Anthony E. Pickering

Activation of Brainstem Pro-opiomelanocortin Neurons Produces Opioidergic Analgesia, Bradycardia and Bradypnoea.

The nucleus of the solitary tract: an integrating station for nociceptive and cardiorespiratory afferents.

Investigation of systemic bupivacaine toxicity using the in situ perfused working heart-brainstem preparation of the rat.

Nociception attenuates parasympathetic but not sympathetic baroreflex via NK1 receptors in the rat nucleus tractus solitarii.

Targeting brain stem centers of cardiovascular control using adenoviral vectors: impact of promoters on transgene expression.

A decerebrate, artificially-perfused in situ preparation of rat: utility for the study of autonomic and nociceptive processing.

Disinhibition of the cardiac limb of the arterial baroreflex in rat: a role for metabotropic glutamate receptors in the nucleus tractus solitarii.

Hierarchical recruitment of the sympathetic and parasympathetic limbs of the baroreflex in normotensive and spontaneously hypertensive rats.

Reflexly evoked coactivation of cardiac vagal and sympathetic motor outflows: observations and functional implications.

Dominant role of aortic baroreceptors in the cardiac baroreflex of the rat in situ.

Retrograde adenoviral vector targeting of nociresponsive pontospinal noradrenergic neurons in the rat in vivo.

Retrograde viral vector-mediated inhibition of pontospinal noradrenergic neurons causes hyperalgesia in rats.

Analgesia in conjunction with normalisation of thermal sensation following deep brain stimulation for central post-stroke pain.

TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord.

An exploration of the control of micturition using a novel in situ arterially perfused rat preparation.

Processing of central and reflex vagal drives by rat cardiac ganglion neurones: an intracellular analysis.

Prolonged ketamine infusion as a therapy for complex regional pain syndrome: synergism with antagonism?

A functional analysis of the influence of β3-adrenoceptors on the rat micturition cycle.

Systemic dexmedetomidine augments inhibitory synaptic transmission in the superficial dorsal horn through activation of descending noradrenergic control: an in vivo patch-clamp analysis of analgesic mechanisms.

Optoactivation of locus ceruleus neurons evokes bidirectional changes in thermal nociception in rats.

Mapping the cellular electrophysiology of rat sympathetic preganglionic neurones to their roles in cardiorespiratory reflex integration: a whole cell recording study in situ.

Increased intrinsic excitability of muscle vasoconstrictor preganglionic neurons may contribute to the elevated sympathetic activity in hypertensive rats.

Intrathecal reboxetine suppresses evoked and ongoing neuropathic pain behaviours by restoring spinal noradrenergic inhibitory tone.

Modelling the vascular response to sympathetic postganglionic nerve activity.

Influence of age on respiratory modulation of muscle sympathetic nerve activity, blood pressure and baroreflex function in humans.

Retrograde optogenetic characterization of the pontospinal module of the locus coeruleus with a canine adenoviral vector.

Characterising the Analgesic Effect of Different Targets for Deep Brain Stimulation in Trigeminal Anaesthesia Dolorosa.

Deep brain stimulation of the periaqueductal gray releases endogenous opioids in humans.

Brainstem sources of cardiac vagal tone and respiratory sinus arrhythmia.

Resolving the Brainstem Contributions to Attentional Analgesia.

Single Electrode Deep Brain Stimulation with Dual Targeting at Dual Frequency for the Treatment of Chronic Pain: A Case Series and Review of the Literature.

Muro-Neuro-Urodynamics; a Review of the Functional Assessment of Mouse Lower Urinary Tract Function.

Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats.

Characterization of mouse neuro-urological dynamics in a novel decerebrate arterially perfused mouse (DAPM) preparation.

Ultrasound-guided, open-source microneurography: Approaches to improve recordings from peripheral nerves in man.

Abnormal Locus Coeruleus Sleep Activity Alters Sleep Signatures of Memory Consolidation and Impairs Place Cell Stability and Spatial Memory.

Locus Coeruleus tracking of prediction errors optimises cognitive flexibility: An Active Inference model.

Sildenafil, a phosphodiesterase type 5 inhibitor, augments sphincter bursting and bladder afferent activity to enhance storage function and voiding efficiency in mice.

Modulation of Bladder Wall Micromotions Alters Intravesical Pressure Activity in the Isolated Bladder.

Platelet dysfunction after Out of Hospital Cardiac Arrest. Results from POHCAR: A prospective observational, cohort study.

Behavioral correlates of activity of optogenetically identified locus coeruleus noradrenergic neurons in rats performing T-maze tasks.

Assessing Long-term Neurodevelopmental Outcome Following General Anesthesia in Early Childhood: Challenges and Opportunities.

Influence of sildenafil on the purinergic components of nerve-mediated and urothelial ATP release from the bladder of normal and spinal cord injured mice.

Hedonic drinking engages a supraspinal inhibition of thermal nociception in adult rats.

On the presence and functional significance of sympathetic premotor neurons with collateralized spinal axons in the rat.

Acceptability of a primary care-based opioid and pain review service: a mixed-methods evaluation in England.

Redefining Noradrenergic Neuromodulation of Behavior: Impacts of a Modular Locus Coeruleus Architecture.

Evaluation of a primary care-based opioid and pain review service: a mixed-methods evaluation in two GP practices in England.

Regulation of food intake by astrocytes in the brainstem dorsal vagal complex.

Interventions to treat pain in paediatric CFS/ME: a systematic review.

Locus coeruleus norepinephrine activity mediates sensory-evoked awakenings from sleep.

Probabilistic, spinally-gated control of bladder pressure and autonomous micturition by Barrington's nucleus CRH neurons.

Noradrenaline Release from Locus Coeruleus Terminals in the Hippocampus Enhances Excitation-Spike Coupling in CA1 Pyramidal Neurons Via β-Adrenoceptors.

Sweet taste does not modulate pain perception in adult humans.

Parallel cortical-brainstem pathways to attentional analgesia.

The effects of xenon on sevoflurane anesthesia-induced acidosis and brain cell apoptosis in immature rats.

Anatomically and functionally distinct locus coeruleus efferents mediate opposing effects on anxiety-like behavior.

The safety of anaesthetists and intensivists during the first COVID-19 surge supports extension of use of airborne protection PPE to ward staff.

Loss of cortical control over the descending pain modulatory system determines the development of the neuropathic pain state in rats.

Central pain modulatory mechanisms of attentional analgesia are preserved in fibromyalgia.

Identification of the source events for aerosol generation during oesophago-gastro-duodenoscopy.

Multisite silicon probes enable simultaneous recording of spontaneous and evoked activity in multiple isolated C-fibres in rat saphenous nerve.

Evaluating the association of TRPA1 gene polymorphisms with pain sensitivity: a protocol for an adaptive recall by genotype study.

Simultaneous brain, brainstem, and spinal cord pharmacological-fMRI reveals involvement of an endogenous opioid network in attentional analgesia.

Advancing respiratory-cardiovascular physiology with the working heart-brainstem preparation over 25 years.

Pro-opiomelanocortin neurons in the nucleus of the solitary tract mediate endorphinergic endogenous analgesia in mice.