Alvin C. Powers

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine

Affiliated withVanderbilt University School of Medicine Vanderbilt University Medical Center VA Tennessee Valley Healthcare System

Research Area

Biology

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2023

Other Publications

Article	Year
Compartmentalization of transport and phosphorylation of glucose in a hepatoma cell line. The Biochemical journal\| PubMed ID: 15473866	2005
Ascorbic acid recycling by cultured beta cells: effects of increased glucose metabolism. Free radical biology & medicine\| PubMed ID: 15477012	2004
Assessment of pancreatic islet mass after islet transplantation using in vivo bioluminescence imaging. Transplantation\| PubMed ID: 15818318	2005
Reovirus delays diabetes onset but does not prevent insulitis in nonobese diabetic mice. Journal of virology\| PubMed ID: 16501117	2006
Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression. Developmental biology\| PubMed ID: 16962573	2006
Glucose metabolism in vivo in four commonly used inbred mouse strains. Diabetes\| PubMed ID: 18398139	2008
Glucose-dependent blood flow dynamics in murine pancreatic islets in vivo. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 20071562	2010
Conditional gene targeting in mouse pancreatic ÃŸ-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes\| PubMed ID: 20802254	2010
Tamoxifen-Induced Cre-loxP Recombination Is Prolonged in Pancreatic Islets of Adult Mice. PloS one\| PubMed ID: 22470452	2012
Enhanced expression of VEGF-A in β cells increases endothelial cell number but impairs islet morphogenesis and β cell proliferation. Developmental biology\| PubMed ID: 22546694	2012
VEGF-A recruits a proangiogenic MMP-9-delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue. Blood\| PubMed ID: 22966168	2012
The MafA transcription factor becomes essential to islet β-cells soon after birth. Diabetes\| PubMed ID: 24520122	2014
Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding. Development (Cambridge, England)\| PubMed ID: 24574008	2014
β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. The Journal of clinical endocrinology and metabolism\| PubMed ID: 24712577	2014
β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. Diabetes care\| PubMed ID: 24812433	2014
Suppression of insulin production and secretion by a decretin hormone. Cell metabolism\| PubMed ID: 25651184	2015
Glucagon receptor inactivation leads to α-cell hyperplasia in zebrafish. The Journal of endocrinology\| PubMed ID: 26446275	2015
The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 26554594	2016
p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion. Nature medicine\| PubMed ID: 26950362	2016
Stress-impaired transcription factor expression and insulin secretion in transplanted human islets. The Journal of clinical investigation\| PubMed ID: 27064285	2016
Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function. Cell metabolism\| PubMed ID: 27133132	2016
Replicative capacity of β-cells and type 1 diabetes. Journal of autoimmunity\| PubMed ID: 27133598	2016
G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress. Endocrinology\| PubMed ID: 27300767	2016
Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas. Cell metabolism\| PubMed ID: 27732837	2016
Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity. Diabetologia\| PubMed ID: 27785529	2017
Signals in the pancreatic islet microenvironment influence β-cell proliferation. Diabetes, obesity & metabolism\| PubMed ID: 28880471	2017
Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling. The Journal of clinical investigation\| PubMed ID: 28920919	2017
Structural abnormalities in islets from very young children with cystic fibrosis may contribute to cystic fibrosis-related diabetes. Scientific reports\| PubMed ID: 29222447	2017
The obesity epidemic and rising diabetes incidence in a low-income racially diverse southern US cohort. PloS one\| PubMed ID: 29324894	2018
β-Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes. Diabetes\| PubMed ID: 30150306	2018
Use of human islets to understand islet biology and diabetes: progress, challenges and suggestions. Diabetologia\| PubMed ID: 30547228	2019
Gut-Proglucagon-Derived Peptides Are Essential for Regulating Glucose Homeostasis in Mice. Cell metabolism\| PubMed ID: 31495689	2019
Tacrolimus- and sirolimus-induced human β cell dysfunction is reversible and preventable. JCI insight\| PubMed ID: 31941840	2020
Pancreatic islet beta cell-specific deletion of G6pc2 reduces fasting blood glucose. Journal of molecular endocrinology\| PubMed ID: 32213654	2020
Integrated human pseudoislet system and microfluidic platform demonstrate differences in GPCR signaling in islet cells. JCI insight\| PubMed ID: 32352931	2020
Decreased pancreatic acinar cell number in type 1 diabetes. Diabetologia\| PubMed ID: 32388592	2020
Dapagliflozin Does Not Directly Affect Human α or β Cells. Endocrinology\| PubMed ID: 32428240	2020
SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells. Cell metabolism\| PubMed ID: 33207245	2020
RIPK3-mediated inflammation is a conserved β cell response to ER stress. Science advances\| PubMed ID: 33355143	2020
COVID-19 vaccine prioritisation for type 1 and type 2 diabetes. The lancet. Diabetes & endocrinology\| PubMed ID: 33476583	2021
Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33619103	2021
Type 1 diabetes mellitus: much progress, many opportunities. The Journal of clinical investigation\| PubMed ID: 33759815	2021
Coordinated interactions between endothelial cells and macrophages in the islet microenvironment promote β cell regeneration. NPJ Regenerative medicine\| PubMed ID: 33824346	2021
Distinguishing the real from the hyperglycaemia: does COVID-19 induce diabetes? The lancet. Diabetes & endocrinology\| PubMed ID: 33838106	2021
The Human Islet: Mini-Organ With Mega-Impact. Endocrine reviews\| PubMed ID: 33844836	2021
Endocrine toxicities of immune checkpoint inhibitors. Nature reviews. Endocrinology\| PubMed ID: 33875857	2021
What is a β cell? - Chapter I in the Human Islet Research Network (HIRN) review series. Molecular metabolism\| PubMed ID: 34416394	2021
Debates in Pancreatic Beta Cell Biology: Proliferation Versus Progenitor Differentiation and Transdifferentiation in Restoring β Cell Mass. Frontiers in endocrinology\| PubMed ID: 34421829	2021
Combinatorial transcription factor profiles predict mature and functional human islet α and β cells. JCI insight\| PubMed ID: 34428183	2021
Human islet T cells are highly reactive to preproinsulin in type 1 diabetes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 34611019	2021
Microvessels enhance vascularization and function of transplanted insulin-producing cells. Cell metabolism\| PubMed ID: 34731653	2021
Understanding islet dysfunction in type 2 diabetes through multidimensional pancreatic phenotyping: The Human Pancreas Analysis Program. Cell metabolism\| PubMed ID: 36206763	2022
Images From the Exeter Archival Diabetes Biobank Now Accessible via Pancreatlas. Diabetes care\| PubMed ID: 36239401	2022
AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics. bioRxiv : the preprint server for biology\| PubMed ID: 36712052	2023
Understanding cell fate acquisition in stem-cell-derived pancreatic islets using single-cell multiome-inferred regulomes. Developmental cell\| PubMed ID: 37040771	2023
Pancreatic islet α cell function and proliferation requires the arginine transporter SLC7A2. bioRxiv : the preprint server for biology\| PubMed ID: 37645716	2023
Exocrine pancreas in type 1 and type 2 diabetes: different patterns of fibrosis, metaplasia, angiopathy, and adiposity. Diabetes\| PubMed ID: 37881846	2023