypertensive rats.
The Journal of physiology Mar, 2007 | Pubmed ID: 17170043
Reflexly evoked coactivation of cardiac vagal and sympathetic motor outflows: observations and functional implications.
Clinical and experimental pharmacology & physiology Dec, 2006 | Pubmed ID: 17184509
Dominant role of aortic baroreceptors in the cardiac baroreflex of the rat in situ.
Autonomic neuroscience : basic & clinical Nov, 2008 | Pubmed ID: 18479978
Retrograde adenoviral vector targeting of nociresponsive pontospinal noradrenergic neurons in the rat in vivo.
The Journal of comparative neurology Jan, 2009 | Pubmed ID: 19003793
Retrograde viral vector-mediated inhibition of pontospinal noradrenergic neurons causes hyperalgesia in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2009 | Pubmed ID: 19828800
Analgesia in conjunction with normalisation of thermal sensation following deep brain stimulation for central post-stroke pain.
Pain Dec, 2009 | Pubmed ID: 19833434
TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord.
The European journal of neuroscience Jun, 2010 | Pubmed ID: 20497466
An exploration of the control of micturition using a novel in situ arterially perfused rat preparation.
Frontiers in neuroscience , 2011 | Pubmed ID: 21625609
Processing of central and reflex vagal drives by rat cardiac ganglion neurones: an intracellular analysis.
The Journal of physiology Dec, 2011 | Pubmed ID: 22005679
Prolonged ketamine infusion as a therapy for complex regional pain syndrome: synergism with antagonism?
British journal of clinical pharmacology Feb, 2014 | Pubmed ID: 23701138
A functional analysis of the influence of β3-adrenoceptors on the rat micturition cycle.
The Journal of pharmacology and experimental therapeutics Nov, 2013 | Pubmed ID: 24008334
Systemic dexmedetomidine augments inhibitory synaptic transmission in the superficial dorsal horn through activation of descending noradrenergic control: an in vivo patch-clamp analysis of analgesic mechanisms.
Pain Mar, 2014 | Pubmed ID: 24355412
Optoactivation of locus ceruleus neurons evokes bidirectional changes in thermal nociception in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2014 | Pubmed ID: 24647936
Mapping the cellular electrophysiology of rat sympathetic preganglionic neurones to their roles in cardiorespiratory reflex integration: a whole cell recording study in situ.
The Journal of physiology May, 2014 | Pubmed ID: 24665100
Increased intrinsic excitability of muscle vasoconstrictor preganglionic neurons may contribute to the elevated sympathetic activity in hypertensive rats.
Journal of neurophysiology Dec, 2014 | Pubmed ID: 25122704
Intrathecal reboxetine suppresses evoked and ongoing neuropathic pain behaviours by restoring spinal noradrenergic inhibitory tone.
Pain Feb, 2015 | Pubmed ID: 25599454
Modelling the vascular response to sympathetic postganglionic nerve activity.
Journal of theoretical biology Apr, 2015 | Pubmed ID: 25698230
Influence of age on respiratory modulation of muscle sympathetic nerve activity, blood pressure and baroreflex function in humans.
Experimental physiology Sep, 2015 | Pubmed ID: 26154775
Retrograde optogenetic characterization of the pontospinal module of the locus coeruleus with a canine adenoviral vector.
Brain research Jun, 2016 | Pubmed ID: 26903420
Characterising the Analgesic Effect of Different Targets for Deep Brain Stimulation in Trigeminal Anaesthesia Dolorosa.
Stereotactic and functional neurosurgery , 2016 | Pubmed ID: 27322524
Deep brain stimulation of the periaqueductal gray releases endogenous opioids in humans.
NeuroImage Feb, 2017 | Pubmed ID: 27554530
Brainstem sources of cardiac vagal tone and respiratory sinus arrhythmia.
The Journal of physiology Dec, 2016 | Pubmed ID: 27654879
Resolving the Brainstem Contributions to Attentional Analgesia.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2017 | Pubmed ID: 28096471
Single Electrode Deep Brain Stimulation with Dual Targeting at Dual Frequency for the Treatment of Chronic Pain: A Case Series and Review of the Literature.
Brain sciences Jan, 2017 | Pubmed ID: 28098766
Muro-Neuro-Urodynamics; a Review of the Functional Assessment of Mouse Lower Urinary Tract Function.
Frontiers in physiology , 2017 | Pubmed ID: 28220079
Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats.
eLife Oct, 2017 | Pubmed ID: 29027903
Characterization of mouse neuro-urological dynamics in a novel decerebrate arterially perfused mouse (DAPM) preparation.
Neurourology and urodynamics Apr, 2018 | Pubmed ID: 29333621
Ultrasound-guided, open-source microneurography: Approaches to improve recordings from peripheral nerves in man.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Nov, 2018 | Pubmed ID: 30107982
Abnormal Locus Coeruleus Sleep Activity Alters Sleep Signatures of Memory Consolidation and Impairs Place Cell Stability and Spatial Memory.
Current biology : CB Nov, 2018 | Pubmed ID: 30393040
Locus Coeruleus tracking of prediction errors optimises cognitive flexibility: An Active Inference model.
PLoS computational biology Jan, 2019 | Pubmed ID: 30608922
Sildenafil, a phosphodiesterase type 5 inhibitor, augments sphincter bursting and bladder afferent activity to enhance storage function and voiding efficiency in mice.
BJU international Jul, 2019 | Pubmed ID: 30636087
Modulation of Bladder Wall Micromotions Alters Intravesical Pressure Activity in the Isolated Bladder.
Frontiers in physiology , 2018 | Pubmed ID: 30687132
Platelet dysfunction after Out of Hospital Cardiac Arrest. Results from POHCAR: A prospective observational, cohort study.
Resuscitation Mar, 2019 | Pubmed ID: 30716426
Behavioral correlates of activity of optogenetically identified locus coeruleus noradrenergic neurons in rats performing T-maze tasks.
Scientific reports Feb, 2019 | Pubmed ID: 30718532
Assessing Long-term Neurodevelopmental Outcome Following General Anesthesia in Early Childhood: Challenges and Opportunities.
Anesthesia and analgesia Apr, 2019 | Pubmed ID: 30883414
Influence of sildenafil on the purinergic components of nerve-mediated and urothelial ATP release from the bladder of normal and spinal cord injured mice.
British journal of pharmacology Jul, 2019 | Pubmed ID: 30924527
Hedonic drinking engages a supraspinal inhibition of thermal nociception in adult rats.
Pain May, 2019 | Pubmed ID: 31008815
On the presence and functional significance of sympathetic premotor neurons with collateralized spinal axons in the rat.
The Journal of physiology Jul, 2019 | Pubmed ID: 31077360
Acceptability of a primary care-based opioid and pain review service: a mixed-methods evaluation in England.
The British journal of general practice : the journal of the Royal College of General Practitioners Feb, 2020 | Pubmed ID: 31594772
Redefining Noradrenergic Neuromodulation of Behavior: Impacts of a Modular Locus Coeruleus Architecture.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2019 | Pubmed ID: 31619493
Evaluation of a primary care-based opioid and pain review service: a mixed-methods evaluation in two GP practices in England.
The British journal of general practice : the journal of the Royal College of General Practitioners Feb, 2020 | Pubmed ID: 31791939
Regulation of food intake by astrocytes in the brainstem dorsal vagal complex.
Glia Jun, 2020 | Pubmed ID: 31880353
Interventions to treat pain in paediatric CFS/ME: a systematic review.
BMJ paediatrics open , 2020 | Pubmed ID: 32201745
Locus coeruleus norepinephrine activity mediates sensory-evoked awakenings from sleep.
Science advances Apr, 2020 | Pubmed ID: 32285002
Probabilistic, spinally-gated control of bladder pressure and autonomous micturition by Barrington's nucleus CRH neurons.
eLife Apr, 2020 | Pubmed ID: 32347794
Noradrenaline Release from Locus Coeruleus Terminals in the Hippocampus Enhances Excitation-Spike Coupling in CA1 Pyramidal Neurons Via β-Adrenoceptors.
Cerebral cortex (New York, N.Y. : 1991) Nov, 2020 | Pubmed ID: 32607551
Sweet taste does not modulate pain perception in adult humans.
Wellcome open research , 2020 | Pubmed ID: 32704547
Parallel cortical-brainstem pathways to attentional analgesia.
NeuroImage Feb, 2021 | Pubmed ID: 33186712
The effects of xenon on sevoflurane anesthesia-induced acidosis and brain cell apoptosis in immature rats.
Paediatric anaesthesia Mar, 2021 | Pubmed ID: 33187024
Anatomically and functionally distinct locus coeruleus efferents mediate opposing effects on anxiety-like behavior.
Neurobiology of stress Nov, 2020 | Pubmed ID: 33344735
The safety of anaesthetists and intensivists during the first COVID-19 surge supports extension of use of airborne protection PPE to ward staff.
Clinical medicine (London, England) Mar, 2021 | Pubmed ID: 33509933
Loss of cortical control over the descending pain modulatory system determines the development of the neuropathic pain state in rats.
eLife Feb, 2021 | Pubmed ID: 33555256
Central pain modulatory mechanisms of attentional analgesia are preserved in fibromyalgia.
Pain Jan, 2022 | Pubmed ID: 33941755
Identification of the source events for aerosol generation during oesophago-gastro-duodenoscopy.
Gut May, 2022 | Pubmed ID: 34187844
Multisite silicon probes enable simultaneous recording of spontaneous and evoked activity in multiple isolated C-fibres in rat saphenous nerve.
Journal of neuroscience methods Feb, 2022 | Pubmed ID: 34800543
Evaluating the association of TRPA1 gene polymorphisms with pain sensitivity: a protocol for an adaptive recall by genotype study.
BMC medical genomics Jan, 2022 | Pubmed ID: 35022050
Simultaneous brain, brainstem, and spinal cord pharmacological-fMRI reveals involvement of an endogenous opioid network in attentional analgesia.
eLife Jan, 2022 | Pubmed ID: 35080494
Advancing respiratory-cardiovascular physiology with the working heart-brainstem preparation over 25 years.
The Journal of physiology May, 2022 | Pubmed ID: 35294064
Pro-opiomelanocortin neurons in the nucleus of the solitary tract mediate endorphinergic endogenous analgesia in mice.
Pain May, 2023 | Pubmed ID: 36448978
Aidan P. Nickerson1,2,
Graeme W. T. Newton1,
James H. O'Sullivan3,
Manuel Martinez-Perez4,
Anna C. Sales1,
Gethin Williams5,
Anthony E. Pickering1,
James P. Dunham1
1Anaesthesia, Pain, and Critical Care Sciences, School of Physiology, Pharmacology, & Neuroscience, University of Bristol,
2, Eli Lilly and Company,
3Department of Computer Science, University of Bristol,
4Department of Aerospace Engineering, University of Bristol,
5Research Computing, University of Bristol
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